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The advent of language marked both a catastrophic rupture from immediate experience and the foundation of human civilization, creating an inherent tension between linguistic limitation and expressive aspiration. This study examines how the fundamental poverty of language — its symbolic arbitrariness, linear constraints, and social regulation — paradoxically becomes the generative source of poetic abundance and aesthetic transcendence. Through theoretical analysis drawing on semiotics, phenomenology, and literary criticism, this research investigates the mechanisms by which poets transform linguistic deficiency into creative opportunity, examining works by Hai Zi, Zang Di, Emily Dickinson, and others alongside theoretical frameworks from Adorno, Saussure, and Foucault. The analysis reveals that poetry’s power emerges precisely from language’s failures: metaphorical displacement breaks logical chains, silence and blank space activate reader co-construction of meaning, rhythmic disruption transcends linear temporality, and grammatical reconstruction liberates semantic potential. Poetry exists not as a supplement to language but as its productive contradiction—a continuous refutation of linguistic fatalism that explores the depths of human consciousness at the boundaries where language encounters its own impossibility, suggesting new possibilities for poetic expression in the digital age.

With the global climate change poses a major threat to human society, more and more countries begin to “carbon neutral” as a national strategy. As a major country in the global carbon emissions, China and the United States focus on the development of the clean industry - photovoltaic industry to increase investment, in order to deal with global climate problems. At the same time, China and the United States for the photovoltaic industry game also presents a two-way interaction situation, on the one hand, the two countries for the “carbon neutral” energy strategy affects the two countries’ trade borders, on the other hand, the two countries’ trade strategy also affects the global “carbon neutral” process. This article will be based on the current stage of the two sides of the energy use, the development of photovoltaic industry strength comparison and other aspects of the photovoltaic energy game between China and the United States to discuss.

Viral vectors play a pivotal role in the field of gene therapy, with several related drugs having already gained clinical approval from the EMA and FDA. However, numerous viral gene therapy vectors are currently undergoing pre-clinical research or participating in clinical trials. Despite advancements, the innate response remains a significant barrier impeding the clinical development of viral gene therapy. The innate immune response to viral gene therapy vectors and transgenes is still an important reason hindering its clinical development. Extensive studies have demonstrated that different DNA and RNA sensors can detect adenoviruses, adeno-associated viruses, and lentiviruses, thereby activating various innate immune pathways such as Toll-like receptor (TLR), cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING), and retinoic acid-inducible gene I–mitochondrial antiviral signaling protein (RLR-MAVS). This review focuses on elucidating the mechanisms underlying the innate immune response induced by three widely utilized viral vectors: adenovirus, adeno-associated virus, and lentivirus, as well as the strategies employed to circumvent innate immunity.

Photocatalysis holds great promise as an efficient and sustainable oxidation technology for application in wastewater treatment. Rapid progress developing novel materials has propelled photocatalysis to the forefront of sustainable wastewater treatments. This review presents the latest progress on applications of photocatalytic wastewater treatment. Our focus is on strategies for improving performance. Challenges and outlooks in this promising field are also discussed. We hope this review will help researchers design low-cost and high-efficiency photocatalysts for water treatment.

Alzheimer’s Disease (AD) is a global chronic disease in adults with beta-amyloid (Aβ) deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although the exact etiology of AD is still not fully elucidated, aberrant metabolism including insulin signaling and mitochondria dysfunction plays an important role in the development of AD. Binding to insulin receptor substrates, insulin can transport through the blood-brain barrier (BBB), thus mediating insulin signaling pathways to regulate physiological functions. Impaired insulin signaling pathways, including PI3K/Akt/GSK3β and MAPK pathways, could cause damage to the brain in the pathogenesis of AD. Mitochondrial dysfunction and overexpression of TXNIP could also be causative links between AD and DM. Some antidiabetic medicines may have benefits in the treatment of AD. Metformin can be beneficial for cognition improvement in AD patients, although results from clinical trials were inconsistent. Exendin-4 may affect AD in animal models but there is a lack of clinical trials. Liraglutide and dulaglutide could also benefit AD patients in adequate clinical studies but not semaglutide. Dipeptidyl peptidase IV inhibitors (DPP4is) such as saxagliptin, vildagliptin, linagliptin, and sitagliptin could boost cognitive function in animal models. And SGLT2 inhibitors such as empagliflozin and dapagliflozin were also considerably protective against new-onset dementia in T2DM patients. Insulin therapy is a promising therapy but some studies indicated that it may increase the risk of AD. Herbal medicines are helpful for cognitive function and neuroprotection in the brain. For example, polyphenols, alkaloids, glycosides, and flavonoids have protective benefits in cognition function and glucose metabolism. Focusing on glucose metabolism, we summarized the pharmacological mechanism of hypoglycemic drugs and herbal medicines. New treatment approaches including antidiabetic synthesized drugs and herbal medicines would be provided to patients with AD. More clinical trials are needed to produce definite evidence for the effectiveness of hypoglycemic medications.

