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"Yang, Kan"
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Identify Changes of Brain Regional Homogeneity in Bipolar Disorder and Unipolar Depression Using Resting-State fMRI
To identify changes in brain activation patterns in bipolar disorder (BD) and unipolar depression (UD) patients.
Resting-state fMRI scans of 16 healthy controls, 17 BD and 16 UD patients were obtained. T-test of normalized regional homogeneity (ReHo) was performed in a voxel-by-voxel manner. A combined threshold of á = 0.05, minimum cluster volume of V = 10503 mm(3) (389 voxels) were used to determine ReHo differences between groups. In UD group, fMRI revealed ReHo increases in the left middle occipital lobe, right inferior parietal lobule, right precuneus and left convolution; and ReHo decreases in the left parahippocampalgyrus, right precentralgyrus, left postcentralgyrus, left precentralgyrus and left cingulated. In BD group, ReHo increases in the right insular cortex, left middle frontal gyrus, left precuneus, left occipital lobe, left parietal, left superior frontal gyrus and left thalamus; and ReHo decreases in the right anterior lobe of cerebellum, pons, right precentralgyrus, left postcentralgyrus, left inferior frontal gyrus, and right cingulate. There were some overlaps in ReHo profiles between UD and BD groups, but a marked difference was seen in the thalamus of BD.
The resting-state fMRI and ReHo mapping are a promising tool to assist the detection of functional deficits and distinguish clinical and pathophysiological signs of BD and UD.
Journal Article
PDCSA: A parallel discrete crow search algorithm for influence maximization in social networks
The essence of the influence maximization (IM) problem is how to identify the set of seed nodes so that the node numbers ultimately affected in the network reach the maximum under a certain spreading model. In the field of influence maximization research, the investigation of seed nodes identifying algorithms is a hot yet challenging work. Although conventional greedy algorithms and heuristic algorithms have high performance, their efficiency remains a challenge when applied to large-scale social networks. In recent years, swarm intelligence-based optimization algorithms have seen increasing application in addressing this problem, with notable improvements in performance. However, the efficiency of these swarm intelligence-based algorithms still needs to be improved in large-scale social networks. Based on this issue, a parallel discrete crow search algorithm (PDCSA) designed for parallel computing is proposed. Based on the evolution characteristics, PDCSA makes full use of the efficiency advantage of parallel computing to improve the time efficiency of solving IM problems.The results of experiments conducted on six datasets show that PDCSA achieves performance comparable to state-of-the-art algorithms, with the added advantages of high efficiency and robustness.
Journal Article
The value of urinary exosomal microRNA‐21 in the early diagnosis and prognosis of bladder cancer
Bladder cancer (BC) poses high morbidity and mortality, with urinary exosomal microRNA (miR)‐21 showing potential value in its diagnosis and prognosis, and we probed its specific role. We prospectively selected 116 BC patients and 116 healthy volunteers as the BC and control groups, respectively. BC urinary exosomal miR‐146a‐5p, miR‐93‐5p, miR‐663b, miR‐21, and miR‐4454 relative expression levels were assessed. The correlations between clinical indexes and urinary exosomal miR‐21, prognostic value of miR‐21, and diagnostic value of the five candidate miRNAs, urine cytology, and miRNA joint diagnostic panel for BC and urinary exosomal miR‐21, miR‐4454, and urine cytology for Ta‐T1 and T2‐T4 stage BC were analyzed. Urinary exosomal miR‐146a‐5p, miR‐93‐5p, miR‐663b, miR‐21, and miR‐4454 were highly expressed in BC patients. miR‐146a‐5p, miR‐93‐5p, miR‐663b, miR‐21, miR‐4454, miRNA combined diagnostic panel, and urine cytology had certain diagnostic value for BC, with miR‐21, miR‐4454, and miRNA co‐diagnostic panel showing the highest diagnostic value. Collectively, urinary exosomal miR‐21 was closely related to Tumor‐Node‐Metastasis staging and grading in BC patients. Urinary exosomal miR‐21 had high diagnostic value for BC and Ta‐T1 and T2‐T4 stage BC, and had high predictive value for BC poor prognosis, providing an effective indicator for the occurrence, development, and prognostic assessment of BC.
