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"Zhang, Li-Jun"
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Oxidative stress in leukemia and antioxidant treatment
Oxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species (ROS) and the antioxidant defense systems, which can activate various transcription factors and affect their transcriptional pathways. Oxidative stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of leukemia. The standard chemotherapy strategies for the pre-treatment of leukemia have many drawbacks. Hence, the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily applied. This article reviews the research progress of oxidative stress and leukemia. In addition, the application of antioxidants treatment in leukemia has been summarized.
Journal Article
The gland localized CGP1 controls gland pigmentation and gossypol accumulation in cotton
Summary Pigment glands, also known as black glands or gossypol glands, are specific for Gossypium spp. These glands strictly confine large amounts of secondary metabolites to the lysigenous cavity, leading to the glands’ intense colour and providing defence against pests and pathogens. This study performed a comparative transcriptome analysis of glanded versus glandless cotton cultivars. Twenty‐two transcription factors showed expression patterns associated with pigment glands and were characterized. Phenotypic screening of the genes, via virus‐induced gene silencing, showed an apparent disappearance of pigmented glands after the silencing of a pair of homologous MYB‐encoding genes in the A and D genomes (designated as CGP1). Further study showed that CGP1a encodes an active transcription factor, which is specifically expressed in the gland structure, while CGP1d encodes a non‐functional protein due to a fragment deletion, which causes premature termination. RNAi‐mediated silencing and CRISPR knockout of CGP1 in glanded cotton cultivars generated a glandless‐like phenotype, similar to the dominant glandless mutant Gl2e. Microscopic analysis showed that CGP1 knockout did not affect gland structure or density, but affected gland pigmentation. The levels of gossypol and related terpenoids were significantly decreased in cgp1 mutants, and a number of gossypol biosynthetic genes were strongly down‐regulated. CGP1 is located in the nucleus where it interacts with GoPGF, a critical transcription factor for gland development and gossypol synthesis. Our data suggest that CGP1 and GoPGF form heterodimers to control the synthesis of gossypol and other secondary metabolites in cotton.
Journal Article
Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology
Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of
. Modern pharmacology studies and clinical practice demonstrate that brucine possesses wide pharmacological activities, such as anti-tumor, anti-inflammatory, analgesic, and the effects on cardiovascular system and nervous system, etc. However, its central nervous system toxicity severely limits its clinical application. Herein, the physicochemical properties, pharmacological activities, and toxicity of brucine were reviewed, and the novel strategies to address the toxicity issues were discussed, aiming to bring new insights into further research and application of this active component.
Journal Article
Talaroterpenoids A–F: Six New Seco-Terpenoids from the Marine-Derived Fungus Talaromyces aurantiacus
Six new highly oxidized seco-terpenoids, including three 3-nor-labdane type diterpenes, talaroterpenoids A–C (1–3), and three meroterpenoids containing an orthoester group, talaroterpenoids D–F (6–8), together with five known compounds (4–5 and 9–11), were isolated from the marine-derived fungus Talaromyces aurantiacus. Their chemical structures were elucidated through 1D, 2D NMR, HRESIMS, J-based configuration analysis (JBCA), computational ECD calculations, and single-crystal X-ray diffraction analysis. Compounds 1 and 2 contain an unusual 6,20-γ-lactone-bridged scaffold. Compounds 10 and 11 presented inhibitory effects on NO release in lipopolysaccharide (LPS)-induced BV-2 cells with IC50 values of 11.47 and 11.32 μM, respectively. Talaroterpenoid C (3) showed moderate antifungal activity against A. alternata and P. theae Steyaert.
Journal Article
Experimental demonstration of a quantum key distribution without signal disturbance monitoring
In existing quantum key distribution protocols, two legitimate peers, Alice and Bob, must monitor the signal disturbance to place a bound on the potential information leakage. However, in the round-robin differential phase shift (RRDPS) protocol, monitoring of the signal disturbance is unnecessary. Here, we present the first active implementation of the RRDPS protocol. In our experiment, Alice prepares packets of pulses, where each packet is a train with 65 pulses and the global phase of each packet is randomized. Bob uses a novel actively controlled variable-delay interferometer to realize the random switching of different delays. Benefiting from the large pulse number of each packet, and the high stability and low insertion loss of the interferometer, the system can distribute a secret key over a distance of 90 km. Our experimental demonstration and results confirm the feasibility of the RRDPS protocol, particularly in high-error situations.
A round-robin differential phase shift protocol, in which monitoring of the signal disturbance is unnecessary, has been experimentally realized. With 65 pulses in each packet, the system can distribute a secret key over a distance of 90 km.
