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Skin is the outermost layer of the human body that is constantly exposed to environmental stressors, such as UV radiation and toxic chemicals, and is susceptible to mechanical wounding and injury. The ability of the skin to repair injuries is paramount for survival and it is disrupted in a spectrum of disorders leading to skin pathologies. Diabetic patients often suffer from chronic, impaired wound healing, which facilitate bacterial infections and necessitate amputation. Here, we studied the effects of gallic acid (GA, 3,4,5-trihydroxybenzoic acid; a plant-derived polyphenolic compound) on would healing in normal and hyperglucidic conditions, to mimic diabetes, in human keratinocytes and fibroblasts. Our study reveals that GA is a potential antioxidant that directly upregulates the expression of antioxidant genes. In addition, GA accelerated cell migration of keratinocytes and fibroblasts in both normal and hyperglucidic conditions. Further, GA treatment activated factors known to be hallmarks of wound healing, such as focal adhesion kinases (FAK), c-Jun N-terminal kinases (JNK), and extracellular signal-regulated kinases (Erk), underpinning the beneficial role of GA in wound repair. Therefore, our results demonstrate that GA might be a viable wound healing agent and a potential intervention to treat wounds resulting from metabolic complications.

It has long been postulated that dietary restriction is beneficial for ensuring longevity and extending the health span of mammals, including humans. In particular, a reduction in protein consumption has been shown to be specifically linked to the beneficial effect of dietary restriction on metabolic disorders, presumably by reducing the activity of the mechanistic target of rapamycin complex (mTORC) 1 and the reciprocal activation of AMP-activated protein kinase (AMPK) and sirtuin pathways. Although it is widely used as a dietary supplement to delay the aging process in humans, recent evidence suggests that branched-chain amino acids (BCAAs) might be a major cause of the deteriorating effect of a protein diet on aging and related disorders. In this review, we delineate the regulation of metabolic pathways for BCAAs at the tissue-specific level and summarize recent findings regarding the role of BCAAs in the control of metabolic health and disease in mammals. Dietary Restriction Benefits: BCAA’s Influence on Aging and Health This review article illustrates the function of branched-chain amino acids (BCAAs - essential nutrients we get from food) and how they’re processed in our bodies, in relation to health and illness. BCAAs are connected to aging processes and metabolic health - the body’s way of converting food into energy. Recent studies found that reducing BCAA intake can improve the health and lifespan of rodents. Similar studies were also conducted by using different animal models, like yeast, flies, rodents, and primates. It also emphasized the potential influence of BCAAs on human disease and aging metabolic processes. The review article concluded that BCAAs and their processing are vital for metabolic health and lifespan, and more research is needed to understand their effect on human health. Further studies on BCAAs could be important for creating diet plans and treatments for metabolic issues and aging-related diseases. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.

In-cell touch and display integrated panels, along with their integrated readout systems, are widely adopted in mobile devices for their cost-effectiveness and compact design. This paper proposes an analog Gaussian-shaped filter and a current mode compensation technique for dot-matrix Touch Screen Panel (TSP) readout systems. Specifically, this article presents a noise management strategy for both intrinsic and external noise, offering simulation guidelines for determining intrinsic circuit noise levels in relation to scan time and enhancing external noise immunity through the Gaussian-shaped filter response. The system achieved an intrinsic SNR of 66 dB with a 200 kHz TSP driving frequency and a 160 μs scan time, while the 4-bit quantized Gaussian coefficients filter provided 33 dB noise suppression for out-of-band noise. The compensation error in the dot-matrix capacitance compensation was measured at 1.24 pF, which corresponds to a 0.078% deviation. The simulated power consumption of the proposed readout system is 24 mW, with a layout area of 1.017 mm2 for the 10-channel readout front-end.

Optical metasurfaces are two-dimensional arrays of nano-scatterers that modify optical wavefronts at subwavelength spatial resolution. They are poised to revolutionize optics by enabling complex low-cost systems where multiple metasurfaces are lithographically stacked and integrated with electronics. For imaging applications, metasurface stacks can perform sophisticated image corrections and can be directly integrated with image sensors. Here we demonstrate this concept with a miniature flat camera integrating a monolithic metasurface lens doublet corrected for monochromatic aberrations, and an image sensor. The doublet lens, which acts as a fisheye photographic objective, has a small f -number of 0.9, an angle-of-view larger than 60° × 60°, and operates at 850 nm wavelength with 70% focusing efficiency. The camera exhibits nearly diffraction-limited image quality, which indicates the potential of this technology in the development of optical systems for microscopy, photography, and computer vision. Metasurfaces have the potential to be used in imaging systems since they can modify optical wavefronts at subwavelength spatial resolution. Here, Arbabi et al . demonstrate a metasurface lens doublet corrected for monochromatic aberrations, and integrate it with an image sensor to realize a miniature planar camera.

For decades, bioinspired functional materials have been attracting the interest of many researchers for their remarkable characteristics. In particular, some plant leaves are well known for their inherent superhydrophobic nature. Salvinia molesta , a free-floating aquatic fern, has egg-beater-shaped hierarchical trichomes on its surface of leaves. Due to the unique structure and complex wettability of the hairs, this plant has the ability to maintain a stable thick air layer upon the structure when it is submerged underwater. Often referred to as the “Salvinia Effect,” this property is expected to be suitable for use in hydrodynamic drag reduction. However, due to the complex shape of the trichome, currently applied fabrication methods are using a three-dimensional printing system, which is not applicable to mass production because of its severely limited productivity. In this work, artificial Salvinia leaf inspired by S. molesta was fabricated using a conventional soft lithography method assisted with capillary-force-induced clustering of micropillar array. The fabrication method suggested in this work proposes a promising strategy for the manufacturing of Salvinia -inspired hydrodynamic drag reduction surfaces. Salvinia molesta plant has the ability to maintain a stable air layer when submerged underwater due to its specific form. The authors propose here a soft lithography fabrication method of artificial Salvinia leaf assisted with capillary-force induced clustering of micropillar array, for hydrodynamic drag reduction.

