Explore the vast range of titles available.

Neutrophilic inflammation occurs during asthma exacerbation, and especially, in patients with steroid-refractory asthma, but the underlying mechanisms are poorly understood. Recently, a significant accumulation of neutrophil extracellular traps (NETs) in the airways of neutrophilic asthma has been documented, suggesting that NETs may play an important role in the pathogenesis. In this study, we firstly demonstrated that NETs could induce human airway epithelial cell damage . In a mouse asthmatic model of neutrophil-dominated airway inflammation, we found that NETs were markedly increased in bronchoalveolar lavage (BAL), and the formation of NETs exacerbated the airway inflammation. Additionally, a small-molecule drug necrostatin-1 (Nec-1) shown to inhibit NETs formation was found to alleviate the neutrophil-dominated airway inflammation. Nec-1 reduced total protein concentration, myeloperoxidase activity, and the levels of inflammatory cytokines in BAL. Finally, further experiments proved that the inhibition of Nec-1 on NETs formation might be related to its ability to inhibiting mixed lineage kinase domain-like (MLKL) phosphorylation and perforation. Together, these results document that NETs are closely associated with the pathogenesis of neutrophilic asthma and inhibition of the formation of NETs by Nec-1 may be a new therapeutic strategy to ameliorate neutrophil-dominated airway inflammation.

Circular electron positron colliders, such as the CEPC and FCC-ee, have been proposed to measure Higgs boson properties precisely, test the Standard Model, search for physics beyond the Standard Model, and so on. One of the important goals of these colliders is to measure the W boson mass with great precision by taking data around the W -pair production threshold. In this paper, the data-taking scheme is investigated to maximize the achievable precisions of the W boson mass and width with a threshold scan, when various systematic uncertainties are taken into account. The study shows that an optimal and realistic data-taking scheme is to collect data at three center-of-mass energies and that precisions of 1.0 MeV and 3.4 MeV can be achieved for the mass and width of the W boson, respectively, with a total integrated luminosity of L = 3.2  ab - 1 and several assumptions of the systematic uncertainty sources.

In the present study, we explored whether sirtuin-3 (SIRT3) regulates the proliferation and migration of esophageal squamous cell carcinoma (ESCC) and investigated the mechanisms underlying the oncogene role of SIRT3. siRNA was used to transfect Eca109 cells and downregulate SIRT3. The proliferation and migration of Eca109 cells were examined by the CCK-8 assay, colony formation assay, Transwell assay, and scratch test. Quantitative real-time PCR and Western blotting were used to detect SIRT3, hexokinase 2, AKT, and p-AKT in Eca109 cells. Functional assays showed that downregulation of SIRT3 could inhibit the proliferation and migration of ESCC cells. Reduced SIRT3 expression downregulated hexokinase 2 expression and inhibited AKT activation in ESCC. These results indicated that SIRT3 promote ESCC development and progression by regulating hexokinase 2 through the AKT signaling pathway. SIRT3 promote ESCC proliferation and migration by regulating HK-2 through the AKT signaling pathway.

The super τ-charm facility (STCF) is an electron−positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5 × 10 35 cm −2·s −1 or higher. The STCF will produce a data sample about a factor of 100 larger than that of the present τ-charm factory - the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R&D and physics case studies.

Aiming at the problem of noise and vibration of distribution transformer body and base connector under heavy load, the corresponding relationship between vibration and noise, load and power factor of distribution transformer is studied in this paper. In order to improve the operation reliability of distribution transformer, a noise and vibration suppression method based on load scenario optimization is proposed. From the aspects of design reliability, data detection and noise level correction, the typical relationship between the increase of noise level and DC current, noise spectrum and DC bias noise is obtained, and the DC bias limiting measures and correction suggestions are given.

Transmission lines are an important part of the power system and the main artery for the transmission of electrical energy. The safe operation of overhead lines is critical to the safe and stable operation of the entire power grid. This paper takes the main body of the transmission conductor as the main research object. According to the line load calculation theory, risk assessment theory and fuzzy prediction theory, first establish a transmission line risk assessment model that takes into account the influence of temperature changes under weather forecast, and then uses the GA optimized TS-FNN The prediction of the sag of the transmission line has verified the feasibility and accuracy of the proposed theory and method through simulation analysis.

