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We study a quantum absorption refrigerator, in which a target qubit is cooled by two machine qubits in a nonequilibrium steady-state. It is realized by a strong internal coupling in the two-qubit fridge and a vanishing tripartite interaction among the whole system. The coherence of a machine virtual qubit is investigated as quantumness of the fridge. A necessary condition for cooling shows that the quantum coherence is beneficial to the nonequilibrium fridge, while it is detrimental as far as the maximum coefficient of performance (COP) and the COP at maximum power are concerned. Here, the COP is defined only in terms of heat currents caused by the tripartite interaction, with the one maintaining the two-qubit nonequilibrium state being excluded. The later can be considered to have no direct involvement in extracting heat from the target, as it is not affected by the tripartite interaction.

Classical mixtures of quantum states often give rise to decoherence and are generally considered detrimental to quantum processing. However, in the framework of sequential measurement, such mixtures can be beneficial for state discrimination. We investigate the sequential discrimination of mixed states and compare the results with those of pure states under the condition of equal fidelity. It is found that the successful probability of the mixed-state protocol is superior to the pure one under the equal-fidelity condition. It is shown that the difference between the sequential discrimination of pure and mixed states is more reliable under the equal-fidelity condition than under single-shot discrimination, and this difference increases with the mixability of the initial mixed states. For scenarios in which classical communication is allowed, the optimal successful probability of pure-state discriminations is larger than that for mixed states on the contrary. We also show that the classical mixture of basic vectors from quantum decoherence has a subtle impact on the communication channel induced by the coincidence of the maximal mutual information and optimal successful probability of sequential discrimination for pure states.

Radioresistance remains a major problem in nasopharyngeal carcinoma (NPC) treatment. However, the underlying molecular mechanisms of NPC radioresistance remain poorly understood. The present study aimed to investigate the potential role and mechanism of miR-206 in NPC radioresistance. We observed that miR-206 was down-regulated in radioresistant NPC cells. Furthermore, restoration of miR-206 in CNE2-IR cells suppressed enhanced radiosensitivity of NPC cells. In contrast, inhibition of miR-206 in CNE2 cells reduced the radiosensitivity. We also found that miR-206 directly targeted IGF1 and inhibited the PI3K/AKT pathway. Our data demonstrate that miR-206 sensitizes NPC cell to irradiation by targeting IGF1, highlighting the therapeutic potential of miR-206 in NPC radiosensitization.

We investigate the discrimination of pure-mixed (quantum filtering) and mixed-mixed states and compare their optimal success probability with the one for discriminating other pairs of pure states superposed by the vectors included in the mixed states. We prove that under the equal-fidelity condition, the pure-pure state discrimination scheme is superior to the pure-mixed (mixed-mixed) one. With respect to quantum filtering, the coherence exists only in one pure state and is detrimental to the state discrimination for lower dimensional systems; while it is the opposite for the mixed-mixed case with symmetrically distributed coherence. Making an extension to infinite-dimensional systems, we find that the coherence which is detrimental to state discrimination may become helpful and vice versa.

A fundamental problem in quantum information is to explore what kind of quantum correlations is responsible for successful completion of a quantum information procedure. Here we study the roles of entanglement, discord and dissonance needed for optimal quantum state discrimination when the latter is assisted with an auxiliary system. In such process, we present a more general joint unitary transformation than the existing results. The quantum entanglement between a principal qubit and an ancilla is found to be completely unnecessary, as it can be set to zero in the arbitrary case by adjusting the parameters in the general unitary without affecting the success probability. This result also shows that it is quantum dissonance that plays as a key role in assisted optimal state discrimination and not quantum entanglement. A necessary criterion for the necessity of quantum dissonance based on the linear entropy is also presented. PACS numbers: 03.65.Ta, 03.67.Mn, 42.50.Dv.

Quantum information masking (QIM) allows encoding quantum information in multipartite systems. Complete QIM is of great significance in quantum foundation and application. However, the realization of complete QIM, even for single-qubit encoded information, is still lacking. Here, we propose to demonstrate complete QIM with 4-qubit entangled states. The proposed QIM can be readily extended to multipartite systems with arbitrary number of subsystems, enabling quantum secret sharing (QSS) and quantum teleportation between multiplayers. In experiment, we build up a 4-qubit hyperentangled state to implement complete QIM. The trace distance of 16 encoded single-qubit states falls within the range of 0.12 ± 0.02 to 0.03 ± 0.02. Furthermore, we implement QSS between six players by expanding the 4-qubit state to a 6-qubit state entangled in hybrid manner, in which we observe an average fidelity 0.85 ± 0.03 of the recovered states. Our results open the door towards QIM-enabled quantum information processing and provide applications in quantum communications. Quantum information masking allows encoding quantum information in multipartite systems, which is hidden from subsystems and can be recovered from the nonlocal correlation. The authors propose and realize the complete quantum information masking and apply it to quantum secret sharing between six players.