Public awareness of social welfare policies, along with their increasing political influence, has led to growing interest in welfare attitudes. However, there has been insufficient consideration of the effects of different cohorts and social exclusion groups on attitudes to welfare in Korean society, as well as the dynamics of these effects. This article specifically examines changes in attitudes to welfare in South Korea with a focus on cohort and social exclusion perspectives. First, the study found that recent attitudes towards redistribution highlight generational perspectives on intergenerational conflict rather than a focus on social exclusion. Second, cohorts associated with democratisation and the information age displayed reluctance towards tax increases but held favourable views regarding redistributive policies and universal welfare. Third, socially excluded groups tended to favour selective welfare and tax increases. Finally, the current elderly generation, represented by the War-industrialisation cohort, exhibited relatively negative attitudes towards the welfare system compared to subsequent generations. These findings underscore the necessity for expanding government policies to enhance welfare understanding and experiences among the post-war generation and socially excluded groups. Additionally, it is crucial to address generational distributional justice and to broaden discussions on solidarity.

Transit-oriented development (TOD) is often considered a solution for automobile dependency in the pursuit of sustainability. Although TOD has shown various benefits as sustainable development and smart growth, there are potential downsides, such as transit-induced gentrification (TIG). Even if there were no displacement issues with TIG, existing residents could be disadvantaged by a TOD due to affordability problems. This study focuses on these potential affordability issues and aims to evaluate the effects of TOD using residents’ discretionary income (DI) as an indicator of affordability. The light rail transit-oriented development (LRTOD) in Phoenix, AZ, is selected because of the timing of the introduction of development and the simplicity of the light rail transit line. In order to counteract problems induced by a non-random location of TODS, propensity score matching is used. The results indicate that LRTOD can give benefit to all TOD residents. Moreover, the effects of LRTOD on discretionary income of various types of households are not statistically significantly different. We have identified the different magnitudes of the effects of TOD between propensity score matching (PSM)-controlled and uncontrolled models. These indicate the existence of the selection bias of TOD implementation, justifying the adoption of the PSM method.

This paper presents a mutual capacitance touch readout IC architecture for 120 Hz high-refresh-rate AMOLED displays. In high-refresh-rate AMOLED panels, whole pixels in a horizontal line should be updated without any time-sharing with each other, leading to an amplified display noise on touch screen panel (TSP) electrodes. The proposed system architecture mitigates severe display noise by synchronizing the driving for the TSP and AMOLED pixel circuits. The proposed differential sensing technique, which is based on noise suppression in reference to mutual capacitance channels, minimizes common-mode display noise. In the front-end circuit, intrinsic circuit offset is cancelled by a chopping scheme, which correlates to the phase of the driving signals in the TSP driver and operating clocks of the front-end. Operating at a 120 Hz scan-rate, it reduces display noise by more than 11.6 dB when compared with the conventional single-ended TSP sensing method. With a built-in 130-nm CMOS, a prototype IC occupies an area of 8.02 mm2 while consuming 6.4-mW power from a 3.3 V analog voltage supply.

The Youngstown Neighborhood Development Corporation initiated a 'Lots of Green' programme to reuse vacant land in 2010. We performed a difference-in-differences analysis of the effects of this programme on crime in and around newly treated lots, in comparison to crimes in and around randomly selected and matched, untreated vacant lot controls. The effects of two types of vacant lot treatments on crime were tested: a cleaning and greening 'stabilisation' treatment and a 'community reuse' treatment mostly involving community gardens. The combined effects of both types of vacant lot treatments were also tested. After adjustment for various sociodemographic factors, linear and Poisson regression models demonstrated statistically significant reductions in all crime classes for at least one lot treatment type. Regression models adjusted for spatial autocorrelation found the most consistent significant reductions in burglaries around stabilisation lots, and in assaults around community reuse lots. Spill-over crime reduction effects were found in contiguous areas around newly treated lots. Significant increases in motor vehicle thefts around both types of lots were also found after they had been greened. Community-initiated vacant lot greening may have a greater impact on reducing more serious, violent crimes.

Due to intense interest in the potential applications of quantum computing, it is critical to understand the basis for potential exponential quantum advantage in quantum chemistry. Here we gather the evidence for this case in the most common task in quantum chemistry, namely, ground-state energy estimation, for generic chemical problems where heuristic quantum state preparation might be assumed to be efficient. The availability of exponential quantum advantage then centers on whether features of the physical problem that enable efficient heuristic quantum state preparation also enable efficient solution by classical heuristics. Through numerical studies of quantum state preparation and empirical complexity analysis (including the error scaling) of classical heuristics, in both ab initio and model Hamiltonian settings, we conclude that evidence for such an exponential advantage across chemical space has yet to be found. While quantum computers may still prove useful for ground-state quantum chemistry through polynomial speedups, it may be prudent to assume exponential speedups are not generically available for this problem. The extent of problems in quantum chemistry for which quantum algorithms could provide a speedup is still unclear, as well as the kind of speedup one should expect. Here, the authors look at the problem of ground state energy estimation, and gather theoretical and numerical evidence for the fact that an exponential quantum advantage is unlikely for generic problems of interest.