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Corporate citizenship
Corporate citizenship is a prominent international issue as contemporary corporations are no longer expected to perform financially, but are also expected to have an ethical relationship of responsibility between the corporate itself and the society in which it operates and performs it business activities. Provides an up-to-date theoretical content pertaining to corporate citizenship, providing local and global examples and case studies.
Book
Sex Differences in Attention and Attitude Toward Infant and Sexual Images
Reproduction in mammals includes two general categories of behaviors: mating and parenting. Historically and cross-culturally, men invest more than women in mating; women invest more than men in parenting. Sex differences in attention and attitude toward mating and parenting stimuli have rarely been assessed together despite theoretical interest. To evaluate these differences simultaneously in a naturalistic setting, 582 study participants (459 women, 123 men) were presented with sexual and infant images, online in the privacy of their home, at three time periods spanning several weeks for a more reliable result. Attention was measured by covertly recording viewing time of images using Qualtrics software, and attitude was measured via self-report after each viewing session. Men reported a more positive attitude than women toward the sexual images; women reported a more positive attitude than men toward the infant images. Women viewed the infant images marginally longer than did men, and the infant-to-sexual viewing ratio was larger for women. The sexual-to-infant viewing ratio was larger for men than for women. Unexpectedly, both genders viewed the sexual images longer than the infant images, with no significant gender difference in the sexual image viewing time. The results suggest that women and men may give equal attention to visual sexual stimuli despite self-reported sex differences in interest. The possibly underestimated valence of visual sexual stimuli for women is discussed.
Journal Article
insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis
Insects use hydrocarbons as cuticular waterproofing agents and as contact pheromones. Although their biosynthesis from fatty acyl precursors is well established, the last step of hydrocarbon biosynthesis from long-chain fatty aldehydes has remained mysterious. We show here that insects use a P450 enzyme of the CYP4G family to oxidatively produce hydrocarbons from aldehydes. Oenocyte-directed RNAi knock-down of Drosophila CYP4G1 or NADPH-cytochrome P450 reductase results in flies deficient in cuticular hydrocarbons, highly susceptible to desiccation, and with reduced viability upon adult emergence. The heterologously expressed enzyme converts C ₁₈-trideuterated octadecanal to C ₁₇-trideuterated heptadecane, showing that the insect enzyme is an oxidative decarbonylase that catalyzes the cleavage of long-chain aldehydes to hydrocarbons with the release of carbon dioxide. This process is unlike cyanobacteria that use a nonheme diiron decarbonylase to make alkanes from aldehydes with the release of formate. The unique and highly conserved insect CYP4G enzymes are a key evolutionary innovation that allowed their colonization of land.
Journal Article
Functional genomics of mountain pine beetle (Dendroctonus ponderosae) midguts and fat bodies
Background
The mountain pine beetle (
Dendroctonus ponderosae
) is a significant coniferous forest pest in western North America. It relies on aggregation pheromones to colonize hosts. Its three major pheromone components,
trans
-verbenol,
exo
-brevicomin, and frontalin, are thought to arise via different metabolic pathways, but the enzymes involved have not been identified or characterized. We produced ESTs from male and female midguts and associated fat bodies and used custom oligonucleotide microarrays to study gene expression patterns and thereby made preliminary identification of pheromone-biosynthetic genes.
Results
Clones from two un-normalized cDNA libraries were directionally sequenced from the 5' end to yield 11,775 ESTs following sequence cleansing. The average read length was 550 nt. The ESTs clustered into 1,201 contigs and 2,833 singlets (4,034 tentative unique genes). The ESTs are broadly distributed among GO functional groups, suggesting they reflect a broad spectrum of the transcriptome. Among the most represented genes are representatives of sugar-digesting enzymes and members of an apparently Scolytid-specific gene family of unknown function. Custom NimbleGen 4-plex arrays representing the 4,034 tentative unique genes were queried with RNA from eleven different biological states representing larvae, pupae, and midguts and associated fat bodies of unfed or fed adults. Quantitative (Real-Time) RT-PCR (qRT-PCR) experiments confirmed that the microarray data accurately reflect expression levels in the different samples. Candidate genes encoding enzymes involved in terminal steps of biosynthetic pathways for
exo
-brevicomin and frontalin were tentatively identified.
