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Recognition of multifrequency microwave (MW) electric fields is challenging because of the complex interference of multifrequency fields in practical applications. Rydberg atom-based measurements for multifrequency MW electric fields is promising in MW radar and MW communications. However, Rydberg atoms are sensitive not only to the MW signal but also to noise from atomic collisions and the environment, meaning that solution of the governing Lindblad master equation of light-atom interactions is complicated by the inclusion of noise and high-order terms. Here, we solve these problems by combining Rydberg atoms with deep learning model, demonstrating that this model uses the sensitivity of the Rydberg atoms while also reducing the impact of noise without solving the master equation. As a proof-of-principle demonstration, the deep learning enhanced Rydberg receiver allows direct decoding of the frequency-division multiplexed signal. This type of sensing technology is expected to benefit Rydberg-based MW fields sensing and communication. Rydberg atoms are sensitive to microwave signals and hence can be used to detect them. Here the authors demonstrate a Rydberg receiver enhanced by deep learning, Rydberg atoms acting as antennae, to receive, extract, and decode the multi-frequency microwave signal effectively.

Background Drought stress limits significantly the crop productivity. However, plants have evolved various strategies to cope with the drought conditions by adopting complex molecular, biochemical, and physiological mechanisms. Members of the nuclear factor Y (NF-Y) transcription factor (TF) family constitute one of the largest TF classes and are involved in plant responses to abiotic stresses. Results TaNF-YB2 , a NY-YB subfamily gene in T. aestivum , was characterized in this study focusing on its role in mediating plant adaptation to drought stress. Yeast two-hybrid (Y-2 H), biomolecular fluoresence complementation (BiFC), and Co-immunoprecipitation (Co-IP) assays indicated that TaNF-YB2 interacts with the NF-YA member TaNF-YA7 and NF-YC family member TaNF-YC7, which constitutes a heterotrimer TaNF-YB2/TaNF-YA7/TaNF-YC7. The TaNF-YB2 transcripts are induced in roots and aerial tissues upon drought signaling; GUS histochemical staining analysis demonstrated the roles of cis -regulatory elements ABRE and MYB situated in TaNF-YB2 promoter to contribute to target gene response to drought. Transgene analysis on TaNF-YB2 confirmed its functions in regulating drought adaptation via modulating stomata movement, osmolyte biosynthesis, and reactive oxygen species (ROS) homeostasis. TaNF-YB2 possessed the abilities in transcriptionally activating TaP5CS2 , the P5CS family gene involving proline biosynthesis and TaSOD1 , TaCAT5 , and TaPOD5 , the genes encoding antioxidant enzymes. Positive correlations were found between yield and the TaNF-YB2 transcripts in a core panel constituting 45 wheat cultivars under drought condition, in which two types of major haplotypes including TaNF-YB2-Hap1 and -Hap2 were included, with the former conferring more TaNF-YB2 transcripts and stronger plant drought tolerance. Conclusions TaNF-YB2 is transcriptional response to drought stress. It is an essential regulator in mediating plant drought adaptation by modulating the physiological processes associated with stomatal movement, osmolyte biosynthesis, and reactive oxygen species (ROS) homeostasis, depending on its role in transcriptionally regulating stress response genes. Our research deepens the understanding of plant drought stress underlying NF-Y TF family and provides gene resource in efforts for molecular breeding the drought-tolerant cultivars in T. aestivum .

Higher-order and fractional discrete time crystals (DTCs) are exotic phases of matter where the discrete time translation symmetry is broken into higher-order and non-integer category. Generation of these unique DTCs has been widely studied theoretically in different systems. However, no current experimental methods can probe these higher-order and fractional DTCs in any quantum many-body systems. We demonstrate an experimental approach to observe higher-order and fractional DTCs in Floquet-driven Rydberg atomic gases. We have discovered multiple n -DTCs with integer values of n = 2, 3, and 4, and others ranging up to 14, along with fractional n -DTCs with n values beyond the integers. The system response can transition between adjacent integer DTCs, during which the fractional DTCs are investigated. Study of higher-order and fractional DTCs expands fundamental knowledge of non-equilibrium dynamics and is promising for discovery of more complex temporal symmetries beyond the single discrete time translation symmetry. Discrete-time crystal (DTC) is a special phase of matter that exhibits a spontaneous breaking of the discrete time translational symmetry. Here, Bang Liu et al. demonstrate an experimental approach to observe higher-order and fractional DTCs in Floquet-driven Rydberg atomic gases.

A time crystal is an exotic phase of matter where time-translational symmetry is broken; this phase differs from the spatial symmetry breaking induced in conventional crystals. Lots of experiments report the transition from a thermal equilibrium phase to a time crystal phase. However, there is no experimental method to probe the bifurcation effect of distinct continuous time crystals in quantum many-body systems. Here, in a driven and dissipative many-body Rydberg atom system, we observe multiple continuous dissipative time crystals and emergence of more complex temporal symmetries beyond the single time crystal phase. Bifurcation of time crystals in strongly interacting Rydberg atoms is observed; the process manifests as a transition from a time crystal of long periodicity to a time crystal of short periodicity, or vice versa. By manipulating the driving field parameters, we observe the time crystal’s bistability and a hysteresis loop. These investigations indicate new possibilities for control and manipulation of the temporal symmetries of non-equilibrium systems. The time crystal is an exotic phase of matter where time-translational symmetry is broken. Here, the authors observe multiple continuous dissipative time crystals and bifurcation of time crystals in driven and dissipative Rydberg atomic gas.

