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"Yu, Ning"
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Lee Kuan Yew through the eyes of Chinese scholars
\"A compilation of essays by highly-respected Chinese scholars in which they evaluate the life, work and philosophy of Lee Kuan Yew, founding Prime Minister of Singapore. Presenting a range of views from a uniquely Chinese/Asian perspective, this book provides valuable insights for those who wish to gain a fuller and deeper understanding of Lee Kuan Yew, the man, as well as Singapore, his nation\"-- Provided by publisher.
Book
Short-chain fatty acids in diseases
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such as monocarboxylate transporter 1 and sodium-coupled monocarboxylate transporter 1, which promote cellular metabolism. An increasing number of studies have implicated metabolites produced by microorganisms as crucial executors of diet-based microbial influence on the host. SCFAs are important fuels for intestinal epithelial cells (IECs) and represent a major carbon flux from the diet, that is decomposed by the gut microbiota. SCFAs play a vital role in multiple molecular biological processes, such as promoting the secretion of glucagon-like peptide-1 by IECs to inhibit the elevation of blood glucose, increasing the expression of G protein-coupled receptors such as GPR41 and GPR43, and inhibiting histone deacetylases, which participate in the regulation of the proliferation, differentiation, and function of IECs. SCFAs affect intestinal motility, barrier function, and host metabolism. Furthermore, SCFAs play important regulatory roles in local, intermediate, and peripheral metabolisms. Acetate, propionate, and butyrate are the major SCFAs, they are involved in the regulation of immunity, apoptosis, inflammation, and lipid metabolism. Herein, we review the diverse functional roles of this major class of bacterial metabolites and reflect on their ability to affect intestine, metabolic, and other diseases.
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Video Abstract
Journal Article
Sliding ferroelectricity in van der Waals layered γ-InSe semiconductor
Two-dimensional (2D) van-der-Waals (vdW) layered ferroelectric semiconductors are highly desired for in-memory computing and ferroelectric photovoltaics or detectors. Beneficial from the weak interlayer vdW-force, controlling the structure by interlayer twist/translation or doping is an effective strategy to manipulate the fundamental properties of 2D-vdW semiconductors, which has contributed to the newly-emerging sliding ferroelectricity. Here, we report unconventional room-temperature ferroelectricity, both out-of-plane and in-plane, in vdW-layered γ-InSe semiconductor triggered by yttrium-doping (InSe:Y). We determine an effective piezoelectric constant of ∼7.5 pm/V for InSe:Y flakes with thickness of ∼50 nm, about one order of magnitude larger than earlier reports. We directly visualize the enhanced sliding switchable polarization originating from the fantastic microstructure modifications including the stacking-faults elimination and a subtle rhombohedral distortion due to the intralayer compression and continuous interlayer pre-sliding. Our investigations provide new freedom degrees of structure manipulation for intrinsic properties in 2D-vdW-layered semiconductors to expand ferroelectric candidates for next-generation nanoelectronics.
Exploring two-dimensional layered ferroelectric semiconductors is highly desired for ferroelectric-based devices. Here, the authors realize the room-temperature ferroelectricity in layered Y-doped γ-InSe due to the microstructure modifications.
Journal Article
Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer
In this trial, the addition of six cycles of docetaxel to androgen-deprivation therapy resulted in longer median progression-free and overall survival than that with ADT alone in patients with metastatic prostate cancer.
Regressions of metastatic prostate cancer were first documented in the 1940s and were achieved with surgical castration; subsequently, androgen-deprivation therapy (ADT) became the mainstay of therapy.
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Attempts to improve the efficacy or decrease the treatment burden of ADT have included the use of antiandrogens alone, intermittent dosing of ADT, and the use of an antiandrogen combined with medical or surgical castration.
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A meta-analysis revealed an increase in survival of 3 percentage points at 5 years with concurrent use of a nonsteroidal antiandrogen at the time of initiation of ADT.
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However, resistance to ADT occurs in most patients, with the . . .
Journal Article
Metabolic Reprogramming in Chloroplasts under Heat Stress in Plants
Increases in ambient temperatures have been a severe threat to crop production in many countries around the world under climate change. Chloroplasts serve as metabolic centers and play a key role in physiological adaptive processes to heat stress. In addition to expressing heat shock proteins that protect proteins from heat-induced damage, metabolic reprogramming occurs during adaptive physiological processes in chloroplasts. Heat stress leads to inhibition of plant photosynthetic activity by damaging key components functioning in a variety of metabolic processes, with concomitant reductions in biomass production and crop yield. In this review article, we will focus on events through extensive and transient metabolic reprogramming in response to heat stress, which included chlorophyll breakdown, generation of reactive oxygen species (ROS), antioxidant defense, protein turnover, and metabolic alterations with carbon assimilation. Such diverse metabolic reprogramming in chloroplasts is required for systemic acquired acclimation to heat stress in plants.
