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A comprehensive literature search was conducted across the PubMed, Embase, and Cochrane Library databases up to June 3, 2020. The primary outcome was major adverse cardiac events (MACEs). The secondary outcomes were all-cause mortality, cardiovascular (CV) death, heart failure (HF), and myocardial infarction (MI). Pooled estimations and 95% confidence intervals (CIs) were assessed using a random-effects model. Twenty-two articles that enrolled a total of 17,432 patients with CAD were included in the final analysis. CAD patients in the highest categories of baseline sST2 had a significantly higher risk of MACEs (HR: 1.42, 95% CI: 1.09-1.76), all-cause mortality (HR: 2.00, 95% CI: 1.54-2.46), and CV death (HR: 1.42, 95% CI: 1.15-1.68), HF (HR: 2.41, 95% CI: 1.87-2.94), but not that of MI (HR: 1.15, 95% CI: -0.73-3.04), than those in the lowest categories. These results were consistent when baseline sST2 was presented as continuous values in one unit increments. Moreover, subgroup analysis showed that elevated baseline sST2 levels increased the long-term risk of MACEs in the acute coronary syndrome (ACS) population (HR: 1.74, 95% CI: 1.39-2.09) but only showed a trend toward higher risk of MACEs in the non-ACS population (HR: 1.09, 95% CI: 0.87-1.30). The findings suggest that a higher concentration of baseline sST2 is associated with a higher risk of MACEs, all-cause mortality, CV death, and HF in patients with CAD. Elevated sST2 levels could significantly predict future MACEs in the ACS population but not in the non-ACS population.

In the past decade, artificial intelligence and Internet of things (IoT) technology have been rapid development, gradually began to integrate with each other, especially in coming 5G era. Admittedly, image recognition is the key technology due to a huge number of video cameras integrated in intelligent IoT equipment, such as driverless cars. However, the rapidly growing body of research in adversarial machine learning has demonstrated that the deep learning architectures are vulnerable to adversarial examples. Thus, the raises questions about the security of intelligent Internet of thing (IoT) and trust sensitive areas. This emphasizes the urgent need for practical defense technology that can be deployed to real-time combat attacks at any time. Well-crafted small perturbations lead to the misclassification of legitimate images by neural networks, but not the human visual system. It is worth noting that many attack strategies are designed to disrupt image pixels in a visually imperceptible manner. Therefore, we propose a new defense method and take full advantage of 5G high-speed bandwidth and mobile edge computing (MEC) effectively. We use singular value decomposition (SVD) which is the optimal approximation of matrix in the sense of square loss to eliminate the perturbation. We have conducted extensive and large-scale experiments with German Traffic Sign Recognition Benchmark (GTSRB) datasets and the results show that adversarial attacks, such as Carlini-Wagner’s l2, Deepfool, and I-FSGM, can be better eliminated by the method and provide lower latency.

In 2024, the H10N5 AIV was first reported to infect humans. Concurrently, we isolated a strain of H10N5 from wild birds that was highly similar to the human H10N5 strain. However, the zoonotic potential and the associated public health risks of the H10N5 virus remain unclear. In this study, we systematically evaluated the replication characteristics of human H10N5, wild bird H10N5, and poultry H10N8 in human lung epithelial cells, the virulence in mice, the transmission capabilities in guinea pigs, and the receptor-binding properties. Our results demonstrate that these novel H10N5 viruses have not yet acquired the ability to transmit in guinea pigs, but they possess the potential to infect mammals. These findings provide timely insights and warnings for the development of public health prevention strategies.

The 2022 and 2024 monkeypox (mpox) outbreak highlighted the urgent need for effective, durable, and safe vaccines. In addition to the traditional smallpox vaccines that could bring cross-protection against mpox, mRNA and protein-subunit mpox vaccines were extensively studied after the outbreak of mpox. In this study, we engineered monkeypox virus (MPXV) nanoparticle vaccines by conjugating the M1R and A35R, two well-characterized protective antigens to the mi3 nanoparticle using the SpyTag-SpyCatcher system, generating mi3-M1R and mi3-A35R constructs. An equimolar mixture of mi3-M1R and mi3-A35R formed a bivalent MPXV vaccine candidate, termed mi3-AM. When administered intraperitoneally with the Mn adjuvant, the mi3-AM vaccine induced robust humoral and antigen-specific cellular immune responses. Notably, the mi3-AM vaccine provided long-lasting protection against a lethal challenge with vaccinia virus Western Reserve strain (VACV-WR) in mice. With ongoing mpox outbreaks and the limitations of current vaccines, our candidate represents a promising, deployable solution with potential to bridge existing gaps in global orthopoxvirus prevention.