Although growing advances have been made in the regulation of lupus nephritis recently, lupus nephritis is still one of the major causes of death in SLE patients and the pathogenesis remains largely unknown. Therefore, exploring the pathological mechanisms is urgently needed for designing and developing novel therapeutic strategies for lupus nephritis. Human renal mesangial cells (HRMCs) were transfected with sh-NEAT1, miR-146b mimic, pcDNA-NEAT1, miR-146b inhibitor, or sh-TRAF6 to modify their expression. Lipopolysaccharide (LPS) was used to induce inflammatory injury. Cell viability was examined with CCK8. Apoptosis was determined by flow cytometry and Hoechst staining. qRT-PCR and western blot were used to analyze gene expression. The secretion of inflammatory cytokines was examined with ELISA. The bindings of NEAT1 with miR-146b and miR-146b with TRAF6 were tested by dual-luciferase reporter assay. NEAT1 was upregulated in LPS-treated HRMCs. Both the knockdown of NEAT1 and TRAF6 suppressed the LPS-induced inflammatory injury in HRMCs. NEAT1 directly targeted miR-146b to control miR-146b-mediated regulation of TRAF6 expression in HRMCs. NEAT1 promoted the expression of TRAF6 via targeting miR-146b to accelerate the LPS-mediated renal mesangial cell injury in HRMCs. Moreover, TRAF6 activated the NF-κB signaling in HRMCs. NEAT1 accelerated renal mesangial cell injury via directly targeting miR-146b, promoting the expression of TRAF6, and activating the NF-κB signaling in lupus nephritis. Our investigation elucidated novel pathological mechanisms and provided potential therapeutic targets for lupus nephritis.

The hydrogen, H, bonding, wettability and sorption behaviors of the poly(vinyl alcohol), PVA and tea polyphenols, TP, blended composites with various blending ratios were quantitatively evaluated. The H-bonding of PVA/TP composites has been found contributed from not only the pure PVA and TP, but also the formed composites and would be enhanced with the TP percent increase. The pure PVA has better hydrophilicity and the PVA/TP composites would enhance the hydrophobicity with the increase of TP percent. According to wetting results, the added TP percent at about 35% seeming to be a critical turning point for PVA/TP composites to change the wettability. The sorption of PVA/TP composites was greatly influenced by the pH of solution due to it greater in the base solution and smaller in the acid solution as comparison with the referenced water sorption. In all these cases, the sorption amount was basically reduced with the TP percent increase.

The interplay between strong long-range interactions and the coherent driving contribute to the formation of complex patterns, symmetry, and novel phases of matter in many-body systems. However, long-range interactions may induce an additional dissipation channel, resulting in non-Hermitian many-body dynamics and the emergence of exceptional points in spectrum. Here, we report experimental observation of interaction-induced exceptional points in cold Rydberg atomic gases, revealing the breaking of charge-conjugation parity symmetry. By measuring the transmission spectrum under increasing and decreasing probe intensity, the interaction-induced hysteresis trajectories are observed, which give rise to non-Hermitian dynamics. We record the area enclosed by hysteresis loops and investigate the dynamics of hysteresis loops. The reported exceptional points and hysteresis trajectories in cold Rydberg atomic gases provide valuable insights into the underlying non-Hermitian physics in many-body systems, allowing us to study the interplay between long-range interactions and non-Hermiticity. Long-range interactions in many-body quantum systems may induce dissipation channels described by non-Hermitian dynamics. Here, the authors report the observation of higher-order exceptional points, a hallmark of non-Hermitian physics, in a Rydberg atom gas. This enables design of quantum dynamics around these points, providing insight into phase transitions.

