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Magnetic lineations on Mars, the remanent magnetization presents east–west-trending banded features, were suggested to be associated with seafloor spreading, dike intrusion, hot spot tracking, mantle convection, discrete source merging, etc. However, a missing link remains between the magnetization layer’s geometry, controlled by these processes, and the scale and magnitude of magnetic signals in the satellite orbit. Combining the magnetic field anomalies with the geometry of the crust, we find high correlations between the polarity of the radial field and the crustal thickness in the Martian southern highlands. Forward modeling is also used to reproduce the magnetic lineations based on the magnetization layer with a nonuniform thickness in a 25 km crust. The forward modeling results show lateral variation in the radial field ranges 10∼40 nT per degree, comparable to the result from the spherical harmonic model based on satellite data. Our study suggests the mantle plume upwelling causes the nonuniformity in the magnetization layer, producing strip-shaped magnetic anomalies with periodic polarity reversals.

The Martian dynamo evolution is critical for understanding Mars’s interior structure, thermal evolution, and climate change. It has been inferred to shut down at ∼4.1–4.0 Ga based on the magnetic signatures of large impact craters, but be present at ∼3.9 Ga and ∼3.7 Ga from the paleomagnetic studies and magnetic fields above volcanic units. Here, we investigate the magnetic signatures of the Iota crater, located inside the CT3-G area with a centrally strong magnetic anomaly. The Iota crater shows a weak central magnetic field with an inside-outside strength ratio of 0.39. Forward modeling is established to explore the relationship between the magnetic field signatures of craters and the magnetization caused by impact. The results show that the average magnetization of the retained materials beneath the Iota crater is about 20% of the maximum of the surroundings, indicating that the dynamo strength at that time became weak. The magnetic signatures of Iota and CT3-G reveal that the Martian dynamo decayed at ∼4.1 Ga, but did not stop completely.

Kelvin–Helmholtz (K-H) instability is a fundamental boundary instability between two fluids with different speeds, exchanging the mass, momentum, and energy across the boundary. Although the K-H instability has been suggested to play a critical role in atmospheric ion loss on Mars, the knowledge about its formation and evolution is still poor, due to the limitation of spacecraft missions and a dearth of dedicated simulation codes. In this study, we combine observations from the Mars Atmosphere and Volatile EvolutioN mission and global 3D kinetic simulations to investigate the solar wind–Mars interaction. For the first time, it is found that K-H waves prominently appear in the −E hemisphere, which is attributed to the stronger proton velocity shear therein associated with the asymmetric diamagnetic drift motion of protons. The K-H instability is mainly excited in the −E hemisphere and propagates downstream along the boundary, with the waves also able to be generated near the subsolar point. The K-H waves produce plasma clouds with a net oxygen ion escape rate of about 1.5 × 1024 s−1, contributing to almost half of the global loss on present-day Mars. This heavy ion escape pattern associated with K-H instability is cyclic and could occur on other nonmagnetized planets, potentially influencing planetary atmosphere evolution and habitability.

Magnetic field signatures over impact craters provide constraints for the history of the Martian dynamo. Due to limitations of the spatial resolution of magnetic field models, previous studies primarily focused on large impact craters (mostly ≥ 500 km in diameter). To fill the impact crater age gaps of previous studies, we investigate the magnetic field signature of 23 intermediate-sized craters (150–500 km in diameter) on Mars using both MAVEN data and a magnetic field model. Ten impact craters located in the South Province, the unmagnetized primordial crust, exhibit no or weak magnetic field signatures. The other 13 impact craters produce stronger magnetic anomalies, with the ratio of the averaged magnetic field inside and outside the craters (B in/B out) ranging from 0.4 to 1.2. The B in/B out values exhibit correlation coefficients of −0.54, −0.57, and −0.69 with the diameters of craters, calculated from the MAVEN data, the crustal field model at the surface, and 150 km altitude, respectively. A B in/B out larger than 1.0 usually appears in craters with smaller diameters, which is also demonstrated by the forward modeling in this study. Furthermore, the results of the forward modeling indicate that the craters of stronger magnetizations show a larger B in/B out. According to this, the Martian dynamo can be associated with the magnetization of craters of different ages, and the characteristic time of the dynamo can be limited. Our study supports the hypothesis that the Martian dynamo weakened or ceased at ∼4.0 Ga and a late dynamo was perhaps active at ∼3.7 Ga.

As part of the Chinese Tianwen-1 mission, the Zhurong Rover began its scientific investigation in the southern Utopia Planitia after its successful landing in 15 May, 2021. The Zhurong Rover magnetometer (RoMAG), one of the six payloads onboard the rover, includes two identical high-sensitivity triaxial fluxgate magnetometers and can implement mobile magnetic measurements on the surface of Mars. Although a rover magnetic compensation procedure was conducted to remove the magnetic interferences pre-launch, due to the different state of the payloads and electric power system such as the solar panel, an along-track calibration of the magnetometer is necessary to obtain a more accurate Martian magnetic field. Two methods, mast yaw rotations and Rover yaw rotations were utilized separately to determine the Martian horizontal magnetic components. Results show that the Martian horizontal magnetic components determined by the two methods are in good agreement, with the root mean square deviation less than 2.0 nT. The vertical component was also constrained through the pitch movements of the mast by assuming the interferences field distributes like a dipole field. A linear correlation between magnetic field measurements and the solar array currents was derived to calibrate the body field during the regular exploration. We conclude that more accurate measurements could be made when applying the calibration results in the magnetic survey on the surface of Mars.

