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result(s) for
"Yum, Hyewon"
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Mom, it's my first day of kindergarten!
A five-year-old boy, ready and eager on his first day at \"the big kids' school,\" must calm his very worried mother.
Book
Ode to a Bad Day
Our nameless youngster lists the day's pesky peccadilloes, large to small (looking at you, \"Line Cutter\"!). Rhythmic text, with preschool-perfect sounds and gripes, is interspersed with rhyming couplets hinting at the inevitable emotional rebound. True to child minded melodrama, each bad event, object, or feeling is a capital-C Character, all honorably served by Yum's scribbly illustrations zeroing-in on tantrum-y details. Despite the \"Bad Day\" half of its title, this picture book is an authentic slice-of-life celebration-or Ode-to resilient early childhood.
Magazine Article
Saturday is swimming day
\"Swimming lessons are on Saturdays, and every Saturday one little girl has a stomachache. When she gets to the pool it's loud, the floor is wet and slippery, and her swim cap is too tight. Her swimming instructor, Mary, says it's OK to sit by the edge if she doesn't want to get in the water this week. The next Saturday the girl has a stomachache again, but with Mary's gentle encouragement, she eventually manages to make it into the pool to practice her kicks. Little by little, the girl's confidence grows -- until one Saturday comes around when she has no stomachache at all! In a charming and relatable story about trying something new, author-illustrator Hyewon Yum shows that sometimes a little bravery and a lot of patience are all you need to face your fear\" -- The publisher.
Book
In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration
Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age‑related macular degeneration (AMD), lead to progressive vision loss through photoreceptor degeneration; RP begins with the gradual loss of peripheral rods, whereas AMD causes central‑vision loss mainly because macular cones and parafoveal rods degenerate. The neural retina leucine zipper (NRL) directs rod photoreceptor differentiation, and its disruption has been linked to upregulated cone-specific markers in rods. This study investigates the therapeutic potential of a cell-penetrating asymmetric small interfering RNA targeting NRL (cp-asiNRL) to induce rod-to-cone conversion and mitigate retinal degeneration. cp-asiNRL was administered intravitreally to C57BL/6J wild-type (WT), neovascular AMD (nAMD), and RP (Rho
P23H/+
) mouse models. Subsequent analyses included cone marker expression levels and electroretinographic evaluations, and single-cell RNA sequencing. Administration of cp-asiNRL suppressed NRL expression, increased cone marker expression, and improved retinal function in both WT and nAMD models. In RP mice, cone marker expression was also elevated, although functional improvements were comparatively modest, likely reflecting the advanced disease stage. Single-cell RNA sequencing revealed a rod-to-cone-like transdifferentiation, suggesting that cp-asiNRL-mediated NRL knockdown partially preserved photoreceptor integrity. cp-asiNRL-mediated NRL silencing shows considerable promise as a therapeutic intervention for retinal degenerative conditions. By promoting rod-to-cone transdifferentiation and supporting photoreceptor survival, this approach may offer a novel strategy for vision preservation.
Journal Article
Puddle
\"A mother and son use their imagination to have fun on a rainy day.\"-- Provided by publisher.
Book
Long-term outcome in children with infantile epileptic spasms syndrome: a multicenter retrospective study in Korea
Background: Infantile epileptic spasms syndrome (IESS) is a severe form of infantile epilepsy with a high lifetime morbidity burden.Purpose: We aimed to assess the long-term epilepsy and neurodevelopmental outcomes based on how children with IESS have been managed over the past few decades.Methods: This retrospective multicenter study included children diagnosed with IESS between 1994 and 2021 with a minimum follow-up period of 2 years. Data on demographics, clinical features, medical history, diagnostic evaluations, and treatments used to control spasms were collected. Epilepsy and neurodevelopmental outcomes were assessed at final follow-up.Results: A total of 378 infants with IESS were included. The mean age at onset of spasms was 7.3 (range, 1–24) months and mean follow-up duration was 7.9 (range, 2–28) years. Etiologies were identified in 65.1% of cases, with acquired structural etiologies being the most prevalent (29.9%). Among the genetic and genetic-structural etiologies, tuberous sclerosis complex (n=35), Down syndrome (n=8), Miller-Dieker syndrome (n=3), and 15q duplication syndrome (n=3) were the most common. Vigabatrin was prescribed to 93.9% of the patients, suggesting that it was the mainstay of treatment. At the last follow-up, 77.8% of the children remained on antiseizure medications and 29.1% had drug-resistant epilepsy. Approximately 90% had intellectual disabilities, and half of the eligible individuals had received special education.Conclusion: The IESS imposes a substantial burden on affected children and their families and often leads to chronic epilepsy and impaired cognitive function. Consensus diagnostic and treatment guidelines tailored to the Korean clinical practice are necessary to ensure early diagnosis and timely treatment.
Journal Article
Bark in the park! : poems for dog lovers
\"Go on a walk to the park with all different kinds of dogs and their owners in this funny and charming poetry picture book. Enjoy Avery Corman's canine poetry for an Afghan hound, basset hound, beagle, bloodhound, Daschshund, boxer, greyhound, and more as they stroll with their owners to the park\"-- Provided by publisher.
Book
Hematopoietic Stem Cell Transplantation-Associated Neurological Complications and Their Brain MR Imaging Findings in a Pediatric Population
Purpose: To determine the prognostic indicators for hematopoietic stem cell transplantation (HSCT)-associated neurological complications, the clinical characteristics and brain magnetic resonance imaging (MRI) lesions in pediatric HSCT recipients were reviewed. Methods: This retrospective study included 51 patients who had underwent a brain MRI due to newly developed neurological symptoms or infection signs during chemotherapy or HSCT. We reviewed the demographics, received treatments, treatment-related morbidities, laboratory findings and brain MRI findings, which were compared between good and poor neurologic outcome groups. Results: Thirty-seven patients (72.5%) fully recovered from the neurologic deficits and fourteen (27.5%) persisted or aggravated. The children with an underlying malignant disease had significantly poorer neurological outcomes (p = 0.015). The neurologic complications associated with infection were more frequent in the poor outcome group (p = 0.038). In the neuroimaging findings, the extent of the white matter lesions was significantly higher in the poor outcome group, as was that of abnormal enhancement, ventriculomegaly, cortical change, deep gray matter abnormalities and cerebellar abnormalities. Conclusion: Most children with neurologic complications and neuroimaging abnormalities during HSCT had recovered. However, children with neurologic complications associated with infectious causes, malignant disease or severe brain MRI abnormalities should be more carefully monitored during HSCT.
Journal Article
Someday, Narwhal
\"A tiny narwhal in a fishbowl discovers that sometimes the difference between staying home and a big adventure is a group of loving friends\"-- Provided by publisher.
Book
A piece of home
\"When Hee Jun's family moves from Korea to West Virginia, he struggles to adjust to his new home. His eyes are not big and round like his classmates, and he can't understand anything the teacher says, even when she speaks s-l-o-w-l-y and loudly at him. As he lies in bed at night, the sky seems smaller and darker. But little by little Hee Jun begins to learn English words and make friends on the playground. And one day he is invited to a classmate's house, where he sees a flower he knows from his garden in Korea, \"mugunghwa,\" or Rose of Sharon, as his friend tells him and Hee Jun is happy to bring a shoot to his grandmother to plant a \"piece of home\" in their new garden.\"--Provided by publisher.
Book