During our surveillance of avian influenza viruses (AIVs) in wild birds across China, H10Nx viruses were isolated from diverse migratory flyways between 2022 and 2024. We identified one wild-bird H10N5 strain that shared a common ancestor with the human H10N5 virus in multiple gene segments. Phylogenetic and molecular dating revealed the origin and evolution of H10N5, highlighting the need for continued monitoring.

This study evaluated the effects of dietary soybean lecithin (SBL) on the growth, haematological indices, immunities, antioxidant capabilities, and inflammatory and intestinal barrier functions because little information of dietary SBL could be obtained in juvenile largemouth bass (Micropterus salmoides). The fish were fed identical diets except for SBL added at 0, 2, 4 and 8%. It was found that 4 and 8% SBL significantly increased fish weight gain and daily growth rate (p < 0.05), while 4% SBL was optimal for enhancing RBC, HGB, PLT, MCV, MCH, WBC and MON in blood, and ALB and ALP in serum (p < 0.05). SBL (4%) also significantly elevated the antioxidant enzymes activities of T-SOD, CAT, GR, GPx, GST and T-AOC and GSH contents; increased mRNA transcription levels of Nrf2, Cu/Zn-SOD, CAT, GR, GST3 and GPx3; and decreased MDA contents. Keap1a and Keap1b levels were markedly down-regulated (p < 0.05). SBL (4%) significantly enhanced levels of the immune factors (ACP, LZM and C3) and the mRNA expression levels of innate immune-related genes (C3, C4, CFD, HEPC and MHC-I) compared with the control groups (0%) (p < 0.05). SBL (4%) significantly increased IgM and T-NOS in the intestine (p < 0.05) and significantly decreased levels of TNF-α, IL-8, IL-1β and IFN-γ and increased TGF-β1 at both transcription and protein levels in the liver and intestine (p < 0.05). The mRNA expression levels of MAPK13, MAPK14 and NF-κB P65 were significantly decreased in the intestine in the 4% SBL groups (p < 0.05). Histological sections also demonstrated that 4% SBL protected intestinal morphological structures compared with controls. This included increased intestinal villus height and muscular thickness (p < 0.05). Furthermore, the mRNA expression levels of the intestinal epithelial cell tight junction proteins (TJs) (ZO-1, claudin-3, claudin-4, claudin-5, claudin-23 and claudin-34) and mucin-5AC were significantly up-regulated in the 4% SBL groups compared with the controls (p < 0.05). In conclusion, these results suggested that 4% dietary SBL could not only improve growth, haematological indices, antioxidant capabilities, immune responses and intestinal functions, but also alleviate inflammatory responses, thereby providing reference information for the feed formulations in cultured largemouth bass.

This study investigated the effects of fish oil (FO), soybean oil (SO), rapeseed oil (RO), peanut oil (PO) and lard oil (LO) on growth, immunity and muscle quality in juvenile largemouth bass. After 8 weeks, the results showed that FO and RO could increase weight gain and serum alkaline phosphatase and apelin values compared with LO (p < 0.05). Except lower crude lipid contents, higher amounts of n-3 polyunsaturated fatty acids (15.83% and 14.64%) were present in the dorsal muscle of the FO and RO groups. Meanwhile, FO and RO could heighten mRNA levels of immune defense molecules (lysozyme, hepcidin, and transforming growth factor β1) compared with PO (p < 0.05). While SO could increase potential inflammatory risk via rising counts of white blood cells, platelets, neutrophils and monocytes, and mRNA levels of interleukins (IL-1β, IL-8, IL-12 and IL-15), FO and RO could improve hardness, chewiness and springiness through increasing amounts of hydroxyproline, collagen and lysyl oxidase, and mRNA levels of collagen 1α2 and prolyl hydroxylase in the fish dorsal muscle. Moreover, FO and RO could improve firmness through increasing glycogen and glycogen synthase 1 levels when compared with LO (p < 0.05). Therefore, these results could provide dietary lipid source references during the feeding process of adult largemouth bass.

