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The transcultural streams of Chinese Canadian identities
\"Highlighting the geopolitical and economic circumstances that have prompted migration from Hong Kong and mainland China to Canada, The Transcultural Streams of Chinese Canadian Identities examines the Chinese Canadian community as a simultaneously transcultural, transnational, and domestic social and cultural formation. Essays in this volume argue that Chinese Canadians, a population that has produced significant cultural imprints on Canadian society, must create and constantly redefine their identities as manifested in social science, literary, and historical spheres. These perpetual negotiations reflect social and cultural ideologies and practices and demonstrate Chinese Canadians&' recreations of their self-perception, self-expression, and self-projection in relation to others. Contextualized within larger debates on multicultural society and specific Chinese Canadian cultural experiences, this book considers diverse cultural presentations of literary expression, the “model minority” and the influence of gender and profession on success and failure, the gendered dynamics of migration and the growth of transnational (“astronaut”) families in the 1980s, and inter-ethnic boundary crossing. Taking an innovative approach to the ways in which Chinese Canadians adapt to and construct the Canadian multicultural mosaic, The Transcultural Streams of Chinese Canadian Identities explores various patterns of Chinese cultural interchanges in Canada and how they intertwine with the community's sense of disengagement and belonging.\"-- Provided by publisher.
Book
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of human cancer. Transcriptional dysregulation of SCC cells is orchestrated by
tumor protein p63 (TP63)
, a master transcription factor (TF) and a well-researched SCC-specific oncogene. In the present study, both Gene Set Enrichment Analysis (GSEA) of SCC patient samples and in vitro loss-of-function assays establish fatty-acid metabolism as a key pathway downstream of TP63. Further studies identify
sterol regulatory element binding transcription factor 1 (SREBF1)
as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics. Moreover, a feedback co-regulatory loop consisting of SREBF1/TP63/
Kruppel like factor 5 (KLF5)
is identified, which promotes overexpression of all three TFs in SCCs. Downstream of SREBF1, a non-canonical, SCC-specific function is elucidated: SREBF1 cooperates with TP63/KLF5 to regulate hundreds of cis-regulatory elements across the SCC epigenome, which converge on activating cancer-promoting pathways. Indeed, SREBF1 is essential for SCC viability and migration, and its overexpression is associated with poor survival in SCC patients. Taken together, these data shed light on mechanisms of transcriptional dysregulation in cancer, identify specific epigenetic regulators of lipid metabolism, and uncover SREBF1 as a potential therapeutic target and prognostic marker in SCC.
The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathway regulation.
Journal Article
Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment
The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze the microenvironment of esophageal squamous cell carcinoma (ESCC) using single-cell transcriptome sequencing in 62,161 cells from blood, adjacent nonmalignant and matched tumor samples from 11 ESCC patients. We uncover heterogeneity in most cell types of the ESCC stroma, particularly in the fibroblast and immune cell compartments. We identify a tumor-specific subset of CST1
+
myofibroblasts with prognostic values and potential biological significance. CST1
+
myofibroblasts are also highly tumor-specific in other cancer types. Additionally, a subset of antigen-presenting fibroblasts is revealed and validated. Analyses of myeloid and T lymphoid lineages highlight the immunosuppressive nature of the ESCC microenvironment, and identify cancer-specific expression of immune checkpoint inhibitors. This work establishes a rich resource of stromal cell types of the ESCC microenvironment for further understanding of ESCC biology.
The microenvironment of oesophageal squamous cell carcinomas (ESCC) is heterogeneous and can strongly impact response to treatment. Here, the authors characterize the ESCC tumour microenvironment with single-cell RNA-seq, finding CST1 + myofibroblasts with potential biological and prognostic significance as well as immunosuppression signatures.
Journal Article
الاستراتيجيات العسكرية في الصين القديمة
يدور موضوع الكتاب حول \"الاستراتيجيات العسكرية في الصين القديمة\" هذا العنوان يدخل في حقل الكتب العسكرية أو ما يعرف بـ (الأدب العسكري) وهو حسب مؤلفه الصيني \"لي تشينغ بين\" أحد أعظم ميراث ثقافي للأمة الصينية، أدب غني بالدلالات الثقافية والمزايا الفريدة التي تعرف إليها المؤلف بعد أن بحث في الأدب العسكري القديم في بلاده بما في ذلك أحد أعظم أعماله وهي فن الحرب لما يفوق الثلاثين عاما. لقد صرح أن هذا الأدب يتمتع بحكمة كبيرة، واستراتيجيات بالإضافة إلى مفاتيح النجاح ويمكن أن يتم الرجوع إلى الكتب العسكرية القديمة لتقييم الاستراتيجيات الفعالة من قبل العديد من الأشخاص، بمن فيهم القادة العسكريون، السياسيون، الدبلوماسيون، رجال الأعمال، وحتى الناس العاديون. ولأن الكتب العسكرية تلعب دور ناقل الثقافة، لذلك، يفترض المؤلف أنه من الأفضل لكل شخص متعلم أن يقرأ هذا النوع من الكتب بغض النظر عن مهنته. كتاب \"الاستراتيجيات العسكرية في الصين القديمة\" هو نقطة في بحر العدد الهائل من الكتب الصينية الكلاسيكية القديمة بالإضافة للأدب العسكري العميق، لقد اختار المؤلف ما يزيد عن ثلاثمائة بند في ثمانين كتابا عسكريا قديما وأضاف الشروحات الصينية والترجمات الإنجليزية المتوافقة في هذا الكتاب بهدف مساعدة القراء في فهم ودراسة الأدب العسكري القديم. يتضمن هذا الكتاب ترجمة الأصل الإنجليزي \"Military Strategies in Ancient China\" نقلته إلى العربية نهى حسن ويأتي باللغتين العربية والصينية مما يسهم في تعلم اللغة الصينية للناطقين بالضاد.
