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Introduction and hypothesisIn the present study, we aimed to compare the efficacy and safety of quinolones with trimethoprim-sulfamethoxazole (TMP/SMX), nitrofurantoin, fosfomycin, and β-lactams for the treatment of uncomplicated urinary tract infections (UTIs) in adults.MethodsAll controlled clinical trials assessing quinolones for uncomplicated UTIs in adults were searched from PubMed, Embase, and Cochrane Library databases. Meta-analyses were used to evaluate the efficacy and safety in randomized controlled trials (RCTs).ResultsA total of 47 RCTs consisting of 8992 patients were included in the present analysis. The clinical and bacteriological remission rates of quinolones were significantly higher (P < 0.01) compared with β-lactams and nitrofurantoin, while quinolones showed similar clinical and bacteriological remission rates compared with TMP/SMX and fosfomycin. Moreover, the bacterial resistance and relapse rates of quinolones were significantly lower (P < 0.01) compared with TMP/SMX, β-lactams, and nitrofurantoin. Regarding the adverse drug reactions (ADRs), quinolones did not bring higher risks, while the incidence of ADRs in the quinolone group was also even significantly lower (P < 0.01) compared with the TMP/SMX and nitrofurantoin groups, including the most reported ADRs associated with the gastrointestinal tract.ConclusionsCompared with other anti-UTI drugs, quinolones exerted an excellent effect on clinical remission and bacteriological eradication, and the application of quinolones did not bring a higher risk of ADRs.

In naval and ocean engineering, accurate simulation of incident waves is essential for predicting the motion response of offshore structures. Traditional wave generation methods, such as piston- and flap-type wave makers, often face challenges in accurately replicating the orbital motion of water particles beneath the free surface, which can limit their applicability in high-fidelity simulations. In this study, a numerical investigation is conducted to compare the performance of piston-type, flap-type, and double-flap-type wave makers using STAR-CCM+2310(18.06.006-R8). The influence of water depth on wave height accuracy is evaluated across different measurement locations within a numerical wave tank. Theoretical analysis of wave generation mechanisms is incorporated to clarify the applicability limits of linear theory and to better interpret the numerical results. Results indicate that, under the tested two-dimensional CFD conditions, the double-flap-type wave maker tended to provide closer agreement with theoretical predictions, particularly at greater depths, compared with conventional methods. These findings suggest potential advantages of the double-flap configuration and provide insights for refining wave generation techniques in numerical and experimental wave tanks, thereby supporting more reliable hydrodynamic analyses of floating structures.

The antibiotic‐resistant Klebsiella pneumoniae (Kp) has become a significant crisis in treating pneumonia. Low‐frequency ultrasound (LFU) is promising to overcome the obstacles. Mice were infected with bioluminescent Kp Xen39 by intratracheal injection to study the therapeutic effect of LFU in combination with antibiotics. The counts per second (CPS) were assessed with an animal biophoton imaging system. Bacterial clearance, histopathology, and the concentrations of cytokines were determined to evaluate the therapeutic effect. LC–MS/MS was used to detect the distribution of antibiotics in the lung and plasma. LFU in combination with meropenem (MEM) or amikacin (AMK) significantly improved the behavioural state of mice. The CPS of the LFU combination group were more significantly decreased compared with those of the antibiotic alone groups. The average colony‐forming units of lung tissue in the LFU combination groups were also lower than those of the antibiotic groups. Although no significant changes of cytokines (IL‐6 and TNF‐α) in plasma and bronchoalveolar lavage fluid were observed, LFU in combination with antibiotics showed less inflammatory damage from histopathological results compared with the antibiotic‐alone groups. Moreover, 10 min of LFU treatment promoted the distribution of MEM and AMK in mouse lung tissue at 60 and 30 min, respectively, after dosage. LFU could enhance the effectiveness of MEM and AMK in the treatment of Kp‐induced pneumonia, which might be attributed to the fact that LFU could promote the distribution of antibiotics in lung tissue and reduce inflammatory injury. In the present in vivo study, we provide evidence showing that LFU can improve the efficacy of meropenem (MEM) or amikacin (AMK) in Kp pneumonia model. LFU combined with antibiotics significantly improved the survival state of mice, decrease the counts per second (CPS), accelerated the clearance of bacteria and reduced inflammatory injury of lung. The application of LFU in the treatment of pulmonary infection may have far‐reaching significance.

Recently, smart port systems connected to autonomous ships have attracted increasing interest. Thus, an intelligent port system can automatically berth to create an intelligent port system. To ensure the safety of large ships moored in open coastal terminals, which are often subjected to bad weather such as strong winds, it is necessary to calculate and evaluate their mooring security on a case-by-case basis. In this study, the mooring capacities of the large ships were estimated according to the port and fishing port design criteria of the Ministry of Ocean and Fisheries. Under the wind speed of 14 m/s, the longitudinal and lateral forces acting on the JBC, KCS, and KVLCC ships are 41.2 and 340 kN, 38.7 and 837 kN, and 77.2 and 222 kN, while under the wind speed of 30 m/s, they are 43 and 1674 kN, 132.7 and 4118 kN, and 159.2 and 1091 kN, respectively, for the mooring forces.

Compared with the traditional mooring system, the automated vacuum mooring system can meet the development needs of large-scale ship automation, port automation, and environmental protection. This review describes the latest research focuses, progress, applications, and future perspectives regarding the automated vacuum mooring system. First, the components, working principles, advantages, limits, and risks of the automated vacuum mooring system are discussed. Secondly, typical application cases of automated vacuum mooring systems are introduced, looking at two aspects of the ship-based system and shore-based system. Then, the routine maintenance of the automated vacuum mooring system is introduced. Finally, a discussion on the challenges and future perspectives of the automated vacuum mooring system is provided in this review. The advantages of an automated vacuum mooring system make it a potentially highly effective and economical option for a wider range of ship mooring than a traditional mooring system.

