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"Yi, Zeng-zhou"
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The Experimental Study of the Validity of the Lagrange–Helmholtz Relationship in Geomagnetic Fields
Streak cameras, known for their ultra-high spatiotemporal resolution, rely heavily on the spatial resolution capabilities of their core component, the streak tube, to ensure engineering stability. However, factors such as assembly inaccuracies and external magnetic fields, including geomagnetic interference, often cause deformation and shifts in the imaging plane. To enhance equipment stability and accelerate engineering advancements, a dual approach involving hardware improvements and computational imaging-based software corrections is essential. Future image reconstruction efforts in software require robust benchmarks; however, existing benchmarks are predominantly validated under idealized conditions, neglecting real-world interference factors. This study, grounded in electron optical imaging principles, experimentally confirms that the Lagrange–Helmholtz relationship remains valid within streak tube systems under geomagnetic field influences. These findings affirm that the imaging plane retains spatial resolution consistency despite such environmental disturbances. Consequently, the need for specific image orientations during reconstruction can be eliminated, enabling the development of more robust and efficient image reconstruction algorithms.
Journal Article
Inhibiting autophagy overcomes docetaxel resistance in castration-resistant prostate cancer cells
BackgroundThis study investigates the docetaxel-resistant mechanism and explores the effect of tea polyphenols (TP) on autophagy and its related mechanism in human castration-resistant prostate cancer (CRPC) cell lines PC3 and DU145.MethodsImmunofluorescence assay and annexin V-FITC/PI double staining flow cytometry were used to analyze the apoptosis and autophagy of PC3 and DU145 cells. The expression of autophagy-related proteins was detected by western bolt.ResultsDocetaxel could induce autophagy and apoptosis, together with the expression increase in p-JNK, p-Bcl-2 and Beclin1. The level of autophagy was remarkably decreased, but apoptosis was increased after combining with TP. In addition, the expression of p-mTOR was increased after combining with TP.ConclusionDocetaxel induces protective autophagy in CRPC cells by JNK pathway activation and then Bcl-2 phosphorylation and Beclin1 dissociation. TP activates mTOR pathway, which ultimately inhibits docetaxel-induced autophagy and improves therapeutic efficacy of docetaxel in CRPC cells.
Journal Article
Expression and clinical significance of EGFL7 in malignant glioma
Purpose Tumor angiogenesis is an important factor for the continuous growth of human malignancies and can be used to predict the prognosis for patients. In the current study, we examined the expression of EGF-like domain 7 (EGFL7), an endothelial cell-derived secreted factor, in malignant gliomas and explored its clinical significance. Methods We determined the steady-state mRNA levels of EGFL7 from 36 fresh glioma samples by semi-quantitative RT-PCR and the protein levels from 45 paraffin-embedded glioma samples by immunohistochemistry, respectively. Normal brain tissues from 10 patients with brain trauma were used as control. We also analyzed the correlations between the expression levels of EGFL7 and various clinical parameters, including patient gender, age, tumor grade, tumor proliferation marker Ki-67, and microvessel density (MVD). Results We found that EGFL7 was not detectable in normal brain tissues, but was up-regulated in both tumor cells and vascular endothelial cells within malignant glioma. The expression level of EGFL7 in malignant glioma significantly correlated with the tumor grade, Ki-67 expression and MVD (P < 0.01). Conclusions Our data suggest that EGFL7 expression is a novel predictive factor for the clinical progression of malignant glioma, and may constitute a therapeutic target for anti-angiogenesis therapy in patients with the disease.
Journal Article
Hg-mining-induced soil pollution by potentially toxic metal(loid)s presents a potential environmental risk and threat to human health: A global meta-analysis
● Agricultural activities may promote the conversion of inorganic Hg to MeHg in soil. ● Hg and As present an extremely and a moderately contaminated level, respectively. ● The human health risks posed by As, Hg, and Ni merit more attention. ● Pokeweed may be considered as a potential Hg hyperaccumulator.