In this paper, we construct toy models of the black hole and the white hole by setting proper boundaries in the Minkowski spacetime, according to the modern definition. We calculate the thermal effect of the black hole with the tunneling mechanism. We consider the role of boundary conditions at the singularity and on the horizon. In addition, we show that the white hole possesses a thermal absorption.

The temperature field distribution and thermal history of Fe-9Cr2WVTa reduced activation steel prepared by laser melting deposition (LMD) have been calculated with Gaussian and Ring laser beams, and the nucleation and growth behaviors of M 23 C 6 precipitates in the 1st, 7th and 19th layers have been calculated using the modified classical nucleation theory and Svoboda Fischer Fratzl Kozeschnik model. The energy distribution shows W-shape with Ring laser beam while it shows V-shape with Gaussian laser beam, which results in the more uniform M 23 C 6 size in the same layer with Ring laser beam. Precipitates in the bottom (i.e., the 1st layer) have the minimum size and the size increases with the layer number with Gaussian and Ring laser beams. The temperature history, the instantaneous nucleation rate and the size evolution of M 23 C 6 have been systematically discussed. The results indicate that the nucleation, growth and re-dissolution of precipitates in reduced activation steel depend on the amount of energy absorbed in the thermal cycle during LMD. The continuous accumulation of energy during the thermal cycle leads to larger M 23 C 6 at the top area. The unsteady state precipitation dynamics of M 23 C 6 carbides during thermal cycling are consistent with the simulation results.

Familial hypercholesterolemia (FH) is a common monogenic autosomal dominant disorder, primarily mainly caused by pathogenic mutations in the low-density lipoprotein receptor (LDLR) gene. Through phenotypic-genetic linkage analysis, two LDLR pathogenic mutations were identified in FH families: c.G1027A (p.Gly343Ser) and c.G1879A (p.Ala627Thr). Whole exome sequencing was conducted on the proband with familial hypercholesterolemia to identify the target gene and screen for potential pathogenic mutations. The suspicious responsible mutation sites in 14 family members were analyzed using Sanger sequencing to assess genotype-phenotype correlations. Mutant and wild type plasmids were constructed and transfected into HEK293T cells to evaluate LDLR mRNA and protein expression. In parallel, bioinformatics tools were employed to predict structural and functional changes in the mutant LDLR. Immunofluorescence analysis revealed no significant difference in the intracellular localization of the p.Gly343Ser mutation, whereas protein expression of the p.Ala627Thr mutation was decreased and predominantly localized in the cytoplasm. Western blotting has showed that protein expression levels of the mutant variants were markedly declined in both cell lysates and supernatants. Enzyme linked immunosorbent assay has demonstrated that LDLR protein levels in the supernatant of cell culture medium was not significant different from those of the wild-type group. However, LDLR protein levels in the cell lysate of both the Gly343Ser and Ala627Thr variants groups were significantly lower than those in the wild-type group. Bioinformatic predictions further suggested that these mutations may affect post-translational modifications of the protein, providing additional insight into the mechanisms underlying the observed reduction in protein expression. In this study, we identified two heterozygous pathogenic variants in the LDLR gene, c.G1027A (p.Gly343Ser) and c.G1879A (p.Ala627Thr), in a family with familial hypercholesterolemia. We also conducted preliminary investigations into the mechanisms by which these mutations contribute to disease pathology.

A series of new cyclometalated btp-based iridium(III) complexes with three different ancillary ligands, Ir(btp)2(bozp) (3a), Ir(btp)2(btzp) (3b) and Ir(btp)2(izp) (3c) (btp = 2-(benzo[b]thiophen-2-yl)pyridine, bozp =2-(benzo[d]oxazol-2-yl)phenol, btzp =2-(benzo[d]thiazol-2-yl)phenol, izp = 2-(2 H-indazol-2-yl)phenol), have been synthesized and fully characterized. The crystal structure of 3b has been determined by single crystal X-ray diffraction analysis. A comparative study has been carried out for complexes 3a − 3c by UV-vis absorption spectroscopy, photoluminescence spectroscopy, cyclic voltammetry and DFT calculations. This observation illustrates that the substitution of N or S in ancillary ligand can lead to a marked bathochromic shift of absorption and emission wavelengths. The spectroscopic characterisation of these complexes has been complemented by DFT and TD-DFT calculations, supporting the assignment of 3MLCT/3LC to the lowest energy excited state.