Journal Article
Advancing EIA framework for deep-sea mining: a critical review of current regulations and proposals
On June 25, 2021, Nauru informed the Council of International Seabed Authority that its sponsored entity Nauru Ocean Resources Inc. intended to apply for approval of a plan of work for exploitation in the international seabed area and requested the Council to complete the adoption of relevant regulations, triggering the “two-year rule”. This has intensified the urgency to finalize the Exploitation Regulations as the current draft regulations remain insufficient to address the environmental challenges posed by mining activities. Deep-see mining may have an irreversible impact on the marine environment, with disputes centred on how to effectively implement environmental impact assessment to improve environmental protection. The current regulatory texts, including the 2024 Revised Consolidated Text, exhibit significant limitations, particularly in the areas of environmental risk assessment, alternatives, cumulative impact assessment, and stakeholder participation within the environmental impact assessment framework. It highlights the need for clear review standards and quantitative models for environmental risk assessment, well-defined scopes and review mechanisms for alternatives, precise definitions and processes for cumulative impact assessment, and robust stakeholder engagement mechanisms. These recommendations are essential for developing a comprehensive legal mechanism that can effectively address the environmental challenges associated with deep-sea mining activities, thereby contributing to the sustainable management of the resources in “the Area”.
Journal Article
Relationships between Big Five Personality Traits and Psychological Well-Being: A Mediation Analysis of Social Support for University Students
University life is a critical period for personality development and psychological well-being. This study, which investigated the relationships between the Big Five personality traits, social support, and psychological well-being, particularly the mediation role of social support, has yielded significant findings. A total of 848 university students (570 females, 67.2%) were conveniently sampled in Taiwan. The results, which showed that female students scored significantly higher on conscientiousness, neuroticism, and social support than male students, with no gender differences for other traits and psychological well-being, provide valuable insights. The mediation analysis, when controlling for gender, demonstrated that social support only mediates the two personality traits (extraversion and agreeableness). Specifically, under the control of social support, the Big Five traits, except for agreeableness, still directly affect psychological well-being. Further, conscientiousness, neuroticism, and openness can directly affect students’ psychological well-being without being mediated by social support, while extraversion can affect psychological well-being in both direct and indirect pathways. Moreover, agreeableness can affect psychological well-being completely by an indirect pathway through social support. These findings not only contribute to the existing body of knowledge but also underscore the importance of personality traits and social support for higher education students’ mental health and adaptive functioning.
Journal Article
Controlling guest conformation for efficient purification of butadiene
Conventional adsorbents preferentially adsorb the small, high-polarity, and unsaturated 1,3-butadiene molecule over the other C₄ hydrocarbons from which it must be separated. We show from single-crystal x-ray diffraction and computational simulation that a hydrophilic metal-organic framework, [Zn₂(btm)₂], where H₂btm is bis(5-methyl-1H-1,2,4-triazol-3-yl)methane, has quasi-discrete pores that can induce conformational changes in the flexible guest molecules, weakening 1,3-butadiene adsorption through a large bending energy penalty. In a breakthrough operation at ambient temperature and pressure, this guest conformation–controlling adsorbent eluted 1,3-butadiene first, then butane, butene, and isobutene. Thus, 1,3-butadiene can be efficiently purified (≥99.5%) while avoiding high-temperature conditions that can lead to its undesirable polymerization.
Journal Article
Prevalence of Depression and Anxiety in Colorectal Cancer Patients: A Literature Review
Background: We aimed to review published studies to obtain the best estimate of the risk of depression and anxiety among colorectal cancer (CRC) patients. Methods: We searched the PubMed/Medline database, Web of Science, and Google Scholar on the prevalence of depression or anxiety in CRC patients. A review of 15 studies published between June 1967 and June 2018 were conducted, and 93,805 CRC patients were included. Results: The prevalence of depression among patients diagnosed with CRC ranged from 1.6%–57%, and those of anxiety ranged from 1.0%–47.2%. Studies in which an expert (psychiatrist) administered the interviews reported lower prevalence of both depression and anxiety. Conclusion: The findings of this review suggest that patients with CRC exhibited a significantly high prevalence of both depression and anxiety, and these symptoms can persist even after cancer treatment is completed. However, the correlation of age and the emergence of depression or anxiety in CRC patients still remain controversial.
Journal Article
Atomic-level polarization reversal in sliding ferroelectric semiconductors
Intriguing “slidetronics” has been reported in van der Waals (vdW) layered non-centrosymmetric materials and newly-emerging artificially-tuned twisted moiré superlattices, but correlative experiments that spatially track the interlayer sliding dynamics at atomic-level remain elusive. Here, we address the decisive challenge to in-situ trace the atomic-level interlayer sliding and the induced polarization reversal in vdW-layered yttrium-doped γ-InSe, step by step and atom by atom. We directly observe the real-time interlayer sliding by a 1/3-unit cell along the armchair direction, corresponding to vertical polarization reversal. The sliding driven only by low energetic electron-beam illumination suggests rather low switching barriers. Additionally, we propose a new sliding mechanism that supports the observed reversal pathway, i.e., two bilayer units slide towards each other simultaneously. Our insights into the polarization reversal via the atomic-scale interlayer sliding provide a momentous initial progress for the ongoing and future research on sliding ferroelectrics towards non-volatile storages or ferroelectric field-effect transistors.
Polarization reversal dynamics in sliding ferroelectrics is important for the application in slidetronics. Here, the authors observe the interlayer directional sliding induced polarization switching with simultaneous hysteresis response in γ-InSe:Y.
Journal Article