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With the development of industrial intelligence, traditional material handling systems suffer from insufficient flexibility, low functional integration, and weak fire safety response. To solve these problems, this paper designs an Arduino-based multifunctional intelligent material handling crane system with integrated fire safety protection. The system adopts a modular multi-sensor fusion architecture, realizing environmental perception, automatic path planning, and dual fire safety protection (smoke alarm + automatic fire extinguishing). Experiments were carried out in a laboratory-controlled environment with the system in as the benchmark; the results show that the operation efficiency of object handling is improved by 29.6%. This prototype system provides an experimental reference for the intelligent and safe upgrading of small and medium-sized warehousing material handling equipment. All experiments were completed in a controlled laboratory environment.

Although the appropriateness of hospital utilization of adults and the elderly in China was audited by several studies, the appropriateness of hospital use by children in Shanghai remains to be determined. This study aims to assess the level of inappropriate hospital admissions and hospital days, to detect factors associated with inappropriateness, and to elucidate reasons for inappropriateness. A retrospective review of the records of 291 admissions and 1449 hospital days of children inpatients from a secondary hospital in Shanghai was performed by two reviewers using the Chinese version Pediatric Appropriateness Evaluation Protocol (C-PAEP). Demographics, socio-economic characteristics, and other admission- or hospital stay-related information were collected and analyzed to determine factors associated with inappropriateness utilizing multivariate regression models. 38.5% (n = 112) of admissions and 9.5% (n = 137) of hospital days were categorized as inappropriate, according to the C-PAEP. Children who were non-Shanghai residents (p < 0.001), admitted through the emergency sector (p = 0.030), and/or received services in a surgical ward (p < 0.001) had a higher risk of being admitted inappropriately. Payment method (p = 0.006), service type (p < 0.001), comorbidity (p = 0.016), length of stay (p = 0.007), and appropriateness of admission (p < 0.001) were found to be associated with prevalence of inappropriate hospital days. Approximately three-fourths of the inappropriate admissions were premature admissions (75.9%, n = 85). The most frequent reasons for inappropriate hospital days were awaiting test results (34.3%, n = 47), awaiting surgery (19.7%, n = 27), awaiting test execution (10.9%, n = 15), and family unprepared for home care (10.9%, n = 15). Although the extent of inappropriate hospital days was moderate compared with that found by previous investigations, the prevalence of inappropriateness of admission was considerable. To enhance the appropriateness of hospital care for children, interventions could be implemented according to the associated factors and identified causes.

This study analyzes the transient axial force of a centrifugal pump under variable operating conditions using wavelet analysis and a novel technique called windowed multi-resolution dynamic mode decomposition (wmrDMD). Numerically simulating the sampled time series allows the reconstruction of the impeller’s axial force information, providing validation for this innovative data-driven analysis technique. The comparison between the reconstructed results and the original axial force data demonstrates a remarkable agreement, as all data points exhibit error values below 2.49%. The wmrDMD technique systematically decomposes the impeller’s axial force field into dynamically significant modes across various time scales. Removing the mean flow field in this study resolves the transient motion of the impeller’s axial force, facilitating the identification of positions with high-frequency axial force oscillations and fluctuations in intensity amplitude. The high-frequency axial force of the impeller exhibits stable periodic variations within the operating range of 1.0nr-1.0Qr, whereas the changes are insignificant within the range of 0.4nr-0.4Qr. However, within the operating range of 1.0nr-0.4Qr, both the position and intensity amplitude of the axial force exhibit significant variations without a stable trend. Furthermore, cross-wavelet and wavelet coherence analyses reveal that within the operating range of 0.4nr-0.4Qr, the axial forces on the front and rear cover plates show the strongest correlation at the periodic scale. Within the operating range of 1.0nr-1.0Qr, the next highest correlation is observed, whereas the correlation is lowest within the 1.0nr-0.4Qr operating range.

