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"Yan, Ming"
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Yan Pei-Ming
The first monograph on important Franco-Chinese contemporary artist Yan Pei-Ming, whose work blends Eastern and Western cultural influences. Yan Pei-Ming is one of the most important figures in contemporary art. His large-scale, monochrome paintings portraits of politically charged figures such as Mao, Pope John Paul II, Barack Obama, and Vladimir Putin, as well as cultural icons Marilyn Monroe, Michael Jackson, Bruce Lee, and Picasso are the result of a powerful combination of conceptual rigor and the passionate, dynamic gestures with which he \"attacks\" the canvas. Having grown up in Shanghai during the Chinese Cultural Revolution and resettled in Dijon, France, Ming s work stands for an entire generation that has experienced and survived the dramatic changes that global geopolitics have undergone since the end of the Cold War. Ming s art is in the collections of a number of prestigious institutions including the Centre Georges Pompidou, Honolulu Museum of Art, Museum Ludwig in Cologne, National Museum of Modern Art in Tokyo, National Gallery of Australia, and the Shanghai Art Museum. This significant volume is the first comprehensive book on Ming s practice and is prepared by the internationally renowned curator Francesco Bonami.\"
Book
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1
Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma (CSCC) clinical specimens identified upregulation of miR-221-3p. Here, we show that miR-221-3p is closely correlated with peritumoral lymphangiogenesis and lymph node (LN) metastasis in CSCC. More importantly, miR-221-3p is characteristically enriched in and transferred by CSCC-secreted exosomes into human lymphatic endothelial cells (HLECs) to promote HLECs migration and tube formation in vitro, and facilitate lymphangiogenesis and LN metastasis in vivo according to both gain-of-function and loss-of-function experiments. Furthermore, we identify vasohibin-1 (VASH1) as a novel direct target of miR-221-3p through bioinformatic target prediction and luciferase reporter assay. Re-expression and knockdown of VASH1 could respectively rescue and simulate the effects induced by exosomal miR-221-3p. Importantly, the miR-221-3p-VASH1 axis activates the ERK/AKT pathway in HLECs independent of VEGF-C. Finally, circulating exosomal miR-221-3p levels also have biological function in promoting HLECs sprouting in vitro and are closely associated with tumor miR-221-3p expression, lymphatic VASH1 expression, lymphangiogenesis, and LN metastasis in CSCC patients. In conclusion, CSCC-secreted exosomal miR-221-3p transfers into HLECs to promote lymphangiogenesis and lymphatic metastasis via downregulation of VASH1 and may represent a novel diagnostic biomarker and therapeutic target for metastatic CSCC patients in early stages.
Journal Article
Plant Hormone Signaling Crosstalks between Biotic and Abiotic Stress Responses
In the natural environment, plants are often bombarded by a combination of abiotic (such as drought, salt, heat or cold) and biotic (necrotrophic and biotrophic pathogens) stresses simultaneously. It is critical to understand how the various response pathways to these stresses interact with one another within the plants, and where the points of crosstalk occur which switch the responses from one pathway to another. Calcium sensors are often regarded as the first line of response to external stimuli to trigger downstream signaling. Abscisic acid (ABA) is a major phytohormone regulating stress responses, and it interacts with the jasmonic acid (JA) and salicylic acid (SA) signaling pathways to channel resources into mitigating the effects of abiotic stresses versus defending against pathogens. The signal transduction in these pathways are often carried out via GTP-binding proteins (G-proteins) which comprise of a large group of proteins that are varied in structures and functions. Deciphering the combined actions of these different signaling pathways in plants would greatly enhance the ability of breeders to develop food crops that can thrive in deteriorating environmental conditions under climate change, and that can maintain or even increase crop yield.
