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"Yue, Liang"
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مبادئ الحكم في الصين القديمة
يتناول كتاب (مبادئ الحكم في الصين القديمة) والذي قامه بتأليفه (وي تشينغ) في حوالي (211) صفحة من القطع المتوسط موضوع (تاريخ الصين قديم) مستعرضا المحتويات التالية : قبل أكثر من ألف وربعمائة عام، أصدر الإمبراطور تاي تسونغ إمبراطور أسرة تانغ الملكية (618-907) مرسوما بأن يجمع أربعة من أشهر علماء الصين وسياسييها وأمهرهم وقتها المعارف التاريخية حول مبادئ الحكم الإمبراطوري من الكتب الكلاسيكية القديمة الستة، والمجموعات التاريخية الأربع، والمئات من مؤلفات المدارس الفكرية الصينية، وأن يرتبوها ويستخرجوا منها الدروس الاكثر اهمية حول تهذيب النفس وإصلاحها، وإدارة العائلة، والحكم الجيد للبلاد، وسبل جلب السلام للعالم. وكانت النتيجة مجموعة عنوانها \"تشيونشو تشيياو\" التي أقتبست بعناية من أربعة عشر ألف كتاب، وتسع وثمانين ألف مخطوطة من الكتابات القديمة، بإجمالي خمسمائة ألف فقرة مكتوبة، تغطي خمسة وشتين صنفا من الكتب. وقد ساعد هذا الكتاب الإمبراطور تاي سونغ والكثير من الأباطرة من بعده في أمور الحكم، ويعود الفضل في تحقيق الرخاء والسلام في المراحل اللاحقة بالصين القديمة بنسبة كبيرة إلى هذا الكتاب.
BOOK
Stiffness-switchable DNA-based constitutional dynamic network hydrogels for self-healing and matrix-guided controlled chemical processes
Constitutional dynamic networks (CDNs) attract interest as signal-triggered reconfigurable systems mimicking natural networks. The application of CDNs to control material properties is, however, a major challenge. Here we report on the design of a CDN consisting of four toehold-modified constituents, two of which act as bidentate units for chain-elongating, while the other two form a tetradentate structure acting as a crosslinking unit. Their hybridization yields a hydrogel of medium stiffness controlled by the balance between bidentate and tetradentate units. Stabilization of the tetradentate constituent by an auxiliary effector up-regulates the crosslinking unit, yielding a high-stiffness hydrogel. Conversely, stabilization of one of the bidentate constituents by an orthogonal effector enriches the chain-elongation units leading to a low-stiffness hydrogel. Using appropriate counter effectors, the hydrogels are reversibly switched across low-, medium- and high-stiffness states. The hydrogels are used to develop self-healing and controlled drug-release matrices and functional materials for operating biocatalytic cascades.
Dynamic hydrogels with controllable properties are of interest for a range of applications. Here, the authors report on a DNA hydrogel system which can be tailored to have reversible mechanical changes, reversible shape changes, is self-healing and can be used for controlled release applications.
Journal Article
Bioavailability of Tea Catechins and Its Improvement
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed.
Journal Article
Hyperunified field theory and gravitational gauge–geometry duality
A hyperunified field theory is built in detail based on the postulates of gauge invariance and coordinate independence along with the conformal scaling symmetry. All elementary particles are merged into a single hyper-spinor field and all basic forces are unified into a fundamental interaction governed by the hyper-spin gauge symmetry SP(1, Dh-1). The dimension Dh of hyper-spacetime is conjectured to have a physical origin in correlation with the hyper-spin charge of elementary particles. The hyper-gravifield fiber bundle structure of biframe hyper-spacetime appears naturally with the globally flat Minkowski hyper-spacetime as a base spacetime and the locally flat hyper-gravifield spacetime as a fiber that is viewed as a dynamically emerged hyper-spacetime characterized by a non-commutative geometry. The gravitational origin of gauge symmetry is revealed with the hyper-gravifield that plays an essential role as a Goldstone-like field. The gauge–gravity and gravity–geometry correspondences bring about the gravitational gauge–geometry duality. The basic properties of hyperunified field theory and the issue on the fundamental scale are analyzed within the framework of quantum field theory, which allows us to describe the laws of nature in deriving the gauge gravitational equation with the conserved current and the geometric gravitational equations of Einstein-like type and beyond.
Journal Article
Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19
(–)-Epigallocatechin-3-O-gallate (EGCG), the most abundant component of catechins in tea (Camellia sinensis (L.) O. Kuntze), plays a role against viruses through inhibiting virus invasiveness, restraining gene expression and replication. In this paper, the antiviral effects of EGCG on various viruses, including DNA virus, RNA virus, coronavirus, enterovirus and arbovirus, were reviewed. Meanwhile, the antiviral effects of the EGCG epi-isomer counterpart (+)-gallocatechin-3-O-gallate (GCG) were also discussed.
