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"Yang, Wei-ying"
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Metal‐organic framework‐based cancer theranostic nanoplatforms
The rapid development of imaging technologies provides a visual diagnostic tool for scientists and surgeons to comprehensively and accurately understand the pathogenesis and pathological processes of complicated diseases, especially cancer. Theranostic platforms integrating various imaging technologies and treatment strategies for the diagnosis and treatment of cancer have been extensively studied. Notably, metal‐organic frameworks (MOFs) – an emerging porous organic‐inorganic hybrid material composed of metal ions/ion clusters as nodes and organic ligands as linkers bridged by coordination bonds – have been widely used as intelligent carriers for cancer theranostics in recent years due to their fascinating properties, including facile synthesis, diverse compositions, high surface areas and porosities, tailorable sizes, multiple physicochemical properties, easy surface functionalization, and good biocompatibility. This review summarizes the recent advanced developments and achievements of MOFs as smart theranostic platforms for effective cancer diagnosis and treatment guided by monomodal imaging technologies, including optical imaging, magnetic resonance imaging, computed tomography imaging, positron emission tomography imaging, and photoacoustic imaging, and multimodal imaging technologies. Moreover, the development prospects and critical challenges of MOFs for cancer theranostics are also addressed. The advanced achievements of MOFs as theranostic platforms for effective cancer diagnosis and treatment guided by monomodal imaging technologies, including OI, MRI, CT imaging, PET imaging, and PA imaging, and multimodal imaging technologies are summarized, and the development prospects and critical challenges of MOF‐based theranostic systems are also discussed.
Journal Article
Aggregation‐induced emission systems involving supramolecular assembly
Aggregation‐induced emission (AIE), as an exciting photophysical phenomenon, has been regarded as one frontier research topic within both ranges of molecular luminescence and materials science over the last two decades. Since controllable molecular ensembles with particular morphologies and tunable functions can be elegantly constructed in the realm of supramolecular chemistry, the integration of supramolecular assembly and AIE systems can expectedly bring about luminescent materials with tunable emission and tailorable well‐ordered architectures. In this review, we will provide a summary of the creation and working mechanisms of AIE systems involving supramolecular systems that are driven by different supramolecular driving forces including hydrogen bonding, host−guest interactions, metal coordination, and π–π interactions. The morphological and photoluminescent features of these AIE‐active supramolecular assemblies will be elucidated, and the regulated fluorescence properties of the AIEgens induced by the assembling–disassembling processes will be discussed in detail. AIE systems involving supramolecular assembly are illustrated, where the assembly processes are driven by hydrogen bonding, host−guest interactions, metal coordination, and π–π interactions. The most recent advances in this very field are discussed in detail, covering the construction methods of the assemblies with different morphologies, the adjustable fluorescence properties of the assembled AIEgens, and the structure–property linkage of these systems.
Journal Article
Supramolecular nanomaterials based on hollow mesoporous drug carriers and macrocycle-capped CuS nanogates for synergistic chemo-photothermal therapy
Multifunctional supramolecular nanoplatforms that integrate the advantages of different therapeutic techniques can trigger multimodal synergistic treatment of tumors, thus representing an emerging powerful tool for cancer therapeutics.
: In this work, we design and fabricate a multifunctional supramolecular drug delivery platform, namely Fa-mPEG@CP5-CuS@HMSN-Py nanoparticles (FaPCH NPs), consisting of a pyridinium (Py)-modified hollow mesoporous silica nanoparticles-based drug reservoir (HMSN-Py) with high loading capacity, a layer of NIR-operable carboxylatopillar[5]arene (CP5)-functionalized CuS nanoparticles (CP5-CuS) on the surface of HMSN-Py connected through supramolecular host-guest interactions between CP5 rings and Py stalks, and another layer of folic acid (Fa)-conjugated polyethylene glycol (Fa-PEG) antennas by electrostatic interactions capable of active targeting at tumor lesions, in a controlled, highly integrated fashion for synergistic chemo-photothermal therapy.
: Fa-mPEG antennas endowed the enhanced active targeting effect toward cancer cells, and CP5-CuS served as not only a quadruple-stimuli responsive nanogate for controllable drug release but also a special agent for NIR-guided photothermal therapy. Meanwhile, anticancer drug doxorubicin (DOX) could be released from the HMSN-Py reservoirs under tumor microenvironments for chemotherapy, thus realizing multimodal synergistic therapeutics. Such a supramolecular drug delivery platform showed effective synergistic chemo-photothermal therapy both
and
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: This novel supramolecular nanoplatform possesses great potential in controlled drug delivery and tumor cellular internalization for synergistic chemo-photothermal therapy, providing a promising approach for multimodal synergistic cancer treatment.
