Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
20,898
result(s) for
"Yan, Ming"
Sort by:
Yan Pei-Ming
The first monograph on important Franco-Chinese contemporary artist Yan Pei-Ming, whose work blends Eastern and Western cultural influences. Yan Pei-Ming is one of the most important figures in contemporary art. His large-scale, monochrome paintings portraits of politically charged figures such as Mao, Pope John Paul II, Barack Obama, and Vladimir Putin, as well as cultural icons Marilyn Monroe, Michael Jackson, Bruce Lee, and Picasso are the result of a powerful combination of conceptual rigor and the passionate, dynamic gestures with which he \"attacks\" the canvas. Having grown up in Shanghai during the Chinese Cultural Revolution and resettled in Dijon, France, Ming s work stands for an entire generation that has experienced and survived the dramatic changes that global geopolitics have undergone since the end of the Cold War. Ming s art is in the collections of a number of prestigious institutions including the Centre Georges Pompidou, Honolulu Museum of Art, Museum Ludwig in Cologne, National Museum of Modern Art in Tokyo, National Gallery of Australia, and the Shanghai Art Museum. This significant volume is the first comprehensive book on Ming s practice and is prepared by the internationally renowned curator Francesco Bonami.\"
Book
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1
Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma (CSCC) clinical specimens identified upregulation of miR-221-3p. Here, we show that miR-221-3p is closely correlated with peritumoral lymphangiogenesis and lymph node (LN) metastasis in CSCC. More importantly, miR-221-3p is characteristically enriched in and transferred by CSCC-secreted exosomes into human lymphatic endothelial cells (HLECs) to promote HLECs migration and tube formation in vitro, and facilitate lymphangiogenesis and LN metastasis in vivo according to both gain-of-function and loss-of-function experiments. Furthermore, we identify vasohibin-1 (VASH1) as a novel direct target of miR-221-3p through bioinformatic target prediction and luciferase reporter assay. Re-expression and knockdown of VASH1 could respectively rescue and simulate the effects induced by exosomal miR-221-3p. Importantly, the miR-221-3p-VASH1 axis activates the ERK/AKT pathway in HLECs independent of VEGF-C. Finally, circulating exosomal miR-221-3p levels also have biological function in promoting HLECs sprouting in vitro and are closely associated with tumor miR-221-3p expression, lymphatic VASH1 expression, lymphangiogenesis, and LN metastasis in CSCC patients. In conclusion, CSCC-secreted exosomal miR-221-3p transfers into HLECs to promote lymphangiogenesis and lymphatic metastasis via downregulation of VASH1 and may represent a novel diagnostic biomarker and therapeutic target for metastatic CSCC patients in early stages.
Journal Article
Plant Hormone Signaling Crosstalks between Biotic and Abiotic Stress Responses
In the natural environment, plants are often bombarded by a combination of abiotic (such as drought, salt, heat or cold) and biotic (necrotrophic and biotrophic pathogens) stresses simultaneously. It is critical to understand how the various response pathways to these stresses interact with one another within the plants, and where the points of crosstalk occur which switch the responses from one pathway to another. Calcium sensors are often regarded as the first line of response to external stimuli to trigger downstream signaling. Abscisic acid (ABA) is a major phytohormone regulating stress responses, and it interacts with the jasmonic acid (JA) and salicylic acid (SA) signaling pathways to channel resources into mitigating the effects of abiotic stresses versus defending against pathogens. The signal transduction in these pathways are often carried out via GTP-binding proteins (G-proteins) which comprise of a large group of proteins that are varied in structures and functions. Deciphering the combined actions of these different signaling pathways in plants would greatly enhance the ability of breeders to develop food crops that can thrive in deteriorating environmental conditions under climate change, and that can maintain or even increase crop yield.
Journal Article
الاستراتيجيات العسكرية في الصين القديمة
يدور موضوع الكتاب حول \"الاستراتيجيات العسكرية في الصين القديمة\" هذا العنوان يدخل في حقل الكتب العسكرية أو ما يعرف بـ (الأدب العسكري) وهو حسب مؤلفه الصيني \"لي تشينغ بين\" أحد أعظم ميراث ثقافي للأمة الصينية، أدب غني بالدلالات الثقافية والمزايا الفريدة التي تعرف إليها المؤلف بعد أن بحث في الأدب العسكري القديم في بلاده بما في ذلك أحد أعظم أعماله وهي فن الحرب لما يفوق الثلاثين عاما. لقد صرح أن هذا الأدب يتمتع بحكمة كبيرة، واستراتيجيات بالإضافة إلى مفاتيح النجاح ويمكن أن يتم الرجوع إلى الكتب العسكرية القديمة لتقييم الاستراتيجيات الفعالة من قبل العديد من الأشخاص، بمن فيهم القادة العسكريون، السياسيون، الدبلوماسيون، رجال الأعمال، وحتى الناس العاديون. ولأن الكتب العسكرية تلعب دور ناقل الثقافة، لذلك، يفترض المؤلف أنه من الأفضل لكل شخص متعلم أن يقرأ هذا النوع من الكتب بغض النظر عن مهنته. كتاب \"الاستراتيجيات العسكرية في الصين القديمة\" هو نقطة في بحر العدد الهائل من الكتب الصينية الكلاسيكية القديمة بالإضافة للأدب العسكري العميق، لقد اختار المؤلف ما يزيد عن ثلاثمائة بند في ثمانين كتابا عسكريا قديما وأضاف الشروحات الصينية والترجمات الإنجليزية المتوافقة في هذا الكتاب بهدف مساعدة القراء في فهم ودراسة الأدب العسكري القديم. يتضمن هذا الكتاب ترجمة الأصل الإنجليزي \"Military Strategies in Ancient China\" نقلته إلى العربية نهى حسن ويأتي باللغتين العربية والصينية مما يسهم في تعلم اللغة الصينية للناطقين بالضاد.
