Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
9,162
result(s) for
"Yu, Ge"
Sort by:
الصين فى عشر كلمات
يسلط الكاتب أضواء كاشفة على تعاظم سرعة \"المعجزة الاقتصادية\" في الصين، ويبدو أن كل شي تغير في مثل لمح البصر، وكان ذلك على غرار القفز الطويل حيث جعل الصينيين يقفزون من عصر العوز المادي إلي عصر البذخ والتبذير، ومن عصر السياسة في المقام الأول إلى عصر المال أولا، ومن عصر غريزة القمع إلي عصر الاندفاع والتهور والانغماس في اللهو والمجون، لقد انقضي ثلاثون عاما وأكثر كأنها قفزة في الهواء. وكأن كاتبنا، الذي عاش في كنف التغيرات الهائلة والتحولات الكبري التي اجتاحت الصين في نصف القرن الأخير كان كالسمكة التي تسكن بحورا عميقة تروح وتجئ وسط الغموض تغزل طريقها بين سيقان أعشاب ضخمة فوق أماكن تضوي فيها أشعة الشمس، وتغوص إلى أسفل وأسفل حتى تصل إلي ظلام بارد عميق غامض، وفجأة تنطلق إلى السطح وتلهو فوق الأمواج التي تداعبها الريح، يمسك كاتبنا مبضعه الأدبي-النفسي، ويوضح نقطة سيكولوجية مهمة كأنه الطبيب النفسي الذي يشرح داخل وأعماق النفس الإنسانية، ويقول : إن عصر الكبت المتطرف بعد أن شهد التغيرات الاجتماعية الهائلة من المحتوم أن ينبثق منه عصر آخر مغاير تماما من التسامح المتطرف، وذلك يشبه اللعب على الأرجوحة حيث عندما ينخفض أحد طرفيها، فمن المؤكد أن يعلو كثيرا الطرف الآخر المتأرجح. ولا ينفك يحذر من مغبة أن الحياة الاجتماعية غير المتوازنة من المؤكد أن تجلب الأحلام غير المتوازنة التي بدروها تفرز أحلام التطرف والسعي وراء النجاحات السريعة والقفز فوق المراحل.
Book
Combined Single‐Cell and Spatial Transcriptomics Reveal the Metabolic Evolvement of Breast Cancer during Early Dissemination
Breast cancer is now the most frequently diagnosed malignancy, and metastasis remains the leading cause of death in breast cancer. However, little is known about the dynamic changes during the evolvement of dissemination. In this study, 65 968 cells from four patients with breast cancer and paired metastatic axillary lymph nodes are profiled using single‐cell RNA sequencing (scRNA‐seq) and spatial transcriptomics. A disseminated cancer cell cluster with high levels of oxidative phosphorylation (OXPHOS), including the upregulation of cytochrome C oxidase subunit 6C and dehydrogenase/reductase 2, is identified. The transition between glycolysis and OXPHOS when dissemination initiates is noticed. Furthermore, this distinct cell cluster is distributed along the tumor's leading edge. The findings here are verified in three different cohorts of breast cancer patients and an external scRNA‐seq dataset, which includes eight patients with breast cancer and paired metastatic axillary lymph nodes. This work describes the dynamic metabolic evolvement of early disseminated breast cancer and reveals a switch between glycolysis and OXPHOS in breast cancer cells as the early event during lymph node metastasis. By single‐cell RNA sequencing and spatial transcriptomics, the early early‐disseminated breast cancer cells are found to travel from the border of primary tumor to axillary lymph nodes. During this metastasis, a switch between glycolysis and oxidative phosphorylation occurs in early disseminated breast cancer cells, indicating an interesting dynamic metabolic evolvement.
