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"Yan, Huang"
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Time-dependent Numerical Model for Studying the Very-high-energy Emissions of Distant Gamma-Ray Burst GRB 201216C
Recently, the MAGIC Collaboration reported a ∼5σ statistical significance of the very-high-energy (VHE) emission from a distant gamma-ray burst (GRB), GRB 201216C. Such distant GRB may be effectively absorbed by the extragalactic background light (EBL). The origin of the VHE emission from such distant objects is still unknown. Here, we propose a numerical model for studying the afterglow emission of this distant GRB. The model solves the continuity equation governing the temporal evolution of electron distribution, and the broadband observed data can be explained by the synchrotron plus synchrotron self-Compton (SSC) radiation of the forward shock. The predicted observed 0.1 TeV flux can reach ∼10−9−10−10 erg cm−2 s−1 at t ∼ 103−104 s, even with strong EBL absorption, such strong sub-teraelectronvolt (sub-TeV) emissions still can be observed by the MAGIC telescope. Using this numerical model, the shock parameters in the modeling are similar to two other sub-TeV GRBs (i.e., GRB 190114C and GRB 180720B), implying that the sub-TeV GRBs have some commonalities: they have energetic burst energy, low circumburst medium density, and a low magnetic equipartition factor. We regard GRB 201216C as a typical GRB, and estimate the maximum redshift of GRB that can be detected by the MAGIC telescope, i.e., z ∼ 1.6. We also find that the VHE photon energy of such distant GRB can only reach ∼0.1 TeV. Improving the low energy sensitivity of the VHE telescope is very important to detect the sub-TeV emissions of these distant GRBs.
Journal Article
Fujian's \Tulou\ : a treasure of Chinese traditional civilian residence
This book analyzes a large number of typical tulou buildings and compact communities in detail, and painstakingly studies the way of life practiced in these communities, their defense systems, building techniques, spatial features, antithetical couplets culture, and historical origins. As such, it offers readers access to a unique treasure of traditional civilian residence, while also representing a valuable asset for architects and researchers in architectural history, cultural relics and fine arts.
Book
Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis
Background
Exosomes play crucial roles in regulating the crosstalk between normal and cancer cells in the tumor microenvironment, and in regulating cancer proliferation, migration and invasion through their cargo molecules.
Methods
We analyzed the pro-invasiveness of exosomal circRNA-100,338 in HCC using the transwell invasion assay. The co-culture of human umbilical vein endothelial cells (HUVEC) and exosomes derived from HCC cell lines were used to evaluate the impact of HCC derived exosomes on HUVEC. Nude mice models were used to validate the findings in vitro. Clinically, quantitative RT-PCR was used to quantify the expression of serum exosomal circRNA-100,338 in HCC patients at both pre-surgery within one week and post-surgery within three weeks.
Results
We aim to investigate the pro-invasive role of exosomal circRNA-100,338 in HCC metastasis. We for the first time demonstrated that circRNA-100,338 was highly expressed in both highly metastatic HCC cells and their secreted exosomes. The transwell invasion assay showed that the overexpression or knockdown of exosomal circRNA-100,338 significantly enhanced or reduced the invasive abilities of HCC cells. Subsequently, in vitro and in vivo assays showed that exosomal circRNA-100,338 affected the cell proliferation, angiogenesis, permeability, and vasculogenic mimicry (VM) formation ability of human umbilical vein endothelial cells (HUVEC), and tumor metastasis. Furthermore, we also observed that the persistent high expression of exosomal circRNA-100,338 in serum of HCC patients who underwent curative hepatectomy may be a risk indicator of pulmonary metastasis and poor survival.
Conclusions
Our findings indicated that metastatic ability of HCC cells could be enhanced by transferring exosomal circRNA-100,338 to recipient HUVECs, which could affect proangiogenic activity by regulating angiogenesis.
Journal Article
معجم أوكسفورد للتداولية
يتميز (معجم أكسفورد للتداولية) بأنه معجم متخصص حاول مؤلفه أن يزود القارئ بشرح وتفسير شامل وحديث لكل مصطلحات التداولية. يشكل المعجم اهتماما بصورة أساسية لطلبة الدراسة الأولية والدراسات العليا الذين يتخصصون في اللسانيات ممن ليس لديهم خلفية سابقة، وهو سيكون مناسبا للطلاب الذين يختارون مادة اللسانيات بوصفها جزءا من المنهج المقرر لشهادة في اللغة أو العلوم الإنسانية أو العلوم الاجتماعية. وكذلك للباحثين في مجالات فلسفة اللغة، وسوسيولوجيا التفاعل وسايكولوجيته، وعلم الإنسان (الأنثربولوجيا) وعلم الإدراك المعرفي، والذكاء الاصطناعي، وعلم الأعصاب وعلم الأمراض اللغوية فضلا عن اللسانيات.