Journal Article
Covalent Organic Frameworks for Membrane Separation
Membranes with switchable wettability, solvent resistance, and toughness have emerged as promising materials for separation applications. However, challenges like limited mechanical strength, poor chemical stability, and structural defects during membrane fabrication hinder their widespread adoption. Covalent organic frameworks (COFs), crystalline materials constructed from organic molecules connected by covalent bonds, offer a promising solution due to their high porosity, stability, and customizable properties. The ordered structures and customizable functionality provide COFs with a lightweight framework, large surface area, and tunable pore sizes, which have attracted increasing attention for their applications in membrane separations. Recent research has extensively explored the preparation strategies of COF membranes and their applications in various separation processes. This review uniquely delves into the influence of various COF membrane fabrication techniques, including interfacial polymerization, layer‐by‐layer assembly, and in situ growth, on membrane thickness and performance. It comprehensively explores the design strategies and potential applications of these methods, with a particular focus on gas separation, oil/water separation, and organic solvent nanofiltration. Furthermore, future opportunities, challenges within this field, and potential directions for future development are proposed. The application of covalent organic frameworks (COFs) in membrane separation represents a significant breakthrough in materials science. This review explores the preparation strategies, synthesis methods, and application performance of COF membranes. It highlights the advantages of COFs in membrane separation and discusses the existing challenges and future development directions.
Journal Article
Grinding-induced supramolecular charge-transfer assemblies with switchable vapochromism toward haloalkane isomers
Synthetic macrocycles have proved to be of great application value in functional charge-transfer systems in the solid state in recent years. Here we show a switchable on-off type vapochromic system toward 1-/2-bromoalkane isomers by constructing solid-state charge-transfer complexes between electron-rich perethylated pillar[5]arene and electron-deficient aromatic acceptors including 4-nitrobenzonitrile and 1,4-dinitrobenzene. These charge-transfer complexes with different colors show opposite color changes upon exposure to the vapors of 1-bromoalkanes (fading) and 2-bromoalkanes (deepening). Single-crystal structures incorporating X-ray powder diffraction and spectral analyses demonstrate that this on-off type vapochromic behavior is mainly attributed to the destruction (off) and reconstruction (on) of the charge-transfer interactions between perethylated pillar[5]arene and the acceptors, for which the competitive host-guest binding of 1-bromoalkanes and the solid-state structural transformation triggered by 2-bromoalkanes are respectively responsible. This work provides a simple colorimetric method for distinguishing positional isomers with similar physical and chemical properties.
The use of macrocycles to develop charge-transfer complexes in the solid state was recently demonstrated. Here, the authors develop an on-off type vapochromic system toward positional bromoalkane isomers by the reassembly and disassembly of charge-transfer complexes between a pillar[5]arene and electron-deficient aromatic guests in the solid state.
Journal Article
Eco‐Friendly Nanoplatforms for Crop Quality Control, Protection, and Nutrition
Agricultural chemicals have been widely utilized to manage pests, weeds, and plant pathogens for maximizing crop yields. However, the excessive use of these organic substances to compensate their instability in the environment has caused severe environmental consequences, threatened human health, and consumed enormous economic costs. In order to improve the utilization efficiency of these agricultural chemicals, one strategy that attracted researchers is to design novel eco‐friendly nanoplatforms. To date, numerous advanced nanoplatforms with functional components have been applied in the agricultural field, such as silica‐based materials for pesticides delivery, metal/metal oxide nanoparticles for pesticides/mycotoxins detection, and carbon nanoparticles for fertilizers delivery. In this review, the synthesis, applications, and mechanisms of recent eco‐friendly nanoplatforms in the agricultural field, including pesticides and mycotoxins on‐site detection, phytopathogen inactivation, pest control, and crops growth regulation for guaranteeing food security, enhancing the utilization efficiency of agricultural chemicals and increasing crop yields are highlighted. The review also stimulates new thinking for improving the existing agricultural technologies, protecting crops from biotic and abiotic stress, alleviating the global food crisis, and ensuring food security. In addition, the challenges to overcome the constrained applications of functional nanoplatforms in the agricultural field are also discussed. The recent advance of nanoplatforms with functional components for pesticides and mycotoxins on‐site detection, phytopathogen inactivation, pest control, and crops growth regulation in the agricultural field are summarized, and the prospects and challenges of nano‐based platforms for the sustainable development of green agriculture are also discussed.
