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Macrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes. They can be divided into pro‐inflammatory macrophages (M1) and anti‐inflammatory macrophages (M2). Diabetic wounds are characterized by a prolonged inflammatory phase and difficulty in healing due to the accumulation of pro‐inflammatory (M1) macrophages in the wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise in promoting diabetic wound healing in clinical applications. However, the precise conversion of pro‐inflammatory M1 to anti‐inflammatory M2 macrophages by simple and biosafe approaches is still a great challenge. Here, an all‐natural hydrogel with the ability to regulate macrophage heterogeneity is developed to promote angiogenesis and diabetic wound healing. The protocatechuic aldehyde hybridized collagen‐based all‐natural hydrogel exhibits good bioadhesive and antibacterial properties as well as reactive oxygen species scavenging ability. More importantly, the hydrogel is able to convert M1 macrophages into M2 macrophages without the need for any additional ingredients or external intervention. This simple and safe immunomodulatory approach shows great application potential for shortening the inflammatory phase of diabetic wound repair and accelerating wound healing. An all‐natural hydrogel composed of small molecules pro‐catechol and collagen is developed to promote diabetic wound healing by modulating macrophage heterogeneity. The hydrogel exhibits good bioadhesive, antibacterial, and reactive oxygen species scavenging abilities. In vitro and in vivo experiments show that the hydrogel is able to promote the conversion of pro‐inflammatory (M1) macrophages to anti‐inflammatory (M2) macrophages and the expression of anti‐inflammatory factors.

We study how monetary policy in China influences banks’ shadow banking activities. We develop and estimate the endogenously switching monetary policy rule that is based on institutional facts and at the same time tractable in the spirit of Taylor (1993). This development, along with two newly constructed micro banking datasets, enables us to establish the following empirical evidence. Contractionary monetary policy during 2009–2015 caused shadow banking loans to rise rapidly, offsetting the expected decline of traditional bank loans and hampering the effectiveness of monetary policy on total bank credit. We advance a theoretical explanation of our empirical findings.

In this paper, we show that one-dimension systems of quasilinear wave equations with null conditions admit global classical solutions for small initial data. This result extends Luli, Yang and Yu’s seminal work (Luli et al. in Adv Math 329:174–188, 2018) from the semilinear case to the quasilinear case. Furthermore, we also prove that the global solution is asymptotically free in the energy sense. In order to achieve these goals, we will employ Luli, Yang and Yu’s weighted energy estimates with positive weights, introduce some space-time weighted energy estimates and pay some special attentions to the highest order energies, then use some suitable bootstrap process to close the argument.

For the Cauchy problem of nonlinear elastic wave equations of three-dimensional isotropic, homogeneous and hyperelastic materials satisfying the null condition, global existence of classical solutions with small initial data was proved in Agemi (Invent Math 142:225–250, 2000) and Sideris (Ann Math 151:849–874, 2000), independently. In this paper, we will consider the asymptotic behavior of global solutions. We first show that the global solution will scatter, i.e., it will converge to some solution of linear elastic wave equations as time tends to infinity, in the energy sense. We also prove the following rigidity result: if the scattering data vanish, then the global solution will also vanish identically. The variational structure of the system will play a key role in our argument.