Conclusions
These EST and microarray data are the first publicly-available functional genomics resources for this devastating forestry pest.
Journal Article
Towards a practical model for community engagement: Advancing the art and science in academic health centers
Community engagement (CE) has become more prevalent among academic health centers (AHCs), with significant diversity in practices and language. The array of approaches to CE contributes to confusion among practitioners.
We have reviewed multiple models of CE utilized by AHCs, Clinical and Translational Science Awards, and higher education institutions overall. Taking these models into consideration, we propose a comprehensive model of CE that encompasses a broader spectrum of activities and programs.
The CE Components Practical Model includes 5 components: Community Outreach and Service, Education, Clinical Care, Research, and Policy and Advocacy. The components are supported by the foundational elements within administrative functions and infrastructure.
This model will accomplish the following: (1) reduce confusion about CE; (2) provide a broader understanding of CE; and (3) increase the ability of CE practitioners to interact with each other through this common reference and engage in advancing CE scholarship.
Journal Article
Veterans’ Adjustment to College: A Qualitative Analysis of Large-Scale Survey Data
Student veterans are not monolithic, but many have shared experiences. As higher education considers ways to serve this growing population, it is important to recognize the rich data that comes from location-specific, branch-specific, and program-specific qualitative studies, in addition to patterns that emerge across geographical and institutional boundaries. The current study explores the transition from military life to student life using two open-ended questions in a survey of 391 student veterans to examine the complexity and ubiquity of student veteran perceptions of their adjustment to college. Data from this study were derived from these items: \"what, if anything, has been the most helpful in transitioning to college?\" and \"what, if anything, has made it challenging to transition to college?\" The analysis was framed using Vacchi and Berger's Combined Ecological Model of veteran adjustment to college. Veterans cited financial support, campus veteran support staff, family, and support from other veterans as helpful. Challenges included a multi-faceted understanding of difference and balance.
Journal Article
Barriers-enablers-ownership approach: a mixed methods analysis of a social intervention to improve surgical antibiotic prescribing in hospitals
ObjectivesTo assess an intervention for surgical antibiotic prophylaxis (SAP) improvement within surgical teams focused on addressing barriers and fostering enablers and ownership of guideline compliance.DesignThe Queensland Surgical Antibiotic Prophylaxis (QSAP) study was a multicentre, mixed methods study designed to address barriers and enablers to SAP compliance and facilitate engagement in self-directed audit/feedback and assess the efficacy of the intervention in improving compliance with SAP guidelines. The implementation was assessed using a 24-month interrupted time series design coupled with a qualitative evaluation.SettingThe study was undertaken at three hospitals (one regional, two metropolitan) in Australia.ParticipantsSAP-prescribing decisions for 1757 patients undergoing general surgical procedures from three health services were included. Six bimonthly time points, pre-implementation and post implementation of the intervention, were measured. Qualitative interviews were performed with 29 clinical team members. SAP improvements varied across site and time periods.InterventionQSAP embedded ownership of quality improvement in SAP within surgical teams and used known social influences to address barriers to and enablers of optimal SAP prescribing.ResultsThe site that reported senior surgeon engagement showed steady and consistent improvement in prescribing over 24 months (prestudy and poststudy). Multiple factors, including resource issues, influenced engagement and sites/time points where these were present had no improvement in guideline compliance.ConclusionsThe barriers-enablers-ownership model shows promise in its ability to facilitate prescribing improvements and could be expanded into other areas of antimicrobial stewardship. Senior ownership was a predictor of success (or failure) of the intervention across sites and time periods. The key role of senior leaders in change leadership indicates the critical need to engage other specialties in the stewardship agenda. The influence of contextual factors in limiting engagement clearly identifies issues of resource distributions/inequalities within health systems as limiting antimicrobial optimisation potential.