Soil pollution caused by potentially toxic metal(loid)s (PTMs) near mercury (Hg) mines has attracted extensive attention, yet the status and potential health risks of PTM contamination in soils near Hg mining sites have rarely been investigated on a large scale. Global data on methylmercury (MeHg), Hg, Cd, Cr, As, Pb, Cu, Zn, Mn, and Ni concentrations in soils from Hg mining areas were obtained from published research articles (1999-2023). Based on the database, pollution levels, spatial distributions, and potential health risks were investigated. Results indicated that the average percentage of MeHg to total Hg in agricultural soils (0.19%) was significantly higher than that in non-agricultural soils (0.013%). Indeed, 72.4% of these study sites were extremely contaminated with Hg. Approximately 45% of the examined sites displayed a moderate level of As contamination or even more. Meanwhile, the examined sites in Spain and Turkey exhibited considerably higher pollution levels of Hg and As than other regions. The mean hazard indices of the nine PTMs were 2.91 and 0.59 for children and adults, with 85.6% and 13.3% of non-carcinogenic risks for children and adults that exceeded the safe level of 1, respectively. In addition, 70.2% and 56.7% of the total cancer risks through exposure to five carcinogenic PTMs in children and adults, respectively, exceeded the safety level. As and Hg showed a high exceedance of non-carcinogenic risks, while As and Ni were the leading contributors to carcinogenic risks. This study demonstrates the urgent necessity for controlling PTM pollution and reducing the health risks in soils near Hg mining sites and provides an important basis for soil remediation.
Journal Article
Parametrization of woods-saxon potential for heavy-ion systems
Several elastic scattering angular distributions of 12C from target nuclei of A≥ 39 are analyzed to extract the Woods-Saxon poten- tial parameters with the fixed imaginary potential and Coulomb radius parameters. Using the best fitted diffuseness parameters, the correlations of the real part parameters with A1/3 1 ＋ A1/3 2and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction. The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by 12C, but also many elastic scattering angular distributions induced by the projectiles other than 12C, thus providing important inputs for the study of nuclear reactions of heavy-ion systems.
Journal Article
Comparative analysis of intermuscular bones in fish of different ploidies
We documented the number, morphology, and distribution of intermuscular bones in five fishes of different ploidy： Carassius auratus （Abbr.WCC, 2n=100）, Carassius auratus variety PengZe （Abbr.PZCC, 3n=150）, improved triploid crucian carp （Abbr.ITCC, 3n=150）, improved red crucian carp （Carassius auratus red var., Abbr.IRCC, , 2n=100）, and improved allotet- raploids （Abbr.GAT, （, 4n=200）. The number of intermuscular bones in WCC, PZCC, and GxAT ranged from 78 to 83 （n =81）, 80 to 86 （n =84）, and 77 to 84 （n=82）, respectively. The numbers in ITCC and IRCC were significantly lower, ranging from 77 to 82 （ n =79） and 58 to 77 （ n =71）, respectively. The average number of intermuscular bones in each sarco- mere, ranked in order from highest to lowest, was 0.721 （WCC）, 0.673 （PZCC）, 0.653 （GAT）, 0.633 （ITCC）, and 0.608 （IRCC）. There was no difference between ITCC and GxAT or between GxAT and PZCC. However, the average number of intermuscular bones in the sarcomeres of ITCC, WCC, and PZCC differed significantly, as did that of IRCC and the four other kinds of fish. The intermuscular bone of these five fishes was divided into seven shape categories, non-forked （I）, one-end-unequal-bi-fork （）, one-end-equal-bi-fork （Y）, one-end-multi-fork, two-end-bi-fork, two-end-multi-fork, and tree- branch types. Generally, the morphological complexity was higher in the anterior intermuscular bones than in the posterior body. The number of intermuscular bones was similar but not equal between the left and right sides of the body. ITCC had sig- nificantly fewer intermuscular bones than either WCC or PZCC, making it of greater commercial value. Additionally, IRCC and ITCC had fewer intermuscular bones than WCC. Our observations are significant in both fish bone developmental biology and genetic breeding.
