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A bstract We present the results of the first complete one-loop matching calculation between the real singlet scalar extension of the Standard Model and the Standard Model effective field theory (SMEFT) at dimension six. Beyond their immediate relevance to the precision calculation of observables in singlet extensions of the Standard Model, our results illustrate a variety of general features of one-loop matching. We explore the interplay between non-supersymmetric non-renormalization theorems, the logarithmic dependence of Wilson coefficients, and the relevance of mixed diagrams in theories with large scale separation. In addition, we highlight some of the subtleties involved in computing observables at next-to-leading order in SMEFT by mapping our results to the T parameter at one loop.

The leading approach to fault tolerant quantum computing requires a continual supply of magic states. When a new magic state is first encoded, its initial fidelity will be too poor for use in the computation. This necessitates a resource-intensive distillation process that occupies the majority of the computer's hardware; creating magic states with a high initial fidelity minimizes this cost and is therefore crucial for practical quantum computing. Here we present the surprising and encouraging result that raw magic states can have a fidelity significantly better than that of the two-qubit gate operations used to construct them. Our protocol exploits post-selection without significantly slowing the rate of generation and tolerates finite error rates in initializations, measurements and single-qubit gates. This approach may dramatically reduce the size of the hardware needed for a given quantum computing task.

Alternative polyadenylation (APA), which induces shortening of the 3′‐UTR, is emerging as an important feature in cancer development and progression. Nevertheless, the effects and mechanisms of APA‐induced 3′‐UTR shortening in nasopharyngeal carcinoma (NPC) remain largely unclear. Fibronectin type III domain containing 3B (FNDC3B) tended to use proximal polyadenylation site and produce shorter 3′‐UTR according to our previous sequencing study. Herein, we found that FNDC3B with shorter 3′‐UTR could escape from miRNA‐mediated gene repression, and caused its increased expression in NPC. Knocking down of FNDC3B inhibited NPC cell proliferation, migration, invasion, and metastasis in vitro and in vivo. Overexpression of FNDC3B, especially those with shorter 3′‐UTR, promoted NPC progression. Furthermore, the mechanism study revealed that FNDC3B could bind to and stabilize myosin heavy chain 9 (MYH9) to activate the Wnt/β‐catenin signaling pathway. In addition, MYH9 could reverse the inhibitory effects of FNDC3B knockdown in NPC. Altogether, our results suggested that the 3′‐UTR shortening of FNDC3B mRNA mediated its overexpression in NPC and promoted NPC progression by targeting MYH9. This newly identified FNDC3B‐MYH9‐Wnt/β‐catenin axis could represent potential targets for individualized treatment in NPC. FNDC3B tended to use proximal polyadenylation site and produced shorter 3′‐UTR. FNDC3B with shorter 3′‐UTR could escape from microRNA‐mediated gene repression, and caused its increased expression in nasopharyngeal carcinoma (NPC) and promoted NPC progression by targeting MYH9.

كان الجو جميلا، فبعد هطول الأمطار، تحول لون القمح إلى اللون الأخضر، وسيطرت على الجو رائحة العشب الأخضر. هذه الرائحة حلوة بعض الشيء ومريرة بعض الشيء، دافئة قليلا وباردة قليلا، كم يُفرح هذا الجوّ القلب وينعش الذهن ! في ذلك الحين، كان قلب \"فان خوا\" يشعر بالراحة والطمأنينية. وفي المساء أثناء موعد عقد الاجتماع شعرت أن رؤوس الحيوانات المفترسة التي تعلو جانبي سقف المسرح جميلة المنظر، وضوء القمر أيضاً ساحر للغاية يشبه ثغر فتاة جميلة تضحك. لذا ابتسمت، إلا أن ضحكتها لم تكن ظاهرة على وجهها، بل كانت مختفية داخل قلبها.