Journal Article
Measuring institutional community engagement: Adding value to academic health systems
Beyond medical schools’ historical focus on pillar missions including clinical care, education, and research, several medical schools now include community engagement (CE) as a mission. However, most academic health systems (AHSs) lack the tools to provide metrics, evaluation, and standardization for quantifying progress and contributions of the CE mission. Several nationwide initiatives, such as that driven by the Institute of Medicine recommending advances in CE metrics at institutions receiving Clinical and Translational Science Awards, have encouraged the research and development of systematic metrics for CE, but more progress is needed. The CE components practical model provides a foundation for analyzing and evaluating different types of CE activities at AHSs through five components: research, education, community outreach and community service, policy and advocacy, and clinical care. At the Medical College of Wisconsin (MCW), an annual survey administered to faculty and staff assessed the types and number of CE activities from the prior year. Survey results were combined to create a CE report for departments across the institution and inform MCW leadership. Insights gathered from the survey have contributed to next steps in CE tracking and evaluation, including the development of a CE dashboard to track CE activities in real time. The dashboard provides resources for how individuals can advance the CE mission through their work and guide CE at the institutional level.
Journal Article
Digitalizing and Upgrading Severe Acute Respiratory Infections Surveillance in Malta: System Development
In late 2020, the European Centre for Disease Prevention and Control and Epiconcept started implementing a surveillance system for severe acute respiratory infections (SARI) across Europe.
We sought to describe the process of digitizing and upgrading SARI surveillance in Malta, an island country with a centralized health system, during the COVID-19 pandemic from February to November 2021. We described the characteristics of people included in the surveillance system and compared different SARI case definitions, including their advantages and disadvantages. This study also discusses the process, output, and future for SARI and other public health surveillance opportunities.
Malta has one main public hospital where, on admission, patient data are entered into electronic records as free text. Symptoms and comorbidities are manually extracted from these records, whereas other data are collected from registers. Collected data are formatted to produce weekly and monthly reports to inform public health actions. From October 2020 to February 2021, we established an analogue incidence-based system for SARI surveillance. From February 2021 onward, we mapped key stakeholders and digitized most surveillance processes.
By November 30, 2021, 903 SARI cases were reported, with 380 (42.1%) positive for SARS-CoV-2. Of all SARI hospitalizations, 69 (7.6%) were admitted to the intensive care unit, 769 (85.2%) were discharged, 27 (3%) are still being treated, and 107 (11.8%) died. Among the 107 patients who died, 96 (89.7%) had more than one underlying condition, the most common of which were hypertension (n=57, 53.3%) and chronic heart disease (n=49, 45.8%).
The implementation of enhanced SARI surveillance in Malta was completed by the end of May 2021, allowing the monitoring of SARI incidence and patient characteristics. A future shift to register-based surveillance should improve SARI detection through automated processes.
Journal Article
Exploring Recovery from the Perspective of People with Psychiatric Disabilities
Although the concept of recovery from severe psychiatric disability is being discussed and written about with increasing frequency, little consensus has been reached about the nature of this phenomenon. The purpose of the current study was to explore the meaning of the recovery process from the perspective of mental health consumers. Seven semi-structured, qualitative interviews and two focus group discussions were carried out with a total of 18 people, and grounded theory analysis was used to identify common, underlying components of the recovery process. A model of the recovery process was developed, which included the higher order categories that recovery is a process of 1) overcoming \"stuckness,\" 2) discovering and fostering self-empowerment, 3) learning and self-redefinition, 4) returning to basic functioning, and 5) improving quality of life. The relationship between the current model and the existing literature on the recovery process is discussed.
Journal Article