This was an original article, mainly explored the effects of the first frozen-thawed embryo transfer (FET) time on pregnancy outcomes after progestin primed ovarian stimulation (PPOS) regimen. Our study implemented a retrospective analysis of 315 infertile patients who underwent in vitro fertilization and embryo transfer (IVF-ET) treatment from January 2021 to June 2023. Patients were divided into three groups based on their first FET time. Group A prepared FET at the first menstrual period after oocyte retrieval; Group B prepared FET at the second menstrual period,; while Group C prepared FET at the third menstrual period. The general information of patients, clinical data of PPOS cycle, clinical data of FET cycle, along with pregnancy outcomes were compared in three groups. The results showed no significant differences in general information of patients, clinical data of PPOS cycle, clinical data of FET cycle and pregnancy outcomes among three groups (P>0.05). The results showed that the choice of the first FET time for whole embryo freezing patients had no significant effect on the outcome of assisted pregnancy. We conclude that the first menstrual cycle after the oocyte retrieval cycle can be considered to select the appropriate FET scheme and performance of the FET. Il s'agissait d'un article original, explorant principalement les effets du premier transfert d'embryons congelés-dégelés (FET) sur l'issue de la grossesse après un régime de stimulation ovarienne amorcée par un progestatif (PPOS). Notre étude a mis en œuvre une analyse rétrospective de 315 patientes infertiles ayant subi un traitement de fécondation in vitro et de transfert d'embryons (FIV-ET) de janvier 2021 à juin 2023. Les patientes ont été divisées en trois groupes en fonction de leur première période de FET. Le groupe A a préparé le FET lors de la première période menstruelle après le prélèvement des ovocytes ; Le groupe B a préparé le FET à la deuxième période menstruelle ; tandis que le groupe C préparait le FET à la troisième période menstruelle. Les informations générales des patients, les données cliniques du cycle PPOS, les données cliniques du cycle FET, ainsi que les issues de grossesse ont été comparées en trois groupes. Les résultats n'ont montré aucune différence significative dans les informations générales des patientes, les données cliniques du cycle PPOS, les données cliniques du cycle FET et les issues de grossesse entre trois groupes (P > 0,05). Les résultats ont montré que le choix du premier moment FET pour les patientes congelées d'embryons entiers n'avait pas d'effet significatif sur l'issue de la grossesse assistée. Nous concluons que le premier cycle menstruel après le cycle de récupération des ovocytes peut être pris en compte pour sélectionner le schéma FET approprié et les performances du FET.

Circularly polarized light (CPL) detection is required in various fields such as drug screening, security surveillance and quantum optics. Conventionally, CPL photodetector needs the installation of optical elements, imposing difficulties for integrated and flexible devices. The established CPL detectors without optical elements rely on chiral organic semiconductor and metal metamaterials, but they suffer from extremely low responsivity. Organic-inorganic hybrid materials combine CPL-sensitive absorption induced by chiral organics and efficient charge transport of inorganic frameworks, providing an option for direct CPL detection. Here we report the CPL detector using chiral organic-inorganic hybrid perovskites, and obtain a device with responsivity of 797 mA W -1 , detectivity of 7.1 × 10 11 Jones, 3-dB frequency of 150 Hz and one-month stability, a competitive combined feature for circularly polarized light detection. Thanks to the solution processing, we further demonstrate flexible devices on polyethylene terephthalate substrate with comparable performance. Optics-free circularly-polarized light detection has suffered from extremely low responsivity. Here Chen et al. demonstrate chiral organic–inorganic hybrid perovskite based detectors to distinguish circularly-polarized light with high responsivity of 797 mA/W.

DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates a complex post-translational network termed DNA damage response (DDR). Our review focuses on three PI3-kinase related protein kinases—ATM, ATR and DNA-PKcs, which situate at the apex of the mammalian DDR. They are recruited to and activated at the DNA damage sites by their respective sensor protein complexes—MRE11/RAD50/NBS1 for ATM, RPA/ATRIP for ATR and KU70–KU80/86 (XRCC6/XRCC5) for DNA-PKcs. Upon activation, ATM, ATR and DNA-PKcs phosphorylate a large number of partially overlapping substrates to promote efficient and accurate DNA repair and to coordinate DNA repair with other DNA metabolic events ( e.g. , transcription, replication and mitosis). At the organism level, robust DDR is critical for normal development, aging, stem cell maintenance and regeneration, and physiological genomic rearrangements in lymphocytes and germ cells. In addition to endogenous damage, oncogene-induced replication stresses and genotoxic chemotherapies also activate DDR. On one hand, DDR factors suppress genomic instability to prevent malignant transformation. On the other hand, targeting DDR enhances the therapeutic effects of anti-cancer chemotherapy, which led to the development of specific kinase inhibitors for ATM, ATR and DNA-PKcs. Using mouse models expressing kinase dead ATM, ATR and DNA-PKcs, an unexpected structural function of these kinases was revealed, where the expression of catalytically inactive kinases causes more genomic instability than the loss of the proteins themselves. The spectrum of genomic instabilities and physiological consequences are unique for each kinase and depends on their activating complexes, suggesting a model in which the catalysis is coupled with DNA/chromatin release and catalytic inhibition leads to the persistence of the kinases at the DNA lesion, which in turn affects repair pathway choice and outcomes. Here we discuss the experimental evidences supporting this mode of action and their implications in the design and use of specific kinase inhibitors for ATM, ATR and DNA-PKcs for cancer therapy.