Journal Article
الاستراتيجيات العسكرية في الصين القديمة
يدور موضوع الكتاب حول \"الاستراتيجيات العسكرية في الصين القديمة\" هذا العنوان يدخل في حقل الكتب العسكرية أو ما يعرف بـ (الأدب العسكري) وهو حسب مؤلفه الصيني \"لي تشينغ بين\" أحد أعظم ميراث ثقافي للأمة الصينية، أدب غني بالدلالات الثقافية والمزايا الفريدة التي تعرف إليها المؤلف بعد أن بحث في الأدب العسكري القديم في بلاده بما في ذلك أحد أعظم أعماله وهي فن الحرب لما يفوق الثلاثين عاما. لقد صرح أن هذا الأدب يتمتع بحكمة كبيرة، واستراتيجيات بالإضافة إلى مفاتيح النجاح ويمكن أن يتم الرجوع إلى الكتب العسكرية القديمة لتقييم الاستراتيجيات الفعالة من قبل العديد من الأشخاص، بمن فيهم القادة العسكريون، السياسيون، الدبلوماسيون، رجال الأعمال، وحتى الناس العاديون. ولأن الكتب العسكرية تلعب دور ناقل الثقافة، لذلك، يفترض المؤلف أنه من الأفضل لكل شخص متعلم أن يقرأ هذا النوع من الكتب بغض النظر عن مهنته. كتاب \"الاستراتيجيات العسكرية في الصين القديمة\" هو نقطة في بحر العدد الهائل من الكتب الصينية الكلاسيكية القديمة بالإضافة للأدب العسكري العميق، لقد اختار المؤلف ما يزيد عن ثلاثمائة بند في ثمانين كتابا عسكريا قديما وأضاف الشروحات الصينية والترجمات الإنجليزية المتوافقة في هذا الكتاب بهدف مساعدة القراء في فهم ودراسة الأدب العسكري القديم. يتضمن هذا الكتاب ترجمة الأصل الإنجليزي \"Military Strategies in Ancient China\" نقلته إلى العربية نهى حسن ويأتي باللغتين العربية والصينية مما يسهم في تعلم اللغة الصينية للناطقين بالضاد.
Book
Restoration of Images Corrupted by Impulse Noise and Mixed Gaussian Impulse Noise Using Blind Inpainting
This article studies the problem of image restoration of observed images corrupted by impulse noise and mixed Gaussian impulse noise. Since the pixels damaged by impulse noise contain no information about the true image, how to find this set correctly is a very important problem. We propose two methods based on blind inpainting and$\\ell_0$minimization that can simultaneously find the damaged pixels and restore the image. By iteratively restoring the image and updating the set of damaged pixels, these methods have better performance than other methods, as shown in the experiments. In addition, we provide convergence analysis for these methods; these algorithms will converge to coordinatewise minimum points. In addition, they will converge to local minimum points (or with probability one) with some modifications in the algorithms. [PUBLICATION ABSTRACT]
Journal Article
Disome-seq reveals widespread ribosome collisions that promote cotranslational protein folding
Background
The folding of proteins is challenging in the highly crowded and sticky environment of a cell. Regulation of translation elongation may play a crucial role in ensuring the correct folding of proteins. Much of our knowledge regarding translation elongation comes from the sequencing of mRNA fragments protected by single ribosomes by ribo-seq. However, larger protected mRNA fragments have been observed, suggesting the existence of an alternative and previously hidden layer of regulation.
Results
In this study, we performed disome-seq to sequence mRNA fragments protected by two stacked ribosomes, a product of translational pauses during which the 5′-elongating ribosome collides with the 3′-paused one. We detected widespread ribosome collisions that are related to slow ribosome release when stop codons are at the A-site, slow peptide bond formation from proline, glycine, asparagine, and cysteine when they are at the P-site, and slow leaving of polylysine from the exit tunnel of ribosomes. The structure of disomes obtained by cryo-electron microscopy suggests a different conformation from the substrate of the ribosome-associated protein quality control pathway. Collisions occurred more frequently in the gap regions between α-helices, where a translational pause can prevent the folding interference from the downstream peptides. Paused or collided ribosomes are associated with specific chaperones, which can aid in the cotranslational folding of the nascent peptides.
Conclusions
Therefore, cells use regulated ribosome collisions to ensure protein homeostasis.
Journal Article
أفكار حول تعميق الإصلاح
يناقش الكتاب سلسلة من الإيضاحات الهامة قدمها الرئيس الصيني والأمين العام للجنة المركزية للحزب الشيوعي الصيني، شي جين بينغ، وتدور حول أفكار الإصلاح وتوسيع الانفتاح على نحو شامل في الصين. يضم الكتاب أكثر من 70 وثيقة هامة على صورة كلمات شي جين بينغ وخطاباته وتعليقاته وتوجيهاته وينقسم الكتاب إلى 12 موضوعا خاصا تتضمن 274 قطعة من مقتطفات الأقوال، نشر بعضها لأول مرة.
Book
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer
With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on the lncRNA‐RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA‐RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6‐methyladenosine (m6A) modification of lncRNAs. In addition, we discussed how the lncRNA‐RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA‐RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.
Journal Article