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The conventional multifocal optical elements cannot precisely control the focal number, spot size, as well as the energy distribution in between. Here, the binary amplitude-type super-oscillatory lens (SOL) is utilized, and a robust and universal optimization method based on the vectorial angular spectrum (VAS) theory and the genetic algorithm (GA) is proposed, aiming to achieve the required focusing performance with arbitrary number of foci in preset energy distribution. Several typical designs of multifocal SOLs are demonstrated. Verified by the finite-difference time-domain (FDTD) numerical simulation, the designed multifocal SOLs agree well with the specific requirements. Moreover, the full-width at half-maximum (FWHM) of the achieved focal spots is close to λ/ 3 for all the cases ( λ being the operating wavelength), which successfully breaks the diffraction limit. In addition, the designed SOLs are partially insensitive to the incident polarization state, functioning very well for both the linear polarization and circular polarization. The optimization method presented provides a useful design strategy for realizing a multiple sub-diffraction-limit foci field of SOLs. This research can find its potentials in such fields as parallel particle trapping and high-resolution microscopy imaging.

Planar super-oscillatory lens (SOL), a far-field subwavelength-focusing diffractive device, holds great potential for achieving sub-diffraction-limit imaging at multiple wavelengths. However, conventional SOL devices suffer from a numerical-aperture-related intrinsic tradeoff among the depth of focus (DoF), chromatic dispersion and focusing spot size. Here, we apply a multi-objective genetic algorithm (GA) optimization approach to design an apochromatic binary-phase SOL having a prolonged DoF, customized working distance (WD), minimized main-lobe size, and suppressed side-lobe intensity. Experimental implementation demonstrates simultaneous focusing of blue, green and red light beams into an optical needle of ~0.5λ in diameter and DOF > 10λ at WD = 428 μm. By integrating this SOL device with a commercial fluorescence microscope, we perform, for the first time, three-dimensional super-resolution multicolor fluorescence imaging of the “unseen” fine structures of neurons. The present study provides not only a practical route to far-field multicolor super-resolution imaging but also a viable approach for constructing imaging systems avoiding complex sample positioning and unfavorable photobleaching. Conventional super-oscillatory devices suffer from numerical-aperture related issue including depth of focus, chromatic dispersion, and focusing, Here, the authors utilised multi-objective genetic algorithm to optimise the design and experimentally demonstrated lens with an extended depth of focus, ultra-large working distance and suppressed side-lobes.

Sulfur hexafluoride (SF6) gas is extensively utilized as an insulating and arc-quenching medium in the circuit breakers and isolating switches of electrical equipment. It effectively isolates the circuits from the atmosphere and promptly extinguishes arcs. Therefore, the issue of SF6 gas leakage poses a significant threat to the related application fields, and the detection of SF6 gas leakage becomes extremely important. Infrared imaging detection offers advantages including non-contact, high precision, and visualization. However, most existing infrared detection systems are equipped with only one filter to detect SF6 gas. The images captured contain background noise and system noise, making these systems vulnerable to interference from such noises. To address these issues, we propose a method for monitoring SF6 gas leakage based on a customized binocular imaging (CBI) system. The CBI system has two filters, greatly reducing the interference of system noise and background noise. The first filter features the absorption resonant peak of SF6 gas. The second filter is used to record background noise and system noise. One aspect to note is that, in order to avoid the interference of other gases, the central wavelength of this second filter should keep away from the absorption resonant peaks of those gases. Accordingly, the central wavelengths of our customized filters were determined as 10,630 nm and 8370 nm, respectively. Then, two cameras of the same type were separately assembled with a customized filter, and the CBI prototype was accomplished. Finally, we utilized the difference method using two infrared images captured by the CBI system, to monitor the SF6 gas leakage. The results demonstrate that our developed system achieves a high accuracy of over 99.8% in detecting SF6 gas. Furthermore, the CBI system supports a plug-and-play customization to detect various gases for different scenarios.

