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Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low bioavailability, low water solubility, and variable pharmacokinetic profiles. Importantly, lack of patentability of the drug substance also limits the likelihood of an expensive, full development programme in anything other than orphan indications. Potential avenues to overcome these issues with CBD include self-emulsifying drug delivery systems, improved crystal formulations and other solid-state delivery formulations, which are mostly in the pre-clinical or early clinical stages of development. This review identifies issues compromising current delivery of solid-state CBD, and how advanced pharmaceutical development strategies can enable CBD to realise the full potential as a successful therapeutic agent.

Ultra-wideband, three-dimensional (3D) imaging spectrometry in the millimeter–submillimeter (mm–submm) band is an essential tool for uncovering the dust-enshrouded portion of the cosmic history of star formation and galaxy evolution1–3. However, it is challenging to scale up conventional coherent heterodyne receivers4 or free-space diffraction techniques5 to sufficient bandwidths (≥1 octave) and numbers of spatial pixels2,3 (>102). Here, we present the design and astronomical spectra of an intrinsically scalable, integrated superconducting spectrometer6, which covers 332–377 GHz with a spectral resolution of F/ΔF ~ 380. It combines the multiplexing advantage of microwave kinetic inductance detectors (MKIDs)7 with planar superconducting filters for dispersing the signal in a single, small superconducting integrated circuit. We demonstrate the two key applications for an instrument of this type: as an efficient redshift machine and as a fast multi-line spectral mapper of extended areas. The line detection sensitivity is in excellent agreement with the instrument design and laboratory performance, reaching the atmospheric foreground photon noise limit on-sky. The design can be scaled to bandwidths in excess of an octave, spectral resolution up to a few thousand and frequencies up to ~1.1 THz. The miniature chip footprint of a few cm2 allows for compact multi-pixel spectral imagers, which would enable spectroscopic direct imaging and large-volume spectroscopic surveys that are several orders of magnitude faster than what is currently possible1–3.By using a superconducting integrated circuit to filter incoming millimetre, submillimetre and far-infrared light from distant galaxies, a prototype spectrometer holds promise for wideband spectrometers that are small, sensitive and scalable to wideband spectroscopic imagers.

Ultraviolet-C (UV-C) radiation exposure is an attractive option for rapid and consistent disinfection of interior surfaces in aircraft cabins. In this study, fabric and plastic materials commonly used in aircraft cabins were exposed to UV-C radiation to determine their sensitivity to cumulative damage from frequent application. No significant effect on flame retardancy occurred up to 269 J/cm2 dose, and no effect on tensile or tear strength occurred up to 191 J/cm2 . Changes in color or appearance can occur at lower doses. A limit of 40 J/cm2 is proposed to avoid perceptible changes in appearance.

Recently, agonist antibodies to glucocorticoid-induced tumor necrosis factor receptor (GITR) (tumor necrosis factor receptor superfamily 18) have been shown to neutralize the suppressive activity of CD4+CD25+regulatory T cells. It was anticipated that this would be the role of the physiological ligand. We have identified and expressed the gene for mouse GITR ligand and have confirmed that its interaction with GITR reverses suppression by CD4+CD25+T cells. It also, however, provides a costimulatory signal for the antigen-driven proliferation of$na{\\ddot \\imath} ve$T cells and polarized T helper 1 and T helper 2 clones. RT-PCR and mAb staining revealed mouse GITR ligand expression in dendritic cells, macrophages, and B cells. Expression was controlled by the transcription factor NF-1 and potentially by alternative splicing of mRNA destabilization sequences.

We are developing an ultra-wideband spectroscopic instrument, DESHIMA (DEep Spectroscopic HIgh-redshift MApper), based on the technologies of an on-chip filter bank and microwave kinetic inductance detector (MKID) to investigate dusty starburst galaxies in the distant universe at millimeter and submillimeter wavelengths. An on-site experiment of DESHIMA was performed using the ASTE 10-m telescope. We established a responsivity model that converts frequency responses of the MKIDs to line-of-sight brightness temperature. We estimated two parameters of the responsivity model using a set of skydip data taken under various precipitable water vapor (PWV 0.4–3.0 mm) conditions for each MKID. The line-of-sight brightness temperature of sky is estimated using an atmospheric transmission model and the PWVs. As a result, we obtain an average temperature calibration uncertainty of 1 σ = 4 %, which is smaller than other photometric biases. In addition, the average forward efficiency of 0.88 in our responsivity model is consistent with the value expected from the geometrical support structure of the telescope. We also estimate line-of-sight PWVs of each skydip observation using the frequency response of MKIDs and confirm the consistency with PWVs reported by the Atacama Large Millimeter/submillimeter Array.