Regular inspections and hull cleanings are essential to prevent bio-fouling on ships. However, traditional cleaning methods such as brush cleaning and high-pressure water-jet cleaning at docks are ineffective in cleaning niche areas like bow thrusters and sea chests. Consequently, cleaning robots based on brushes and water jets have been developed to effectively remove bio-fouling. However, there are concerns that brushes may damage hull coatings, allowing bio-fouling to penetrate the damaged areas. In this study, removal experiments were conducted to identify the most dominant factor in fouling removal using water jet-based cleaning, in preparation for the development of non-contact cavitation high-pressure water jet-cleaning robots. The Taguchi method was used to identify influential factors and generate experimental conditions, and equipment systems for the removal experiments were established. Image analysis was performed to assess the bio-fouling occurrences on each specimen before and after cleaning, and numerical simulations of the nozzle were conducted to estimate stagnation pressure and wall shear stress to confirm the effect on micro-fouling removal. The results indicated that pump pressure is the most influential factor in removing large bio-fouling organisms grown in marine environments and on ship surfaces.

Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that plays a vital role in promoting fracture healing, wound repair, immunomodulation, and reducing inflammation. Its anti-inflammatory effects are manifested by decreased pro-inflammatory cytokines and chemokines, accelerated regression of immune cell invasion, and accelerated damage repair. Although the anti-inflammatory mechanism of LIPUS is not very clear, many in vitro and in vivo studies have shown that LIPUS may play its anti-inflammatory role by activating signaling pathways such as integrin/Focal adhesion kinase (FAK)/Phosphatidylinositol 3-kinase (PI3K)/Serine threonine kinase (Akt), Vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS), or inhibiting signaling pathways such as Toll-like receptors (TLRs)/Nuclear factor kappa-B (NF-κB) and p38-Mitogen-activated protein kinase (MAPK). As a non-invasive physical therapy, the anti-inflammatory and immunomodulatory effects of LIPUS deserve further exploration.

Abstract Background In the present study, we aimed to compare the efficacy and safety of plazomicin with comparators for the treatment of Enterobacterales infections. Methods Randomized controlled trials (RCTs) assessing plazomicin for Enterobacterales infections were searched on the PubMed, Embase, and Cochrane Library databases. Meta-analyses were used to evaluate the efficacy and safety in RCTs. Results A total of 3 RCTs consisting of 761 patients were included in the present analysis. The study population included complex urinary tract infections (cUTIs), bloodstream infections (BSIs), and hospital-acquired pneumonia (HAP). Plazomicin had a clinical remission rate in the modified intention-to-treat (MITT) population that was similar to that of comparators (odds ratio [OR], 1.02; 95% CI, 0.60–1.73; I2 = 45%) in the pooled analysis of the 3 studies. The overall microbiologic eradication rate in the microbiological MITT (mMITT) population was similar to that of the comparators group (OR, 1.46; 95% CI, 0.72–2.95; I2 = 0%). However, the microbiologic recurrence rate of plazomicin for Enterobacterales was lower than that in the comparators group (OR, 0.38; 95% CI, 0.17–0.86; P = .02; I2 = 0%). No significant differences were found between plazomicin and comparators for the risk of any adverse events (OR, 0.78; 95% CI, 0.55–1.11; I2 = 0%). Conclusions Plazomicin is as good as comparators in terms of efficacy and tolerance in the treatment of Enterobacterales infections. Therefore, plazomicin is a suitable choice for antibiotic treatment in adult patients with cUTIs, BSIs, or HAP.

The availability of graphene and other two-dimensional (2D) materials on a wide range of substrates forms the basis for large-area applications, such as graphene integration with silicon-based technologies, which requires graphene on silicon with outperforming carrier mobilities. However, 2D materials were only produced on limited archetypal substrates by chemical vapor deposition approaches. Reliable after-growth transfer techniques, that do not produce cracks, contamination, and wrinkles, are critical for layering 2D materials onto arbitrary substrates. Here we show that, by incorporating oxhydryl groups-containing volatile molecules, the supporting films can be deformed under heat to achieve a controllable conformal contact, enabling the large-area transfer of 2D films without cracks, contamination, and wrinkles. The resulting conformity with enhanced adhesion facilitates the direct delamination of supporting films from graphene, providing ultraclean surfaces and carrier mobilities up to 1,420,000 cm 2 V −1 s −1 at 4 K. Reliable transfer techniques are critical for the integration of 2D materials with arbitrary substrates. Here, the authors describe a method to transfer 4-inch and A4-sized defect-free graphene films onto rigid and flexible substrates with controllable conformal contact, leading to improved electrical properties and uniformity.

Cancer stemness represents a major source of development and progression of colorectal cancer (CRC). c-Met critically contributes to CRC stemness, but how c-Met is activated in CRC remains elusive. We previously identified the lipolytic factor ABHD5 as an important tumour suppressor gene in CRC. Here, we show that loss of ABHD5 promotes c-Met activation to sustain CRC stemness in a non-canonical manner. Mechanistically, we demonstrate that ABHD5 interacts in the cytoplasm with the core subunit of the SET1A methyltransferase complex, DPY30, thereby inhibiting the nuclear translocation of DPY30 and activity of SET1A. In the absence of ABHD5, DPY30 translocates to the nucleus and supports SET1A-mediated methylation of YAP and histone H3, which sequesters YAP in the nucleus and increases chromatin accessibility to synergistically promote YAP-induced transcription of c-Met, thus promoting the stemness of CRC cells. This study reveals a novel role of ABHD5 in regulating histone/non-histone methylation and CRC stemness. This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.