Journal Article
Preparation, characteristics and cytotoxicity of green synthesized selenium nanoparticles using Paenibacillus motobuensis LY5201 isolated from the local specialty food of longevity area
Selenium is an essential micronutrient element. For the extremely biotoxic of selenite, Selenium nanoparticles (SeNPs) is gaining increasing interest. In this work, a selenium-enriched strain with highly selenite-resistant (up to 173 mmol/L) was isolated from the local specialty food of longevity area and identified as
Paenibacillus motobuensis
(
P. motobuensis
) LY5201. Most of the SeNPs were accumulated extracellular. SeNPs were around spherical with a diameter of approximately 100 nm. The X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy showed that the purified SeNPs consisted of selenium and proteins. Our results suggested that
P. motobuensis
LY5201could be a suitable and robust biocatalyst for SeNPs synthesis. In addition, the cytotoxicity effect and the anti-invasive activity of SeNPs on the HepG2 showed an inhibitory effect on HepG2, indicating that SeNPs could be used as a potential anticancer drug.
Journal Article
A Recent Lineage Split in Cladium mariscus Preceding the Disjunction of Two Biodiversity Hotspots: Evidence From Plastid Genomes
We report the complete chloroplast genomes of two geographically disjunct populations of Cladium mariscus from the Yaluzangbu Valley (Bomi) and the Hengduan Mountains (Ninglang). Phylogenomic analysis supports the basal position of Cladium within Cyperaceae. We identify a Late Pleistocene lineage split (~68 kya) coinciding with the MIS4 glaciation, likely facilitated by earlier northward expansion during a warm period followed by glacial isolation. The chloroplast genomes show a contracted IR region and expanded LSC region, and exhibit strong A/T bias in SSRs, indicating compositional constraints. Additionally, C. mariscus displays distinct genomic features, including structural variation, compared to other Cyperaceae. This study highlights the role of Quaternary climate changes in driving divergence in high‐altitude wetlands and provides valuable genomic resources for further research. Our complete plastome analysis of Cladium mariscus reveals a Late Pleistocene divergence (~68.5 kya) between disjunct Tibetan (Bomi) and Yunnanese (Ninglang) populations—predating the tectonic disjunction of the Hengduan and Yarlung Tsangpo biodiversity hotspots. Climate‐driven habitat fragmentation during MIS4 glacial isolation, shaped this biogeographic split, with geothermal refugia enabling persistence in high‐altitude wetlands. The contracted IR regions and A/T‐biased SSRs in its chloroplast genome reflect adaptive evolution to dynamic wetland environments, providing key genomic insights for conserving relict species in biodiversity hotspots under climate change.
Journal Article
Protective effects of gallocatechin gallate against ultraviolet B induced skin damages in hairless mice
Epigallocatechin gallate (EGCG) has the effect to protect skin from ultraviolet B (UVB) induced damages, but it is unstable under ambient conditions, being susceptible to become brown in color. Gallocatechin gallate (GCG), an epimer counterpart of EGCG, is more stable chemically than EGCG. The potential effects of GCG against UVB-induced skin damages has not been available. The objective of this study was to investigate the protective effects of GCG against UVB-induced skin photodamages. GCG was topically applied on the skin of hairless mice at three dosage levels (LL, 12.5 mg/mL; ML 25 mg/mL; HL, 50 mg/mL), with EGCG and a commercially available baby sunscreen lotion SPF50 PA
+++
as control. The mice were then irradiated by UVB (fluence rate 1.7 µmol/m
2
s) for 45 min. The treatments were carried out once a day for 6 consecutive days. Skin measurements and histological studies were performed at the end of experiment. The results show that GCG treatments at ML and HL levels inhibited the increase in levels of skin oil and pigmentation induced by UVB irradiation, and improved the skin elasticity and collagen fibers. GCG at ML and HL levels inhibited the formation of melanosomes and aberrations in mitochondria of UVB-irradiated skin in hairless mice. It is concluded that GCG protected skin from UVB-induced photodamages by improving skin elasticity and collagen fibers, and inhibiting aberrations in mitochondria and formation of melanosomes.
Journal Article
Influence of internal variability on future changes in surface wind speed in China with two large ensemble simulations
Wind energy, as one of the renewable energy sources, plays a crucial role in the global energy system’s transition to clean energy. China possesses vast and widely distributed wind energy resources, and in recent years, it has rapidly developed and begun large-scale commercial utilization. Therefore, studying changes in surface wind speeds (SWSs) is highly important for wind energy development in China. This study utilizes two initial condition large ensemble simulations to project future changes in SWSs over China. The two sets of initial large ensemble models used are CanESM2-LE and CESM1-LE. By comparing the results from these two large ensemble models, the influence of internal variability of the climate system on SWSs in China are studied. Both models can effectively reproduce the climatological spatial distribution of SWSs in reanalysis. Results from both models indicate that external forcing leads to an increase in winter SWSs in eastern China, while SWSs decreases in the southeastern coastal areas and southwestern Tibet. In summer, SWSs exhibits a pattern of decrease in the north and increase in the south. The magnitude of wind speed changes is greater in winter than in summer. Additionally, as the projected period extends, the magnitude of these changes intensifies. The research results can provide a scientific basis for the future planning of wind power deployment.
Journal Article