Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
156
result(s) for
"Yu, Da-Ming"
Sort by:
Micro-Size Layers Evaluation of CIGSe Solar Cells on Flexible Substrates by Two-Segment Process Improved for Overall Efficiencies
This paper details the enhancement of the optoelectronic properties of Cu-(In, Ga)-Se2 (CIGSe) solar cells through a two-segment process in the ultraviolet (UV)–visible spectral range. These include fine-tuning the DC sputtering power of the absorber layer (ranging from 20 to 40 W at segment I) and thoroughly checking the trace micro-chemistry composition of the absorber layer (CdS, ZnO/CdS, ZnMgO/CdS, and ZnMgO at segment II). After segment I of treatment, the optimal 30 W CIGSe absorber layer (i.e., with a 0.95 CGI ratio) can be obtained, it can be seen that the Cu-rich film exhibits the ability to significantly promote grain growth and can effectively reduce its trap state density. After the segment II process aimed at replacing toxic CdS, the optimal metal alloy (Zn0.9Mg0.1O) composition (buffer layer) achieved the highest conversion efficiency (η) of 8.70%, also emphasizing its role in environmental protection. Especially within the tunable bandgap range (2.48–3.62 eV), the developed overall internal and external quantum efficiency (IQE/EQE) is significantly improved by 13.15% at shorter wavelengths. A photovoltaic (PV) module designed with nine optimal CIGSe cells demonstrated commendable stability. Variation remained within ±5% throughout the 60-day experiment. The PV modules in this study represent a breakthrough benchmark toward a significant advance in the scientific understanding of renewable energy. Furthermore, this research clearly promotes the practical application of PV modules, harmonizes with sustainable goals, and actively contributes to the creation of eco-friendly communities.
Journal Article
Mechanism of Black Strips Generated on Surface of CSP Hot-Rolled Silicon Steel
Because of the effect of silicon on the formation of oxide scale, black strip defect is common on the surface of compact strip production （CSP） hot-rolled silicon steel, which leads to difficulty in pickling process compared with plain carbon steels. Although high-temperature oxidation of Fe-Si alloy has been discussed a lot, few studies have explained the mechanism of black strip defect generated on the surface of hot-rolled silicon steel and proposed means to prevent it effectively. Thermogravimetric analyzer （TGA） is used to simulate oxidation of Fe-2.2Si alloy for 30 min under air condition, and temperature range is from 1000 to 1150 ℃. Effect of rolling deformation on scale morphology is also discussed. Electron probe microanalysis （EPMA） is used to analyze cross-sectional morphology and elemental distribution of the oxide scale. Schematic diagram of formation of black strip defect is obtained, which helps to provide theoretic basis for proposing of solutions for the Problem. It is proposed that lowering furnace tem-perature and shortening time to stay at high teniperature condition after rolling will be helpful tO relieve the black strip problem.
Journal Article
Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2
Phosphatidylinositol 3-phosphate （PI3P） plays essential roles in vesicular trafficking, organelle biogenesis and autophagy. Two class III phosphatidylinositol 3-kinase （PI3KC3） complexes have been identified in mammals, the AT- G14L complex （PI3KC3-C1） and the UVRAG complex （PI3KC3-C2）. PI3KC3-C1 is crucial for autophagosome bio- genesis, and PI3KC3-C2 is involved in various membrane trafficking events. Here we report the cryo-EM structures of human PI3KC3-C1 and PI3KC3-C2 at sub-nanometer resolution. The two structures share a common L-shaped overall architecture with distinct features. EM examination revealed that PI3KC3-C1 ＂stands up＂ on lipid monolayers, with the ATG14L BATs domain and the VPS34 C-terminal domain （CTD） directly contacting the membrane. Biochemical dissection indicated that the ATG14L BATs domain is responsible for membrane anchoring, whereas the CTD of VPS34 determines the orientation. Furthermore, PI3KC3-C2 binds much more weakly than PI3KC3-C1 to both PI-containing liposomes and purified endoplasmic reticulum （ER） vesicles, a property that is specifically determined by the ATG14L BATs domain. The in vivo ER localization analysis indicated that the BATs domain was required for ER localization of PI3KC3. We propose that the different lipid binding capacity is the key factor that differentiates the functions of PI3KC3-C1 and PI3KC3-C2 in autophagy.
