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The space charge layer (SCL) is generally considered one of the origins of the sluggish interfacial lithium-ion transport in all-solid-state lithium-ion batteries (ASSLIBs). However, in-situ visualization of the SCL effect on the interfacial lithium-ion transport in sulfide-based ASSLIBs is still a great challenge. Here, we directly observe the electrode/electrolyte interface lithium-ion accumulation resulting from the SCL by investigating the net-charge-density distribution across the high-voltage LiCoO 2 /argyrodite Li 6 PS 5 Cl interface using the in-situ differential phase contrast scanning transmission electron microscopy (DPC-STEM) technique. Moreover, we further demonstrate a built-in electric field and chemical potential coupling strategy to reduce the SCL formation and boost lithium-ion transport across the electrode/electrolyte interface by the in-situ DPC-STEM technique and finite element method simulations. Our findings will strikingly advance the fundamental scientific understanding of the SCL mechanism in ASSLIBs and shed light on rational electrode/electrolyte interface design for high-rate performance ASSLIBs. Understanding the effect of the space charge layer (SCL) in all-solid-state lithium-ion batteries is challenging due to lack of direct experimental observations. Here the authors visualize the SCL using an in-situ DPC-STEM imaging technique, based on which they further introduce a built-in electric field to suppress its formation.

Although the theoretical specific capacity of LiCoO2 is as high as 274 mAh g−1, the superior electrochemical performances of LiCoO2 can be barely achieved due to the issues of severe structure destruction and LiCoO2/electrolyte interface side reactions when the upper cutoff voltage exceeds 4.5 V. Here, a bifunctional self‐stabilized strategy involving Al+Ti bulk codoping and gradient surface Mg doping is first proposed to synchronously enhance the high‐voltage (4.6 V) performances of LiCoO2. The comodified LiCoO2 (CMLCO) shows an initial discharge capacity of 224.9 mAh g−1 and 78% capacity retention after 200 cycles between 3.0 and 4.6 V. Excitingly, the CMLCO also exhibits a specific capacity of up to 142 mAh g−1 even at 10 C. Moreover, the long‐term cyclability of CMLCO/mesocarbon microbeads full cells is also enhanced significantly even at high temperature of 60 °C. The synergistic effects of this bifunctional self‐stabilized strategy on structural reversibility and interfacial stability are demonstrated by investigating the phase transitions and interface characteristics of cycled LiCoO2. This work will be a milestone breakthrough in the development of high‐voltage LiCoO2. It will also present an instructive contribution for resolving the big structural and interfacial challenges in other high‐energy‐density rechargeable batteries. A bifunctional self‐stabilized strategy involving Al+Ti bulk codoping and gradient surface Mg doping is first proposed to synchronously enhance the high‐voltage (4.6 V) performances of LiCoO2. The comodified LiCoO2 shows excellent long‐term cyclability and high‐rate capability in both half and full cells even at high temperature of 60 °C.

It is demonstrated that a novel eutectic solution including 1,3,5‐trioxane (TXE) and succinonitrile (SN) can be converted into solid‐state polymer electrolyte (SPE) via in situ polymerization triggered by lithium difluoro(oxalato)borate (LiDFOB). It is worth noting that all the precursors (LiDFOB, TXE, and SN) of this novel SPE are totally solid and nonvolatile at room temperature, where, LiDFOB works as a lithium salt and an initiator simultaneously to avoid the introduction of impurity. It is noted that such SPE presents a considerable ionic conductivity of 1.14 × 10−4 S cm−1 and a sufficiently wide electrochemical window of 4.5 V, which is significant for supporting the high‐energy lithium batteries. In addition, this dedicatedly designed in situ polymerization is powerful to build kinetically favorable polymer‐based protective layers on LiCoO2 cathode and Li metal anode simultaneously, guaranteeing outstanding cycling stability (capacity retention of 88% after 200 cycles) of 4.3 V LiCoO2/lithium metal batteries at room temperature. More intriguingly, soft packed LiCoO2/SPE/Li metal batteries can still light a blue light emitting diode (LED) under the harsh conditions of being bent, cut, and stroked by a hammer, demonstrating excellent safety characteristics. A new type of solid‐state polymer electrolyte (SPE) free of additional initiators and flammable precursors is dedicatedly designed through an in situ polymerization of novel eutectic solution by LiDFOB. Such SPE can build kinetically favorable protective layers on LiCoO2 and Li simultaneously, guaranteeing outstanding cycling stability of 4.3 V LiCoO2/Li metal battery.