Book
Restoration of Images Corrupted by Impulse Noise and Mixed Gaussian Impulse Noise Using Blind Inpainting
This article studies the problem of image restoration of observed images corrupted by impulse noise and mixed Gaussian impulse noise. Since the pixels damaged by impulse noise contain no information about the true image, how to find this set correctly is a very important problem. We propose two methods based on blind inpainting and $\\ell_0$ minimization that can simultaneously find the damaged pixels and restore the image. By iteratively restoring the image and updating the set of damaged pixels, these methods have better performance than other methods, as shown in the experiments. In addition, we provide convergence analysis for these methods; these algorithms will converge to coordinatewise minimum points. In addition, they will converge to local minimum points (or with probability one) with some modifications in the algorithms. [PUBLICATION ABSTRACT]
Journal Article
Disome-seq reveals widespread ribosome collisions that promote cotranslational protein folding
Background
The folding of proteins is challenging in the highly crowded and sticky environment of a cell. Regulation of translation elongation may play a crucial role in ensuring the correct folding of proteins. Much of our knowledge regarding translation elongation comes from the sequencing of mRNA fragments protected by single ribosomes by ribo-seq. However, larger protected mRNA fragments have been observed, suggesting the existence of an alternative and previously hidden layer of regulation.
Results
In this study, we performed disome-seq to sequence mRNA fragments protected by two stacked ribosomes, a product of translational pauses during which the 5′-elongating ribosome collides with the 3′-paused one. We detected widespread ribosome collisions that are related to slow ribosome release when stop codons are at the A-site, slow peptide bond formation from proline, glycine, asparagine, and cysteine when they are at the P-site, and slow leaving of polylysine from the exit tunnel of ribosomes. The structure of disomes obtained by cryo-electron microscopy suggests a different conformation from the substrate of the ribosome-associated protein quality control pathway. Collisions occurred more frequently in the gap regions between α-helices, where a translational pause can prevent the folding interference from the downstream peptides. Paused or collided ribosomes are associated with specific chaperones, which can aid in the cotranslational folding of the nascent peptides.
Conclusions
Therefore, cells use regulated ribosome collisions to ensure protein homeostasis.
Journal Article
أفكار حول تعميق الإصلاح
يناقش الكتاب سلسلة من الإيضاحات الهامة قدمها الرئيس الصيني والأمين العام للجنة المركزية للحزب الشيوعي الصيني، شي جين بينغ، وتدور حول أفكار الإصلاح وتوسيع الانفتاح على نحو شامل في الصين. يضم الكتاب أكثر من 70 وثيقة هامة على صورة كلمات شي جين بينغ وخطاباته وتعليقاته وتوجيهاته وينقسم الكتاب إلى 12 موضوعا خاصا تتضمن 274 قطعة من مقتطفات الأقوال، نشر بعضها لأول مرة.
Book
Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF‐κB signaling pathway
Summary Aims Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent anti‐inflammation and neuroprotective properties; however, its effects during Alzheimer's disease (AD) treatment have not been well studied. This study aimed to investigate the effects of BAI pretreatment on cognitive impairment and neuronal protection against microglia‐induced neuroinflammation and to explore the mechanisms underlying its anti‐inflammation effects. Methods To determine whether BAI plays a positive role in ameliorating the memory and cognition deficits in APP (amyloid beta precursor protein)/PS1 (presenilin‐1) mice, behavioral experiments were conducted. We assessed the effects of BAI on microglial activation, the production of proinflammatory cytokines, and neuroinflammation‐mediated neuron apoptosis in vivo and in vitro using Western blot, RT‐PCR, ELISA, immunohistochemistry, and immunofluorescence. Finally, to elucidate the anti‐inflammation mechanisms underlying the effects of BAI, the protein expression of NLRP3 inflammasomes and the expression of proteins involved in the TLR4/NF‐κB signaling pathway were measured using Western blot and immunofluorescence. Results The results indicated that BAI treatment attenuated spatial memory dysfunction in APP/PS1 mice, as assessed by the passive avoidance test and the Morris water maze test. Additionally, BAI administration effectively decreased the number of activated microglia and proinflammatory cytokines, as well as neuroinflammation‐mediated neuron apoptosis, in APP/PS1 mice and LPS (lipopolysaccharides)/Aβ‐stimulated BV2 microglial cells. Lastly, the molecular mechanistic study revealed that BAI inhibited microglia‐induced neuroinflammation via suppression of the activation of NLRP3 inflammasomes and the TLR4/NF‐κB signaling pathway. Conclusion Overall, the results of the present study indicated that BAI is a promising neuroprotective compound for use in the prevention and treatment of microglia‐mediated neuroinflammation during AD progression.
Journal Article