Journal Article
التحول الأخضر للمدن الصينية : تحديات التغير المناخي وآليات استجابة بكين
يتناول كتاب (التحول الأخضر للمدن لصينية : تحديات التغير المناخي وآليات استجابة بكين) والذي قام بتأليفه (دو شوو خو) في حوالي (334) صفحة من القطع المتوسط موضوع (التنمية الاقتصادية الصينية) مستعرضا المحتويات في الأبواب التالية : الأول : تحديات تغير المناخ وسبل الاستجابة لها، الباب الثاني : التنمية المستدامة للبيئة الإيكولوجية الحضرية، الباب الثالث : حماية ومعالجة البيئة الجوية الحضرية، الباب الرابع : بناء نظم مؤشرات تقييم مدن \"النوع الثالث\"
Book
Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis
Copy number alterations (CNAs) are pivotal genetic events in triple-negative breast cancer (TNBC). Here, our integrated copy number and transcriptome analysis of 302 TNBC patients reveals that gene alpha-endosulfine (
ENSA
) exhibits recurrent amplification at the 1q21.3 region and is highly expressed in TNBC. ENSA promotes tumor growth and indicates poor patient survival in TNBC. Mechanistically, we identify ENSA as an essential regulator of cholesterol biosynthesis in TNBC that upregulates the expression of sterol regulatory element-binding transcription factor 2 (SREBP2), a pivotal transcription factor in cholesterol biosynthesis. We confirm that ENSA can increase the level of p-STAT3 (Tyr705) and activated STAT3 binds to the promoter of SREBP2 to promote its transcription. Furthermore, we reveal the efficacy of STAT3 inhibitor Stattic in TNBC with high ENSA expression. In conclusion, the amplification of
ENSA
at the 1q21.3 region promotes TNBC progression and indicates sensitivity to STAT3 inhibitors.
Copy number alterations are pivotal genetic events in triple-negative breast cancer. Here the authors show the amplification of ENSA at the 1q21.3 region promotes the progression of TNBC via up-regulation of cholesterol biosynthesis.
Journal Article
تحديث الاقتصاد الصيني
في كتابه \"تحديث الاقتصاد الصيني\" يتناول تشياو جنغ عملية الإصلاح الاقتصادي في الصين خلال ثلاثة عقود تم فيها وصف التطور السريع لاقتصاد الصين ب\"المعجزة الاقتصادية\"، ولكنه وصف غير دقيق -بتعبير المؤلف- وبمعنى أكثر دقة، يعتبر التطور السريع لاقتصاد الصين مجرد عملية انتعاش اقتصادي. إنها عملية مواكبة لاقتصادات الأسواق في المناطق المتقدمة.
Book
Combined lifestyle factors, incident cancer, and cancer mortality: a systematic review and meta-analysis of prospective cohort studies
Background
Cancer poses a huge disease burden, which could be reduced by adopting healthy lifestyles mainly composed of healthy diet, body weight, physical activity, limited alcohol consumption, and avoidance of smoking. However, no systematic review has summarised the relations of combined lifestyle factors with cancer morbidity and mortality.
Methods
EMBASE and PubMed were searched up to April 2019. Cohort studies investigating the association of combined lifestyle factors with risks of incident cancer and cancer mortality were selected. Summary hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using random-effects models. Heterogeneity and publication bias tests were conducted.
Results
The HRs (95% CIs) comparing individuals with the healthiest versus the least healthy lifestyles were 0.71 (0.66–0.76; 16 studies with 1.9 million participants) for incident cancer and 0.48 (0.42–0.54; 30 studies with 1.8 million participants) for cancer mortality. Adopting the healthiest lifestyles was also associated with 17 to 58% lower risks of bladder, breast, colon, endometrial, oesophageal, kidney, liver, lung, rectal, and gastric cancer. The relations were largely consistent and significant among participants with different characteristics in the subgroup analyses.
Conclusions
Adopting healthy lifestyles is associated with substantial risk reduction in cancer morbidity and mortality, and thus should be given priority for cancer prevention.
Journal Article
Wire and arc additive manufacturing of metal components: a review of recent research developments
Wire arc additive manufacturing (WAAM) is an important metal 3D printing method, which has many advantages, such as rapid deposition rate, low cost, and suitability for large complex metal components manufacturing, and it has received extensive attention. This paper summarizes the research developments of WAAM in recent years, including the WAAM-suitable metal materials and processing technology, deposition strategy optimization including slicing and path planning algorithm, multi-sensor monitoring and intelligent control, and the large complex metal components manufacturing technology. The promising development directions of WAAM are prospected, including the research of new materials and new technology, composite manufacturing, multi-sensor and real-time monitoring, algorithmic optimization of metal filling strategy, and the application of artificial intelligence technology in WAAM, etc.
Journal Article
A xonotlite nanofiber bioactive 3D-printed hydrogel scaffold based on osteo-/angiogenesis and osteoimmune microenvironment remodeling accelerates vascularized bone regeneration
Background
Coordination between osteo-/angiogenesis and the osteoimmune microenvironment is essential for effective bone repair with biomaterials. As a highly personalized and precise biomaterial suitable for repairing complex bone defects in clinical practice, it is essential to endow 3D-printed scaffold the above key capabilities.
