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SPICA is a cooled, single large-mirror space-telescope, which is under discussion as an succsesor of the ASTRO-F mission. One of the most ambitious challenges of the SPICA mission is the direct observations of exoplanets with a coronagraph instrument. We report cryogenic infrared optics to realize high quality wavefronts for the SPICA coronagraph. The SPICA satellite will be launched by an H-IIA rocket to Sun-Earth L2 Halo orbit early in the 2010s. The SPICA telescope is a Ritchey-Chretien optics with 3.5m diameter primary mirror, and cooled down to 4.5 K in orbit by radiation cooling and mechanical cryo-coolers. Main working wavelengths are 5–200 micron. Advantages of the SPICA coronagraph are the infrared wavelenths where the contrast between planets and central stars are smaller than the optical wavelengths, and that the cooled space telescope consists of monolithic mirrors. Development of light-weight cooled telescope is one of the most important tasks to realize SPICA. At the present, sintered SiC and carbon fiber reinforced SiC (C/SiC) composite are candidate materials for the mirrors, truss, and optical bench. For these materials, estimations and improvements of basic property and surface roughness in cryogenic temperatures have been carried out. Deformation of trial product mirrors by cooling is also examined. We are developing cryogenic deformable mirrors (DMs) because wave front accuracy of the SPICA telescope is 0.35 micron RMS, which is not enough for our coronagraphic instrument. For MEMS (Micro Electro Mechanical System) DM and some others, measurements of thermal deformation by cooling, electrical response, and heat generation are undergoing. Developments of a tip-tilt system for cryogenic usage started to cancel vibration caused by the cryo-coolers and other components and to realize a diffraction limit resolution. The first result of our binary mask coronagraph experiment is also shown.

We present results of our survey observations of the [C II] 158 micron line emission from the Galactic plane using the Balloon-borne Infrared Carbon Explorer (BICE). Our survey covers a wide area (350 deg < l < 25 deg, |b| < 3 deg) with a spatial resolution of 15'. We employed a new observing method called the ``fast spectral scanning'' to make large-scale observations efficiently. Strong [C II] line emission was detected from almost all areas we observed. In the general Galactic plane, the spatial distribution of the [C II] line emission correlates very well with that of far-infrared continuum emission, but diffuse components are more prominent in the [C II] line emission; the I_[CII]/I_FIR ratio is ~0.6 % for diffuse components but is ~0.2 % for compact sources such as active star-forming regions. In the Galactic center region, on the other hand, the distribution of the [C II] line emission is quite different from that of the far-infrared continuum emission, and the I_[CII]/I_FIR ratio is systematically lower there. The FWHM velocity resolution of our instrument is 175 km/s, but we determined the central velocity of the line at each observed point very precisely with statistical errors as small as +- 6 km/s. The longitudinal distribution of the central velocity clearly shows the differential rotation pattern of the Galactic disk and also violent velocity fields around the Galactic center.

We have observed the [CII] 158 micron line emission from the Galactic plane (-10 deg < l < 25 deg, |b| <= 3 deg) with the Balloon-borne Infrared Carbon Explorer (BICE). The observed longitudinal distribution of the [CII] line emission is clearly different from that of the far-infrared continuum emission; the Galactic center is not the dominant peak in the [CII] emission. Indeed, the ratio of the [CII] line emission to far-infrared continuum (I_[CII] / I_FIR) is systematically low within the central several hundred parsecs of the Galaxy. The observational results indicate that the abundance of the C+ ions themselves is low in the Galactic center. We attribute this low abundance mainly to soft UV radiation with fewer C-ionizing photons. This soft radiation field, together with the pervasively high molecular gas density, makes the molecular self-shielding more effective in the Galactic center. The self-shielding further reduces the abundance of C+ ions, and raises the temperature of molecular gas at the C+/C/CO transition zone.

C-type natriuretic peptide (CNP) and its receptor are abundantly distributed in the brain, especially in the arcuate nucleus (ARC) of the hypothalamus associated with regulating energy homeostasis. To elucidate the possible involvement of CNP in energy regulation, we examined the effects of intracerebroventricular administration of CNP on food intake in mice. The intracerebroventricular administration of CNP-22 and CNP-53 significantly suppressed food intake on 4-h refeeding after 48-h fasting. Next, intracerebroventricular administration of CNP-22 and CNP-53 significantly decreased nocturnal food intake. The increment of food intake induced by neuropeptide Y and ghrelin was markedly suppressed by intracerebroventricular administration of CNP-22 and CNP-53. When SHU9119, an antagonist for melanocortin-3 and melanocortin-4 receptors, was coadministered with CNP-53, the suppressive effect of CNP-53 on refeeding after 48-h fasting was significantly attenuated by SHU9119. Immunohistochemical analysis revealed that intracerebroventricular administration of CNP-53 markedly increased the number of c-Fos–positive cells in the ARC, paraventricular nucleus, dorsomedial hypothalamus, ventromedial hypothalamic nucleus, and lateral hypothalamus. In particular, c-Fos–positive cells in the ARC after intracerebroventricular administration of CNP-53 were coexpressed with α-melanocyte–stimulating hormone immunoreactivity. These results indicated that intracerebroventricular administration of CNP induces an anorexigenic action, in part, via activation of the melanocortin system.