Purpose. Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods. A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epithelium scratching were examined daily with a slit lamp microscope for corneal opacification and ulceration. Subsequent in vitro experimentation was carried out in human corneal epithelial cells (HCECs) as well as THP-1 macrophages infected with A. fumigatus. Inhibitors, including CLI-095, Poly (I), SCH772984, and SP600125, were used to assess the role of proteins like toll-like receptor 4 (TLR4), lectin-type oxidized LDL receptor 1 (LOX-1), extracellular signal-regulated kinases (ERK1/2), and c-Jun N-terminal kinase (JNK) in ATF4 expression as a response to A. fumigatus infection. This assessment was made in both mouse models and HCECs using western blot. Results. Compared to the controls, ATF4 was increased in corneas from two kinds of A. fumigatus keratitis models at 3 days after infection. ATF4 expression was upregulated with A. fumigatus conidia both in HCECs and THP-1 macrophages 16 hours after stimulation. Furthermore, ATF4 expression in response to A. fumigatus infection was shown to be dependent on TLR4 and LOX-1 expression, and ERK1/2 and JNK contributed to the expression of ATF4 in response to A. fumigatus. Conclusion. Our results clearly indicate that ATF4 was involved in the host antifungal immune response to A. fumigatus keratitis; expression was found to be dependent on TLR4, LOX-1 expression, and MAPKs pathway.

PurposeQuercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. However, the mechanism is not completely understood. In this study, a mechanism related to proteasome-glycogen synthesis kinase 3 (GSK-3) was elucidated in rats and primary neonatal cardiomyocytes.MethodsRats were subjected to sham or constriction of abdominal aorta surgery groups and treated with or without quercetin for 8 weeks. Angiotensin II (Ang II)-induced primary cardiomyocytes were cultured with quercetin treatment or not for 48 h. Echocardiography, real-time RT-PCR, histology, immunofluorescence, and Western blotting were conducted. Proteasome activities were also detected using a fluorescent peptide substrate.ResultsEchocardiography showed that quercetin prevented constriction of abdominal aorta-induced cardiac hypertrophy and improved the cardiac diastolic function. In addition, quercetin also significantly reduced the Ang II-induced hypertrophic surface area and atrial natriuretic factor (ANF) mRNA level in primary cardiomyocytes. Proteasome activities were obviously inhibited in the quercetin-treated group both in vivo and in vitro. Quercetin also decreased the levels of proteasome subunit beta type (PSMB) 1, PSMB2, and PSMB5 of the 20S proteasome as well as the levels of proteasome regulatory particle (Rpt) 1 and Rpt4 of the 19S proteasome. In particular, the PSMB5 level in the nucleus was reduced after quercetin treatment. Furthermore, phosphorylated GSK-3α/β (inactivation of GSK-3) was decreased, which means that GSK-3 activity was increased. The phosphorylation levels of upstream AKT (PKB (protein kinase B)) and liver kinase B1/AMP activated protein kinase (LKB1/AMPKα) and those of downstream extracellular signal-regulated kinase (ERK), histone H3, β-catenin, and GATA binding protein 4 (GATA4) were reduced after quercetin treatment, while hypertrophy was reversed after treatment with the GSK-3 inhibitor.ConclusionIn summary, quercetin prevents cardiac hypertrophy, which is related to proteasome inhibition and activation of GSK-3α/β. Upstream (AKT, LKB1/AMPKα) and downstream hypertrophic factors, such as ERK, histone H3, β-catenin, and GATA4, may also be involved.

Inter-object relations underpin spatial intelligence, yet existing representations -- linguistic prepositions or object-level scene graphs -- are too coarse to specify which regions actually support, contain, or contact one another, leading to ambiguous and physically inconsistent layouts. To address these ambiguities, a part-level formulation is needed; therefore, we introduce PARSE, a framework that explicitly models how object parts interact to determine feasible and spatially grounded scene configurations. PARSE centers on the Part-centric Assembly Graph (PAG), which encodes geometric relations between specific object parts, and a Part-Aware Spatial Configuration Solver that converts these relations into geometric constraints to assemble collision-free, physically valid scenes. Using PARSE, we build PARSE-10K, a dataset of 10,000 3D indoor scenes constructed from real-image layout priors and a curated part-annotated shape database, each with dense contact structures and a part-level contact graph. With this structured, spatially grounded supervision, fine-tuning Qwen3-VL on PARSE-10K yields stronger object-level layout reasoning and more accurate part-level relation understanding; furthermore, leveraging PAGs as structural priors in 3D generation models leads to scenes with substantially improved physical realism and structural complexity. Together, these results show that PARSE significantly advances geometry-grounded spatial reasoning and supports the generation of physically consistent 3D scenes.

Human modeling and relighting are two fundamental problems in computer vision and graphics, where high-quality datasets can largely facilitate related research. However, most existing human datasets only provide multi-view human images captured under the same illumination. Although valuable for modeling tasks, they are not readily used in relighting problems. To promote research in both fields, in this paper, we present UltraStage, a new 3D human dataset that contains more than 2,000 high-quality human assets captured under both multi-view and multi-illumination settings. Specifically, for each example, we provide 32 surrounding views illuminated with one white light and two gradient illuminations. In addition to regular multi-view images, gradient illuminations help recover detailed surface normal and spatially-varying material maps, enabling various relighting applications. Inspired by recent advances in neural representation, we further interpret each example into a neural human asset which allows novel view synthesis under arbitrary lighting conditions. We show our neural human assets can achieve extremely high capture performance and are capable of representing fine details such as facial wrinkles and cloth folds. We also validate UltraStage in single image relighting tasks, training neural networks with virtual relighted data from neural assets and demonstrating realistic rendering improvements over prior arts. UltraStage will be publicly available to the community to stimulate significant future developments in various human modeling and rendering tasks. The dataset is available at https://miaoing.github.io/RNHA.