In the field of rehabilitation, the electromyography (EMG) signal plays an important role in interpreting patients’ intentions and physical conditions. Nevertheless, utilizing merely the EMG signal suffers from difficulty in recognizing slight body movements, and the detection accuracy is strongly influenced by environmental factors. To address the above issues, multisensory integration-based EMG pattern recognition (PR) techniques have been developed in recent years, and fruitful results have been demonstrated in diverse rehabilitation scenarios, such as achieving high locomotion detection and prosthesis control accuracy. Owing to the importance and rapid development of the EMG centered multisensory fusion technologies in rehabilitation, this paper reviews both theories and applications in this emerging field. The principle of EMG signal generation and the current pattern recognition process are explained in detail, including signal preprocessing, feature extraction, classification algorithms, etc. Mechanisms of collaborations between two important multisensory fusion strategies (kinetic and kinematics) and EMG information are thoroughly explained; corresponding applications are studied, and the pros and cons are discussed. Finally, the main challenges in EMG centered multisensory pattern recognition are discussed, and a future research direction of this area is prospected.

Ruthenium dioxide electrocatalysts for acidic oxygen evolution reaction suffer from mediocre activity and rather instability induced by high ruthenium-oxygen covalency. Here, the tensile strained strontium and tantalum codoped ruthenium dioxide nanocatalysts are synthesized via a molten salt-assisted quenching strategy. The tensile strained spacially elongates the ruthenium-oxygen bond and reduces covalency, thereby inhibiting the lattice oxygen participation and structural decomposition. The synergistic electronic modulations among strontium-tantalum-ruthenium groups both optimize deprotonation on oxygen sites and intermediates absorption on ruthenium sites, lowering the reaction energy barrier. Those result in a well-balanced activity-stability profile, confirmed by comprehensive experimental and theoretical analyses. Our strained electrode demonstrates an overpotential of 166 mV at 10 mA cm −2 in 0.5 M H 2 SO 4 and an order of magnitude higher S-number, indicating comparable stability compared to bare catalyst. It exhibits negligible degradation rates within the long-term operation of single cell and PEM electrolyzer. This study elucidates the effectiveness of tensile strain and strategic doping in enhancing the activity and stability of ruthenium-based catalysts for acidic oxygen evolution reactions. Ruthenium dioxide electrocatalysts for acidic oxygen evolution suffer from mediocre activity and poor stability due to high ruthenium-oxygen covalency. Here, the authors report the effectiveness of tensile strain and electronic dopants in improving both activity and stability.

Primary human aortic valvular interstitial cells (pHAVICs) play crucial roles in maintaining the mechanical structure and microenvironmental homeostasis of aortic valves. Pathologic processes such as inflammation, senescence, apoptosis, and metabolic disorders of valvular interstitial cells often lead to calcified aortic valve disease (CAVD). However, the lack of clinically relevant cellular models has impeded our understanding of CAVD. Here, we immortalized primary HAVICs with SV40 LTA. The iHAVICs (immortalized human aortic valvular interstitial cells) were maintained in a nonsenescent state and still had the potential to be induced into a senescent phenotype. In calcification induction experiments, iHAVICs can be induced to transform into osteogenic phenotypes via different stimuli via different pathways, accompanied by variations in different markers. In conclusion, we established and characterized a novel human immortalized aortic valve interstitial cell line as a practical in vitro experimental tool for the study of aortic valve calcification disease.

The coordinated development of urban quality and technology innovation is an important element of China’s technology innovation development strategy in the new era. Based on entropy TOPSIS, coupling coordination models, the gravity center and standard deviation ellipse method, the geographic probe, the GWR, and other methods, we explore the spatial variation and influencing factors of the coupling coordination relationship between urban quality and technology innovation in the Guangdong-Hong Kong-Macao Greater Bay Area from 2011 to 2020. It is found that: (1) the spatial distribution of the coupling coordination shows a characteristic of \"high in the middle and low in the surroundings,\" and (2) the level of benign interaction in the central region is becoming more prominent. The center of gravity of coupling coordination moves toward the northeast, and the standard deviation ellipse shows a contraction trend away from the southwest. (3) Agglomeration capacity, human capital, cultural development, and infrastructure can significantly drive the improvement of the coupling coordination of urban quality and technology innovation, and the two-factor influence is significantly increased after the interaction. (4) The feedback effects of the coupling and coordination states of different cities on each factor have significant spatial differences and show the characteristics of hierarchical band distribution.