REF-BOOK
Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy
Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms’ composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.
Journal Article
Different Treatments on the Physicochemical Properties and Volatile Components of Tea Wine During Storage Period
Tea wine has garnered significant attention due to its unique fusion of tea and wine flavors, as well as its alleged health benefits. This study aimed to investigate the effects of various treatments on the physicochemical properties of tea wine, including viable cell counts, pH, acidity, total ester content, tea polyphenol content, and volatile flavoring substances during the storage period. The findings indicated that tea wine subjected to low-temperature plasma (LTPS) treatment exhibited superior quality maintenance and an enhanced tea polyphenol content compared to untreated, UV-treated, and HTHP-treated tea wine. Analysis of volatile compounds revealed that the LTPS group exhibited the highest relative content of alcohols and esters (89.72%) during storage, thereby enhancing the fruity and sweet aroma of the tea wine. This study provides a theoretical basis for the application of low-temperature plasma technology in the storage of tea wine.
Journal Article
An all-inorganic three-dimensional polyoxoniobate framework with ppb-level chemiresistive sensing for ammonia
Fabrication of gas sensors with high sensibility appears particularly important due to the urgent demand for toxic gases monitoring in public safety and atmosphere detection, especially for the detection requirement of ultra-low concentration gases. Here, we present a rare three-dimensional (3D) all-inorganic polyoxoniobate (PONb) framework based on {Cu
4
@Nb
29
} secondary building units linked with both tetranuclear {Cu
4
(OH)
5
} clusters and mononuclear [Cu(H
2
O)]
2+
units. Remarkably, this 3D PONb framework exhibits an ultrasensitive response to NH
3
with a lowest limit of detection of 1.64 ppt up to now. Furthermore, the NH
3
induced single-crystal-to-single-crystal transformation as well as density functional theory analysis reveal that the strong coordination affinity of [Cu(H
2
O)]
2+
linker for NH
3
, along with more injection of charge into the framework, results in a ultrasensitivity chemiresistive responses to NH
3
, at atomic-level insight.
This paper presents a rare all-inorganic three-dimensional polyoxoniobate framework with high stability, exhibiting sensitive response to NH
3
at room temperature with a low limit of detection of 1.64 ppt.
Journal Article
Ligustrazine monomer against cerebral ischemia/ reperfusion injury
Ligustrazine （2,3,5,6-tetramethylpyrazine） is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mecha- nism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present. This study summarizes its protective effect, the optimum time window of administra- tion, and the most effective mode of administration for clinical treatment of cerebral ischemia/ reperfusion injury. We examine the effects of ligustrazine on suppressing excitatory amino acid release, promoting migration, differentiation and proliferation of endogenous neural stem cells. We also looked at its effects on angiogenesis and how it inhibits thrombosis, the inflammatory response, and apoptosis after cerebral ischemia. We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury. The time window of ligustrazine admin- istration is limited. The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[（1,1-dimethylethyl）oxidoimino]methyl]-3,5,6-trimethylpyrazine, CXC137 and CXC 195 after cerebral ischemia were better than ligustrazine.
Journal Article
Biological Control Strategies for Mosquito Vectors of Arboviruses
Historically, biological control utilizes predatory species and pathogenic microorganisms to reduce the population of mosquitoes as disease vectors. This is particularly important for the control of mosquito-borne arboviruses, which normally do not have specific antiviral therapies available. Although development of resistance is likely, the advantages of biological control are that the resources used are typically biodegradable and ecologically friendly. Over the past decade, the advancement of molecular biology has enabled optimization by the manipulation of genetic materials associated with biological control agents. Two significant advancements are the discovery of cytoplasmic incompatibility induced by Wolbachia bacteria, which has enhanced replacement programs, and the introduction of dominant lethal genes into local mosquito populations through the release of genetically modified mosquitoes. As various arboviruses continue to be significant public health threats, biological control strategies have evolved to be more diverse and become critical tools to reduce the disease burden of arboviruses.
Journal Article