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"Yang, Yu"
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Fundamentals of foundation engineering
\"This book aims to introduce the principal and design of various foundations, covering shallow foundations, mat foundations, earth retaining structures, excavations, pile foundations, and slope stability. Since the analysis and design of a foundation are based on the soil properties under short-term (undrained) or long-term (drained) conditions, the assessment of soil properties from the geotechnical site investigation and the concept of drained or undrained soil properties are discussed in the first two chapters. Foundation elements transfer various load combinations from the superstructure to the underlying soils or rocks. The load transfer mechanisms, vertical stress or earth pressure distributions, and failure modes of each foundation type are clearly explained in this book. After understanding the soil responses subjected to the loadings from the foundation, the design methods, required factors of safety, and improvement measures for each foundation type are elaborated. This book presents both theoretical explication and practical applications for readers to easily comprehend the theoretical background, design methods, and practical applications and considerations. Each chapter provides relevant exercise examples and a problem set for self-practice. The analysis methods introduced in the book can be applied in actual analysis and design as they contain the most up-to-date knowledge of foundation design. This book is suitable for teachers and students to use in foundation engineering courses, and engineers who are engaged in foundation design to create a technically sound, construction-feasible, and economical design of the foundation system\"-- Provided by publisher.
Book
Single cell electron collectors for highly efficient wiring-up electronic abiotic/biotic interfaces
By electronically wiring-up living cells with abiotic conductive surfaces, bioelectrochemical systems (BES) harvest energy and synthesize electric-/solar-chemicals with unmatched thermodynamic efficiency. However, the establishment of an efficient electronic interface between living cells and abiotic surfaces is hindered due to the requirement of extremely close contact and high interfacial area, which is quite challenging for cell and material engineering. Herein, we propose a new concept of a single cell electron collector, which is
in-situ
built with an interconnected intact conductive layer on and cross the individual cell membrane. The single cell electron collector forms intimate contact with the cellular electron transfer machinery and maximizes the interfacial area, achieving record-high interfacial electron transfer efficiency and BES performance. Thus, this single cell electron collector provides a superior tool to wire living cells with abiotic surfaces at the single-cell level and adds new dimensions for abiotic/biotic interface engineering.
Efficient management of electron transfer between living cells and solid abiotic surfaces is quite challenging. Here, the authors report the assembling of single cell electron collector for individual cell to promote the biotic/abiotic interfacial electron transfer at the single-cell level.
Journal Article
The development of e-governance in China : improving cybersecurity and promoting informatization as means for modernizing state governance
This book figures out that network security and informatization have entered a development stage of greater permeation and deeper integration into all aspects of the economy and society. In particular since the 2008 financial crisis, the world's major economies have placed a strategic focus on network security and informatization in order to seek out new growth points, alleviate energy and ecological pressures, improve living standards, and improve social governance through new technological transformations in fields such as cloud computing, the Internet of Things, mobile internet, big data, smart cities, and a wave of applications. The effects on the economy and society have emerged and will continue to make significant progress. Based on China's stage of new urbanization, industrialization, informatization, and agricultural modernization and major characteristics, as well as the intrinsic need for synchronized development, this book encourages society to accelerate the pace of development, expand the scope of work and promote informatization and the comprehensive, coordinated, effective linking and deep integration of informatization with all areas of the economy and society.-- Provided by publisher.
BOOK
The parent-of-origin lncRNA MISSEN regulates rice endosperm development
The cereal endosperm is a major factor determining seed size and shape. However, the molecular mechanisms of endosperm development are not fully understood. Long noncoding RNAs (lncRNAs) function in various biological processes. Here we show a lncRNA,
MISSEN
, that plays an essential role in early endosperm development in rice (
Oryza sativa
).
MISSEN
is a parent-of-origin lncRNA expressed in endosperm, and negatively regulates endosperm development, leading to a prominent dent and bulge in the seed. Mechanistically,
MISSEN
functions through hijacking a helicase family protein (HeFP) to regulate tubulin function during endosperm nucleus division and endosperm cellularization, resulting in abnormal cytoskeletal polymerization. Finally, we revealed that the expression of
MISSEN
is inhibited by histone H3 lysine 27 trimethylation (H3K27me3) modification after pollination. Therefore,
MISSEN
is the first lncRNA identified as a regulator in endosperm development, highlighting the potential applications in rice breeding.
The cereal endosperm is a major determinant of seed size and shape. Here the authors show that a lncRNA,
MISSEN
, is expressed from the maternally derived allele in rice seeds and regulates a helicase family protein to support efficient nuclear division, distribution and cellularization in the endosperm.
