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Varicocele (VC) is present in 35 - 40% of men with infertility. However, current surgical and antioxidant treatments are not completely effective. In addition to oxidative stress, it is likely that other factors such as testicular immune microenvironment disorder contribute to irreversible testicular. Evidence suggests that VC is associated with anti-sperm antibodies (ASAs), spermatogenesis and testosterone secretion abnormalities, and testicular cytokine production. Moreover, inhibition of inflammation can alleviate VC-mediated pathogenesis. The normal function of the testis depends on its immune tolerance mechanism. Testicular immune regulation is complex, and many infectious or non-infectious diseases may damage this precision system. The testicular immune microenvironment is composed of common immune cells and other cells involved in testicular immunity. The former includes testicular macrophages, T cells, dendritic cells (DCs), and mast cells, whereas the latter include Leydig cells and Sertoli cells (SCs). In animal models and in patients with VC, most studies have revealed an abnormal increase in the levels of ASAs and pro-inflammatory cytokines such as interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha in the seminal plasma, testicular tissue, and even peripheral blood. It is also involved in the activation of potential inflammatory pathways, such as the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing (NLRP)-3 pathway. Finally, the development of VC-mediated infertility (VMI) may be facilitated by abnormal permeability of proteins, such as claudin-11, that constitute the blood-testis barrier (BTB). The testicular immune response, including the production of ASAs and inflammatory factors, activation of inflammatory pathways, and destruction of the BTB may be involved in the pathogenesis of VMI it is necessary to further explore how patient outcomes can be improved through immunotherapy.

Child maltreatment as a significant risk factor for suicide behavior is one of major challenges faced by the child welfare system in China. However, few studies have focused on child maltreatment of rural Chinese children. Furthermore, research has not examined the protective factors between the linkage of child maltreatment and suicide ideation. This study aimed to fill the research gap by investigating the mediating role of self-compassion and the moderating role of school belonging in the association between child maltreatment and suicidal ideation. We used convenience sampling strategy to collect data from four schools and 31 classes in rural area in Hunan, China in 2018. Participants included 1167 students in grades seven through nine. SPSS macro PROCESS was used to examine the mediating effect of self-compassion and moderating effect of school belonging in the association between child maltreatment and suicide ideation. The findings indicated that rural children reported a higher level of child maltreatment history than their urban counterparts. Emotional abuse, emotional and physical neglect were all positively associated with suicide ideation through decreased self-compassion. In addition, school belonging could moderate the direct relations between emotional abuse and suicide ideation. The findings suggested that it is of great importance to include self-compassion and school belonging into mental health intervention programs for rural adolescents with child maltreatment experiences. Programs that teach students self-compassion and resources that help adolescents develop a sense of school belonging and inclusion should be provided in schools in rural China.

The Tian Shan has been deformed during the Cenozoic as a far-field response to the India-Eurasia collision. This contribution reports new apatite fission-track (AFT) and apatite (U-Th)/He data from the northern Tian Shan, including areas along the southern margin of the Junggar Basin and adjacent to the western segment of the Bolokenu-Aqikekuduk Fault (BAF). Thermal history modeling of the presented data suggests that the Cenozoic exhumation along the basin margin started >20 Ma, and the oblique-slip BAF could have been active since at least ∼10 Ma with a total exhumation magnitude of ∼2 km during the late Cenozoic. Since then, the mean exhumation rate on southern wall of the BAF is comparable to the Quaternary uplift rate previously measured on the same segment of the fault. To examine the extent of the Miocene acceleration of the transpressional deformation pattern, an exhumation model since 50 Ma was established by inverse modeling >1000 published and new AFT and (U-Th)/He ages from the Tian Shan and the northeastern Tibetan Plateau. The model suggests that after the initial unroofing, a significant acceleration in exhumation occurred during 15-10 Ma, in regions including the interiors of northern and southwestern Tian Shan near major strike-slip structures. This change coincided with the northward propagation of the Pamir and the eastward expansion of the northeastern Tibetan Plateau along the west and south margins of the Tarim Basin, respectively.

The appearance of detritus shed from mountain ranges along the northern margin of the Tibetan Plateau heralds the Cenozoic development of high topography. Current estimates of the age of the basal conglomerate in the Qaidam basin place this event in Paleocene-Eocene. Here we present new magnetostratigraphy and mammalian biostratigraphy that refine the onset of basin fill to ∼25.5 Myr and reveal that sediment accumulated continuously until ∼4.8 Myr. Sediment provenance implies a sustained source in the East Kunlun Shan throughout this time period. However, the appearance of detritus from the Qilian Shan at ∼12 Myr suggests emergence of topography north of the Qaidam occurred during the late Miocene. Our results imply that deformation and mountain building significantly post-date Indo-Asian collision and challenge the suggestion that the extent of the plateau has remained constant through time. Rather, our results require expansion of high topography during the past 25 Myr. The timing of mountain building along the Tibetan Plateau remains unclear. Here, the authors present new magnetostratigraphic and mammalian biostratigraphic data from sediments to show that mountain building at the edge of the Tibetan Plateau commenced at 25.5 Ma with a separate emergence in the north at 12 Ma.