Journal Article
Comparison of seven cyclosporine A formulations for dry eye disease: A systematic review and network meta-analysis
Background: Dry eye disease is a common ocular surface disease affecting tens of millions of people worldwide. It is characterized by an unstable tear film and increasing prevalence. Different commercial formulations of cyclosporine A for dry eye have been approved, however, it is still unclear whether the differences in formulations of these products will make a difference in clinical efficacy and safety. Methods: Randomized controlled trials of commercial cyclosporine A formulation for dry eye disease were searched in Pubmed, EMBASE, Scopus, and Cochrane controlled trials registries and Web of Science from inception till 1 December 2021. Independent literature screening, data extraction, quality evaluation, and the study in line with quality standards were analyzed by using Stata16.0 software. The study is registered with PROSPERO under the number CRD42022301423. Code and data for this study is publicly available ( https://github.com/DongYangGao/Dongyang.github.io.git ). Results: 21 randomized clinical trials with a total of 4,107 participants were included in this study. Restasis ® (OR-4.82, 95% CI-6.18 to 3.45, SUCRA 77.2%) was the most effective commercial formulation for reducing OSDI, Zirun ® (SUCRA 73.9%) performed better in improving Schirmer’s test. TJ Cyporin ® (SUCRA 65.3%) ranked first in terms of improving tear film break-up time. For treatment-emergent adverse events incidence, Clacier ® was close to placebo. The risk of reporting bias is considered low. Conclusion: In the comparison of outcomes included in this study, the optimal order of various commercial cyclosporine A formulations is different, so it is difficult to select the optimal formula. Appropriate commercial formulations should be selected according to patients’ conditions in clinical practice.
Journal Article
Low SOX12 Expression Is Correlated With Poor Prognosis in Patients With Gastric Cancer
Background:
SRY-related HMG box-12, which is associated with the prognosis of cancer, has been frequently described. However, both SRY-related HMG box-12 expression and its relationship with clinicopathological variables and patient survival have not been defined in gastric cancer. The aim of our study was to examine the prognostic value of SRY-related HMG box-12 expression in patients with gastric cancer.
Methods:
In this study, we determined SRY-related HMG box-12 expression in 79 primary gastric cancer tissues and 79 matched adjacent nontumor tissues by immunohistochemistry and then calculated the survival rate using the Kaplan-Meier method. Cox proportional hazard regression model was used to analyze predictors of gastric cancer. Western blot and quantitative real-time polymerase chain reaction were used to investigate the difference in SRY-related HMG box-12 expression between normal gastric epithelial cells and gastric cancer cells at the protein level and RNA level, respectively.
Results:
SRY-related HMG box-12 was downregulated in gastric cancer tissues. Low SRY-related HMG box-12 expression was significantly associated not only with lymph node metastasis (P = .027) and TNM stage (P = .021) but also with disease-specific survival in patients with gastric cancer. Multivariate analysis demonstrated TNM stage was an independent factor predicting poor survival (P = .034).
Conclusions:
Low SRY-related HMG box-12 expression is associated with poor clinical outcomes in gastric cancer.
Journal Article
Platelet Parameters, C-Reactive Protein, and Depression: An Association Study
This study aims to investigate the correlation of platelet parameters and C-reactive protein (CRP) with depression.
The clinical data of 61 patients with depression and 30 healthy control subjects were collected to compare the platelet parameters, CRP levels, and Hamilton Depression Rating Scale (HAMD) scores of the two groups for correlation analysis.
The results revealed that the body mass index (BMI) of patients with depression was lower (P < 0.05) than that of the healthy control subjects, and that this difference was more significant in women than in men. Patients with severe depression showed an increased mean platelet volume (MPV) (P < 0.05). In the patients with depression, MPV was positively correlated (P < 0.05) with HAMD scores for work and interest, gastrointestinal symptoms, hopelessness, the anxiety/somatization factor, and the hopelessness factor. Platelet count (PLT) was negatively correlated (P < 0.05) with HAMD scores for hypochondriasis, and plateletcrit (PCT) was negatively correlated (P < 0.05) with HAMD scores for middle insomnia and hypochondriasis. Platelet distribution width (PDW) was positively correlated (P < 0.05) with HAMD scores for gastrointestinal and systemic symptoms as well as hopelessness. Higher CRP levels (P < 0.05) were found in the patients with depression than in the healthy control subjects. Furthermore, in the patients with depression, CRP levels were positively correlated (P < 0.05) with HAMD scores for guilt and the cognitive impairment factor.