Although the theoretical specific capacity of LiCoO 2 is as high as 274 mAh g −1 , the superior electrochemical performances of LiCoO 2 can be barely achieved due to the issues of severe structure destruction and LiCoO 2 /electrolyte interface side reactions when the upper cutoff voltage exceeds 4.5 V. Here, a bifunctional self‐stabilized strategy involving Al+Ti bulk codoping and gradient surface Mg doping is first proposed to synchronously enhance the high‐voltage (4.6 V) performances of LiCoO 2 . The comodified LiCoO 2 (CMLCO) shows an initial discharge capacity of 224.9 mAh g −1 and 78% capacity retention after 200 cycles between 3.0 and 4.6 V. Excitingly, the CMLCO also exhibits a specific capacity of up to 142 mAh g −1 even at 10 C. Moreover, the long‐term cyclability of CMLCO/mesocarbon microbeads full cells is also enhanced significantly even at high temperature of 60 °C. The synergistic effects of this bifunctional self‐stabilized strategy on structural reversibility and interfacial stability are demonstrated by investigating the phase transitions and interface characteristics of cycled LiCoO 2 . This work will be a milestone breakthrough in the development of high‐voltage LiCoO 2 . It will also present an instructive contribution for resolving the big structural and interfacial challenges in other high‐energy‐density rechargeable batteries.

Topology, an important branch of mathematics, is an ideal theoretical tool to describe topological states and phase transitions. Many topological concepts have found their physical entities in real or reciprocal spaces identified by topological invariants, which are usually defined on orientable surfaces, such as torus and sphere. It is natural to investigate the possible physical realization of more intriguing non-orientable surfaces. Herein, we show that the set of spin-induced ferroelectric polarizations in cubic perovskite oxides A Mn 3 Cr 4 O 12 ( A  = La and Tb) reside on the topological Roman surface—a non-orientable two-dimensional manifold formed by sewing a Möbius strip edge to that of a disc. The induced polarization may travel in a loop along the non-orientable Möbius strip or orientable disc, depending on the spin evolution as controlled by an external magnetic field. Experimentally, the periodicity of polarization can be the same or twice that of the rotating magnetic field, which is consistent with the orientability of the disc and the Möbius strip, respectively. This path-dependent topological magnetoelectric effect presents a way to detect the global geometry of a surface and deepens our understanding of topology in both mathematics and physics. A non-orientable surface can mirror reflecting the man travelling on it. Realizing such topological object is fascinating. Here, the authors discover that antiferromagnetic-induced polarization in a solid can realize a non-orientable Roman surface.

Introduction Early-stage poorly differentiated lung adenocarcinoma (LUAD) is plagued by a high risk of postoperative recurrence, and its prognostic heterogeneity complicates treatment and surveillance planning. We conducted this integrative multi-omics study to identify those patients with a truly high risk of adverse outcomes. Methods Whole-exome, RNA and whole methylome sequencing were carried out on 101 treatment-naïve early-stage poorly differentiated LUADs. Integrated analyses were conducted to disclose molecular characteristics and explore molecular subtyping. Functional validation of key molecules was carried out through in vitro and in vivo experiments. Results Recurrent tumors exhibited significantly higher ploidy ( p  = 0.024), the fraction of the genome altered (FGA, p  = 0.042), and aneuploidy ( p  < 0.05) compared to non-recurrent tumors, as well as a higher frequency of CNVs. Additionally, recurrent tumors showed hypomethylation at both the global level and in CpG island regions. Integrative transcriptomic and methylation analyses identified three molecular subtypes (C1, C2, and C3), with the C1 subtype presenting the worst prognosis ( p  = 0.024). Although frequently mutated genes showed similar mutation frequencies across the three subtypes, the C1 subtype exhibited the highest tumor mutation burden (TMB), mutant-allele tumor heterogeneity (MATH), aneuploidy, and HLA loss of heterozygosity (HLA-LOH), along with relatively lower immune cell infiltration. Furthermore, GINS1 and CPT1C were found to promote LUAD progression, and their high expression correlated with a poor prognosis. Conclusions This multi-omics study identified three integrative subtypes with distinct prognostic implications, paving the way for more precise management and postoperative monitoring of early-stage poorly differentiated LUAD.

