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يناقش الكتاب سلسلة من الإيضاحات الهامة قدمها الرئيس الصيني والأمين العام للجنة المركزية للحزب الشيوعي الصيني، شي جين بينغ، وتدور حول أفكار الإصلاح وتوسيع الانفتاح على نحو شامل في الصين. يضم الكتاب أكثر من 70 وثيقة هامة على صورة كلمات شي جين بينغ وخطاباته وتعليقاته وتوجيهاته وينقسم الكتاب إلى 12 موضوعا خاصا تتضمن 274 قطعة من مقتطفات الأقوال، نشر بعضها لأول مرة.

Background Patients with coexisting type 2 diabetes and hypertension generally exhibit poor adherence to self-management, which adversely affects their disease control. Therefore, identification of the factors related to patient adherence is warranted. In this study, we aimed to examine (i) the socio-demographic correlates of patient adherence to a set of self-management behaviors relevant to type 2 diabetes and hypertension, namely, medication therapy, diet therapy, exercise, tobacco and alcohol avoidance, stress reduction, and self-monitoring/self-care, and (ii) whether health attitudes and self-efficacy in performing self-management mediated the associations between socio-demographic characteristics and adherence. Methods We performed a secondary analysis of data collected in a randomized controlled trial. The sample comprised 148 patients with coexisting type 2 diabetes mellitus and hypertension. Data were collected by a questionnaire and analyzed using logistic regression. Results Female patients were found to be less likely to exercise regularly (odds ratio [OR] = 0.49, P  = 0.03) and more likely to avoid tobacco and alcohol (OR = 9.87, P  < 0.001) than male patients. Older patients were found to be more likely to adhere to diet therapy (OR = 2.21, P  = 0.01) and self-monitoring/self-care (OR = 2.17, P  = 0.02). Patients living with family or others (e.g., caregivers) were found to be more likely to exercise regularly (OR = 3.44, P  = 0.02) and less likely to avoid tobacco and alcohol (OR = 0.10, P  = 0.04) than those living alone. Patients with better perceived health status were found to be more likely to adhere to medication therapy (OR = 2.02, P  = 0.03). Patients with longer diabetes duration (OR = 2.33, P  = 0.01) were found to be more likely to adhere to self-monitoring/self-care. Self-efficacy was found to mediate the association between older age and better adherence to diet therapy, while no significant mediating effects were found for health attitudes. Conclusions Adherence to self-management was found to be associated with socio-demographic characteristics (sex, age, living status, perceived health status, and diabetes duration). Self-efficacy was an important mediator in some of these associations, suggesting that patient adherence may be improved by increasing patients’ self-management efficacy, such as by patient empowerment, collaborative care, or enhanced patient–physician interactions.

PurposeE-commerce live streaming is a new influencer advertising method that allows influencers to interact directly with consumers on e-commerce platforms. Although evidence suggests that influencer live-streaming advertisements (ads) on social media can increase consumers’ buying impulses, little research examined how this similar but new advertising method on e-commerce platforms may influence consumers’ urge to buy impulsively. This study explores the role of influencer credibility, celebrity effect, perceived entertainment, trust and perceived usefulness on consumers’ attitudes toward influencer ads and their urge to buy impulsively.Design/methodology/approachA questionnaire containing seven constructs was developed and distributed to participants using a convenient sample and snowball sampling approach. The constructs were measured based on validated measurement items from the literature and adjusted according to this study’s focus. A total of 236 valid responses were obtained from the survey and used for data analysis. A partial least squares structural equation modeling approach was employed for parameter estimation and model testing.FindingsThe empirical results show that all constructs influenced consumers’ urge to buy impulsively via attitude toward influencer ads. The proposed research model explains 61.7% of the variance in attitude toward influencer ads and 19.4% of the urge to buy impulsively.Originality/valueThis is an early study investigating the relationship between influencer advertising and impulse buying. The results provide valuable insights into improving the design of influencer ads and marketing strategies.HighlightsI-eIB model tests the mechanism of influencer ads on consumers’ buying impulse.Consumers’ attitude towards influencer ads affects their urge to buy impulsively.Influencer credibility affects consumer attitude via celebrity effect as a mediator.Trust affects consumer attitude via perceived usefulness as a mediator.Entertaining ads help develop favorable consumer attitude.