Background Metabolic syndrome (MS) comprises a set of conditions that are risk factors for cardiovascular diseases and diabetes. Numerous epidemiological studies on MS have been conducted, but there has not been a systematic analysis of the prevalence of MS in the Chinese population. Therefore, the aim of this study was to estimate the pooled prevalence of MS among subjects in Mainland China. Methods We performed a systematic review by searching both English and Chinese literature databases. Random or fixed effects models were used to summarize the prevalence of MS according to statistical tests for heterogeneity. Subgroup, sensitivity, and meta-regression analyses were performed to address heterogeneity. Publication bias was evaluated using Egger’s test. Results Thirty-five papers were included in the meta-analysis, with a total population of 226,653 Chinese subjects. Among subjects aged 15 years and older, the pooled prevalence was 24.5 % (95 % CI: 22.0–26.9 %). By sex, the prevalences were 19.2 % (95 % CI: 16.9–21.6 %) in males and 27.0 % (95 % CI: 23.5–30.5 %) in females. The pooled prevalence of MS increased with age (15–39 years: 13.9 %; 40–59 years: 26.4 %; and ≥60 years: 32.4 %). Individuals living in urban areas (24.9 %, 95 % CI: 18.5–31.3 %) were more likely to suffer from MS than those living in rural areas (19.2 %, 95 % CI: 14.8–23.7 %). Hypertension was the most prevalent component of MS in males (52.8 %), while the most prevalent component of MS for females was central obesity (46.1 %). Conclusions Our systematic review suggested a high prevalence of MS among subjects in Mainland China, indicating that MS is a serious public health problem. Therefore, more attention should be paid to the prevention and control of MS.

Objective Thise study is aimed to identify the biomarkers for predicting refractory Mycoplasma pneumoniae pneumonia in Chinese children at the time of the hospital admission. Methods The case control study retrospectively analyzed the clinical characteristics and laboratory results of Chinese pediatric patients presenting with common and refractory Mycoplasma pneumoniae pneumonia (CMPP and RMPP). Overall, there were 216 cases in the CMPP group and 88 cases in the RMPP group. Venous blood was collected, and serum ferritin (SF), lactate dehydrogenase (LDH), D-dimer, C-reactive protein (CRP), procalcitonin (PCT), neutrophil count/lymphocyte count (NLR), and other indexes were measured. A single factor analysis, an ROC curve analysis, and a logistic regression analysis were used to determine the independent risk factors of RMPP and find combination of initial markers for RMPP. Results There were significant differences between the RMPP group and the CMPP group in mean SF (529.82 [357.86] vs. 147.22 [122.68] ng/mL), LDH (522.08 [389.08] vs. 286.85 [101.02] U/L), D-dimer (6.65 [5.66] vs. 1.46 [2.45] μg/mL), CRP (62.80 [52.15] vs. 19.03 [24.50] mg/L), PCT (0.80 [2.61] vs. 0.16 [0.44]) ng/mL, and NLR (4.14 [2.52] vs. 2.62 [1.55]), with P  < 0.05 for each comparison. ROC cut-off values of the above indexes were 329.01 ng/mL, 375.50 U/L, 2.10 μg/mL, 43.08 mg/L, 0.08 ng/mL, and 2.96, respectively. The logistic regression analysis showed that SF, D-dimer, and CRP are independent risk factors to predict RMPP. Conclusion SF, D-dimer, and CRP are statistically significant biomarkers to predict RMPP in Chinese children patients in the settings of pediatric emergency department.

