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"Yan, Ming"
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Yan Pei-Ming
The first monograph on important Franco-Chinese contemporary artist Yan Pei-Ming, whose work blends Eastern and Western cultural influences. Yan Pei-Ming is one of the most important figures in contemporary art. His large-scale, monochrome paintings portraits of politically charged figures such as Mao, Pope John Paul II, Barack Obama, and Vladimir Putin, as well as cultural icons Marilyn Monroe, Michael Jackson, Bruce Lee, and Picasso are the result of a powerful combination of conceptual rigor and the passionate, dynamic gestures with which he \"attacks\" the canvas. Having grown up in Shanghai during the Chinese Cultural Revolution and resettled in Dijon, France, Ming s work stands for an entire generation that has experienced and survived the dramatic changes that global geopolitics have undergone since the end of the Cold War. Ming s art is in the collections of a number of prestigious institutions including the Centre Georges Pompidou, Honolulu Museum of Art, Museum Ludwig in Cologne, National Museum of Modern Art in Tokyo, National Gallery of Australia, and the Shanghai Art Museum. This significant volume is the first comprehensive book on Ming s practice and is prepared by the internationally renowned curator Francesco Bonami.\"
Book
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1
Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma (CSCC) clinical specimens identified upregulation of miR-221-3p. Here, we show that miR-221-3p is closely correlated with peritumoral lymphangiogenesis and lymph node (LN) metastasis in CSCC. More importantly, miR-221-3p is characteristically enriched in and transferred by CSCC-secreted exosomes into human lymphatic endothelial cells (HLECs) to promote HLECs migration and tube formation in vitro, and facilitate lymphangiogenesis and LN metastasis in vivo according to both gain-of-function and loss-of-function experiments. Furthermore, we identify vasohibin-1 (VASH1) as a novel direct target of miR-221-3p through bioinformatic target prediction and luciferase reporter assay. Re-expression and knockdown of VASH1 could respectively rescue and simulate the effects induced by exosomal miR-221-3p. Importantly, the miR-221-3p-VASH1 axis activates the ERK/AKT pathway in HLECs independent of VEGF-C. Finally, circulating exosomal miR-221-3p levels also have biological function in promoting HLECs sprouting in vitro and are closely associated with tumor miR-221-3p expression, lymphatic VASH1 expression, lymphangiogenesis, and LN metastasis in CSCC patients. In conclusion, CSCC-secreted exosomal miR-221-3p transfers into HLECs to promote lymphangiogenesis and lymphatic metastasis via downregulation of VASH1 and may represent a novel diagnostic biomarker and therapeutic target for metastatic CSCC patients in early stages.
Journal Article
Plant Hormone Signaling Crosstalks between Biotic and Abiotic Stress Responses
In the natural environment, plants are often bombarded by a combination of abiotic (such as drought, salt, heat or cold) and biotic (necrotrophic and biotrophic pathogens) stresses simultaneously. It is critical to understand how the various response pathways to these stresses interact with one another within the plants, and where the points of crosstalk occur which switch the responses from one pathway to another. Calcium sensors are often regarded as the first line of response to external stimuli to trigger downstream signaling. Abscisic acid (ABA) is a major phytohormone regulating stress responses, and it interacts with the jasmonic acid (JA) and salicylic acid (SA) signaling pathways to channel resources into mitigating the effects of abiotic stresses versus defending against pathogens. The signal transduction in these pathways are often carried out via GTP-binding proteins (G-proteins) which comprise of a large group of proteins that are varied in structures and functions. Deciphering the combined actions of these different signaling pathways in plants would greatly enhance the ability of breeders to develop food crops that can thrive in deteriorating environmental conditions under climate change, and that can maintain or even increase crop yield.