Journal Article
Fluorescence Resonance Energy Transfer Systems in Supramolecular Macrocyclic Chemistry
The fabrication of smart materials is gradually becoming a research focus in nanotechnology and materials science. An important criterion of smart materials is the capacity of stimuli-responsiveness, while another lies in selective recognition. Accordingly, supramolecular host-guest chemistry has proven a promising support for building intelligent, responsive systems; hence, synthetic macrocyclic hosts, such as calixarenes, cucurbiturils, cyclodextrins, and pillararenes, have been used as ideal building blocks. Meanwhile, manipulating and harnessing light artificially is always an intensive attempt for scientists in order to meet the urgent demands of technological developments. Fluorescence resonance energy transfer (FRET), known as a well-studied luminescent activity and also a powerful tool in spectroscopic area, has been investigated from various facets, of which the application range has been broadly expanded. In this review, the innovative collaboration between FRET and supramolecular macrocyclic chemistry will be presented and depicted with typical examples. Facilitated by the dynamic features of supramolecular macrocyclic motifs, a large variety of FRET systems have been designed and organized, resulting in promising optical materials with potential for applications in protein assembly, enzyme assays, diagnosis, drug delivery monitoring, sensing, photosynthesis mimicking and chemical encryption.
Journal Article
Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges
Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived from the oral cavity. This tumor‐resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, F. nucleatum can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non‐antibiotic approaches to eradicate F. nucleatum and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat F. nucleatum and F. nucleatum biofilms. This review summarizes the latest advancements in anti‐F. nucleatum research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC. This review summarizes strategies to combat F. nucleatum and F. nucleatum biofilms for enhanced treatment of CRC, including natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, and vaccines. Additionally, the review highlights recent advances in anti‐F. nucleatum research, elucidates the antimicrobial mechanisms of the proposed anti‐F. nucleatum systems, and discusses the benefits and drawbacks of these antimicrobial technologies.
Journal Article
An Antibiotic Nanobomb Constructed from pH‐Responsive Chemical Bonds in Metal‐Phenolic Network Nanoparticles for Biofilm Eradication and Corneal Ulcer Healing
In the treatment of refractory corneal ulcers caused by Pseudomonas aeruginosa, antibacterial drugs delivery faces the drawbacks of low permeability and short ocular surface retention time. Hence, novel positively‐charged modular nanoparticles (NPs) are developed to load tobramycin (TOB) through a one‐step self‐assembly method based on metal‐phenolic network and Schiff base reaction using 3,4,5‐trihydroxybenzaldehyde (THBA), ε‐poly‐ʟ‐lysine (EPL), and Cu2+ as matrix components. In vitro antibacterial test demonstrates that THBA‐Cu‐TOB NPs exhibit efficient instantaneous sterilization owing to the rapid pH responsiveness to bacterial infections. Notably, only 2.6 µg mL−1 TOP is needed to eradicate P. aeruginosa biofilm in the nano‐formed THBA‐Cu‐TOB owing to the greatly enhanced penetration, which is only 1.6% the concentration of free TOB (160 µg mL−1). In animal experiments, THBA‐Cu‐TOB NPs show significant advantages in ocular surface retention, corneal permeability, rapid sterilization, and inflammation elimination. Based on molecular biology analysis, the toll‐like receptor 4 and nuclear factor kappa B signaling pathways are greatly downregulated as well as the reduction of inflammatory cytokines secretions. Such a simple and modular strategy in constructing nano‐drug delivery platform offers a new idea for toxicity reduction, physiological barrier penetration, and intelligent drug delivery. Novel positively‐charged modular nanoparticles (NPs) are developed to load tobramycin (TOB) through a one‐step self‐assembly method based on metal‐phenolic network and Schiff base reaction. Like a nano‐grenade, NPs exhibit efficient instantaneous sterilization owing to the rapid pH responsiveness to bacterial infections. Such a simple and modular strategy in constructing nano‐drug delivery platforms offers a new idea for toxicity reduction, physiological barrier penetration, and intelligent drug delivery.
Journal Article