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A spectroscopic study of cubic silicon nitride (γ-Si 3 N 4 ) at cryogenic temperatures of 8 K in the near IR - VUV range of spectra with synchrotron radiation excitation provided the first experimental evidence of direct electronic transitions in this material. The observed photoluminescence (PL) bands were assigned to excitons and excited and centers formed after the electron capture by neutral structural defects. The excitons are weakly quenched on neutral and strongly on charged defects. The fundamental band-gap energy of 5.05 ± 0.05 eV and strong free exciton binding energy ~0.65 eV were determined. The latter value suggests a high efficiency of the electric power transformation in light in defect-free crystals. Combined with a very high hardness and exceptional thermal stability in air, our results indicate that γ-Si 3 N 4 has a potential for fabrication of robust and efficient photonic emitters.

High-pressure synthesis is a powerful method for the preparation of novel materials with high elastic moduli and hardness. Additionally, such materials may exhibit interesting thermal, optoelectronic, semiconductuing, magnetic or superconducting properties. Here, we report on the high-pressure synthesis of zirconium and hafnium nitrides with the stoichiometry M 3 N 4 , where M = Zr, Hf. Synthesis experiments were performed in a laser-heated diamond anvil cell at pressures up to 18 GPa and temperatures up to 3,000 K. We observed formation of cubic Zr 3 N 4 and Hf 3 N 4 (c-M 3 N 4 ) with a Th 3 P 4 -structure, where M-cations are eightfold coordinated by N anions. The c-M 3 N 4 phases are the first binary nitrides with such a high coordination number. Both compounds exhibit high bulk moduli around 250 GPa, which indicates high hardness. Moreover, the new nitrides, c-Zr 3 N 4 and c-Hf 3 N 4 , may be the first members of a larger group of transition metal and/or lanthanide nitrides with interesting ferromagnetic or superconducting behaviour.

Picosecond acoustic interferometry is used to monitor in time the motion of the phase transition boundary between two water ice phases, VII and VI, coexisting at a pressure of 2.15 GPa when compressed in a diamond anvil cell at room temperature. By analyzing the time-domain Brillouin scattering signals accumulated for a single incidence direction of probe laser pulses, it is possible to access ratios of sound velocity values and of the refractive indices of the involved phases, and to distinguish between the structural phase transition and a recrystallization process. Two-dimensional spatial imaging of the phase transition dynamics indicates that it is initiated by the pump and probe laser pulses, preferentially at the diamond/ice interface. This method should find applications in three-dimensional monitoring with nanometer spatial resolution of the temporal dynamics of low-contrast material inhomogeneities caused by phase transitions or chemical reactions in optically transparent media.

PurposePolysorbates are critical stabilizers in biopharmaceutical protein formulations. However, they may degrade in drug substance (DS) or drug product (DP) during storage. Degradation catalyzed by lipases present in host cell proteins (HCPs) is one suspected root cause. The purpose of this study was to develop an assay to detect lipolytic activity in biopharmaceutical DS and DP formulations.MethodsThe assay is based on the hydrolysis of the lipase substrate 4-methylumbelliferyl oleate to yield the fluorescent product 4-methylumbelliferone.ResultsFirst, the assay components and their concentrations (buffer salts and pH, solvent and inhibitor Orlistat) were established and optimized using a model lipase (Porcine pancreatic lipase) and cell culture harvest fluid that exhibited lipolytic activity. The assay was then successfully applied and thereby qualified in protein formulations and at lipase concentrations possibly encountered in actual biopharmaceutical DS and DP formulations.ConclusionThe lipase assay can be used to detect lipolytic activity in intermediate and final DS, for example during process optimization in downstream purification, to better and specifically reduce the level, or deplete, lipases from HCPs. The assay is also suitable to be applied during root cause investigations related to polysorbate degradation in biopharmaceutical DP.

