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Metabolic dysfunction-associated steatotic liver disease is marked by fat accumulation and inflammation, partly due to impaired lipophagy—a cellular process in which lipid droplets are broken down through autophagy. Rubicon, a protein that inhibits this process, worsens the condition by blocking fat breakdown. Small interfering RNA molecules targeting Rubicon show therapeutic potential but face challenges such as instability and off-target effects. Here we show a dual-targeted nanoparticle system designed for efficient delivery of Rubicon-targeting small interfering RNA to liver cells. This system has a core-shell structure that ensures stability in the bloodstream and responsiveness to oxidative stress, commonly found in metabolic dysfunction-associated steatotic liver disease. Once inside the liver cells, the nanoparticles release the RNA molecules, which reduce Rubicon levels, restore lipophagy, and alleviate fatty liver buildup. This strategy offers a flexible platform for targeted gene silencing therapy in liver diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by fat accumulation and inflammation, partly due to impaired lipophagy. Here, Lan et al. present a dual-targeted nanoparticle system designed to deliver siRNA to liver cells, silencing the protein Rubicon to restore lipophagy for treatment of MASLD.

Black silicon fabrication and manipulation have been well reported by institutes around the world and are quite useful for solar absorption and photovoltaic conversion. In this study, silicon micro-nano hybrid structures were fabricated, and the morphologies of the hybrid structures were analyzed. This paper studied nanostructures formed on tips, pits and a flat surface using a dry etching method and a wet etching method. In terms of nanostructure morphology, nanostructures etched by the wet etching method (13 μm) were taller than those etched by the dry etching method (1 μm), but the wet etched morphology was less organized. After the nanostructures were grown, six samples with nano sturctures and three samples with micro sturctures were measured by a photometer for reflectivity testing. The nine samples were compared and analyzed using the integral of reflectivity and solar emissivity at the earth’s surface. The results show that the nanostructures grown on a tip surface using the wet etching method had the minimum reflectivity in the wavelength range of 300 nm–1100 nm, in consideration of the forbidden energy gap of silicon.

The imperative for energy conservation and environmental protection has led to the development of innovative aircraft designs. This study explored a novel thrust control configuration for blended-wing-body (BWB) aircraft with distributed electric boundary-layer ingestion (BLI) propulsors, addressing the issues of sagging and altitude loss during landing. The research focused on a small-scale BWB demonstrator equipped with six BLI fans, each with a 90 mm diameter. Various thrust control configurations were evaluated to achieve significant thrust reduction while maintaining lift, including dual-layer sleeve, separate flap-type, single-stage linkage flap-type, and dual-stage linkage flap-type configurations. The separate flap-type configuration was tested through ground experiments. Control experiments were conducted under three different experimental conditions as follows: deflection of the upper cascades only, deflection of the lower cascades only, and symmetrical deflection of both cascades. For each condition, the deflection angles tested were 0°, 10°, 20°, 30°, 40°, 50°, and 60°. The thrust reductions observed for these three conditions were 0%, 37.5%, and 27.5% of the maximum thrust, respectively, without additional changes in the pitch moment. A combined thrust adjustment method maintaining a zero pitch moment demonstrated a linear thrust reduction to 20% of its initial value. The experiment concluded that the novel thrust control configuration effectively adjusted thrust without altering the BLI fans’ rotation speed, solving the coupled lift–thrust problem and enhancing BWB landing stability.

Epilepsy is a chronic neurological disorder characterized by abnormal synchronous discharges of neurons in the brain. It affects approximately 70 million people worldwide, and approximately 30% of patients are resistant to existing antiepileptic drugs. Repeated seizures can lead to neuronal damage, glial cell activation and neuroinflammation, creating a vicious cycle of seizures, inflammation, and neuronal damage. Recent studies have shown that microRNAs play a key role in the pathological process of epilepsy by regulating the phenotype, inflammatory response and metabolic function of astrocytes and microglia. In addition, long noncoding RNAs, as upstream regulators of miRNAs, influence miRNA function by acting as competitive endogenous RNAs, further regulating glial cell activation and inflammatory responses. This paper is the first to systematically elucidate the synergistic role of miRNAs and lncRNAs in epilepsy through glial cell polarization, metabolic imbalance and exosome-mediated transcellular communication, providing a theoretical framework for the development of multitargeted intervention strategies.

Due to a large amount of time‐series data (e.g. precipitation, temperature, humidity) in the air, reliable and fast data collection is a challenging issue. Using an unmanned aerial vehicle (UAV) as a data collector to collect time‐series data is an effective method. However, due to the limited storage capacity of the UAV, the UAV must access the sensor multiple times to collect time‐series data from the deployed sensors and dump the data to the data centre, which leads to significantly increased time and cost for data collection mission. To address this challenge, an efficient time‐series data collection framework is proposed based on the Internet of UAVs. In this system, a min‐maximum data processing strategy is adopted based on data value to store the collected time‐series data. Specifically, efficient data compression storage is achieved with minimal loss of precision by extracting the dominant dataset with maximum value. Furthermore, an efficient affine transformation method is proposed to improve the efficiency of the system. Extensive case studies on some real‐world datasets demonstrate that the proposed framework can achieve efficient data management and compressed storage.

Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024. A total of 39 patients who completed bone metabolism and BMD evaluations after 1 year of PER treatment were included in the PER group. The control group comprised 44 patients with newly diagnosed epilepsy. A cross‐sectional analysis was conducted between the two groups. We conducted a subgroup analysis of patients stratified by seizure frequency and type. Patients in the PER group were further stratified according to their seizure frequency and seizure type. Finally, we performed a cohort study involving 10 PER‐treated patients whose baseline data were available prior to initiating PER therapy. Results No significant differences in bone mineral density were observed between the experimental groups and the control group. With respect to bone metabolism, minor alterations were observed only in thyroid hormone levels and serum magnesium concentrations relative to those of the controls. No significant differences in bone metabolism or BMD were observed before or after PER treatment. Significance Short‐term PER treatment did not significantly affect bone mineral density in adult patients with epilepsy. Plain Language Summary This study investigated how PER, a drug used to treat epilepsy, affects bone health in adult patients. Researchers compared 39 patients who were treated with PER for 1 year with 44 patients with newly diagnosed epilepsy. They did not observe significant differences in BMD between the two groups. Some minor changes were observed in thyroid hormone and magnesium levels in the blood, but overall, PER treatment did not have a major effect on bone metabolism or BMD. This study suggested that the short‐term use of PER does not significantly affect bone health in people with epilepsy.

Existing research on enterprise innovation focuses on internal perspectives such as resource and capabilities. However, enterprise innovation needs not only the input of enterprises themselves, but also the support of institutional environments. Based on the institution–strategy–performance research paradigm, which combines perspectives from both institutional theory and resource-based theory, this research explores the mechanism of institutional support on the innovation performance of new ventures, focusing on the mediating role of entrepreneurial orientation and the moderating role of innovative resource acquisition. An empirical analysis based on 278 survey samples shows that: (formal/informal) institutional support positively affects the innovation performance of new ventures; entrepreneurial orientation plays an intermediary role between institutional support and the innovation performance of new ventures; innovation resource acquisition not only positively regulates the relationship between entrepreneurial orientation and the innovation performance of new ventures, but also enhances the mediation of entrepreneurial orientation between institutional support and innovation performance. The conclusion shows that institutional support plays an important role in the innovation practice of new ventures, and can provide guidance for the innovation management practices of new ventures. This study discusses the theoretical and managerial implications for enterprise innovation research in detail by identifying and testing the relationships among these constructs.

Pump is a vital component for expelling the perfusate in small animal isolated organ normothermic machine perfusion (NMP) systems whose flexible structure and rhythmic contraction play a crucial role in maintaining perfusion system homeostasis. However, the continuous extrusion forming with the rigid stationary shaft of the peristaltic pumps can damage cells, leading to metabolic disorders and eventual dysfunction of transplanted organs. Here, we developed a novel biomimetic blood‐gas system (BBGs) for preventing cell damage. This system mimics the cardiac cycle and features an adjustable inspiratory‐to‐expiratory (IE) ratio to mitigate acidosis caused by continuous oxygen inhalation. In our study, adipose stem cells (ADSCs) were cultured within the circulatory system for 10 min, 2, and 4 h. Compared to the peristaltic pump, the BBGs significantly reduced cell apoptosis and morphological injury while enhancing cell proliferation and adhesion. Additionally, when the supernatant from ADSCs was introduced to LPS‐induced macrophages for 24 h, the BBGs group demonstrated a more pronounced anti‐inflammatory effect, characterized by reduced M1 macrophage expression. Besides, with isolated rat livers from donation after circulatory death (DCD) perfusion with ADSCs for 6 h by the BBGs, we detected fewer apoptotic cells and a reduced inflammatory response, evidenced by down‐regulated TNF‐α expression. The development of BBGs demonstrates the feasibility of recreating physiological liquid–gas circulation in vitro, offering an alternative platform for isolated organ perfusion, especially for applications involving cell therapy.

Owing to its extremely low light absorption, black silicon has been widely investigated and reported in recent years, and simultaneously applied to various disciplines. Black silicon is, in general, fabricated on flat surfaces based on the silicon substrate. However, with three normal fabrication methods—plasma dry etching, metal-assisted wet etching, and femtosecond laser pulse etching—black silicon cannot perform easily due to its lowest absorption and thus some studies remained in the laboratory stage. This paper puts forward a novel secondary nanostructured black silicon, which uses the dry-wet hybrid fabrication method to achieve secondary nanostructures. In consideration of the influence of the structure’s size, this paper fabricated different sizes of secondary nanostructured black silicon and compared their absorptions with each other. A total of 0.5% reflectance and 98% absorption efficiency of the pit sample were achieved with a diameter of 117.1 μm and a depth of 72.6 μm. In addition, the variation tendency of the absorption efficiency is not solely monotone increasing or monotone decreasing, but firstly increasing and then decreasing. By using a statistical image processing method, nanostructures with diameters between 20 and 30 nm are the majority and nanostructures with a diameter between 10 and 40 nm account for 81% of the diameters.