Journal Article
Contrast-enhanced Ultrasound in Detecting Endoleaks with Failed Computed Tomography Angiography Diagnosis after Endovascular Abdominal Aortic Aneurysm Repair
Background： Endovascular aneurysnl repair （EVAR） is one of the first-line therapies of abdominal aortic aneurysms. Postoperative endoleak is the most common complication of EVAR. Computed tomography angiography （CTA）, which is routine for follow-up, has side effects （e.g., radiation） and also has a certain percentage of missed diagnosis. Preliminary studies on contrast-enhanced ultrasound （CEUS） have shown that the sensitivity of CEUS for detecting endoleak is no lower than that of CTA. To investigate the advantages of CEUS, we conducted CEUS examinations of post-EVAR cases in which CTA failed to detect endoleak or could not verify the type of endoleak. Methods： Post-EVAR patients, who were clinically considered to have endoleak and met the inclusion criteria were enrolled between March 2013 and November 2014. All of the patients underwent color Doppler flow imaging （CDFI） and a CEUS examination. Size, location, microbubble dispersion, and hemodynamic characteristics of leaks were recorded. Comparison between the diagnosis of CEUS and CDF1 was conducted using Fisher＇s exact test and clinical outcomes of all patients were followed up. Results： Sixteen patients were enrolled, and 12 （75%） had endoleaks with verified types by CEUS. Among 12 cases of endoleaks were positive by CEUS, 10 were CDFl-positive, and the four CEUS-negative cases were all negative by CDFI. The diagnostic values of CEUS and CDFI were statistically difl＇erent （P = 0,008）. Six patients with high-pressure endoleaks received endovascular re-intervention guided by CEUS results. One patient with type Ⅲ endoleak had open surgery when endovascular repair failed. Conclusions： C EUS is a new, safe, and effective means for detection ofendoleaks post-EVAR. This technique can be used as a supplement for routine CTA follow-up to provide more detailed information on endoleak and its category.
Journal Article
Variations and trends of trans-boundary runoff in the longitudinal range-gorge region
The mountainous hydrological process usually shows high variation to climate change and human action. In the Longitudinal Range-Gorge Region（LRGR）, Southwestern China and Southeast Asian, the transboundary runoff variations are much more sensitive and complex under the interaction of climate change, ＂corridor-barrier＂ functions in LRGR,and dams building. In this paper, based on the long hydrological records（1956-2013） from three mainstream hydrological stations in Nu River,Lancang River, and Red River, the region runoff variations were analyzed. The results show out： i） the regional runoff changes were strongly influenced by the ＂Corridor-Barrier＂ functions in LRGR from west to east, the variability extent of annual runoff increased, but tended to decrease after 2009 and the reduced extents also increased; ii） the annual runoff change in the three rivers had high concentration degrees; iii） there were periodicities of 33 years of runoff change in Nu River and Lancang River, and 30 years in Red River, and the lower flow period would continue for 8-9 years in Nu River and Lancang River but only for 4 years in Red River; iv） since 2010, as the two mega dams of Xiaowan and Nuozhadu built in Lancang River mainstream, their variations of annual runoff were quite different. The research results could offer a scientific base for sustainable utilization,conservation, and management of the regional water resources
Journal Article
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma
There is increasing evidence that bone morphogenetic proteins (BMP) are involved in the proliferation and drug tolerance of kidney cancer. However, the molecular mechanism of BMP8A in renal cell proliferation and drug tolerance is not clear. Here we showed that BMP8A was highly expressed in renal cell carcinoma, which suggests a poor prognosis of ccRCC. Promotion of cell proliferation and inhibition of apoptosis were detected by CCK‐8 assay, Trypan Blue staining, flow cytometry and bioluminescence. BMP8A promoted resistance of As2O3 by regulating Nrf2 and Wnt pathways in vitro and in vivo. Mechanistically, BMP8A enhanced phosphorylation of Nrf2, which, in turn, inhibited Keap1‐mediated Nrf2 ubiquitination and, ultimately, promoted nuclear translocation and transcriptional activity of Nrf2. Nrf2 regulates the transcription of TRIM24 detected by ChIP‐qPCR. BMP8A was highly expressed in ccRCC, which suggests a poor prognosis. BMP8A was expected to be an independent prognostic molecule for ccRCC. On the one hand, activated Nrf2 regulated reactive oxygen balance, and on the other hand, by regulating the transcription level of TRIM24, it was involved in the regulation of the Wnt pathway to promote the proliferation, invasion and metastasis of ccRCC and the resistance of As2O3. Taken together, our findings describe a regulatory axis where BMP8A promotes Nrf2 phosphorylation and activates TRIM24 to promote survival and drug resistance in ccRCC. BMP8A can promote Nrf2 phosphorylation and nuclear translocation to exert antioxidative stress and transcriptional activity. At the same time, Nrf2 acts as a transcription factor of TRIM24, promotes the expression of TRIM24, activates the Wnt pathway and increases chemotherapy tolerance.