The next generation of far infrared radiation detectors is aimed to reach photon noise limited performance in space based observatories such as SPICA and BLISS. These detectors operate at loading powers of the astronomical signal of a few Attowatt (10 −18 W) or less, corresponding to a sensitivity expressed in noise equivalent power as low as . We have developed a cryogenic test setup for microwave Kinetic Inductance Detectors (MKIDs) that aims to reach these ultra-low background levels. Stray light is stopped by using a box in a box design with a sample holder inside another closed box. Microwave signals for the MKID readout enters the outer box through custom made coax cable filters. The stray light loading per pixel is estimated to be less than 60×10 −18 W during nominal operation, a number limited by the intrinsic sensitivity of the MKIDs used to validate the system.

Integrated superconducting spectrometer (ISS) technology will enable ultra-wideband, integral-field spectroscopy for (sub)millimeter-wave astronomy, in particular, for uncovering the dust-obscured cosmic star formation and galaxy evolution over cosmic time. Here, we present the development of DESHIMA 2.0, an ISS for ultra-wideband spectroscopy toward high-redshift galaxies. DESHIMA 2.0 is designed to observe the 220–440 GHz band in a single shot, corresponding to a redshift range of z  = 3.3–7.6 for the ionized carbon emission ([C II] 158  μ m). The first-light experiment of DESHIMA 1.0, using the 332–377 GHz band, has shown an excellent agreement among the on-sky measurements, the laboratory measurements, and the design. As a successor to DESHIMA 1.0, we plan the commissioning and the scientific observation campaign of DESHIMA 2.0 on the ASTE 10-m telescope in 2023. Ongoing upgrades for the full octave-bandwidth system include the wideband 347-channel chip design and the wideband quasi-optical system. For efficient measurements, we also develop the observation strategy using the mechanical fast sky-position chopper and the sky-noise removal technique based on a novel data-scientific approach. In the paper, we show the recent status of the upgrades and the plans for the scientific observation campaign.

Levetiracetam (LEV) is used in the setting of acute brain injury for seizure treatment or prophylaxis but its safety and efficacy in this setting is unknown. We retrospectively analyzed the patterns of use and safety/efficacy of LEV in 379 patients treated in the neuroscience intensive care unit (NSICU). We extracted from the charts clinical data including diagnosis, AED therapy before and during stay in the NSICU, complications of treatment, length of stay, and clinical outcomes (improvement, Glasgow Coma Scale, and death). We analyzed the data using binary and ordered (multi-category) logistic regression. Overall, our findings are that phenytoin used prior to the NSICU admission was frequently replaced with LEV monotherapy (P < 0.001). Patients treated with LEV monotherapy when compared to other AEDs had lower complication rates and shorter NSICU stays. Older patients and patients with brain tumors or strokes were preferentially treated with LEV for prevention and/or management of seizures (all P < or = 0.014). The results of this study suggest that LEV is a frequently used AED in the setting of acute brain injury and that it may be a desirable alternative to phenytoin. Prospective studies evaluating the long-term safety, efficacy and outcomes of LEV in this setting are indicated.

Detector requirements for far infrared astronomy generally result in devices which exhibit a few-moded response to incident radiation. The sensitivity and spatial form of the individual modes to which such a detector is sensitive can be determined with knowledge of the complex valued cross-spectral density of the system, which we label the detector response function (DRF). A matrix representing the discretized cross-spectral density can be measured from the complex amplitudes of interference fringes generated by two identical sources as they are independently scanned through the field of view. We provide experimental verification of this technique using monochromatic THz beams generated by photomixers in which the relative phase is varied with fiber stretchers. We use this system to characterize the modal response of a single pixel from an array of microwave kinetic inductance detectors (MKIDs).

Integrated superconducting spectrometer (ISS) technology will enable ultra-wideband, integral-field spectroscopy for (sub)millimeter-wave astronomy, in particular, for uncovering the dust-obscured cosmic star formation and galaxy evolution over cosmic time. Here we present the development of DESHIMA 2.0, an ISS for ultra-wideband spectroscopy toward high-redshift galaxies. DESHIMA 2.0 is designed to observe the 220-440 GHz band in a single shot, corresponding to a redshift range of \\(z\\)=3.3-7.6 for the ionized carbon emission ([C II] 158 \\(\\mu\\)m). The first-light experiment of DESHIMA 1.0, using the 332-377 GHz band, has shown an excellent agreement among the on-sky measurements, the lab measurements, and the design. As a successor to DESHIMA 1.0, we plan the commissioning and the scientific observation campaign of DESHIMA 2.0 on the ASTE 10-m telescope in 2023. Ongoing upgrades for the full octave-bandwidth system include the wideband 347-channel chip design and the wideband quasi-optical system. For efficient measurements, we also develop the observation strategy using the mechanical fast sky-position chopper and the sky-noise removal technique based on a novel data-scientific approach. In the paper, we show the recent status of the upgrades and the plans for the scientific observation campaign.