Journal Article
Lee Kuan Yew through the eyes of Chinese scholars
\"A compilation of essays by highly-respected Chinese scholars in which they evaluate the life, work and philosophy of Lee Kuan Yew, founding Prime Minister of Singapore. Presenting a range of views from a uniquely Chinese/Asian perspective, this book provides valuable insights for those who wish to gain a fuller and deeper understanding of Lee Kuan Yew, the man, as well as Singapore, his nation\"-- Provided by publisher.
Book
Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
Alzheimer’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and intercellular neurofibrillary tangles composed of aggregated β-amyloid (Aβ) and hyperphosphorylated tau protein, respectively. In the past few decades, disease-modifying therapy targeting Aβ has been the focus of AD drug development. Even though it is encouraging that two of these drugs have recently received accelerated US Food and Drug Administration approval for AD treatment, their efficacy or long-term safety is controversial. Tau has received increasing attention as a potential therapeutic target, since evidence indicates that tau pathology is more associated with cognitive dysfunction. Moreover, inflammation, especially neuroinflammation, accompanies AD pathological processes and is also linked to cognitive deficits. Accumulating evidence indicates that inflammation has a complex and tight interplay with tau pathology. Here, we review recent evidence on the interaction between tau pathology, focusing on tau post-translational modification and dissemination, and neuroinflammatory responses, including glial cell activation and inflammatory signaling pathways. Then, we summarize the latest clinical trials targeting tau and neuroinflammation. Sustained and increased inflammatory responses in glial cells and neurons are pivotal cellular drivers and regulators of the exacerbation of tau pathology, which further contributes to its worsening by aggravating inflammatory responses. Unraveling the precise mechanisms underlying the relationship between tau pathology and neuroinflammation will provide new insights into the discovery and clinical translation of therapeutic targets for AD and other tau-related diseases (tauopathies). Targeting multiple pathologies and precision therapy strategies will be the crucial direction for developing drugs for AD and other tauopathies.
Journal Article
The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice
N6-Methyladenosine (m6A) RNA methylation plays important roles during development in different species. However, knowledge of m6A RNA methylation in monocots remains limited. In this study, we reported that OsFIP and OsMTA2 are the components of m6A RNA methyltransferase complex in rice and uncovered a previously unknown function of m6A RNA methylation in regulation of plant sporogenesis. Importantly, OsFIP is essential for rice male gametogenesis. Knocking out of OsFIP results in early degeneration of microspores at the vacuolated pollen stage and simultaneously causes abnormal meiosis in prophase I. We further analyzed the profile of rice m6A modification during sporogenesis in both WT and OsFIP loss-of-function plants, and identified a rice panicle specific m6A modification motif \"UGWAMH\". Interestingly, we found that OsFIP directly mediates the m6A methylation of a set of threonine protease and NTPase mRNAs and is essential for their expression and/or splicing, which in turn regulates the progress of sporogenesis. Our findings revealed for the first time that OsFIP plays an indispensable role in plant early sporogenesis. This study also provides evidence for the different functions of the m6A RNA methyltransferase complex between rice and Arabidopsis.
Journal Article
The prevalence and correlation of cancer-related fatigue and locomotive syndrome in geriatric cancer patients
To explore the relationship between cancer-related fatigue (CRF) and locomotive syndrome (LS) among Chinese older adults with cancer.
This study was a cross-sectional survey. Staged random sampling method was employed to enroll 500 geriatric cancer patients from the Oncology Center of Jiangnan University Hospital in Wuxi, Jiangsu Province, China. Data were collected using General Information Questionnaire, Cancer Fatigue Scale and the Geriatric Locomotive Function Scale. χ2 test, Logistic regression analysis and Spearman analysis were utilized to analyze the data.
A total of 466 geriatric cancer patients were enrolled in this survey. The occurrence of CRF was 43.8%, and the occurrence of LS was 30.9%. LS were risk factors for the occurrence of CRF in geriatric cancer patients. Advanced old age, fear of falling, comorbid with chronic diseases and CRF were risk factors for LS. CRF was positively associated with LS (r = 0.446, P < 0.001).
Our findings indicate a potential link between CRF and LS. By addressing LS from various aspects, including controlling the number of complications due to advanced old age and other factors, as well as spreading proper fall-related knowledge and controlling the awareness of fear of falling, healthcare professionals can indirectly alleviate CRF symptoms and improve the overall quality of life for these patients.
Journal Article