In July 2024, Sunrise completed its third successful science flight. The Sunrise iii observatory had been upgraded significantly after the two previous successful flights in 2009 and 2013, to tackle the most recent science challenges concerning the solar atmosphere. Three completely new instruments focus on the small-scale physical processes and their complex interaction from the deepest observable layers in the photosphere up to chromospheric heights. Previously poorly explored spectral regions and lines are exploited to paint a three-dimensional picture of the solar atmosphere with unprecedented completeness and level of detail. The full polarimetric information is captured by all three instruments to reveal the interaction between the magnetic fields and the hydrodynamic processes. Two slit-based spectropolarimeters, the Sunrise UV Spectropolarimeter and Imager (SUSI) and the Sunrise Chromospheric Infrared spectro-Polarimeter (SCIP), focus on the near-ultraviolet (309 – 417 nm) and the near-infrared (765 – 855 nm) regions respectively, and the imaging spectropolarimeter Tunable Magnetograph ( TuMag ) simultaneously obtains maps of the full field-of-view of 46 × 46  Mm 2 in the photosphere and the chromosphere in the visible (525 and 517 nm). The instruments are operated in an orchestrated mode, benefiting from a new Image Stabilization and Light Distribution unit ( ISLiD ), with the Correlating Wavefront Sensor (CWS) providing the autofocus control and an image stability with a root-mean-square value smaller than 0.005”. A new gondola was constructed to significantly improve the telescope pointing stability, required to achieve uninterrupted observations over many hours. Sunrise iii was launched successfully on 10 July 2024, from the Esrange Space Center of the Swedish Space Corporation near Kiruna (Sweden). It reached the landing site between the Mackenzie River and the Great Bear Lake in Canada after a flight duration of 6.5 days. In this paper, we give an overview of the Sunrise iii observatory and its instruments.

The third science flight of the balloon-borne solar observatory Sunrise carries three entirely new post-focus science instruments with spectropolarimetric capabilities, concurrently covering an extended spectral range from the near ultraviolet to the near infrared. Sampling a larger height range, from the low photosphere to the chromosphere, with the sub-arcsecond resolution provided by the 1-m Sunrise telescope, is key in understanding critical small-scale phenomena which energetically couple different layers of the solar atmosphere. The Sunrise UV Spectropolarimeter and Imager ( SUSI ) operates between 309 nm and 417 nm. A key feature of SUSI is its capability to record up to several hundred spectral lines simultaneously without the harmful effects of the Earth’s atmosphere. The rich SUSI spectra can be exploited in terms of many-line inversions. Another important innovation of the instrument is the synchronized 2D context imaging which allows to numerically correct the spectrograph scans for residual optical aberrations. In this work we describe the main design aspects of SUSI , the instrument characterization and testing, and finally its operation, expected performance and data products.

It will be shown that in the considered paper, a mistake occurred by handling or editing of experimental data for one of two investigated materials, namely, for cubic germanium nitride having spinel structure (γ-Ge 3 N 4 ). This mistake led to incorrect values of the shear modulus G 0 , Young’s modulus E 0 , and Poisson’s ratio ν 0 of this compound. My effort to recover the elastic moduli of γ-Ge 3 N 4 from the available data gave the following results: G 0 = 124 GPa, E 0 = 326 GPa, and ν 0 = 0.32.

It will be shown that in the considered paper, a mistake occurred by handling or editing of experimental data for one of two investigated materials, namely, for cubic germanium nitride having spinel structure (γ-Ge3N4). This mistake led to incorrect values of the shear modulus G0, Young’s modulus E0, and Poisson’s ratio ν0 of this compound. My effort to recover the elastic moduli of γ-Ge3N4 from the available data gave the following results: G0 = 124 GPa, E0 = 326 GPa, and ν0 = 0.32.

The time-domain Brillouin scattering technique, also known as picosecond ultrasonic interferometry, allows monitoring of the propagation of coherent acoustic pulses, having lengths ranging from nanometres to fractions of a micrometre, in samples with dimension of less than a micrometre to tens of micrometres. In this study, we applied this technique to depth-profiling of a polycrystalline aggregate of ice compressed in a diamond anvil cell to megabar pressures. The method allowed examination of the characteristic dimensions of ice texturing in the direction normal to the diamond anvil surfaces with sub-micrometre spatial resolution via time-resolved measurements of the propagation velocity of the acoustic pulses travelling in the compressed sample. The achieved imaging of ice in depth and in one of the lateral directions indicates the feasibility of three-dimensional imaging and quantitative characterisation of the acoustical, optical and acousto-optical properties of transparent polycrystalline aggregates in a diamond anvil cell with tens of nanometres in-depth resolution and a lateral spatial resolution controlled by pump laser pulses focusing, which could approach hundreds of nanometres.

The synthesis of highly biocompatible polymers is important for modern biotechnologies and medicine. Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature without photo- and thermal activation or addition of initiator. The HEMA monomers are first activated during the compression step but their reactivity is hindered by the dense glass-like environment. The rapid polymerization occurs in only the second step upon decompression to the liquid state. The conversion yield was found to exceed 90% in the recovered samples. The gel permeation chromatography evidences the overriding role of HEMA 2 •• biradicals in the polymerization mechanism. The HPR process extends the application field of HP-induced polymerization, beyond the family of crystallized monomers considered up today. It is also an appealing alternative to typical photo- or thermal activation, allowing the efficient synthesis of highly pure organic materials.