Results
Herein, by introducing xonotlite nanofiber (Ca
6
(Si
6
O
17
) (OH)
2
, CS) into the 3D-printed silk fibroin/gelatin basal scaffold, a novel bone repair system named SGC was fabricated. It was noted that the incorporation of CS could greatly enhance the chemical and mechanical properties of the scaffold to match the needs of bone regeneration. Besides, benefiting from the addition of CS, SGC scaffolds could accelerate osteo-/angiogenic differentiation of bone mesenchymal stem cells (BMSCs) and meanwhile reprogram macrophages to establish a favorable osteoimmune microenvironment. In vivo experiments further demonstrated that SGC scaffolds could efficiently stimulate bone repair and create a regeneration-friendly osteoimmune microenvironment. Mechanistically, we discovered that SGC scaffolds may achieve immune reprogramming in macrophages through a decrease in the expression of Smad6 and Smad7, both of which participate in the transforming growth factor-β (TGF-β) signaling pathway.
Conclusion
Overall, this study demonstrated the clinical potential of the SGC scaffold due to its favorable pro-osteo-/angiogenic and osteoimmunomodulatory properties. In addition, it is a promising strategy to develop novel bone repair biomaterials by taking osteoinduction and osteoimmune microenvironment remodeling functions into account.
Graphical Abstract
Journal Article
Universal topological quantum computation with strongly correlated Majorana edge modes
Majorana-based quantum gates are not complete for performing universal topological quantum computation while Fibonacci-based gates are difficult to be realized electronically and hardly coincide with the conventional quantum circuit models. In reference Hu and Kane (2018 Phys. Rev. Lett. 120 066801), it has been shown that a strongly correlated Majorana edge mode in a chiral topological superconductor can be decomposed into a Fibonacci anyon τ and a thermal operator anyon ɛ in the tricritical Ising model. The deconfinement of τ and ɛ via the interaction between the fermion modes yields the anyon collisions and gives the braiding of either τ or ɛ . With these braidings, the complete members of a set of universal gates, the Pauli gates, the Hadamard gate and extra phase gates for one-qubit as well as controlled-NOT (CNOT) gate for two-qubits, are topologically assembled. Encoding quantum information and reading out the computation results can be carried out through electric signals. With the sparse-dense mixed encodings, we set up the quantum circuit where the CNOT gate turns out to be a probabilistic gate and design the corresponding devices with thin films of the chiral topological superconductor. As an example of the universal topological quantum computing, we show the application to Shor’s integer factorization algorithm.
Journal Article
Changes in mental health services in response to the COVID-19 pandemic in high-income countries: a rapid review
Background
Severe deterioration in mental health and disrupted care provision during the COVID-19 increased unmet needs for mental health. This review aimed to identify changes in mental health services for patients in response to the pandemic and understand the impact of the changes on patients and providers.
Methods
Following the Cochrane guidance for rapid reviews, Cochrane CENTRAL, MEDLINE, Embase and PsycInfo were searched for empirical studies that investigated models of care, services, initiatives or programmes developed/evolved for patients receiving mental health care during COVID-19, published in English and undertaken in high-income countries. Thematic analysis was conducted to describe the changes and an effect direction plot was used to show impact on outcomes.
Results
33 of 6969 records identified were included reporting on patients’ experiences (
n
= 24), care providers’ experiences (
n
= 7) and mixed of both (
n
= 2). Changes reported included technology-based care delivery, accessibility, flexibility, remote diagnostics and evaluation, privacy, safety and operating hours of service provision. These changes had impacts on: (1) care access; (2) satisfaction with telehealth; (3) comparability of telehealth with face-to-face care; (4) treatment effectiveness; (5) continuity of care; (6) relationships between patients and care providers; (7) remote detection and diagnostics in patients; (8) privacy; (9) treatment length and (10) work-life balance.
Conclusions
A shift to telecommunication technologies had a significant impact on patients and care providers’ experiences of mental health care. Improvements to care access, flexibility, remote forms of care delivery and lengths of operating service hours emerged as crucial changes, which supported accessibility to mental health services, increased attendance and reduced dropouts from care. The relationships between patients and care providers were influenced by service changes and were vastly depending on technological literacy and context of patients and availability and care access ranging from regular contact to a loss of in-person contact. The review also identified an increase in care inequality and a feeling of being disconnected among marginalised groups including homeless people, veterans and ethic minority groups. Telehealth in mental care could be a viable alternative to face-to-face service delivery with effective treatment outcomes. Further research is needed to better understand the impact of the changes identified particularly on underserved populations.
Journal Article