Journal Article
الاستراتيجيات العسكرية في الصين القديمة
يدور موضوع الكتاب حول \"الاستراتيجيات العسكرية في الصين القديمة\" هذا العنوان يدخل في حقل الكتب العسكرية أو ما يعرف بـ (الأدب العسكري) وهو حسب مؤلفه الصيني \"لي تشينغ بين\" أحد أعظم ميراث ثقافي للأمة الصينية، أدب غني بالدلالات الثقافية والمزايا الفريدة التي تعرف إليها المؤلف بعد أن بحث في الأدب العسكري القديم في بلاده بما في ذلك أحد أعظم أعماله وهي فن الحرب لما يفوق الثلاثين عاما. لقد صرح أن هذا الأدب يتمتع بحكمة كبيرة، واستراتيجيات بالإضافة إلى مفاتيح النجاح ويمكن أن يتم الرجوع إلى الكتب العسكرية القديمة لتقييم الاستراتيجيات الفعالة من قبل العديد من الأشخاص، بمن فيهم القادة العسكريون، السياسيون، الدبلوماسيون، رجال الأعمال، وحتى الناس العاديون. ولأن الكتب العسكرية تلعب دور ناقل الثقافة، لذلك، يفترض المؤلف أنه من الأفضل لكل شخص متعلم أن يقرأ هذا النوع من الكتب بغض النظر عن مهنته. كتاب \"الاستراتيجيات العسكرية في الصين القديمة\" هو نقطة في بحر العدد الهائل من الكتب الصينية الكلاسيكية القديمة بالإضافة للأدب العسكري العميق، لقد اختار المؤلف ما يزيد عن ثلاثمائة بند في ثمانين كتابا عسكريا قديما وأضاف الشروحات الصينية والترجمات الإنجليزية المتوافقة في هذا الكتاب بهدف مساعدة القراء في فهم ودراسة الأدب العسكري القديم. يتضمن هذا الكتاب ترجمة الأصل الإنجليزي \"Military Strategies in Ancient China\" نقلته إلى العربية نهى حسن ويأتي باللغتين العربية والصينية مما يسهم في تعلم اللغة الصينية للناطقين بالضاد.
Book
Restoration of Images Corrupted by Impulse Noise and Mixed Gaussian Impulse Noise Using Blind Inpainting
This article studies the problem of image restoration of observed images corrupted by impulse noise and mixed Gaussian impulse noise. Since the pixels damaged by impulse noise contain no information about the true image, how to find this set correctly is a very important problem. We propose two methods based on blind inpainting and $\\ell_0$ minimization that can simultaneously find the damaged pixels and restore the image. By iteratively restoring the image and updating the set of damaged pixels, these methods have better performance than other methods, as shown in the experiments. In addition, we provide convergence analysis for these methods; these algorithms will converge to coordinatewise minimum points. In addition, they will converge to local minimum points (or with probability one) with some modifications in the algorithms. [PUBLICATION ABSTRACT]
Journal Article
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer
With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on the lncRNA‐RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA‐RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6‐methyladenosine (m6A) modification of lncRNAs. In addition, we discussed how the lncRNA‐RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA‐RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.
Journal Article
أفكار حول تعميق الإصلاح
يناقش الكتاب سلسلة من الإيضاحات الهامة قدمها الرئيس الصيني والأمين العام للجنة المركزية للحزب الشيوعي الصيني، شي جين بينغ، وتدور حول أفكار الإصلاح وتوسيع الانفتاح على نحو شامل في الصين. يضم الكتاب أكثر من 70 وثيقة هامة على صورة كلمات شي جين بينغ وخطاباته وتعليقاته وتوجيهاته وينقسم الكتاب إلى 12 موضوعا خاصا تتضمن 274 قطعة من مقتطفات الأقوال، نشر بعضها لأول مرة.
Book
Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF‐κB signaling pathway
Summary
Aims
Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent anti‐inflammation and neuroprotective properties; however, its effects during Alzheimer's disease (AD) treatment have not been well studied. This study aimed to investigate the effects of BAI pretreatment on cognitive impairment and neuronal protection against microglia‐induced neuroinflammation and to explore the mechanisms underlying its anti‐inflammation effects.
Methods
To determine whether BAI plays a positive role in ameliorating the memory and cognition deficits in APP (amyloid beta precursor protein)/PS1 (presenilin‐1) mice, behavioral experiments were conducted. We assessed the effects of BAI on microglial activation, the production of proinflammatory cytokines, and neuroinflammation‐mediated neuron apoptosis in vivo and in vitro using Western blot, RT‐PCR, ELISA, immunohistochemistry, and immunofluorescence. Finally, to elucidate the anti‐inflammation mechanisms underlying the effects of BAI, the protein expression of NLRP3 inflammasomes and the expression of proteins involved in the TLR4/NF‐κB signaling pathway were measured using Western blot and immunofluorescence.
Results
The results indicated that BAI treatment attenuated spatial memory dysfunction in APP/PS1 mice, as assessed by the passive avoidance test and the Morris water maze test. Additionally, BAI administration effectively decreased the number of activated microglia and proinflammatory cytokines, as well as neuroinflammation‐mediated neuron apoptosis, in APP/PS1 mice and LPS (lipopolysaccharides)/Aβ‐stimulated BV2 microglial cells. Lastly, the molecular mechanistic study revealed that BAI inhibited microglia‐induced neuroinflammation via suppression of the activation of NLRP3 inflammasomes and the TLR4/NF‐κB signaling pathway.
Conclusion
Overall, the results of the present study indicated that BAI is a promising neuroprotective compound for use in the prevention and treatment of microglia‐mediated neuroinflammation during AD progression.
Journal Article