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This study compares the physical processes responsible for the heavy and light rain variations from the perspective of spring precipitation over Southern China. The results indicate that, heavy rain variation has a closer connection with the western North Pacific anticyclone. Intensified western North Pacific anticyclone and associated warm and humid air transport, coupled with intensified East Asian subtropical jet, favor significant moisture convergence and enhanced convective feedback over the key region, which causes increased heavy rain rather than light rain over there. In comparison, light rain variation shows a close relationship with the anomalous low over Lake Balkhash, which causes lower-tropospheric cyclone over the key region. On the one hand, anomalous cyclone favors lower-tropospheric cooling; concurred with cyclone-induced increased moisture, the lower-tropospheric relative humidity increases over there. On the other hand, the lower-tropospheric cooling center shifts northward with height and causes enhanced atmospheric baroclinity over there. Such atmospheric conditions are conducive to the occurrence of low cloud and more light rain. In addition, intensified East Asian subtropical jet associated with Lake Balkhash anomalous low also provides favorable dynamic lifting condition. Moreover, heavy and light rain variations are more related to El Niño-Southern Oscillation and North Atlantic horseshoe sea surface temperature in preceding winter, respectively. In addition, heavy rain shows a closer relationship with total precipitation amount variation, whereas light rain is more related to extreme consecutive dry days variation.

Construction projects, particularly megaprojects, inherently entail substantial environmental and social challenges. Early research on megaproject social responsibility (MSR) has primarily focused on domestic contexts, such as China, and has explored resident satisfaction mainly through economic or policy lenses. However, these studies have paid limited attention to broader stakeholders, leaving a significant gap in understanding how MSR influences satisfaction with the environmental compensation mechanism (SECM), particularly in international settings. This study aims to fill this gap by examining how MSR at different stages of the project life cycle affects SECM and by analyzing the mediating role of stakeholder environmental activities participation (SEAP) in this relationship. The findings provide theoretical and empirical insights to enhance the design and implementation of environmental compensation in international megaprojects, thereby contributing to improved stakeholder satisfaction and sustainable development outcomes. Grounded in life-cycle and stakeholder theories, this study investigated large-scale projects involving Chinese contractors in Thailand. We employed a two-stage questionnaire survey, beginning with a pilot study (n = 204) to validate the scales, followed by a main study (n = 398) for final analysis. Data were analyzed using factor analysis, Pearson correlation, and multiple linear regression. The results indicate that MSR has a significant positive effect on host-country residents' satisfaction with the environmental compensation mechanism (SECM), with direct effects notably originating from the design and operational stages. Furthermore, stakeholder environmental activities participation (SEAP) partially mediates the relationship between MSR (across all its stages) and SECM. This study enriches the literature by providing transnational empirical evidence on the role of MSR in improving SECM. It highlights the critical importance of the design and operation stages and confirms the mediating role of stakeholder participation. Practically, the findings offer valuable insights for international project managers and policymakers, emphasizing the strategic importance of engaging stakeholders in environmental activities to achieve sustainable development goals and enhance community satisfaction.

The duration of dry periods is closely related to drought conditions and is used to evaluate the degree of drought. In this article, using the rotated empirical orthogonal function (REOF) and K‐medoids clustering methods and considering the spatial continuity, 500 stations in China are divided into 10 clusters to analyze the variation characteristics of consecutive dry days (CDDs) with different durations in spring. In Clusters 1–5 over the middle and lower reaches of the Yangtze River, South China, North China, and eastern and western Southwest China, the contribution percentage of short‐duration CDDs to total dry days decreases, while that of medium‐ and/or long‐duration CDDs increases, which leads to an increase in the total dry days and the duration of CDDs. In Clusters 6–8, the total dry days decrease, which are mainly contributed by the decreases in medium‐duration CDDs (for Cluster 6 over southern Northeast China) or long‐duration CDDs (for Clusters 7–8 over northern Northeast China and southern Xinjiang). The total dry days change little in Clusters 9–10 over eastern Northwest China and northern Xinjiang, which is attributed to the offset among the changes in the three‐type duration CDDs. In Clusters 6–10, the duration of CDDs shortens overall. The decadal changes of spring dry days in China exhibit remarkable regional differences. The total day days and three‐type duration CDDs in some clusters (1, 4, and 8) all have significant decadal changes, but they have not in Cluster 7. And the decadal change times also exhibit regional differences. The investigation of different‐duration CDDs in this study provides more information on droughts at different time scales in China. Schematic diagram of the variations in total dry days and short‐, medium‐, and long‐duration CDDs in 10 clusters of China. Different (black) marks in China indicate the stations (central station) of each cluster. The (solid) arrows of ↑ and ↓ denote the (significant) increasing and decreasing trends, and the arrow of → represents almost no change. The values in the brackets denote the years when the significant decadal change occurs, and the marks of +/− indicate the increase/decrease decadal change.