To reveal the dynamic evolution mechanism of hydraulic fracturing in hydraulic tunnels under different confining pressures and overcome the limitations of traditional tests and numerical methods in simulating complex crack propagation and multi-field coupling problems, a meshless numerical simulation framework suitable for hydraulic fracturing in hydraulic tunnels is constructed using the Smoothed Particle Hydrodynamics (SPH) method. Through the definition of the contact force transmission mechanism between matrix particles and water particles as well as the particle failure criterion, the dynamic tracking of the entire process of crack initiation, propagation, and penetration is realized. Multiple schemes with confining pressure ratios λ ( σ x / σ y ) of 0.2, 0.4, 0.6, and 0.8 are set up to systematically investigate the influence of confining pressure ratio on the hydraulic fracturing process. The research results show that the SPH method can effectively reproduce the evolution of complex crack networks in hydraulic fracturing and overcome the defects of traditional grid methods in dealing with discontinuity problems. The confining pressure ratio is a key parameter regulating the crack morphology. With the increase of λ , the crack network gradually transforms from a dendritic shape ( λ  = 0.2) to a m-shaped pattern ( λ  = 0.4) and a snowflake-like structure ( λ  = 0.6, 0.8). The increase in the proportion of horizontal stress significantly promotes the lateral propagation of secondary cracks. A common mechanism of “corner stress concentration dominating crack initiation” exists under different confining pressure ratios. Moreover, with the simultaneous increase of σ x and σ y , the degree of stress concentration decreases, and the crack propagation rate slows down. This study provides theoretical support and quantitative tools for the analysis of water-mechanics coupling disaster-causing mechanisms and engineering disaster prevention and control in hydraulic tunnels.

Alpine grasslands and alpine deserts represent two major ecosystems on the Tibetan Plateau. However, whether the two ecosystems differ in soil microbial community diversity and co-occurrence network structure remains poorly understood. This study assessed the composition and diversity of soil bacterial communities across alpine grasslands and alpine deserts on the Tibetan Plateau via 16S high-throughput sequencing, analysis of variance (ANOVA), mantel test, and other methods. Our results revealed that soil alkaline-hydrolyzable nitrogen (SAN), soil total nitrogen (STN), soil total phosphorus (STP), soil available phosphorus (SAP), and soil organic carbon (SOC) were significantly higher in grassland than in desert (p < 0.05). The microbial community composition and diversity differed significantly between alpine grasslands and alpine deserts. Analysis of microbial co-occurrence networks revealed that grassland systems possessed significantly more nodes, edges, and a higher average degree than desert systems, along with greater network robustness—indicating a more complex and stable microbial community structure. Correlation analysis further revealed that SOC and STN were positively correlated with microbial diversity, while electrical conductivity (EC), SOC, STN, and SAN showed positive associations with microbial community composition. In conclusion, alpine grasslands harbor greater soil microbial diversity and more stable microbial co-occurrence networks than alpine deserts, suggesting that alpine grasslands may hold greater ecological value than alpine deserts in maintaining soil biodiversity and ecosystem functioning. This study not only elucidates the distribution patterns and diversity of soil microbial communities across Tibetan grasslands, but also offers critical insights into the mechanisms governing ecosystem functioning, thereby informing ecological conservation and sustainable management strategies on the plateau.

Background Fish scales are typical products of biomineralization and play an important role in the adaptation of fish to their environment. The Gymnocypris przewalskii scales are highly specialized, with scales embedded in only specific parts of the dermis, such as the areas around the anal fin and branchiostegite, making G. przewalskii an ideal material for biomineralization research. In this study, we aimed to unveil genes and pathways controlling scale formation through an integrated analysis of both transcriptome and proteome, of which G. przewalskii tissues of the dorsal skin (no scales) and the rump side skin (with scales) were sequenced. The sequencing results were further combined with cellular experiments to clarify the relationship between genes and signaling pathways. Results The results indicated the following: (1) a total of 4,904 differentially expressed genes were screened out, including 3,294 upregulated genes and 1,610 downregulated genes (with a filtering threshold of |log2Fold-Change|> 1 and p -adjust < 0.05). The identified differentially expressed genes contained family members such as FGF , EDAR , Wnt10 , and bmp . (2) A total of 535 differentially expressed proteins (DEPs) were filtered out from the proteome, with 204 DEPs downregulated and 331 DEPs upregulated (with a filtering threshold of |Fold-Change|> 1.5 and p  < 0.05). (3) Integrated analyses of transcriptome and proteome revealed that emefp1 , col1a1 , col6a2 , col16a1 , krt8 , and krt18 were important genes contributing to scale development and that PI3K-AKT was the most important signaling pathway involved. (4) With the use of the constructed G. przewalskii fibroblast cell line, emefp1 , col1a1 , col6a2 , col16a1 , krt8 , and krt18 were confirmed to be positively regulated by the PI3K-AKT signaling pathway. Conclusion This study provides experimental evidence for PI3K-AKT controlled scale development in G. przewalskii and would benefit further study on stress adaptation, scale biomineralization, and the development of skin appendages.