Extrinsic Fabry–Perot (FP) interferometric sensors are being intensively applied for partial discharge (PD) detection and localization. Previous research work has mainly focused on novel structures and materials to improve the sensitivity and linear response of these sensors. However, the directional response behavior of an FP ultrasonic sensor is also of particular importance in localizing the PD source, which is rarely considered. Here, the directional sensitivity of a microelectromechanical system (MEMS)-based FP ultrasonic sensor with a 5-μm-thick micromechanical vibrating diaphragm is experimentally investigated. Ultrasonic signals from a discharge source with varying incident angles and linear distances are measured and analyzed. The results show that the sensor has a 5.90 dB amplitude fluctuation over a ±60° incident range and an exciting capability to detect weak PD signals from 3 m away due to its high signal–noise ratio. The findings are expected to optimize the configuration of a sensor array and accurately localize the PD source.

Methylation of DNA CpG motifs is modulated in part by the TET family of epigenetic regulators. Aifantis and colleagues show that loss of TET1 function biases hematopoiesis toward the B cell lineage and promotes hematopoietic malignancies. The methylcytosine dioxygenase TET1 (‘ten-eleven translocation 1’) is an important regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished expression of TET proteins and loss of 5hmC in many tumors suggests a critical role for the maintenance of this epigenetic modification. Here we found that deletion of Tet1 promoted the development of B cell lymphoma in mice. TET1 was required for maintenance of the normal abundance and distribution of 5hmC, which prevented hypermethylation of DNA, and for regulation of the B cell lineage and of genes encoding molecules involved in chromosome maintenance and DNA repair. Whole-exome sequencing of TET1-deficient tumors revealed mutations frequently found in non-Hodgkin B cell lymphoma (B-NHL), in which TET1 was hypermethylated and transcriptionally silenced. Our findings provide in vivo evidence of a function for TET1 as a tumor suppressor of hematopoietic malignancy.

Background The transition to residential care facilities can be stressful for older people, entailing numerous challenges. Many qualitative studies focused on the adjustment and the experiences associated with older adults’ admission to residential care facilities. However, there have been few studies to synthesize qualitative studies and pay attention to the cultural factors influencing adaptation. The aim is to appraise the adaptation of older people’ s transition to the residential care facilities. Methods We followed the method of Preferred Reporting Items of Systematic Review and Meta-Analysis (PRISMA). Six databases (CINHAL, Cochrane, Embase, Pubmed, PsycInfo, and Web of Science) were searched systematically from their inception until April 2020 using Medical Subject Headings (MSH) or Subject Headings plus free-text words. The CASP evaluation for qualitative studies was used for quality appraisal and meta-aggregation was used in the data analysis. Results Ten studies (from 7 countries on 3 continents) were included in this review. We synthesized two main findings: the impacts of culture on adaptation and the transition process. Conclusions Understanding the cultural factors helps nursing staff to gain new insight into older adults’ transition to residential care facilities. The consideration of cultural factors might be incorporated into tailored interventions for residents during transition. Nursing staff is advised to pay attention to the decision-making process before residents’ admission to the residential care facilities, and care plans are best made by residents, family members, and staff members together at the beginning of the decision-making process.

