Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
23
result(s) for
"Yasuda, Anita"
Sort by:
Rick Riordan
\"Part of a biography series that profiles children's authors of the twentieth century. Explores the life of Rick Riordan and his most popular books, with additional facts provided through a timeline, awards, and fan information. Includes photographs, creative writing tips, and instruction on how to write a biography report. Intended for fourth to sixth grade students\"--Provided by publisher.
BOOK
Kagome Kagome
Yasuda features Kagome Kagome, a Japanese game that is hundreds of years old. Instruction on how to play the game is also presented.
Magazine Article
The new nation through the eyes of George Washington
\"Experience the new nation from President George Washington's perspective. Learn about the challenges he faced, how he responded to difficult issues, and how he shaped the country during this pressing time in office\"--Publisher's website.
BOOK
The crazy clues
Dot the Diplodocus is puzzled by the strange behavior of her family and friends, but when she investigates she finds a trail of popcorn that leads her to an answer.
Book
Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring
Experimental data indicate that low-calcemic vitamin D derivatives (VDDs) exhibit anticancer properties, both in vitro and in vivo. In our search for a vitamin D analog as potential anticancer agent, we investigated the influence of chirality in the side chain of the derivatives of 1,25-dihydroxyergocalciferol (1,25D2) on their activities. In this study, we synthesized modified analogs at the side chain and the A-ring, which differed from one another in their absolute configuration at C-24, namely (24S)- and (24R)-1,25-dihydroxy-19-nor-20a-homo-ergocalciferols (PRI-5105 and PRI-5106, respectively), and evaluated their activity. Unexpectedly, despite introducing double-point modifications, both analogs served as very good substrates for the vitamin D-hydroxylating enzyme. Irrespective of their absolute C-24 configuration, PRI-5105 and PRI-5106 showed relatively low resistance to CYP24A1-dependent metabolic deactivation. Additionally, both VDDs revealed a similar antiproliferative activity against HT-29 colorectal cancer cells which was higher than that of 1,25D3, the major biologically active metabolite of vitamin D. Furthermore, PRI-5105 and PRI-5106 significantly enhanced the cell growth-inhibitory activity of 5-fluorouracil on HT-29 cell line. In conclusion, although the two derivatives showed a relatively high anticancer potential, they exhibited undesired high metabolic conversion.
Journal Article
The mystery coins
Using Ty the Tyrannosaurus Rex's new invention, the Dino Detectives find a bag of strange coins at the beach and trace them back to a carnival.
Book
Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D 2 Derivatives Modified at the Side Chain and the A-Ring
Experimental data indicate that low-calcemic vitamin D derivatives (VDDs) exhibit anticancer properties, both
and
. In our search for a vitamin D analog as potential anticancer agent, we investigated the influence of chirality in the side chain of the derivatives of 1,25-dihydroxyergocalciferol (1,25D2) on their activities. In this study, we synthesized modified analogs at the side chain and the A-ring, which differed from one another in their absolute configuration at C-24, namely (24
)- and (24
)-1,25-dihydroxy-19-
-20a-homo-ergocalciferols (PRI-5105 and PRI-5106, respectively), and evaluated their activity. Unexpectedly, despite introducing double-point modifications, both analogs served as very good substrates for the vitamin D-hydroxylating enzyme. Irrespective of their absolute C-24 configuration, PRI-5105 and PRI-5106 showed relatively low resistance to CYP24A1-dependent metabolic deactivation. Additionally, both VDDs revealed a similar antiproliferative activity against HT-29 colorectal cancer cells which was higher than that of 1,25D3, the major biologically active metabolite of vitamin D. Furthermore, PRI-5105 and PRI-5106 significantly enhanced the cell growth-inhibitory activity of 5-fluorouracil on HT-29 cell line. In conclusion, although the two derivatives showed a relatively high anticancer potential, they exhibited undesired high metabolic conversion.
Journal Article