Developing multifunctional flexible composites with high-performance electromagnetic interference (EMI) shielding, thermal management, and sensing capacity is urgently required but challenging for next-generation smart electronic devices. Herein, novel nacre-like aramid nanofibers (ANFs)-based composite films with an anisotropic layered microstructure were prepared via vacuum-assisted filtration and hot-pressing. The formed 3D conductive skeleton enabled fast electron and phonon transport pathways in the composite films. As a result, the composite films showed a high electrical conductivity of 71.53 S/cm and an outstanding thermal conductivity of 6.4 W/m·K when the mass ratio of ANFs to MXene/AgNWs was 10:8. The excellent electrical properties and multi-layered structure endowed the composite films with superior EMI shielding performance and remarkable Joule heating performance, with a surface temperature of 78.3 °C at a voltage of 2.5 V. Additionally, it was found that the composite films also exhibited excellent mechanical properties and outstanding flame resistance. Moreover, the composite films could be further designed as strain sensors, which show great promise in monitoring real-time signals for human motion. These satisfactory results may open up a new opportunity for EMI shielding, thermal management, and sensing applications in wearable electronic devices.

Polypropylene fibers (PPFs), characterized by their low density, cost-effectiveness, and superior corrosion resistance, can be effectively incorporated into concrete to enhance the impact resistance of wall panels. This study introduces an innovative composite wall panel utilizing polypropylene fiber-reinforced concrete (PFRC) as the core material. Initially, an experimental investigation into the mechanical properties of PFRC was conducted, and based on these results, a constitutive model for PFRC was established. Subsequently, the impact-induced mechanical behavior of the innovative composite wall panel was investigated through finite element simulations employing ABAQUS, version 2020, software. The findings indicate that polypropylene fibers significantly improve both the compressive strength and ductility of concrete, with an optimal coarse fiber content of 1%. The inclusion of glass fiber grids and polypropylene fibers reduced the number of cracks and the overall deformation of the composite wall panel. The integration of glass fiber grids coupled with fiber reinforcement resulted in 7.2% and 27.8% enhancements in impact resistance, respectively. Parametric studies demonstrated that greater concrete panel thickness effectively diminishes post-impact peak and residual displacements in composite wall systems. Furthermore, the impact resistance was found to be weaker at the panel edges and stronger at a quarter of the panel height.

Global warming and rapid urban industrialization are profoundly transforming land-use patterns and carbon storage capacity in terrestrial ecosystems. A rigorous analysis of spatiotemporal variations in regional land-use changes and carbon storage dynamics provides critical insights for sustainable land-use planning and ecological security, particularly within the context of achieving carbon peaking and carbon neutrality targets. In this study, the PLUS-InVEST model was coupled with climate change and policy constraints to construct six future scenarios. We analyzed the characteristics of land-use evolution and the spatial and temporal changes in carbon storage in the Sanjiangyuan region from 2000 to 2020. We also predicted the potential impacts of land-use shift on carbon storage. The results show the following: (1) Land-use transitions exerted significant impacts on carbon stock. The Sanjiangyuan region experienced a net carbon stock reduction of 9.9 × 106 t during 2000–2020, with the most pronounced decline (6.1 × 106 t) occurring between 2000 and 2010. (2) Under the same climate scenario, the natural development (ND) scenario exhibited decreasing carbon reserves relative to 2020 baseline levels. Notably, land-use planning scenarios demonstrated spatially heterogeneous impacts, with the ecological protection (EP) scenario consistently maintaining higher carbon stocks compared to the ND scenario. (3) Multivariate driver interactions exerted stronger control over spatial carbon storage patterns than any individual factor. These findings inform targeted land-use management strategies to enhance regional carbon sequestration capacity, promote sustainable development, and support China’s carbon peaking and neutrality objectives.

Accurate quantification of creatinine (Cre) is important to estimate glomerular filtration rate (GFR). Differences among various methods of Cre quantification were previously noted. This study aims to develop a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for serum Cre and compare this method with clinical routine methods. LC-MS/MS analysis was performed on API 4000 triple quadrupole mass spectrometer coupled with an Agilent 1200 liquid chromatography system. After adding isotope-labeled Cre-d3 as internal standard, serum samples were prepared via a one-step protein precipitation with methanol. The LC-MS/MS method was compared with frequently used enzymatic method and Jaffe method. This developed method, with a total run time of 3 min, had a lower limit of quantification of 4.4 μmol/L, a total imprecision of 1.15%-3.84%, and an average bias of 1.06%. No significant matrix effect, carryover, and interference were observed for the LC-MS/MS method. The reference intervals of serum Cre measured by LC-MS/MS assay were 41-79 μmol/L for adult women, and 46-101 μmol/L for adult men. Using LC-MS/MS as a reference, the enzymatic method showed an average bias of -2.1% and the Jaffe method showed a substantial average bias of 11.7%. Compared with the LC-MS/MS method, significant negative bias was observed for the enzymatic and Jaffe methods in hemolytic and lipimic samples. We developed a simple, specific, and accurate LC-MS/MS method to analyze serum Cre. Discordance existed among different methods.