Circular RNAs (circRNAs) have gained significant attention in recent years. This bibliometric analysis aimed to provide insights into the current state and future trends of global circRNA research. The scientific output on circRNAs from 2010 to 2022 was retrieved from the Web of Science Core Collection with circRNA-related terms as the subjects. Key bibliometric indicators were calculated and evaluated using CiteSpace. A total of 7385 studies on circRNAs were identified. The output and citation number have increased rapidly after 2015. China, the USA, and Germany were top three publishing countries. Currently, circCDR1as, circHIPK3, circPVT1, circSHPRH, and circZNF609 are the most studied circRNAs; and all are related to cancer. The theme of research have shifted from transcript, exon circularization and miRNA sponge topics to the transcriptome, tumor suppressor, and biomarkers, indicating that research interests have evolved from basic to applied research. CircRNAs will continue to be a highly active research area in the near future. From the current understanding of circRNA characterization and regulatory mechanisms as miRNA sponges in cancer, future directions may examine potential diagnostic and therapeutic roles of circRNAs in cancers or the function and mechanism of circRNAs in other diseases. Graphical Abstract

CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human malignancies, such as breast cancer. However, their application to other tumor types and intrinsic resistance mechanisms are still unclear. Here, we demonstrate that MYC amplification confers resistance to CDK4/6i in bladder, prostate and breast cancer cells. Mechanistically, MYC binds to the promoter of the E3 ubiquitin ligase KLHL42 and enhances its transcription, leading to RB1 deficiency by inducing both phosphorylated and total pRB1 ubiquitination and degradation. We identify a compound that degrades MYC, A80.2HCl, which induces MYC degradation at nanomolar concentrations, restores pRB1 protein levels and re-establish sensitivity of MYC high-expressing cancer cells to CDK4/6i. The combination of CDK4/6i and A80.2HCl result in marked regression in tumor growth in vivo. Altogether, these results reveal the molecular mechanisms underlying MYC-induced resistance to CDK4/6i and suggest the utilization of the MYC degrading molecule A80.2HCl to potentiate the therapeutic efficacy of CDK4/6i. Several molecular mechanisms, including retinoblastoma protein RB1 deficiency, explain CDK4/6 inhibitors resistance in cancer. Here, the authors show that MYC amplification induces CDK4/6 inhibitors resistance through transcriptional regulation of KLHL42, leading to RB1 degradation and targeting MYC overcomes CDK4/6 resistance in preclinical cancer models.

Precision measurements of the electron’s electric dipole moment (eEDM) are critical for testing fundamental symmetries in particle physics, and heavy polar molecules—such as barium monofluoride (BaF)—have emerged as promising candidates for advancing the sensitivity. However, the achievement of a 3D magneto-optical trap (MOT) required slowing BaF molecules to near-zero velocity by scattering over 10 4 photons per molecule, demanding a quasi-cycling transition with minimal leakage. We present a detailed study of the leakage channels, including higher vibrational and rotational states. By combining microwave remixing with optical pumping of rotational and vibrational dark states, we reduced the total leakage fraction to 10 −5 . Using frequency-chirped laser slowing, we slowed a subset of buffer-gas-cooled BaF molecules from approximately 80 ms −1 to near-zero velocity, which is critical for efficient MOT loading. This work establishes the technical foundation for precision eEDM measurements using laser-cooled heavy molecules. Heavy polar molecules like BaF are key to boosting measurement sensitivity of the electron’s electric dipole moment (eEDM), but slowing heavy molecules to near-zero velocity for experiments is challenging. This study achieved reducing BaF’s total leakage fraction to 10 −5 using microwave remixing and optical pumping and slowing buffer-gas-cooled BaF molecules from  ~ 80 m/s to near-zero velocity.

Environmental issues and social responsibility have a significant impact on the natural ecological system and economic development. Hence, it is essential to find a relative balance path between them. Previous studies have sought to explore environmental and social responsibility rather than seek solutions from a systematic perspective, and there seems to be a lack of a systematic quantitative review of periodic solutions or details. To identify multiple impacts and relationships between environmental issues and social responsibility and to illustrate emerging trends and challenges, this article proposes a scientometrics review based on 1,336 articles published from 2001 to 2020, through co-occurrence analysis and co-citation analysis together with cluster and burstiness analysis to reveal the depth and breadth of emerging research. This research demonstrates the research paradigm of environmental issues and social responsibility, extending from a single stakeholder level to a systematic strategic perspective of multiple organizations and stakeholders. The results provide researchers and practitioners with a deeper understanding of future directions and implications.

