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"Yu, Ma"
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Interaction and energy transition between the breather and rogue wave for a generalized nonlinear Schrödinger system with two higher-order dispersion operators in optical fibers
A generalized nonlinear Schrödinger system is investigated, which can be used to describe the optical pulse propagation in inhomogeneous optical fibers with the fourth- and third-order dispersions operators. The Darboux transformation method is extended to construct a mixed breather and rogue wave solution for the system. The interaction behaviors between the breather and rogue wave are studied. As a novel result, the energy transition between the breather and rogue wave is observed. Furthermore, the impacts of the different operators on the mixed solution are analyzed.
Journal Article
Tailoring the component of protein corona via simple chemistry
Control over the protein corona of nanomaterials allows them to function better. Here, by taking graphene/gold as examples, we comprehensively assessed the association of surface properties with the protein corona. As revealed by in vitro measurements and computations, the interaction between graphene/gold and HSA/IgE was inversely correlated with the hydroxyl group availability, whereas the interaction between that and ApoE was comparatively less relevant. Molecular simulations revealed that the number and the distribution of surface hydroxyl groups could regulate the manner in which nanomaterials interact with proteins. Moreover, we validated that ApoE pre-adsorption before injection enhances the blood circulation of nanomaterials relative to their pristine and IgE-coated counterparts. This benefit can be attributed to the invulnerability of the complementary system provided by ApoE, whose encasement does not increase cytotoxicity. Overall, this study offers a robust yet simple way to create protein corona enriched in dysopsonins to realize better delivery efficacy.
The interaction between proteins and nanomaterials is complex and of interest for controlling nanoparticle fate. Here, using experimental and computational methods, the authors report on the effect of hydroxyl groups on protein interaction and how they can be used to enhance circulation times.
Journal Article
MicroRNA-155 Modulates Treg and Th17 Cells Differentiation and Th17 Cell Function by Targeting SOCS1
MicroRNA (miR)-155 is a critical player in both innate and adaptive immune responses. It can influence CD4(+) T cell lineage choice. To clarify the role of miR-155 in CD4(+) CD25(+) regulatory T (Treg)/T helper (Th)17 cell differentiation and function, as well as the mechanism involved, we performed gain-and loss-of-function analysis by transfection pre-miR-155 and anti-miR-155 into purified CD4(+) T cells. The results showed that miR-155 positively regulated both Treg and Th17 cell differentiation. It also induced the release of interleukin (IL)-17A by Th17 cells, but not the release of IL-10 and transforming growth factor (TGF)-β1 by Treg cells. Furthermore, we found that miR-155 reacted through regulating Janus kinase/signal transducer and activator of transcription (JAK/STAT) rather than TGF-β/mothers against decapentaplegic homolog (SMAD) signaling pathway in the process of Treg and Th17 cells differentiation. This may because suppressors of cytokine signaling (SOCS)1, the important negative regulator of JAK/STAT signaling pathway, was the direct target of miR-155 in this process, but SMAD2 and SMAD5 were not. Therefore, we demonstrated that miR-155 enhanced Treg and Th17 cells differentiation and IL-17A production by targeting SOCS1.
Journal Article
Research on Blended Learning in Physical Education During the COVID-19 Pandemic: A Case Study of Chinese Students
The coronavirus virus (COVID-19) epidemic has swept the world, with the World Health Organization defining it as a pandemic on March 11. This in turn has affected the approaches and methods used in education throughout the world. According to United Nations report, by the time of mid-April 2020, 94% of learners in more than 200 countries around the world have been affected, and 1.58 billion students from pre-school to higher education are affected. In response to increased learning needs regarding infection prevention, the Ministry of Education has also provided cloud educational resources and private online learning resources, platforms, and tools to schools at all levels to encourage teachers and students to make effective use of digital resources. Although the government provides abundant teaching resources, the implementation of distance teaching in college physical education still faced with many problems, such as the shortage of course resources, the lack of information literacy of teachers, the difficulty in implementing conventional teaching plans online, the limited conditions for students to exercise at home, and the doubts about online physical education. Therefore, this study proposes a new teaching method, and studies, analyzes and discusses this method. The method of experimental design was adopted in this study to divide the students into two groups: blended learning group (synchronous and asynchronous) and single type learning group (synchronous). The results show that blended learning students perform better than single type learning students in all these aspects, which proves the practicability and effectiveness of the proposed method.
Journal Article
Novel Biomedical Applications of Crosslinked Collagen
Collagen is one of the most useful biopolymers because of its low immunogenicity and biocompatibility. The biomedical potential of natural collagen is limited by its poor mechanical strength, thermal stability, and enzyme resistance, but exogenous chemical, physical, or biological crosslinks have been used to modify the molecular structure of collagen to minimize degradation and enhance mechanical stability. Although crosslinked collagen-based materials have been widely used in biomedicine, there is no standard crosslinking protocol that can achieve a perfect balance between stability and functional remodeling of collagen. Understanding the role of crosslinking agents in the modification of collagen performance and their potential biomedical applications are crucial for developing novel collagen-based biopolymers for therapeutic gain.
Multiple crosslinking techniques have been developed to optimize the properties of fibrillar collagen for different biotechnological applications.
Treatments based on modulating crosslinks within the collagen matrix of damaged tissues have received excellent clinic results for treating diseases such as keratoconus.
Crosslinked collagen-based scaffolds have been extensively studied for tissue engineering to promote tissue regeneration or repair.
Nanoparticles act as crosslinking agents for collagen stabilization as well as functionalized carriers for crosslinking to collagen scaffolds for novel biomolecular applications.
Journal Article