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"Yang, Ying"
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Relationship between parenting stress profiles, work-family conflict, and adolescent problem behavior: Variable-centered and person-centered approaches
Adolescent problem behaviors, including both internalizing (e.g., emotional symptoms) and externalizing difficulties (e.g., conduct problems, hyperactivity), are a significant risk factor in adolescent development. This study assessed the impact of maternal parenting stress on adolescent problem behaviors and explored mechanisms underlying this relationship.
This study aimed to (1) identify potential profiles of maternal parenting stress, (2) examine differences in adolescent problem behaviors across these profiles, and (3) determine whether maternal work-family conflict mediates the relationship between maternal stress profiles and adolescent problem behaviors.
In this cross-sectional study, data were collected from 846 mother-child subject pairs through self-report instruments completed by both mothers and adolescents. Standardized measures were used to assess parenting stress, work-family conflict, and problem behavior. The data were subsequently analyzed using latent profile analysis and mediation analysis.
(1) Four maternal stress profiles were identified: low-stress, middle-stress-low interaction disorder, middle-stress, and high-stress profiles. (2) Significant differences in adolescent problem behaviors were observed across these profiles. (3) The other three profiles significantly predicted adolescent problem behaviors compared to the low-stress group. (4) Using the low-stress type as the reference, maternal work interference with family significantly mediated the relationship between the remaining three stress profiles and adolescent problem behaviors.
Journal Article
Disaster public health and older people
\"Disaster Public Health and Older People introduces professionals, students and fieldworkers to the science and art of promoting health and well-being, preventing diseases and prolonging life among the elderly in the context of humanitarian emergencies, with a particular focus on low and middle-income country settings. This book aims to make lessons learnt from previous disasters available and comprehensible to those working in disaster medicine, disaster public health, humanitarian studies, gerontology and geriatrics, empowering them to take the actions necessary at the individual, community and national levels to reduce the health risk to the elderly posed by disasters\"-- Provided by publisher.
Book
Prolyl isomerase Pin1: a promoter of cancer and a target for therapy
Pin1 is the only known peptidyl-prolyl
cis
–
trans
isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif. The Pin1-mediated structural transformation posttranslationally regulates the biofunctions of multiple proteins. Pin1 is involved in many cellular processes, the aberrance of which lead to both degenerative and neoplastic diseases. Pin1 is highly expressed in the majority of cancers and its deficiency significantly suppresses cancer progression. According to the ground-breaking summaries by Hanahan D and Weinberg RA, the hallmarks of cancer comprise ten biological capabilities. Multiple researches illuminated that Pin1 contributes to these aberrant behaviors of cancer via promoting various cancer-driving pathways. This review summarized the detailed mechanisms of Pin1 in different cancer capabilities and certain Pin1-targeted small-molecule compounds that exhibit anticancer activities, expecting to facilitate anticancer therapies by targeting Pin1.
Journal Article
Cytoplasmic m6A reader YTHDF3 promotes mRNA translation
Dear Editor, N6-methyladenosine （m6A）, as the most abundant internal modification with ubiquitous feature in eukaryotic mRNAs, has been connected with many fundamental aspects of RNA metabolism such as translation [1-3], splicing [4, 5], stability and decay [6]. m6A modification is reversible and can be regulated by three groups of molecules commonly referred to as writers, erasers and readers, m6A writers are the components of the multi-complex methyltransferase catalyzing the formation of m6A methylation, among which METTL3,
Journal Article
Immunomodulatory function and anti-tumor mechanism of natural polysaccharides: A review
Polysaccharides extracted from natural resources have attracted extensive attention in biomedical research and pharmaceutical fields, due to their medical values in anti-tumor, immunomodulation, drug delivery, and many other aspects. At present, a variety of natural polysaccharides have been developed as adjuvant drugs in clinical application. Benefit from their structural variability, polysaccharides have great potential in regulating cellular signals. Some polysaccharides exert direct anti-tumor effects by inducing cell cycle arrest and apoptosis, while the majority of polysaccharides can regulate the host immune system and indirectly inhibit tumors by activating either non-specific or specific immune responses. As the essential of microenvironment in the process of tumor development has been gradually revealed, some polysaccharides were found to inhibit the proliferation and metastasis of tumor cells via tumoral niche modulation. Here, we focused on natural polysaccharides with biomedical application potential, reviewed the recent advancement in their immunomodulation function and highlighted the importance of their signaling transduction feature for the antitumor drug development.
Journal Article
Gene duplications and phylogenomic conflict underlie major pulses of phenotypic evolution in gymnosperms
Inferring the intrinsic and extrinsic drivers of species diversification and phenotypic disparity across the tree of life is a major challenge in evolutionary biology. In green plants, polyploidy (or whole-genome duplication, WGD) is known to play a major role in microevolution and speciation, but the extent to which WGD has shaped macroevolutionary patterns of diversification and phenotypic innovation across plant phylogeny remains an open question. Here, we examine the relationship of various facets of genomic evolution—including gene and genome duplication, genome size, and chromosome number—with macroevolutionary patterns of phenotypic innovation, species diversification, and climatic occupancy in gymnosperms. We show that genomic changes, such as WGD and genome-size shifts, underlie the origins of most major extant gymnosperm clades, and notably, our results support an ancestral WGD in the gymnosperm lineage. Spikes of gene duplication typically coincide with major spikes of phenotypic innovation, while increased rates of phenotypic evolution are typically found at nodes with high gene-tree conflict, representing historic population-level dynamics during speciation. Most shifts in gymnosperm diversification since the rise of angiosperms are decoupled from putative WGDs and instead are associated with increased rates of climatic occupancy evolution, particularly in cooler and/or more arid climatic conditions, suggesting that ecological opportunity, especially in the later Cenozoic, and environmental heterogeneity have driven a resurgence of gymnosperm diversification. Our study provides critical insight on the processes underlying diversification and phenotypic evolution in gymnosperms, with important broader implications for the major drivers of both micro- and macroevolution in plants.
By examining the relationship of various facets of genomic changes with phenotypic evolution, this study found that pulses of phenotypic innovation in gymnosperms are strongly associated with gene duplications and genomic conflict.
Journal Article