Online medical consultation (OMC) is generating considerable interest among researchers and practitioners due to the mandatory quarantine measures implemented during the COVID-19 pandemic in China. However, the acceptance rate of OMC has declined over time. This paper aims to empirically investigate OMC acceptance using a proposed research model by integrating the technology acceptance model (TAM) with trust and its antecedent variables. A quantitative self-administered cross-sectional survey was conducted to collect data from 260 healthcare consumers. A partial least squares structural equation modeling method was used to examine the data. Results revealed that healthcare consumers’ behavioral intention was influenced by attitudes, while perceived usefulness and trust significantly influenced behavioral intention through attitude as a mediator. In addition, perceived risk, perceived privacy protection, network externalities, cognitive reputation, and interactivity directly influenced trust. Overall, the research model explained 50% of the variance in attitude and 71% of the variance in behavioral intention. The study’s findings should provide useful insights into making effective design, development, and implementation decisions for OMC services.

The Hailar-Tamtsag Basin is a typical rift basin where two sets of regional caprocks are developed, i.e., mudstone caprocks （containing a small amount of tuff） developed in strong rifting stage and fault-depression stage, respectively. The caprocks have a cumulative thickness of 50-120 m in general, and a single-layer thickness of 20-50 m, interbedded with sandstone about 1-2 m thick. The large set of mudstone is distributed continuously, as pure mudstone caprock. Forty-three mudstone and tuff samples were taken to perform displacement pressure test with our independently developed displacement pressure tester. Test result shows that the displacement pressure is 0.04-10.00 MPa, which is equivalent to 0.09-20.01 MPa after being cor- rected to the actual burial depth. As the burial depth increases, the displacement pressure rises gradually, and is 1-10 times greater than that of oil-bearing sandstone or conglomerate reservoir at the same burial depth. The difference between dis- placement pressure of mudstone caprock and sandstone or conglomerate reservoir increases greatly if the burial depth exceeds 1000 m. Because of the displacement pressure difference between caprock and reservoir, the maximum height of hydrocarbon column sealed by the caprock ranges from 300 m to 2000 m, much higher than the height of the trap closure at the same burial depth. No hydrocarbons will leak through such caprocks. Analysis of the reservoir GOI, homogeneous temperature, and crude maturity of both deep and shallow reservoirs in Well Wu-20 in the Wuerxun Depression shows that Damoguaihe II Member reservoir is a secondary reservoir developed during adjustment of early reservoir. It is mainly distributed in inverted structures. Faulting is one of the main factors breaking the integrity of caprocks. Three kinds of faults are often related to the migration of hydrocarbons across regional caprocks： the first type refers to the positive inverted faults breaking the early sealing conditions and making the hydrocarbons accumulated in the early period re-migration; the second type refers to the faults with shear mudstone smear structures which lose their continuity and open vertically when the fault throws exceed 5 times of the mud- stone thickness; the third type refers to the normal faults developed in the structural inversion stage, which have a typical cata- clastic structure and are easy to cause vertical migration of hydrocarbons. Hydrocarbon enriched horizons of the rift basins are co-controlled by ＂fault-caprock＂. Specifically, 95% of the geological reserve is controlled by regional caprocks, and only 5% is controlled by open faults, secondary oil/gas reservoirs are developed over regional caprocks.