Journal Article
Novel long noncoding RNA OTUD6B-AS1 indicates poor prognosis and inhibits clear cell renal cell carcinoma proliferation via the Wnt/β-catenin signaling pathway
Background
The long noncoding RNA (lncRNA) OTUD6B antisense RNA 1 (OTUD6B-AS1) is oriented in an antisense direction to the protein-coding gene OTUD6B on the opposite DNA strand. TCGA database data show that the expression of the lncRNA OTUD6B-AS1 is downregulated and that OTUD6B-AS1 acts as an antioncogene in a variety of tumors. However, the expression and biological functions of the lncRNA OTUD6B-AS1 are still unknown in tumors, including clear cell renal cell carcinoma (ccRCC).
Methods
The expression level of OTUD6B-AS1 was measured in 75 paired human ccRCC tissue and corresponding adjacent normal renal tissue samples. The correlations between the OTUD6B-AS1 expression level and clinicopathological features were evaluated using the chi-square test. The effects of OTUD6B-AS1 on ccRCC cells were determined via MTT assay, clone formation assay, transwell assay, and flow cytometry. Furthermore, the impact of OTUD6B-AS1 overexpression on the activation of the Wnt/β-catenin signaling pathway was investigated. Finally, ACHN cells with OTUD6B-AS1 overexpression were subcutaneously injected into nude mice to evaluate the influence of OTUD6B-AS1 on tumor growth in vivo.
Results
In this study, we found that the expression of the lncRNA OTUD6B-AS1 was downregulated in ccRCC tissue samples and that patients with low OTUD6B-AS1 expression had shorter overall survival than patients with high OTUD6B-AS1 expression, which showed that the different expression level of OTUD6B-AS1 indirectly correlated with survival of patients. Lentivirus-mediated OTUD6B-AS1 overexpression significantly decreased the proliferation of ccRCC cells and promoted the apoptosis of the cells. Furthermore, OTUD6B-AS1 overexpression partly inhibited cell migration and invasion. The overexpression of OTUD6B-AS1 decreased the activity of the Wnt/β-catenin pathway and suppressed the expression of epithelial-to-mesenchymal transition (EMT)-related proteins (E-cadherin, N-cadherin and Snail) in ccRCC cells. In addition, compared with the parental ACHN cells, OTUD6B-AS1-overexpressing ACHN cells injected into nude mice exhibited decreased tumor growth in vivo.
Conclusions
Taken together, our findings present a road map for targeting the newly identified lncRNA OTUD6B-AS1 to suppress ccRCC progression in cell lines, and these results elucidate a novel potential therapeutic target for ccRCC treatment.
Journal Article
Quasi‐Helmholtz projector including multibranch Rao‐Wilton‐Glisson basis functions for multiscale objects at low frequency
In this letter, a Quasi‐Helmholtz Projector method including multibranch Rao‐Wilton‐Glisson (MB‐RWG) basis function to calculate the scattering problem of multiscale targets at low frequencies is proposed. The loop basis function and the star basis function including MB‐RWG basis function are constructed, and the loop basis function and the star basis function including MB‐RWG basis function are used to construct the Quasi‐Helmholtz Projector. The proposed method is coined MB‐Quasi‐Helmholtz Projector (MB‐QHP) method. The MB‐QHP method can effectively solve the low frequency breakdown (LFB) problem in electric field integral equation (EFIE). Compared with the MB‐loop‐star method, the condition number is lower, the convergence is faster, and the search for global loop is avoided. Meanwhile, due to the existence of the MB‐RWG basis function, the proposed method can divide the calculation region into several regions with different mesh sizes. Numerical example shows the advantages of the proposed method. In this letter, a Quasi‐Helmholtz Projector method is proposed including multibranch Rao‐Wilton‐Glisson (MB‐RWG) basis function to calculate the scattering problem of multiscale targets at low frequencies.
Journal Article