Classical platelet parameters (PLT, MPV, PCT, PDW) and CRP were shown to be associated with specific depressive symptoms and cognitive impairment factors, including sleep, gastrointestinal symptoms, hypochondriasis, losing interest in work, and despair. These results suggest that both platelet parameters and CRP could be suitable biomarkers for predicting the occurrence and prognosis of depression, thus providing a new target for its treatment.
Journal Article
A controller design method based on the integration of structure search and parameter optimization
For the controller structure design problem, a controller design method based on the integration of structure search and parameter optimization is proposed with the idea of ENAS, which automates the controller structure design work, and searches for the most suitable controller structure and completes the parameter optimization in a relatively short time. The simulation study with the galvano scanner as the controlled plant shows that the number of iterations and the consumption time of the method are only 15% of the traditional method in achieving the same performance compared with the traditional design method.
Journal Article
Study on Residual Load-Bearing Capacity of Composite Steel Truss Bridge Girders After Vehicle Fire
To investigate the residual load-bearing capacity of composite steel truss bridge girders after vehicle fire, a 100 m simple supported composite steel truss bridge girder was selected as the research object, and a typical oil tanker fire was taken as the fire scenario. This study identifies the most critical conditions associated with an oil tanker fire and outlines the degradation pattern of the residual load-bearing capacity of composite steel truss bridge girders after a vehicle fire. It also proposes a damage classification standard and an evaluation method for the load-bearing capacity based on the structural failure path and load-displacement curve. The results indicate that the most critical scenario during a vehicle fire occurs when the fire is located on the bridge deck, particularly in the middle section of the longitudinal bridge and the outermost lane of the transverse bridge. During a vehicle fire, the top chord is the component most affected by the thermal history. Under immersion cooling conditions, the remaining load-bearing capacity of the girder decreases more significantly compared with natural cooling. After the fire, the upper chord first reaches the yield strength, causing load transfer to adjacent horizontal inclined members. The stress of the horizontal inclined rod will develop rapidly, leading to structural instability and eventual failure. Four grades of load-bearing capacity damage for composite steel truss bridge girders after vehicle fire are defined to serve as references for practical engineering applications.
Journal Article
A novel classification, management and long-term outcomes of coronary artery involvement in acute aortic dissection
Background
To introduce a new and simple classification and management of coronary artery involvement in aortic dissection and report results.
Methods
Coronary artery involvement was classified into two types according to the integrity of coronary intima: simple lesion (type S) and complex lesion (type C). Complex lesions were treated by CABG and simple lesions were treated by ostial repair or reimplantation. Data were collected and analyzed retrospectively.
Results
From January 2010 to December 2019, 267 consecutive patients were enrolled in the study, and among them complex lesions occurred in 27 patients (11.1%) and simple lesions was found in 240 patients(89.9%). Eleven untreated vessels with simple lesion were found to be involved again in the same operation and treated by CABG. The two type groups had comparable operative mortality (type S vs. type C, 9.6% vs. 18.5%, P = 0.28). 221 patients received follow-up with a median duration of 52 months. The overall survival rates at 1, 5, and 10 years postoperatively were 88.9%, 85.7%, and 79.8% in type S group and 79.2%, 79.2%, and 79.2% in type C group, respectively (P = 0.47). For the patients who received CABG and survived at discharge, radiographic follow-up with a median duration of 28 (IQR 7-55.5) months showed the freedom from occlusion of vein graft at 1, 5, and 10 years postoperatively were 87.5%, 70.0%, 28.0%.
Conclusions
According to the new classification, two types of lesions could be treated by corresponding methods with satisfactory early and long-term results. Unrepaired coronary artery was at a risk of re-involvement. Vein graft onto arteries without atherosclerosis still had a high occlusion rate.
Journal Article