Journal Article
Quantifying the rise of animals during the Ediacaran–Cambrian using ichnodissimilarity
The trace fossil record provides important insights into the evolution of early animals during the Ediacaran/Cambrian transition, with changes in ichnodiversity through time and between environments informing on the diversification of major body plans, behaviors, and niches. To quantify variation in the diversity of trace fossils across this critical interval, we propose a measure of trace fossil dissimilarity (ichnodissimilarity) based on vector calculation. Furthermore, by comparing discrepancies between the angular bisector and mean vector of two sets of vectorized fossil data, we are able to weigh the relative contribution of increases and decreases in the variation of occurrences of taxa. We used this metric to analyze an expansive dataset of Ediacaran/Cambrian trace fossils. The results allowed us to quantify the diversification of traces across this transition, informing on the timing of first appearance of different behaviors (e.g., foraging, grazing, and resting) and functional groups. By interpreting the results in the context of environmental changes and advancements in motility and sensory capabilities, we were able to pinpoint the onset and sequence of the Fortunian diversification event, Cambrian information revolution, and agronomic revolution, shedding light on the evolution of organismal body plans, behaviors, and locomotion during the Ediacaran/Cambrian transition. We identified two phases of origination and expansion during the divergence of early animal traces. Furthermore, by analyzing shallow- and deep-marine trace fossils, we were able to uncover evidence for a more rapid diversification of traces in shallow-marine environments, with progressive niche partitioning through the Ediacaran to Cambrian.
Journal Article
National-wide survey of ophthalmic human resources in China in 2021
Purpose
To evaluate the availability of human resources for ophthalmic services in mainland China.
Methods
In 2021, we conducted a nationwide survey of ophthalmic outpatient services across 2996 tertiary hospitals and 10,404 secondary hospitals in 31 provinces in mainland China.
Results
The response rate was 73.6% (9856/13400), with 78.7% (7759/9856) providing ophthalmic services. By 2021, the total number of ophthalmologists, ophthalmic nurses, and optometrists was 48,652, 64,495, and 14,320, respectively. The densities (per 50,000 population) were 1.7, 2.25, and 0.47, respectively. The density of ophthalmologists was < 1 only in the XiZang region. The average doctor-patient ratio was 2584.8. In Shanghai and Zhejiang provinces, this ratio exceeded 4000.
Conclusion
There are currently 1.7 ophthalmologists, 2.25 nurses, and 0.47 optometrists for every 50,000 people in China. The number of ophthalmologists has reached the global average, but the number of optometrists is far below the global average. And the medical pressure across China is uneven, with some provinces such as Shanghai and Zhejiang facing enormous pressure.
Journal Article
Experimental Analysis of Atmospheric Ducts and Navigation Radar Over-the-Horizon Detection
Since the height of sea detection radar antenna and ship targets is relatively low, it is generally believed that its over-the-horizon detection is mainly caused by the evaporation duct at sea. To fully understand the influence of atmospheric ducts on radar over-the-horizon detection, a shore-based navigation radar was used to carry out over-the-horizon detection experiments; radiosondes were used to measure the atmospheric profile and evaporation duct monitoring equipment was used to measure the evaporation duct. Based on experimental data and model simulation, a comparative analysis of a navigation radar’s over-the-horizon detection, the evaporation duct, and the lower atmospheric duct is presented in this study. The results show that the atmospheric duct can affect the signal propagation of the navigation radar, thus resulting in over-the-horizon detection. The long-range over-the-horizon detection of the navigation radar is caused by the strong lower atmospheric duct, while the evaporation duct can generally only form weak over-the-horizon detection, which is different from the general cognition.
Journal Article
Combination of High-Sensitivity C-Reactive Protein and Homocysteine Predicts the Post-Stroke Depression in Patients with Ischemic Stroke
In this study, we examined the changes in high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) levels, two of the risk factors, during the acute period of ischemic stroke (IS) and evaluated the relationship between these two factors and long-term post-stroke depression (PSD). In this study, 259 patients with IS had finished the follow-up and were included. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 1 year after stroke. The influence of Hs-CRP/CHY levels on PSD was performed by binary logistic regression analysis and receiver operating characteristic curves (ROC). Totally, 94 out of the 259 patients were diagnosed as PSD (36.3%; 95% CI 30.4–42.1%). In multivariate logistic regression analysis, the third and fourth quartiles of Hs-CRP or HCY were significantly associated with PSD during the observation period compared to the first quartile group (P < 0.05). In addition, patients with depression were older and more frequently were female, living with offspring, widowhood, higher initial stroke severity, and BMI. HCY improved the ability of Hs-CRP [0.72 (95% CI 0.66–0.79)] to diagnose PSD (AUC of the combined model 0.76; 95% CI 0.69–0.82; P = 0.021). The patient group with higher levels of both Hs-CRP and HCY (> median) had an OR of 6.05 (95 % CI 3.13–10.15; P < 0.001) for PSD compared with patients with lower levels of both factors (< median). The data suggests that elevated serum levels of Hs-CRP and HCY were associated with the risk of developing PSD 1 year after the stroke onset, and those two factors combined to add prognostic information in the early evaluation of PSD.
Journal Article