In this paper, the problem of hybrid flow shop scheduling with common due dates (HFSCDD) is studied, and the objectives are to minimize the total waiting time and the total earliness/tardiness issues that arise. This study was motivated by a real-life shop floor, with the predefined goal of meeting the requirements of the final product in many manufacturing industries. Where the final product is assembled from multiple components and, the assembly is only initiated when all components of the product are complete in number. These interrelated components have common due dates. In this study, we developed a mathematical model of HFSCDD which made up of “n” jobs that were processed in “m” machines, located on “I” stages by taking into consideration the common due dates. This problem is classified as being NP-hard, and so an efficient modified genetic algorithm is developed to solve it. The proposed modify GA is developed based on the NSGA II method for large sized problems. The results of the proposed algorithm have been compared with PSO and GA algorithms and showed that the proposed algorithm achieved better performance than existing solutions, since the waiting time and the earliness/tardiness are significantly reduced. This is facilitated by the simultaneous production of components for the same product.

The evolutions of MHD instability behaviors and enhancement of both electrostatic and electromagnetic turbulence towards the plasma disruption have been clearly observed in the HL-2A plasmas. Two types of plasma disruptive discharges have been investigated for similar equilibrium parameters: one with a distinct stage of a small central temperature collapse ( ∼ 5–10%) around 1 millisecond before the thermal quench (TQ), while the other without. For both types, the TQ phase is preceded by a rotating 2/1 tearing mode, and it is the development of the cold bubble from the inner region of the 2/1 island O-point along with its inward convection that causes the massive energy loss. In addition, the micro-scale turbulence, including magnetic fluctuations and density fluctuations, increases before the small collapse, and more significantly towards the TQ. Also, temperature fluctuations measured by electron cyclotron emission imaging enhances dramatically at the reconnection site and expand into the island when approaching the small collapse and TQ, and the expansion is more significant close to the TQ. The observed turbulence enhancement near the X-point cannot be fully interpreted by the linear stability analysis by GENE. Evidences suggest that nonlinear effects, such as the reduction of local E r × B shear and turbulence spreading, may play an important role in governing turbulence enhancement and expansion. These results imply that the turbulence and its interaction with the island facilitate the stochasticity of the magnetic flux and formation of the cold bubble, and hence, the plasma disruption.

A bstract A partial wave analysis on the process e + e − → ωπ + π − is performed using 647 pb − 1 of data sample collected by using the BESIII detector operating at the BEPCII storage ring at center-of-mass (c.m.) energies from 2.000 GeV to 3.080 GeV. The Born cross section of the e + e − → ωπ + π − process is measured, with precision improved by a factor of 3 compared to that of previous studies. A structure near 2.25 GeV is observed in the energy-dependent cross sections of e + e − → ωπ + π − and ωπ 0 π 0 with a statistical significance of 7.6 σ , and its determined mass and width are 2232 ± 19 ± 27 MeV /c 2 and 93 ± 53 ± 20 MeV, respectively, where the first and second uncertainties are statistical and systematic, respectively. By analyzing the cross sections of subprocesses e + e − → ωf 0 (500), ωf 0 (980), ωf 0 (1370), ωf 2 (1270), and b 1 (1235) π , a structure, with mass M = 2200 ± 11 ± 17 MeV/ c 2 and width Γ = 74 ± 20 ± 24 MeV, is observed with a combined statistical significance of 7.9 σ . The measured resonance parameters will help to reveal the nature of vector states around 2.25 GeV.

A bstract Based on e + e − collision data collected by the BESIII detector at the BEPCII collider at center-of-mass energies from 2.000 to 3.080 GeV, a partial-wave analysis is performed for the process e + e − → K + K − π 0 . The Born cross section of the process e + e − → K + K − π 0 and its subprocesses e + e − → ϕπ 0 , K *+ (892) K − and K 2 ∗ + (1430) K − are measured. The results for e + e − → K + K − π 0 and ϕπ 0 are consistent with the BaBar measurements and with improved precision. By analyzing the cross sections of the subprocesses e + e − → K *+ (892) K − and K 2 ∗ + (1430) K − , a structure with mass M R = (2190 ± 19 ± 37) MeV/ c 2 and width Γ R = (191 ± 28 ± 60) MeV is observed with a combined statistical significance of 7.1 σ . The measured resonance parameters suggest it can be identified as the ϕ (2170), thus the results provide valuable input to understand the internal nature of this state.