Gene expression patterns can be used as prognostic biomarkers in various types of cancers. We aimed to identify a gene expression pattern for individual distant metastatic risk assessment in patients with locoregionally advanced nasopharyngeal carcinoma. In this multicentre, retrospective, cohort analysis, we included 937 patients with locoregionally advanced nasopharyngeal carcinoma from three Chinese hospitals: the Sun Yat-sen University Cancer Center (Guangzhou, China), the Affiliated Hospital of Guilin Medical University (Guilin, China), and the First People's Hospital of Foshan (Foshan, China). Using microarray analysis, we profiled mRNA gene expression between 24 paired locoregionally advanced nasopharyngeal carcinoma tumours from patients at Sun Yat-sen University Cancer Center with or without distant metastasis after radical treatment. Differentially expressed genes were examined using digital expression profiling in a training cohort (Guangzhou training cohort; n=410) to build a gene classifier using a penalised regression model. We validated the prognostic accuracy of this gene classifier in an internal validation cohort (Guangzhou internal validation cohort, n=204) and two external independent cohorts (Guilin cohort, n=165; Foshan cohort, n=158). The primary endpoint was distant metastasis-free survival. Secondary endpoints were disease-free survival and overall survival. We identified 137 differentially expressed genes between metastatic and non-metastatic locoregionally advanced nasopharyngeal carcinoma tissues. A distant metastasis gene signature for locoregionally advanced nasopharyngeal carcinoma (DMGN) that consisted of 13 genes was generated to classify patients into high-risk and low-risk groups in the training cohort. Patients with high-risk scores in the training cohort had shorter distant metastasis-free survival (hazard ratio [HR] 4·93, 95% CI 2·99–8·16; p<0·0001), disease-free survival (HR 3·51, 2·43–5·07; p<0·0001), and overall survival (HR 3·22, 2·18–4·76; p<0·0001) than patients with low-risk scores. The prognostic accuracy of DMGN was validated in the internal and external cohorts. Furthermore, among patients with low-risk scores in the combined training and internal cohorts, concurrent chemotherapy improved distant metastasis-free survival compared with those patients who did not receive concurrent chemotherapy (HR 0·40, 95% CI 0·19–0·83; p=0·011), whereas patients with high-risk scores did not benefit from concurrent chemotherapy (HR 1·03, 0·71–1·50; p=0·876). This was also validated in the two external cohorts combined. We developed a nomogram based on the DMGN and other variables that predicted an individual's risk of distant metastasis, which was strengthened by adding Epstein–Barr virus DNA status. The DMGN is a reliable prognostic tool for distant metastasis in patients with locoregionally advanced nasopharyngeal carcinoma and might be able to predict which patients benefit from concurrent chemotherapy. It has the potential to guide treatment decisions for patients at different risk of distant metastasis. The National Natural Science Foundation of China, the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period, the Natural Science Foundation of Guang Dong Province, the National Key Research and Development Program of China, the Innovation Team Development Plan of the Ministry of Education, the Health & Medical Collaborative Innovation Project of Guangzhou City, China, and the Program of Introducing Talents of Discipline to Universities.

يستعرض كتاب \"وسائل النقل\" الذي نشر ضمن سلسلة الصين في مائة عام عن مؤسسة بيت الحكمة عدًدا من المحاور الأساسية منها أحوال الطرق في أواخر عهد أسرة تشينغ، وسمات وسائل النقل بما فيها العربات التي يحملها الرجال، أو تلك التي تجرها الخيول، والعربات الرسمية والمحفات الشعبية التي تقل العامة من الناس، بالإضافة إلى وصف للجسور المتنوعة والسفن وأنواع الزوارق المختلفة، وحركة النقل في عصر الحكومة الوطنية لجمهورية الصين وملامح ظهور وسائل النقل الحديثة، ومنها عربات اليد والحنطور الغربي والدراجة الهوائية والسيارة التي تعمل بالمحرك، بالإضافة إلى تطور السكك الحديدية والقطارات الحديثة، والتطورات الكبيرة في صناعة السفن ووسائل النقل البحري والبواخر المتطورة.

Increasing evidence indicates that long non-coding RNAs (lncRNAs) play vital roles in the tumorigenesis and progression of cancers. However, the functions and regulatory mechanisms of lncRNAs in nasopharyngeal carcinoma (NPC) are still largely unknown. Our previous lncRNA expression profiles identified that LINC01503 was overexpressed in NPC. Here, we verified that LINC01503 was highly expressed in NPC and correlated with poor prognosis. LINC01503 promoted NPC cell proliferation, migration, and invasion in vitro, and facilitated tumor growth and metastasis in vivo. Mechanistically, LINC01503 recruited splicing factor proline-and glutamine-rich (SFPQ) to activate Fos like 1 (FOSL1) transcription, and ectopic expression of FOSL1 reversed the suppressive effect of LINC01503 knockdown on NPC progression. Moreover, androgen receptor (AR)-mediated transcription activation was responsible for the overexpression of LINC01503, and AR ligand-dependent cell growth, migration, and invasion in NPC cells. Taken together, our findings reveal that AR-induced LINC01503 can promote NPC progression through the SFPQ-FOSL1 axis, which represents a novel prognostic biomarker and therapeutic target for NPC patients.