Aim： Microvesicles （MVs） are nanoscale membrane fragments released from virtually all cell types upon activation or apoptosis, and may contribute to the beneficial effects of stem cell therapy. In this study, we investigated the therapeutic effects of mesenchymal stem cell （MSC） derived MVs （MSC-MVs） on pulmonary artery hypertension （PAH） in rats. Methods： MSC-MVs were isolated from rat bone marrow MSCs that were cultured in a serum-free conditioned medium. Transmission electron microscopy （TEM）, flow cytometry and nanoparticle tracking analysis （NTA） were used to characterize the MVs. Adult SD rats were injected with monocrotaline （50 mg/kg, sc） to induce PAH. Three weeks later, the rats were intravenously injected with MSCs, MSC-MVs or saline for 2 weeks. At the end of treatments, the hemodynamic parameters and pathological right ventricular and pulmonary arterial remodeling were analyzed in each group. Results： The MSC-MVs showed general morphologic characteristics of MVs and expressed annexin V and CD29 markers under TEM, and their size ranged from 40 to 300 nm. Intravenous injection of MSC-MVs or MSCs significantly ameliorated the mean pulmonary artery pressure （mPAP） and mean right ventricle pressure （mRVP） in PAH rats. Furthermore, intravenous injection of MSC-MVs or MSCs significantly decreased the right ventricle （RV） hypertrophy and pulmonary arteriole area index （AI） and thickness index （TI） in PAH rats. Conclusion： Intravenous injection of MSC-MVs or MSCs produces similar beneficial effects for treating PAH, and our results provide a basis for cell-free approach in stem cell therapy.

Measuring in-situ stress by using the Kaiser effect in rocks has such advantages as timeefficiency, low cost and little limitation, but the precision of the method is dependent on rock properties and delay time of the measurement. In this paper, experiments on the Kaiser effect in limestones were performed, and it was found that the limestones had good ability to retain a memory of their recent stress history and high time-sensitivity. The longer the experiment was delayed from the extraction of the stone, the larger the Felicity ratio was. As the Felicity ratio approached l, significant Kaiser effect was observed. In-situ stress should be determined by the limestone measurements when the delay time was 40-120 days. Finally, the in-situ stress in a limestone formation could be successfully measured in practice.

Receptor-ligand bond dissociation under applied force is crucial to elucidate its biological functionality when the molecular bond is usually connected to a mechanical probe. While the impact of probe stiffness, k, on bond rupture force has recently at- tracted more and more attention, the mechanism of how it affects the bond lifetime, however, remains unclear. Here we quanti- fied the dissociation lifetime of selectin-ligand bond using an optical trap assay with low stiffness ranging from 3.5×10^-3 to 4.7×10^-2 pN/nm. Our results indicated that bond lifetime yielded distinct distributions with different probe stiffness, implying the stochastic feature of bond dissociation. It was also found that the mean lifetime varied with probe stiffness and that the catch bond nature was visualized at k≥3.0×10^-2 pN/nm. This work furthered the understanding of the forced dissociation of se- lectin-ligand bond at varied probe stiffness, which is physiologically relevant to the tethered rolling of leukoeytes under blood flow.

The widespread use of organophosphorus pesticides （OPs） poses a great threat to human health and has made the detection of OP residues in food an important task, especially in view of the fact that easy and rapid detection methods are needed. Because OPs have inhibitory effects on the activity of α-naphthyl acetate esterase （ANAE） in plants, in this work we evaluated the possibility of detecting OPs in vegetables with ANAE extracted from commercial flour. The limits of detection （LODs） obtained for methamidophos, dichlorvos, phoxim, dimethoate, and malathion in lettuce samples with crude ANAE were 0.17, 0.11, 0.11, 0.96, and 1.70 mg/kg, respectively. Based on the maximum residue limits （MRLs） for OPs in food stipulated by Chinese laws which are 0.05, 0.20, 0.05, 1.00, and 8.00 mg/kg for methamidophos, dichlorvos, phoxim, dimethoate, and malathion, respectively, the esterase inhibition method with crude ANAE had sufficient sensitivity to detect the residues of dichlorvos, dimethoate, and malathion in lettuce, but it could not be used to guarantee the safety of the same samples if methamidophos or phoxim residue was present. The sensitivity of the method was improved by the use of esterase purified by ammonium sulfate salting-out. The LODs obtained for methamidophos and phoxim with purified esterase were lower than the MRLs for these OPs in food. This is a very promising method for the detection of OP residues in vegetables using crude or purified esterase because of its cheapness, sensitivity, and convenience.