Book
The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018
Purpose
We aimed to explore the relationship between the systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018.
Methods
We collected data from the NHANES database from 1999 to 2018. The SII is calculated from the counts of lymphocytes (LC), neutrophils (NC), and platelets (PC). The RA patients were derived from questionnaire data. We used weighted multivariate regression analysis and subgroup analysis to explore the relationship between SII and RA. Furthermore, the restricted cubic splines were used to explore the non-linear relationships.
Result
Our study included a total of 37,604 patients, of which 2642 (7.03%) had rheumatoid arthritis. After adjusting for all covariates, the multivariate logistic regression analysis showed that high SII (In-transform) levels were associated with an increased likelihood of rheumatoid arthritis (OR=1.167, 95% CI=1.025–1.328,
P
=0.020). The interaction test revealed no significant effect on this connection. In the restricted cubic spline regression model, the relationship between ln-SII and RA was non-linear. The cutoff value of SII for RA was 578.25. The risk of rheumatoid arthritis increases rapidly when SII exceeds the cutoff value.
Conclusion
In general, there is a positive correlation between SII and rheumatoid arthritis. Our study shows that SII is a novel, valuable, and convenient inflammatory marker that can be used to predict the risk of rheumatoid arthritis in US adults.
Journal Article
The use of educational psychology-based STEAM education concept in the development of English curriculum resources
The traditional teaching methods are difficult to conform to students’ ways of thinking and hard to meet teachers’ teaching demands. This work studies the teaching philosophy of Sciences, Technology, Engineering, Arts, and Mathematics (STEAM), a practice-oriented interdisciplinary education concept. This work focuses on the psychology of high school students’ English learning, emphasizing their learning interests and English evaluation criteria. It also introduces the STEAM education concept through task planning projects. In addition, the n-gram English learning evaluation model is integrated with the STEAM education concept. The proposed model cultivates senior high school students’ innovative thinking and comprehensive innovation ability. The analysis indicates that students’ innovative thinking has been enhanced across five aspects: flexibility, independence, openness, sophistication, and critical thinking. Moreover, their innovation ability is promoted through independent planning, novel method design, rich content, and comprehensive innovation. Therefore, the proposed STEAM model can provide students with a way of thinking in innovative education.
Journal Article
Apatinib combined with oral etoposide in patients with platinum-resistant or platinum-refractory ovarian cancer (AEROC): a phase 2, single-arm, prospective study
Anti-angiogenic therapy combined with chemotherapy could improve the outcomes of patients with platinum-resistant ovarian cancer. Apatinib is an oral tyrosine kinase inhibitor that selectively inhibits VEGF receptor 2. We assessed the efficacy and safety of the combination therapy of apatinib and oral etoposide, considering the potential advantage of home administration without hospital admission, in patients with platinum-resistant or platinum-refractory ovarian cancer.
In this phase 2, single-arm, prospective study, we recruited patients aged 18–70 years with platinum-resistant or platinum-refractory ovarian cancer at the Sun Yat-sen University Cancer Center (China). The treatment consisted of apatinib at an initial dose of 500 mg once daily on a continuous basis, and oral etoposide at a dose of 50 mg once daily on days 1–14 of a 21-day cycle. Oral etoposide was administered for a maximum of six cycles. Treatment was continued until disease progression, patient withdrawal, or unacceptable toxic effects. The primary endpoint was the proportion of patients achieving an objective response according to Response Evaluation Criteria in Solid Tumors, version 1.1. We used Simon's two-stage design, and analysed efficacy in the intention-to-treat and per-protocol populations. Safety analyses included enrolled patients who had received at least one dose of study medication, but excluded those without any safety data. This study is registered with ClinicalTrials.gov, number NCT02867956.
Between Aug 10, 2016, and Nov 9, 2017, we screened 38 and enrolled 35 patients. At the data cutoff date (Dec 31, 2017), 20 (57%) patients had discontinued the study, and 15 (43%) patients remained on treatment. Objective responses were achieved in 19 (54%; 95% CI 36·6–71·2) of 35 patients in the intention-to-treat population and in 19 (61%; 42·2–78·2) of 31 patients in the per-protocol population. The most common grade 3 or 4 adverse events were neutropenia (17 [50%]), fatigue (11 [32%]), anaemia (ten [29%]), and mucositis (eight [24%]). Serious adverse events were reported in two patients who were admitted to hospital (one patient had anaemia and anorexia; the other patient had increased ascites due to disease progression). No treatment-related deaths were recorded.
The combination of apatinib with oral etoposide shows promising efficacy and manageable toxicities in patients with platinum-resistant or platinum-refractory ovarian cancer, and further study in phase 3 trials is warranted.
None.
Journal Article