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"Yu, Ren"
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Luke Him Sau, architect : China's missing modern
\"Luke Him Sau/Lu Qianshou (1904-1991) is best known internationally and in China as the architect of the iconic Bank of China Headquarters in Shanghai. One of the first Chinese students to be trained at the Architectural Association in London in the late 1920s, Luke's long, prolific and highly successful career in China and Hong Kong offers unique insights into an extraordinary period of Chinese political turbulence that scuppered the professional prospects and historical recognition of so many of his colleagues. Global interest in China has risen exponentially in recent times, creating an appetite for the country's history and culture. This book satiates this by providing a highly engaging and visual account of China's 20th-century architecture through the lens of one of the country's most distinguished yet overlooked designers. It features over 250 new colour photographs by Edward Denison of Luke's buildings and original archive material\"--Provided by publisher.
Book
Amyloid beta： structure, biology and structure-based therapeutic development
Amyloid beta peptide （Aβ） is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein （APP）, by β- and y-secretases. Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer＇s disease, which is the most common form of dementia associated with plaques and tangles in the brain. Currently, it is unclear what the physiological and pathological forms of Aβ are and by what mechanism Aβ causes dementia. Moreover, there are no efficient drugs to stop or reverse the progression of Alzheimer＇s disease. In this paper, we review the structures, biological functions, and neurotoxicity role of Aβ. We also discuss the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and metabolism. Additionally, we summarize the therapeutic developments and recent advances of different strategies for treating Alzheimer＇s disease. Finally, we will report on the progress in searching for novel, potentially effective agents as well as selected promising strategies for the treatment of Alzheimer＇s disease. These prospects include agents acting on Aβ, its receptors and tau protein, such as small molecules, vaccines and antibodies against Aβ inhibitors or modulators of β- and y-secretase; Aβ-degrading proteases; tau protein inhibitors and vaccines; amyloid dyes and microRNAs.
Journal Article
Microplastic Pollution: Threats and Impacts on Global Marine Ecosystems
This study investigates the scope of global marine microplastic pollution and its implications on marine ecosystems and human health. We first delve into how plastic enters the ocean, with an emphasis on the accumulation of plastic along coastlines, particularly the formation and impact of the Great Pacific Garbage Patch (GPGP). Through a concentration map of marine microplastics across five continents, the global distribution of microplastic pollution is revealed. Furthermore, the effects of microplastics on marine wildlife are explored, as well as their potential entry into the human food chain, posing potential public health risks. The results of our research underscore the serious threats of microplastic pollution to global marine ecosystems and human health, emphasizing the need for more scientific research and policy measures to address this challenge.
Journal Article
عبارات \غامضة\ عن الصين : مقالات في الجغرافيا البشرية
هذا الكتاب هو الجزء الأول من سلسلة كتب \"الحكمة الصينية\" ويأتي تحت عنوان (عبارات \"غامضة\" عن الصين : مقالات في الجغرافيا البشرية)، وجمع بين دفتيه ما مجموعة أربعة عشر مصطلحا متعلقا بالجغرافيا البشرية، ومن بينها \"الأقاليم التسعة\"، \"العالم\"، \"النهر الأصفر\"، \"سور الصين العظيم\"، \"المدينة\"، \"و\"العاصمة\"، وغيرها، ويتمثل الغرض الرئيسي للكتاب في تعريف الأطفال بالجغرافيا الصينية التقليدية، وتعميم معارف الجغرافيا البشرية في نفس الوقت، وهو الأمر الذي يترك الأطفال يستكشفون المعنى الثقافي وراء المصطلحات والمفردات الشائعة.
Book
Optical trapping with structured light: a review
Optical trapping describes the interaction between light and matter to manipulate micro-objects through momentum transfer. In the case of 3D trapping with a single beam, this is termed optical tweezers. Optical tweezers are a powerful and noninvasive tool for manipulating small objects, and have become indispensable in many fields, including physics, biology, soft condensed matter, among others. In the early days, optical trapping was typically accomplished with a single Gaussian beam. In recent years, we have witnessed rapid progress in the use of structured light beams with customized phase, amplitude, and polarization in optical trapping. Unusual beam properties, such as phase singularities on-axis and propagation invariant nature, have opened up novel capabilities to the study of micromanipulation in liquid, air, and vacuum. We summarize the recent advances in the field of optical trapping using structured light beams.
Journal Article
Electrochemical reduction of nitrate to ammonia via direct eight-electron transfer using a copper–molecular solid catalyst
Ammonia (NH
3
) is essential for modern agriculture and industry and is a potential energy carrier. NH
3
is traditionally synthesized by the Haber–Bosch process at high temperature and pressure. The high-energy input of this process has motivated research into electrochemical NH
3
synthesis via nitrogen (N
2
)–water reactions under ambient conditions. However, the future of this low-cost process is compromised by the low yield rate and poor selectivity, ascribed to the inert N≡N bond and ultralow solubility of N
2
. Obtaining NH
3
directly from non-N
2
sources could circumvent these challenges. Here we report the eight-electron direct electroreduction of nitrate to NH
3
catalysed by copper-incorporated crystalline 3,4,9,10-perylenetetracarboxylic dianhydride. The catalyst exhibits an NH
3
production rate of 436 ± 85 μg h
−1
cm
−2
and a maximum Faradaic efficiency of 85.9% at −0.4 V versus a reversible hydrogen electrode. This notable performance is achieved by the catalyst regulating the transfer of protons and/or electrons to the copper centres and suppressing hydrogen production.
Electrochemically reducing nitrogen-containing molecules could provide less energy-intense routes to produce ammonia than the traditional Haber–Bosh process. Here the authors use a catalyst comprising Cu embedded in an organic molecular solid to synthesize ammonia from nitrate ions.
Journal Article
Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis
Background
Ferroptosis is a new type of nonapoptotic cell death model that was closely related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute lung injury (ALI) which is caused by severe oxidative stress injury, has been a major cause of accidental death worldwide. The latest evidences indicate nuclear factor (erythroid-derived 2)-like 2 (Nrf2) suppress ferroptosis and maintain cellular redox balance. Here, we test the hypothesis that activation of Nrf2 pathway attenuates seawater drowning-induced ALI via inhibiting ferroptosis.
Methods
we performed studies using Nrf2-specific agonist (dimethyl fumarate), Nrf2 inhibitor (ML385), Nrf2-knockout mice and ferroptosis inhibitor (Ferrostatin-1) to investigate the potential roles of Nrf2 on seawater drowning-induced ALI and the underlying mechanisms.
Results
Our data shows that Nrf2 activator dimethyl fumarate could increase cell viability, reduced the levels of intracellular ROS and lipid ROS, prevented glutathione depletion and lipid peroxide accumulation, increased
FTH1
and
GPX4
mRNA expression, and maintained mitochondrial membrane potential in MLE-12 cells. However, ML385 promoted cell death and lipid ROS production in MLE-12 cells. Furthermore, the lung injury became more aggravated in the Nrf2-knockout mice than that in WT mice after seawater drowning.
Conclusions
These results suggested that Nrf2 can inhibit ferroptosis and therefore alleviate ALI induced by seawater drowning. The effectiveness of ferroptosis inhibition by Nrf2 provides a novel therapeutic target for seawater drowning-induced ALI.
Journal Article