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In antiquity, civilizations employed stone carvings and knotted quipu cords for information preservation. Modern telecommunications rely on optical fibers - silica glass strands engineered for light transmission - yet their capacity as archival media remains untapped. This study explores a novel fiber Bragg grating (FBG) configuration exhibiting thermally programmable memory effects for optical data storage. Capitalizing on temperature-dependent spectral characteristics, we demonstrate finite spectral tuning through controlled thermal annealing, achieving irreversible spectral modifications via a light-induced stress mechanism analogous to the Kovacs memory effect in glassy materials. The engineered dual-dip FBG architecture enables multiplexed wavelength encoding, functioning simultaneously as a thermal history recorder and laser-writable data medium - mirroring the information knots of ancient quipu devices. This optical quipu concept pioneers one-dimensional photonic memory technology, opening new avenues for optical fiber applications in the information age. This work introduces a dual-dip fiber Bragg grating (FBG) with thermally programmable memory. Leveraging light-induced stress and thermal annealing, it enables irreversible spectral tuning—mimicking the Kovacs effect. The FBG serves as a laser-writable, multiplexed optical data storage medium and thermal history recorder.

Genomic analysis of 5,303 Chinese women with recurrent major depressive disorder (MDD) enables the identification and replication of two genome-wide significant loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene; the other in an intron of the LHPP gene. Genetic risk factors for depression This genomic analysis of more than 5,000 Chinese women with recurrent major depressive disorder (MDD) has identified and replicated two genome-wide significant loci contributing to risk of MDD on chromosome 10. One is near the sirtuin1 ( SIRT1 ) gene, and the other is in an intron of the phospholysine phosphohistidine inorganic pyrophosphate phosphatase ( LHPP ) gene. The authors suggest that the association close to SIRT1 may implicate abnormalities in mitochondria as risk factors for the disease. Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide 1 , poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified 2 , despite analysis of more than 9,000 cases 3 . Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene ( P  = 2.53 × 10 −10 ), the other in an intron of the LHPP gene ( P = 6.45 × 10 −12 ). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness.

Objective To elucidate the potential targets and mechanisms of Brucea javanica in the treatment of oral squamous cell carcinoma (OSCC) through network pharmacology and molecular docking, supported by clinical data and in vitro experiments. Methods Potential targets of Brucea javanica and OSCC-related disease targets were identified via the TCMSP, GeneCards, and OMIM databases. A Venn diagram was employed to obtain the intersection targets, which were considered as the potential targets for Brucea javanica in OSCC treatment. The protein–protein interaction (PPI) network was constructed using the STRING database and Cytoscape 3.7.2 to identify core targets. Gene ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the intersection targets were conducted using the Metascape database. Molecular docking between the main components of Brucea javanica and core targets was performed using AutoDockTools software. The expression of core targets in clinical samples was analyzed via the GEO database. Finally, the effects of Brucea javanica oil (BJO) on OSCC proliferation, invasion, and migration, as well as the expression of the EGFR/PI3K/AKT signaling pathway, were verified in vitro. Results A total of 60 potential targets of Brucea javanica against OSCC were identified, with β-sitosterol and luteolin selected as the primary active components. The five targets with the highest connectivity, AKT1, CASP3, PTGS2, TP53, and EGFR, were identified as core targets. KEGG pathway analysis indicated that the anti-OSCC effects of Brucea javanica are primarily mediated through the PI3K-AKT signaling pathway, JAK-STAT signaling pathway, etc. Molecular docking studies demonstrated strong binding affinities between the main components of Brucea javanica and its core targets. Analysis of clinical samples revealed elevated expression levels of core targets in OSCC samples compared to normal samples. The CCK-8 assay and colony formation assay indicated that BJO effectively inhibited OSCC cell proliferation. The scratch test and Transwell test showed that BJO could inhibit the invasion and migration of oral squamous cell carcinoma. In addition, Western blot and RT-qPCR showed that BJO could down-regulate the expression of EGFR/PI3K/AKT signaling pathway-related proteins and mRNA. Conclusion Brucea javanica exhibits multi-target and multi-pathway characteristics in the treatment of oral squamous cell carcinoma, potentially exerting its anti-cancer effects by inhibiting the EGFR/PI3K/AKT signaling pathway.