Journal Article
Seasonal changes in tannin and nitrogen contents of Casuarina equisetifolia branchlets
Seasonal dynamics of total phenolics （TP）, extractable condensed tannins （ECT）, protein-bound condensed tannins （PBCT）, fiber-bound condensed tannins （FBCT）, total condensed tannins （TCT）, and protein precipitation capacity （PPC） in young, mature and senescent branchlets of Casuarina equisetifolia were studied at Chishan Forestry Center of Dongshan County, Fujian Province, China. In addition, nitrogen contents of branchlets at the different developmental stages were also determined. The contents of TP and ECT, and PPC in young branchlets were significantly higher than those in mature and senescent branchlets through the season. However, PBCT contents were significantly higher in senescent branchlets than those in young and mature branchlets; FBCT fluctuated with season. Young branchlets had the highest N content, which decreased during branch maturity and senescence. The highest contents of TP and the lowest contents of TCT and N in young and mature branchlets were observed in summer. There was a significant negative correlation between TP and N contents. In contrast, TCT contents were positively correlated to N contents. Nutrient resorption during senescence and high TCT：N ratios in senescent branchlets are the important nutrient conservation strategies for C. equisetifolia.
Journal Article
Genome-wide identification and comprehensive analysis heat shock transcription factor (Hsf) members in asparagus (Asparagus officinalis) at the seeding stage under abiotic stresses
Heat shock transcription factors (Hsf) are pivotal as essential transcription factors. They function as direct transcriptional activators of genes regulated by thermal stress and are closely associated with various abiotic stresses. Asparagus (
Asparagus officinalis
) is a vegetable of considerable economic and nutritional significance, abundant in essential vitamins, minerals, and dietary fiber. Nevertheless, asparagus is sensitive to environmental stresses, and specific abiotic stresses harm its yield and quality. In this context, Hsf members have been discerned through the reference genome, and a comprehensive analysis encompassing physical and chemical attributes, evolutionary aspects, motifs, gene structure,
cis
-acting elements, collinearity, and expression patterns under abiotic stresses has been conducted. The findings identified 18 members, categorized into five distinct subgroups. Members within each subgroup exhibited analogous motifs, gene structures, and
cis
-acting elements. Collinearity analysis unveiled a noteworthy pattern, revealing that Hsf members within asparagus shared one, two, and three pairs with counterparts in Arabidopsis, Oryza sativa, and Glycine max, respectively.Furthermore, members displayed tissue-specific expression during the seedling stage, with roots emerging as viable target tissue. Notably, the expression levels of certain members underwent modification under the influence of abiotic stresses. This study establishes a foundational framework for understanding Hsf members and offers valuable insights into the potential application of molecular breeding in the context of asparagus cultivation.
Journal Article
Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population
PurposeAlcohol-induced osteonecrosis femoral head necrosis (ONFH) is a disease that seriously affects human health. Abnormal expression of L3MBTL3/PTPN9 gene can cause a variety of human diseases. The purpose of this study is to investigate the effect of L3MBTL3/PTPN9 gene polymorphism on the susceptibility of alcohol-induced ONFH in Chinese Han population.MethodsA total of 308 alcohol‐induced ONFH patients and 425 healthy controls were enrolled in this case–control study. Alleles, genotypes, genetic models, haplotypes, and multifactor dimensionality reduction analyses (MDR) based on age-corrected by using odds ratio (OR) and 95% confidence interval (CI) were performed.ResultsOur result revealed rs2068957 in the L3MBTL3 gene increased the risk of alcohol ONFH under the recessive model after correction. Besides, we also found that rs75393192 in the PTPN9 gene was a protective site in stratification over 40 years of age and stage. In stratified analysis of necrotic sites, we only found that rs2068957 was associated with increased susceptibility of alcohol-induced ONFH under the co-dominant model and recessive model. Haplotype “GC” in the block (rs76107647|rs10851882 in PTPN9 gene) significantly decreased the susceptibility of alcoholic ONFH.ConclusionsOur results provide evidence that L3MBTL3/PTPN9 polymorphisms are associated with alcohol-induced ONFH risk in Chinese Han population.
Journal Article