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Water Sustainability for China and Beyond
Despite investments in water infrastructure, China must address complex human-nature interactions to ensure supply and quality. A water crisis has prompted the Chinese government to develop an ambitious water conservancy plan. However, the plan may not achieve water sustainability and may cause unintended environmental and socioeconomic consequences, unless it accounts for complex human-nature interactions ( 1 ). Water shortages, for example, force people to find alternatives, such as treatment facilities, whose land and energy requirements aggravate food and energy production, which need large amounts of water. Other nations face similar challenges and share real water from China along international rivers and/or virtual water through trade. Water problems are particularly challenging in China, which has the largest population, fastest-growing economy, rising water demand, relatively scarce water, dated infrastructure, and inadequate governance. We highlight China's water crisis and plan, and then offer recommendations.
Journal Article
Natural killer cells in cancer biology and therapy
The tumor microenvironment is highly complex, and immune escape is currently considered an important hallmark of cancer, largely contributing to tumor progression and metastasis. Named for their capability of killing target cells autonomously, natural killer (NK) cells serve as the main effector cells toward cancer in innate immunity and are highly heterogeneous in the microenvironment. Most current treatment options harnessing the tumor microenvironment focus on T cell-immunity, either by promoting activating signals or suppressing inhibitory ones. The limited success achieved by T cell immunotherapy highlights the importance of developing new-generation immunotherapeutics, for example utilizing previously ignored NK cells. Although tumors also evolve to resist NK cell-induced cytotoxicity, cytokine supplement, blockade of suppressive molecules and genetic engineering of NK cells may overcome such resistance with great promise in both solid and hematological malignancies. In this review, we summarized the fundamental characteristics and recent advances of NK cells within tumor immunometabolic microenvironment, and discussed potential application and limitations of emerging NK cell-based therapeutic strategies in the era of presicion medicine.
Journal Article
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer
Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations of metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC. Combining with previously established transcriptomic and genomic data of the same cohort, we conducted a comprehensive analysis linking TNBC metabolome to genomics. Our study classified TNBCs into three distinct metabolomic subgroups: C1, characterized by the enrichment of ceramides and fatty acids; C2, featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer; and C3, having the lowest level of metabolic dysregulation. Based on this newly developed metabolomic dataset, we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets. The transcriptomic luminal androgen receptor (LAR) subtype overlapped with metabolomic C1 subtype. Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate (S1P), an intermediate of the ceramide pathway, is a promising therapy for LAR tumors. Moreover, the transcriptomic basal-like immune-suppressed (BLIS) subtype contained two prognostic metabolomic subgroups (C2 and C3), which could be distinguished through machine-learning methods. We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors. Together, our study reveals the clinical significance of TNBC metabolomics, which can not only optimize the transcriptomic subtyping system, but also suggest novel therapeutic targets. This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC.
Journal Article
A Survey of GNSS Spoofing and Anti-Spoofing Technology
With the development of satellite navigation technology, the research focus of GNSS has shifted from improving positioning accuracy to expanding system application and improving system performance. At the same time, improving the survivability of satellite navigation systems has become a research hotspot in the field of navigation, especially with regard to anti-spoofing. This paper first briefly analyzes the common interference types of satellite navigation and then focuses on spoofing. We analyze the characteristics and technical mechanism of satellite navigation and the positioning signal. Spoofing modes are classified and introduced separately according to signal generation, implementation stage and deployment strategy. After an introduction of GNSS spoofing technology, we summarize the research progress of GNSS anti-spoofing technology over the last decade. For anti-spoofing technology, we propose a new classification standard and analyze and compare the implementation difficulty, effect and adaptability of the current main spoofing detection technologies. Finally, we summarize with considerations, prospective challenges and development trends of GNSS spoofing and anti-spoofing technology in order to provide a reference for future research.
Journal Article
Water quality monitoring and evaluation using remote sensing techniques in China: a systematic review
Introduction: The application of remote-sensing techniques for water quality assessment has become increasingly popular in China. However, existing reviews are often limited to qualitative description and are quite fragmented.
Outcomes: We conducted a quantitative systematic review to display current research status and identify the existing challenges and future directions. Our review revealed that the application of remote-sensing techniques in water quality research has expanded dramatically in China, but the spatial distribution is quite uneven. Second, the ground object spectrometer is the most widely applied data source. Water color indicators such as chlorophyll a and suspended solid are the most widely investigated in China. Third, semiempirical method is the most commonly used inversion method. Existing studies rarely considered the anthropogenic factors, which limited the model robustness and its application in human-dominated aquatic ecosystems.
Discussion and Conclusion: We concluded that, in the past several decades, China has made notable progresses in monitoring and evaluation of water quality using the remote-sensing techniques (especially in inland lakes). We proposed that further improvements would be needed in terms of temporal and spatial coverage, indicator list, the incorporation of human-nature interactions, inversion accuracy, and model generalization.
Journal Article
Improvements in ecosystem services from investments in natural capital
In response to ecosystem degradation from rapid economic development, China began investing heavily in protecting and restoring natural capital starting in 2000. We report on China's first national ecosystem assessment (2000–2010), designed to quantify and help manage change in ecosystem services, including food production, carbon sequestration, soil retention, sandstorm prevention, water retention, flood mitigation, and provision of habitat for biodiversity. Overall, ecosystem services improved from 2000 to 2010, apart from habitat provision. China's national conservation policies contributed significantly to the increases in those ecosystem services.
Journal Article