The last decade has witnessed an explosion of interest in the cutting load analysis for multifarious tools, especially in experiments and classical 2D model. But the cutting load model for broaching tool with grooves is still not clear and functional. In this paper, a new cutting load model applied to the broaching tool, which has some grooves on the flank face of the tooth, is reported. The model takes account of the load reduction effect of grooves on the tool teeth and the load strengthening effect of the bumps on the workpiece. Then, based on the new model, the cutting load simulation analyses for 5 different types of broaching tools are presented and compared with the corresponding experimental results. The results show that cutting load can be well assessed with the proposed new model. And an interesting phenomenon is found that the grooves on the tool teeth are not the more, the better. Among the 5 different types of broaching tools researched, 4/5 type broaching tool shows the best cutting performance.

Serous papillary adenofibroma (SPAF) is a rare benign tumor in gynecological practice. Most patients have no symptoms and occasionally present with pelvic masses during physical examinations. SPAF consists of both fibrous and epithelial parts, which makes it easy to misdiagnose malignancies on pre-surgery examinations. Therefore, clinical and pathological features of SPAF at the Second Affiliated Hospital Zhejiang University School of Medicine (Hangzhou, China) were summarized in the present study to assist clinical practice. A total of 13 cases encountered at our hospital were collected and immunohistochemistry (IHC) staining was performed on their specimens. SPAF appears as a unilocular cystic mass on imaging. Serum estradiol and prolactin levels were elevated in certain patients. The IHC staining of SPAF was estrogen receptor-, progesterone receptor- and human epidermal growth factor receptor 2-positive but Ki-67- and p53-negative. The present study proved the sex hormone sensitivity of SPAF and the benign prognosis of patients. Magnetic resonance imaging is a promising method for differential diagnosis before surgery.

Topology, a mathematical concept in geometry, has become an ideal theoretical tool for describing topological states and phase transitions. Many topological concepts have found their physical entities in real or reciprocal spaces identified by topological/geometrical invariants, which are usually defined on orientable surfaces such as torus and sphere. It is natural to quest whether it is possible to find the physical realization of more intriguing non-orientable surfaces. Herein, we show that the set of spin-induced ferroelectric polarizations in cubic perovskite oxides AMn3Cr4O12 (A = La and Tb) resides on the topological Roman surface, a non-orientable two-dimensional manifold formed by sewing a Mobius strip edge to that of a disc. The induced polarization may travel in a loop along the non-orientable Mobius strip or orientable disc depending on how the spin evolves as controlled by external magnetic field. Experimentally, the periodicity of polarization can be the same or the twice of the rotating magnetic field, being well consistent with the orientability of disc and Mobius strip, respectively. This path dependent topological magnetoelectric effect presents a way to detect the global geometry of the surface and deepens our understanding of topology in both mathematics and physics

In this study, we introduce CT-LLM, a 2B large language model (LLM) that illustrates a pivotal shift towards prioritizing the Chinese language in developing LLMs. Uniquely initiated from scratch, CT-LLM diverges from the conventional methodology by primarily incorporating Chinese textual data, utilizing an extensive corpus of 1,200 billion tokens, including 800 billion Chinese tokens, 300 billion English tokens, and 100 billion code tokens. This strategic composition facilitates the model's exceptional proficiency in understanding and processing Chinese, a capability further enhanced through alignment techniques. Demonstrating remarkable performance on the CHC-Bench, CT-LLM excels in Chinese language tasks, and showcases its adeptness in English through SFT. This research challenges the prevailing paradigm of training LLMs predominantly on English corpora and then adapting them to other languages, broadening the horizons for LLM training methodologies. By open-sourcing the full process of training a Chinese LLM, including a detailed data processing procedure with the obtained Massive Appropriate Pretraining Chinese Corpus (MAP-CC), a well-chosen multidisciplinary Chinese Hard Case Benchmark (CHC-Bench), and the 2B-size Chinese Tiny LLM (CT-LLM), we aim to foster further exploration and innovation in both academia and industry, paving the way for more inclusive and versatile language models.