Structural colors find wide applications for color printing, intelligent display, filtering imaging, etc., owing to their benefits, including high resolution, stable properties, and dynamic tunability. This review first illustrates the mechanisms of structural color generation, such as surface plasmon resonances, localized surface plasmon resonances, Fabry‐Perot resonances, Mie resonances, etc. It then proposes the recent technological strategies employed to realize dynamic structural colors. The integration of structural colors with functional materials like phase‐change, along with the development of color dynamic control mechanisms such as microfluidic chips, micro‐electro‐mechanical system drivers, and microheaters, represents key approaches for spectrum regulation. Furthermore, the review assesses the performance, advantages, and limitations of various technologies for dynamic structural colors. Finally, this review concluded with a section on the future challenges and prospects in large‐area fabrication, practical applications, and performance improvement. It explains the current typical applications, including smart windows, adaptive camouflage, sensors, etc., and explores the processing methods that can achieve large‐area, high‐fidelity preparation of structural colors, such as nanoimprint, deep ultraviolet lithography, immersion lithography, laser printing, etc. This field promises advancements in high‐density data storage, information encryption, and broader market applications. This review explores the principles and recent advances in dynamic structural colors, including SPR, LSPR, FP, and Mie resonances. It highlights key tuning strategies involving functional materials and external stimuli, evaluating their performance and limitations. With applications in displays, sensors, and anti‐counterfeiting, the review emphasizes future challenges in large‐area fabrication and practical implementations, envisioning widespread adoption.

This study describes a novel fiber optic extrinsic Fabry–Perot interferometric (EFPI) ultrasonic sensor comprising a low-cost and high-performance silicon diaphragm. A vibrating diaphragm, 5 μm thick, was fabricated by using the Microelectromechanical Systems (MEMS) processing technology on a silicon-on-insulator (SOI) wafer. The Fabry–Perot (FP) cavity length was solely determined during the manufacturing process of the diaphragm by defining a specific stepped hole on the handling layer of the SOI wafer, which made the assembly of the sensor easier. In addition, the use of cheap and commercially available components and MEMS processing technology in the development of the sensing system, limited the cost of the sensor. The experimental tests showed that the minimum detectable ultrasonic pressure was 1.5 mPa/sqrt(Hz) −0.625 mPa/sqrt(Hz) between 20 kHz and 40 kHz. As a result, this sensor has the potential to successfully detect weak ultrasonic signals.

Ultrasonic wave is a powerful tool for many applications, such as structural health monitoring, medical diagnosis and partial discharges (PDs) detection. The fiber optic extrinsic Fabry–Perot interferometric (EFPI) sensor has become an ideal candidate for detecting weak ultrasonic signals due to its inherent advantages, and each time with a performance enhancement, it can bring great application potential in broadened fields. Herein, an EFPI ultrasonic sensor for PDs detection is proposed. The sensing diaphragm uses a 5-μm-thickness and beam-supported structure to improve the responsive sensitivity of the sensor at the resonant frequency. Furthermore, the ability of the sensor to detect characteristic ultrasonic signal of PDs is further enhanced by assembling a Fresnel-zone-plate (FZP)-based ultrasonic lens with the sensing probe to amplify the ultrasonic wave before it excites the sensing diaphragm. The final testing results show that the originally developed sensor owns the sensitivity of − 19.8 dB re. 1 V/Pa at resonant frequency. While, when the FZP is assembled with the probe, the sensitivity reaches to − 12.4 dB re. 1 V/Pa, and leads to a narrower frequency band, which indicates that the proposed method has a great potential to enhance the detection ability of sensor to characteristic ultrasonic wave of PDs.

The decreasing pixel size of digital image sensors for high-resolution imaging brings a great challenge for the matching color filters. Currently, the conventional dye color filters with pixel size of several microns set a fundamental limit for the imaging resolution. Here, we put forward a kind of structural color filter with circular nanohole-nanodisk hybrid nanostructure arrays at sub-diffraction-limit spatial resolution based on the uncoupled localized surface plasmon polaritons (LSPPs). Due to the uncoupled LSPPs taking effect, the pixel could generate an individual color even though operating as a single element. The pixel size for the minimum color filtering is as small as 180 × 180 nm 2 , translating into printing pixels at a resolution of ~ 141,000 dots per inch (dpi). In addition, through both the experimental and numerical investigations, the structural color thus generated exhibits wide color gamut, large viewing angle, and polarization independence. These results indicate that the proposed structural color can have enormous potential for diverse applications in nanoscale optical filters, microscale images for security purposes, and high-density optical data storage.