Background MYB-related protein B (B-MYB/MYBL2), a member of the myeloblastosis family of transcription factors, has been reported for its role in the genesis and progression of tumors. Forkhead box M1 (FoxM1), another transcriptional factor, is considered to be an independent predictor of poor survival in many solid cancers. The aim of the present study was to investigate the clinical significance of the correlation between MYBL2 and FoxM1 in glioma and the possible mechanism of FoxM1and MYBL2 expression. Methods MYBL2 and FoxM1expression in cancerous tissues and cell lines were determined by reverse transcription-PCR (RT-PCR), Western blotting and immunostaining. The co-expression of MYBL2 and FoxM1 was analyzed in low-grade glioma (LGG) and glioblastoma (HGG) cohorts of TCGA using cBioportal and UCSC Xena. And, the role of MYBL2 and FoxM1 in glioma cell progression and the underlying mechanisms were studied by using small interfering RNA (si-RNA) and pcDNA3.1 + HAvectors. Furthermore, the effects of MYBL2 and FoxM1 in cell proliferation, cell cycle progression, apoptosis, migration, invasion, and adhesion were determined by cell proliferation assays, flow cytometry analysis, transwell migration and cell adhesion assay. Results MYBL2 and FoxM1 expression are significantly associated with clinical stages and overall survival of glioma patients. In cohorts of TCGA, patients with high MYBL2 but without radio-chemotherapy had the highest hazard ratio (adjusted HR = 5.29, 95% CI = 1.475–18.969, P  < 0.05). Meanwhile, MYBL2 closely related to the FoxM1 expression in 79 glioma tissues ( r  = 0.742, p  < 0.05) and LGG ( r  = 0.83) and HGG ( r  = 0.74) cohorts of TCGA. Down regulation of FoxM1 and MYBL2 by siRNAs induced the cell cycle arrest, apoptosis and EMT of glioma cells. Furthermore, inactivations of Akt/FoxM1 signaling by Akt inhibitor and siRNA-FoxM1 reduce the expression of MYBL2 in glioma cells. Conclusions MYBL2 is a key downstream factor of Akt/FoxM1 signaling to promote progression of human glioma, and could be a new candidate gene for molecular targeting therapy and biomarker for radiotherapy of glioma. Trial registration CTXY-1300041-3-2 . ChiCTR-COC-15006186 . Registered date: 13 September 2013.

Background The shortcomings of plaster in water resistance, air permeability, skin comfort, fixed stability and weight of wearing are still to be solved. 3D printed cast can overcome the above shortcomings. At present, there is a relative lack of data on the clinical application of 3D printed cast, probably due to its complexity, relatively long operating time, and high price. We aimed to compare and evaluate the short-term effectiveness, safety and advantages of 3D printed wrist cast versus polymer orthosis in the treatment of Colles fracture. Methods Forty patients with Colles fracture in our hospital from June to December 2022 were selected and divided into an observation group (20 patients, treated with instant 3D printed cast) and a control group (20 cases, treated with polymer orthosis). Both groups treated with manual reduction and external fixation. The visual analogue scale (VAS), immobilization effectiveness and satisfaction scores, Disability of the Arm, Shoulder and Hand (DASH) score, complications and imaging data were collected and compared before immobilization and at 2, 6 and 12 weeks after the fracture. Results VAS at 2 weeks after the fracture was significantly lower in the observation group than in the control group ( P  < 0.05). The immobilization effectiveness and satisfaction scores at 6 weeks after the fracture were significantly higher in the observation group than in the control group (all P  < 0.05). The DASH scores at 2 and 6 weeks after the fracture were significantly lower in the observation group than in the control group (all P  < 0.05). There wasn’t rupture of the printed cast or orthosis in both groups. There were 2 cases of skin irritation in the control group, and no skin irritation occurred in the observation group. The palmar tilt angle and ulnar inclination angle at 2 weeks and 12 weeks after the fracture were significantly higher in the observation group than in the control group (all P  < 0.05). Conclusions Both instant 3D printed cast and polymer orthosis are effective in the treatment of Colles fracture. But instant 3D printed cast is better than polymer orthosis in areas of good clinical and imaging performance, and high patient satisfaction and comfort.

Background Rice is highly sensitive to temperature fluctuations. Recently, the frequent occurrence of high temperature stress has heavily influenced rice production. Proper heading date in specific environmental conditions could ensure high grain yield. Rice heading greatly depends on the accurate measurement of environmental changes, particularly in day length and temperature. In contrary to the detailed understanding of the photoperiod pathway, little has been known about how temperature regulates the genetic control of rice heading. Results Near isogenic lines that were segregated for qHd1 , were developed from a cross between indica rice varieties Zhenshan 97 (ZS97) and Milyang 46 (MY46). Using a five sowing-date experiment in the paddy field, we observed the involvement of qHd1 in temperature responses. With the gradual increase of temperature from Trial I to V, heading date of MY46 homozygotes continued to decrease for about 5 d per trial from 76 to 58 d, while that of ZS97 homozygotes was promoted at the same rate from Trial I to III and then stabilized at 69 d. This thermal response was confirmed in a temperature-gradient experiment conducted in the phytotron. It is also found that tolerance of the ZS97 allele to heading acceleration at high temperature was associated with higher grain weight that resulted in higher grain yield. Then, by qRT-PCR and RNA-seq, we found the pathway OsMADS51-Ehd1-RFT1/Hd3a underlying the qHd1 -mediated floral response to temperature. By sequence comparison, OsMADS51 for qHd1 displayed a 9.5-kb insertion in the 1st intron of the ZS97 allele compared to the MY46 allele. Furthermore, this large insertion is commonly found in major early-season indica rice varieties, but not in the middle- and late-season ones, which corresponds to the requirement for high-temperature tolerance during the heading and grain-filling stages of early-season rice. Conclusions Beneficial alleles at qHd1 confer tolerance to high temperatures at the heading and grain-filling stages, playing a significant role in the eco-geographical adaptation of early-season indica rice during modern breeding. These results, together with the underlying OsMADS51-Ehd1-RFT1/Hd3a floral pathway, provide valuable information for better understanding the molecular mechanism of temperature responsive regulation of heading date and yield traits in rice.