Shortage and high turnover intention rate of physicians are concerning problems in China. Professional identity has been shown as an influential factor for physicians' turnover intention. Enhancing physicians' professional identity in their early phase of career, standardized residency training program (SRTP), may help reduce the turnover rate. This study aimed to investigate the current status of professional identity and explore its associated psychosocial factors among Chinese SRTP trainees, hoping to provide evidence in strengthening the available medical human resources in China. The final sample was comprised of 2,267 Chinese SRTP trainees in this cross-sectional survey conducted from 9 March to 20 March in 2023. Descriptive statistics were calculated. Bivariate analyses and hierarchical multiple linear regression were used to analyze potential associated factors of Chinese SRTP trainees' professional identity. The average score of respondents' professional identity was 47.68 (standard deviation, SD = 8.61). Results from hierarchical multiple linear regression analysis showed that being married (  = 0.066,  < 0.01), having work experience before SRTP (  = 0.036,  < 0.05), being satisfied with annual income (  = 0.062,  < 0.01), psychological distress (  = -0.144,  < 0.001), depersonalization (  = -0.053,  < 0.05), emotional exhaustion (  = -0.380,  < 0.001) and resilience (  = 0.169,  < 0.001) were associated with professional identity (  = 114.301,  < 0.001). All associated factors can explain 41.1% of the variance in professional identity, and individual psychological variables make up a substantial portion (28.6%) of this influence. Individual psychological variables are strongly associated with professional identity. Helping SRTP trainees reduce psychological distress, alleviate burnout and enhance resilience may be effective ways to promote the formation of their professional identity.

Critical thinking is one of the seven essential competencies of the Global Minimum Essential Requirements in Medical Education. It is essential to cultivate medical students' critical thinking as it influences their clinical decision-making. The undergraduate years represent a critical period for medical students in terms of personality development and self-differentiation, which are essential foundations for shaping critical thinking. Therefore, this multicenter cross-sectional study aimed to explore the relationships of critical thinking disposition with personality traits and differentiation of self in medical undergraduates. A total of 1,338 medical students from three institutions in China were selected for this study using a stratified cluster sampling method. The Critical Thinking Disposition Inventory-Chinese Version (CTDI-CV), Eysenck Personality Questionnaire (EPQ) and Differentiation of Self Inventory-Revised (DSI-R) were applied to assess medical students' critical thinking disposition, personality traits and differentiation of self. Multiple linear regression analysis was conducted to test the relationships of critical thinking disposition with personality traits and differentiation of self. Binary logistic regression model was established for sensitivity analysis. Linear regression analysis showed that psychoticism and neuroticism could negatively influence critical thinking disposition [β, 95% confidence interval (CI) = -0.363 (-0.411, -0.316); -0.129 (-0.189, -0.070)]. Conversely, extraversion and differentiation of self could positively influence critical thinking disposition [β, 95% CI = 0.145 (0.096, 0.194); 0.279 (0.224, 0.334)]. The results of the binary logistic regression were consistent with those of the linear regression model. This study suggested the potential need for tailored critical thinking development strategies for medical students with different personality traits and degrees of differentiation of self.

Chronic Insomnia Disorder (CID) is prevalent, yet access to effective treatments is limited. Integrating mindfulness with Cognitive Behavioral Therapy for Insomnia (CBT-I) in an accessible online format may fill this gap. This study evaluated the efficacy of a therapist-guided, internet-delivered Mindfulness-Based Cognitive Therapy for Insomnia (iMBCT-I), which has been scarcely investigated. In this open-label, parallel-group randomized trial, 82 participants with CID were assigned to the 8-week of iMBCT-I group (n = 41) or a control group receiving a single online session of sleep hygiene education (SHE, n = 41). The primary outcomes were insomnia severity assessed with Insomnia Severity Index (ISI) and insomnia remission (ISI < 8) rate. Secondary outcomes included sleep quality, sleep diary and actigraphy parameters, depressive and anxious symptoms, and quality of life. The primary and the follow-up time-points were week 8 and week 20, respectively. Statistical analyses followed the intention-to-treat principle. No serious adverse events were reported. At week 8, the ISI score in the iMBCT-I group showed a significant decrease compared to the SHE group [mean difference, 95% confidence intervals (CI) = 4.00 (2.22, 5.78), < 0.001, Cohen's , 95% CI = 0.99 (0.53, 1.45)]. More participants achieved insomnia remission in the iMBCT-I group [odds ratio, 95% CI = 6.21 (2.24, 17.23), < 0.001]. The iMBCT-I was also superior on improving sleep quality, sleep onset latency, wakefulness after sleep onset, sleep efficiency, rapid eye movement duration, depressive symptoms and both physical and mental quality of life (all < 0.05). Linear mixed-effects model showed the maintenance of these effects at the 20-week follow-up for most outcomes. Therapist-guided iMBCT-I is effective in reducing insomnia severity in adults with CID with benefits sustained for 20 weeks. This study has been registered with the Chinese Clinical Trial Registry https://www.chictr.org.cn/ (Registration Number: ChiCTR2400084300).