The uplift and deformation styles of the Tibetan Plateau have been long debated on stepwise growth and crustal channel flow. Here, we offer new insight into this issue by constraining the pulsed exhumation history of the Yalong thrust belt in eastern Tibet, using apatite and zircon (U–Th)/He data from three ∼1 km vertical transects. The results revealed two rapid cooling pulses in the Late Oligocene (∼24 Ma, 50°C/m.y.) and the Middle Miocene (17–14 Ma, 35 °C/m.y.), respectively, which we ascribe to the staged‐thrusting faulting of this belt. These thrust faulting events indicated upward and eastward growth of the Tibetan Plateau, further suggested that the high topographic relief across the Yalong thrust belt mainly formed (at least) since the Late Oligocene. The available documents from paleoaltimetry, basin sediment accumulation, and thermochronometers and our new results reveal a regional‐scale stepwise propagation pattern of tectonic deformation during the Middle–Late Cenozoic in eastern Tibet. Plain Language Summary The role of faulting in crust thickening has been one of the main controversies in the formation and evolution of the Tibetan Plateau. The Yalong thrust belt in eastern Tibet is a major Cenozoic structure with a 1.8–2.4 km topographic step, and its deformation processes are closely associated with the Cenozoic eastward plateau growth. In this study, we report 79 apatite and 78 zircon (U–Th)/He (AHe and ZHe) ages of 26 granitoid samples from three ∼1 km vertical transects. We suggest that the Yalong thrust belt underwent two rapid cooling (exhumation) pulses in the Late Oligocene (∼24 Ma, 50°C/m.y.) and the Middle Miocene (17–14 Ma, 35°C/m.y.), respectively. These pulses of exhumation and uplift along the Yalong thrust belt contributed to the development of the current morphology across eastern Tibet. Integrating previous findings and those reported in our study allow us to propose a regional‐scale stepwise propagation pattern of tectonic deformation during the Middle–Late Cenozoic in eastern Tibet. We suggest that the dynamic development of the deformation pattern may have been driven by the northward indentation of the Eastern Himalayan Syntaxis and the consequent lower crustal flow into southeastern Tibet. Key Points The Yalong thrust belt underwent two rapid cooling pulses in the Late Oligocene (∼24 Ma) and Middle Miocene (17–14 Ma) The topographic relief across the Yalong thrust belt is mainly the result of pulsed thrusting at least since 24 Ma A regional‐scale stepwise propagation pattern was proposed for the Middle–Late Cenozoic tectonic deformation in eastern Tibet

Up to 50% of infertility is caused by the male side. Varicocele, orchitis, prostatitis, oligospermia, asthenospermia, and azoospermia are common causes of impaired male reproductive function and male infertility. In recent years, more and more studies have shown that microorganisms play an increasingly important role in the occurrence of these diseases. This review will discuss the microbiological changes associated with male infertility from the perspective of etiology, and how microorganisms affect the normal function of the male reproductive system through immune mechanisms. Linking male infertility with microbiome and immunomics can help us recognize the immune response under different disease states, providing more targeted immune target therapy for these diseases, and even the possibility of combined immunotherapy and microbial therapy for male infertility.

This study aims to evaluate the informational quality of oral cancer-related videos on YouTube and Bilibili. A total of 300 oral videos that met the inclusion and exclusion criteria were selected for analysis. The selection comprised 150 videos from 111 uploaders on YouTube and 150 videos from 134 uploaders on Bilibili. YouTube videos received a greater number of views and likes, while there was no significant difference in average likes per 30 days or comments between the two platforms. The majority of YouTube uploaders were hospitals/non-profit organizations (66.7%) and for-profit companies (17.1%), while Bilibili uploaders were mainly self-media (55.2%) and doctors (29.1%). YouTube videos covered a broader range of topics compared to Bilibili videos. Though solo narration was the most prevalent video style across both platforms, YouTube exhibited a higher preference for TV shows/documentaries (31.3%). Video quality was assessed using the four tools: Though mDISCERN (modified DISCERN) and PEMAT-Actionability (Patient Education Materials Assessment Tool) were similar across platforms, YouTube videos scored higher on PEMAT-Understandability, VIQI (Video Information and Quality Index), and GQS (Global Quality Score) in comparison to Bilibili videos. Videos produced by health professionals were considered more reliable. Spearman correlation analysis revealed no strong relationships between video quality and audience interaction. In conclusion, YouTube videos exhibited higher audience engagement and video quality, yet improvements are needed on both platforms. In order to promote high-quality health information, it is essential to encourage the development of more professional content creators and to optimize platform algorithms.

The establishment of continental-scale drainage systems on Earth is largely controlled by topography related to plate boundary deformation and buoyant mantle. Drainage patterns of the great rivers in Asia are thought to be highly dynamic during the Cenozoic collision of India and Eurasia, but the drainage pattern and landscape evolution prior to the development of high topography in eastern Tibet remain largely unknown. Here we report the results of petro-stratigraphy, heavy-mineral analysis, and detrital zircon U-Pb dating from late Cretaceous–early Palaeogene sedimentary basin strata along the present-day eastern margin of the Tibetan Plateau. Similarities in the provenance signatures among basins indicate that a continental-scale fluvial system once drained southward into the Neo-Tethyan Ocean. These results challenge existing models of drainage networks that flowed toward the East Asian marginal seas and require revisions to inference of palaeo-topography during the Late Cretaceous. The presence of a continent-scale river may have provided a stable long-term base level which, in turn, facilitated the development of an extensive low-relief landscape that is preserved atop interfluves above the deeply incised canyons of eastern Tibet. This study provides evidence for a continental-scale river system that existed in eastern Tibet before the India-Asia collision. The river system developed an extensive low-relief landscape, which was uplifted and dissected during the late Cenozoic.