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"Yan, Sheng"
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Fermentation Affects the Antioxidant Activity of Plant-Based Food Material through the Release and Production of Bioactive Components
This review reports on the effects of fermentation on the chemical constituents and antioxidant activity of plant-based food materials. Fermentation involves a series of reactions that modify the chemical components of the substrate. It could be considered a tool to increase the bioactive compounds and functional properties of food plant materials. Oxidative damage is key to the progression of many human diseases, and the production of antioxidant compounds by fermentation will be helpful to reduce the risk of these diseases. Fermentation also can improve antioxidant activity given its association with increased phytochemicals, antioxidant polysaccharides, and antioxidant peptides produced by microbial hydrolysis or biotransformation. Additionally, fermentation can encourage the breakdown of plant cell walls, which helps to liberate or produce various antioxidant compounds. Overall, results indicated that fermentation in many cases contributed to enhancing antioxidants’ content and antioxidant capacity, supporting the fermentation use in the production of value-added functional food. This review provides an overview of the factors that impact the effects of fermentation on bioactive compound composition and antioxidant activity. The impacts of fermentation are summarized as a reference to its effects on food plant material.
Journal Article
لعبة الحياة والموت : رواية
تغطي الرواية الفترة من 1950-2000 وهي ما تسمى بفترة الإصلاح، وصين ما بعد دینغ سياو بينغ، وتحتوي على الكثير من مثل هذه المشاهد المؤثرة وهنا تبدو الرواية شكلا من أشكال التوثيق فتصحب القارئ عبر الزمن من بداية الإصلاح الزراعي في نهاية الحرب الأهلية، ثم خلال تأسيس فرق المعونة التبادلية والتعاونيات الصغرى في أوائل ومنتصف عقد 1950 إلى سنوات \"القفزة الكبرى إلى الأمام\" التي كشر فيها التطرف عن أنيابه، ثم تأخذنا إلى سنوات المجاعة في أواخر عقد 1950 وبداية الستينيات، ثم مرحلة التآكل المنتظم للاقتصاد الشمولي في الحقبة الجديدة التي انطلقت وسادت دون ضوابط، أي مرحلة الاشتراكية بخصائص رأسمالية.
Book
A Multi-Stage Planning Method for Distribution Networks Based on ARIMA with Error Gradient Sampling for Source–Load Prediction
As the scale of distributed renewable energy represented by wind power and photovoltaic continues to expand and load demand gradually changes, the future evolution of the smart distribution network will be directly driven by both distributed generation and user demand. The smart distribution network contains a wide range of flexible resources, and its flexibility and uncertainty will bring great challenges to grid data acquisition and control feedback. To adapt to the precise control and feedback of smart distribution network access equipment under the high proportion of new energy access and to ensure the safe operation of the system, it is urgent to accelerate the study of the evolution of the future distribution grid based on the existing distribution grid. Hence, a multi-stage planning method for distribution networks based on source–load prediction is proposed in this paper. Firstly, a distribution network source–load prediction method based on the autoregressive integrated moving average model (ARIMA) and error gradient sampling is proposed, using ARIMA to predict the scale of source–load development and error gradient sampling based on the generation of source–load scenarios with error intervals. K-means is further used for scenario reduction, to explore multiple operating scenarios of China’s distribution network source–load, and the unit’s output forecast interval and load demand from 2021 to 2030 for typical regions are derived using rolling forecasts by combining the unit’s output, end-demand and clean energy share over the years. Secondly, the planning model of distribution grid evolution in different stages is constructed to analyze the future evolution form of the distribution grid considering the distribution network’s load cross-section, respectively, and to provide a development path reference for the future construction of distribution grid form in China.
Journal Article
A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis
Circular RNAs (circRNAs) are recognized as functional non-coding transcripts in eukaryotic cells. Recent evidence has indicated that even though circRNAs are generally expressed at low levels, they may be involved in many physiological or pathological processes, such as gene regulation, tissue development and carcinogenesis. Although the ‘microRNA sponge’ function is well characterized, most circRNAs do not contain perfect trapping sites for microRNAs, which suggests the possibility that circRNAs have functions that have not yet been defined. In this study, we show that a circRNA containing an open reading frame (ORF) driven by the internal ribosome entry site (IRES) can translate a functional protein. The circular form of the SNF2 histone linker PHD RING helicase (SHPRH) gene encodes a novel protein that we termed SHPRH-146aa. Circular SHPRH (circ-SHPRH) uses overlapping genetic codes to generate a ‘UGA’ stop codon, which results in the translation of the 17 kDa SHPRH-146aa. Both circ-SHPRH and SHPRH-146aa are abundantly expressed in normal human brains and are down-regulated in glioblastoma. The overexpression of SHPRH-146aa in U251 and U373 glioblastoma cells reduces their malignant behavior and tumorigenicity in vitro and in vivo. Mechanistically, SHPRH-146aa protects full-length SHPRH from degradation by the ubiquitin proteasome. Stabilized SHPRH sequentially ubiquitinates proliferating cell nuclear antigen (PCNA) as an E3 ligase, leading to inhibited cell proliferation and tumorigenicity. Our findings provide a novel perspective regarding circRNA function in physiological and pathological processes. Specifically, SHPRH-146aa generated from overlapping genetic codes of circ-SHPRH is a tumor suppressor in human glioblastoma.