The water conservation function plays a vital role in the land–water cycle. As the “Chinese water tower”, the headwaters of the Yellow River are of great significance to the safety of the Yellow River basin and even the global ecosystem. Taking the grassland ecosystem in the Yellow River source area as the research object, the InVEST water yield model with modified parameters and the ecological value evaluation of the modified equivalent factor method were used to explore the simulated spatio-temporal changes and the value of grassland water conservation from 2001 to 2020. The results show that: (1) the average total amount of water conservation in the source area is 549 × 108 m3, which is 16% of the runoff in the Yellow River basin, with a growth rate of 7.5 mm/year 1 and a contribution rate of 30%; (2) the total ecological value of grassland water conservation in 2020 is USD 340.03 × 108. The proportion of improved grassland in ecological restoration and management is only 0.51%, while the proportion of original alpine meadow reaches 67% and its ecological function and value are irreplaceable; (3) based on the comprehensive indicators of water conservation capacity, value and importance, Qumalai, Chengduo and Maduo counties are ranked as priority areas for the ecological protection of water resources.

Deep neural network has been widely used in pattern recognition and speech processing, but its vulnerability to adversarial attacks also proverbially demonstrated. These attacks perform unstructured pixel-wise perturbation to fool the classifier, which does not affect the human visual system. The role of adversarial examples in the information security field has received increased attention across a number of disciplines in recent years. An alternative approach is “like cures like”. In this paper, we propose to utilize common noise and adaptive wiener filtering to mitigate the perturbation. Our method includes two operations: noise addition, which adds natural noise to input adversarial examples, and adaptive wiener filtering, which denoising the images in the previous step. Based on the study of the distribution of attacks, adding natural noise has an impact on adversarial examples to a certain extent and then they can be removed through adaptive wiener filter, which is an optimal estimator for the local variance of the image. The proposed improved adaptive wiener filter can automatically select the optimal window size between the given multiple alternative windows based on the features of different images. Based on lots of experiments, the result demonstrates that the proposed method is capable of defending against adversarial attacks, such as FGSM (Fast Gradient Sign Method), C&W, Deepfool, and JSMA (Jacobian-based Saliency Map Attack). By compared experiments, our method outperforms or is comparable to state-of-the-art methods.

Background. Diabetic kidney disease (DKD) is the most important cause of the end-stage renal disease (ESRD) and the main cause of renal replacement therapy. Excessive inflammatory response and renal fibrosis are the keys to the development of this disease, and the conventional Western medical treatment is difficult to achieve and obtain long-term stable clinical results in all patients with DKD. Many studies have shown that Chinese medicine as a complementary and alternative medicine may be another therapeutic option to mitigate the progression of DKD to ESRD. In recent years, many doctors have used the Bushen Huoxue therapy to assist Western medicine in the treatment of the disease and have achieved certain clinical effects. However, most of the current studies are small sample studies, and there is no evidence-based confirmation. Objective. To systematically evaluate the efficacy and safety of the Bushen Huoxue therapy combined with conventional Western medicine in the treatment of DKD. Methods. A comprehensive search of literature databases such as CNKI, Wanfang, Pubmed, and Cochrane Library was conducted. The screening condition was that the control group was treated with conventional Western medicine and the experimental group was treated with Bushen Huoxue therapy’s RCT on top of the control group, and the RCTs were published from January 2011 to October 2021. The Cochrane risk bias assessment tool was used for literature quality evaluation, and RevMan 5.3 software was used for statistical analysis. Results. A total of 23 RCTs were finally included, with a total of 2,105 patients. Meta-analysis results show that the experimental group can effectively improve the clinical efficacy (RR = 1.28, 95% CI (1.22, 1.34), P<0.01), significantly reduce Crea (SMD = −0.45, 95% CI (−0.57, −0.33), P<0.01), 24 h UTP (SMD = −0.57, 95% CI (−0.69, −0.45), P<0.01), BUN (SMD = −0.36, 95%CI (−0.48, −0.24), P<0.01), UAER (SMD = −1.58, 95% CI (−1.78, −1.37), P<0.01), and blood sugar, and have certain medication safety (RR = 0.00, 95% CI (−0.03, 0.03), P=0.87). Conclusions. Chinese medicine based on the Bushen Huoxue therapy has a good clinical effect in the treatment of diabetic kidney disease and has certain safety. However, due to the limitation of the quality and quantity of the included literature, the above conclusion still needs more rational experiments to further verify.