Journal Article
دراسات حول الفضاء العالمي و\الحزام والطريق\ : (مجلد البيئة الإيكولوجية)
إن معظم الدول والمناطق على طول «الحزام والطريق» هي دول نامية، وتعاني جميعا من مشكلات في البيئة الإيكولوجية أكثر أو أقل، كما إنها تواجه تحديات ضخمة في التوازن بين التنمية وحماية البيئة. وتواجه هذه البلدان النامية فرصا غير مسبوقة أتاحها المفهوم الاستراتيجي لمبادرة «الحزام والطريق»، كما أن كيفية التعامل مع التحدي المتمثل في حماية البيئة الإيكولوجية أثناء بناء وتطوير «الحزام والطريق» هي المهمة الأساسية التي تواجهها البلدان النامية بما فيها الصين. ويناقش هذا الكتاب ويلخص الخلفية البيئية الإيكولوجية للبلدان/ المناطق المشاركة في مبادرة \"الحزام والطريق\" والمشكلات الرئيسية في هذا الجانب.
Book
Liquid metal-filled magnetorheological elastomer with positive piezoconductivity
Conductive elastic composites have been used widely in soft electronics and soft robotics. These composites are typically a mixture of conductive fillers within elastomeric substrates. They can sense strain via changes in resistance resulting from separation of the fillers during elongation. Thus, most elastic composites exhibit a negative piezoconductive effect, i.e. the conductivity decreases under tensile strain. This property is undesirable for stretchable conductors since such composites may become less conductive during deformation. Here, we report a liquid metal-filled magnetorheological elastomer comprising a hybrid of fillers of liquid metal microdroplets and metallic magnetic microparticles. The composite’s resistivity reaches a maximum value in the relaxed state and drops drastically under any deformation, indicating that the composite exhibits an unconventional positive piezoconductive effect. We further investigate the magnetic field-responsive thermal properties of the composite and demonstrate several proof-of-concept applications. This composite has prospective applications in sensors, stretchable conductors, and responsive thermal interfaces.
Liquid metal-filled elastic composites for strain sensing devices exhibit reduced conductivity under strain, which limits their usefulness. Here, the authors report a positive piezoconductive effect in liquid metal-filled magnetorheological elastomers and illustrate proof-of concept applications.
Journal Article
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome. Although the translation of circRNAs was reported, additional coding circRNAs and the functions of their translated products remain elusive. Here, we demonstrate that an endogenous circRNA generated from a long noncoding RNA encodes regulatory peptides. Through ribosome nascent-chain complex-bound RNA sequencing (RNC-seq), we discover several peptides potentially encoded by circRNAs. We identify an 87-amino-acid peptide encoded by the circular form of the long intergenic non-protein-coding RNA
p53
-induced transcript (
LINC-PINT
) that suppresses glioblastoma cell proliferation in vitro and in vivo. This peptide directly interacts with polymerase associated factor complex (PAF1c) and inhibits the transcriptional elongation of multiple oncogenes. The expression of this peptide and its corresponding circRNA are decreased in glioblastoma compared with the levels in normal tissues. Our results establish the existence of peptides encoded by circRNAs and demonstrate their potential functions in glioblastoma tumorigenesis.
Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA
p53
-induced transcript (
LINC-PINT
) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes.
Journal Article
Modular microfluidics for life sciences
The advancement of microfluidics has enabled numerous discoveries and technologies in life sciences. However, due to the lack of industry standards and configurability, the design and fabrication of microfluidic devices require highly skilled technicians. The diversity of microfluidic devices discourages biologists and chemists from applying this technique in their laboratories. Modular microfluidics, which integrates the standardized microfluidic modules into a whole, complex platform, brings the capability of configurability to conventional microfluidics. The exciting features, including portability, on-site deployability, and high customization motivate us to review the state-of-the-art modular microfluidics and discuss future perspectives. In this review, we first introduce the working mechanisms of the basic microfluidic modules and evaluate their feasibility as modular microfluidic components. Next, we explain the connection approaches among these microfluidic modules, and summarize the advantages of modular microfluidics over integrated microfluidics in biological applications. Finally, we discuss the challenge and future perspectives of modular microfluidics.
Journal Article