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The study aimed to evaluate the relationship between baseline platelet-to-red blood cell distribution width ratio (PRR) and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage (SAH). This cohort study of adults with non-traumatic SAH used Medical Information Mart for Intensive Care (MIMIC-IV) data from 2008-2022 admissions at the Intensive Care Unit (ICU). We collected the PRR levels at admission and determined the all-cause death rates for the ICU and hospital. Cox proportional hazards models were utilized to analyze the association between baseline PRR level and all-cause mortality. Kaplan-Meier survival curve analysis was used to examine the consistency of these correlations. Restricted Cubic Splines (RCS) analysis was used to determine the relationship curve between all-cause mortality and PRR level and examine the threshold saturation effect. To evaluate the consistency of correlations, interaction and subgroup analyses were also conducted. A total of 1056 patients with non-traumatic SAH were included in this study. All-cause mortalities in the ICU and hospital were 14.8% (156/1056) and 18.6% (196/1056), respectively. Compared to individuals with lower PRR Q1(≤12.67), the adjusted HR values in Q2 (12.68-15.99), Q3 (16.00-19.41), and Q4 (≥19.42) were 0.61 (95%CI:0.40-0.92, p = 0.017), 0.60 (95%CI: 0.39-0.92, p = 0.020), and 0.60 (95% CI:0.39-0.93, p = 0.019), respectively. Kaplan-Meier analysis showed that patients with low PRR levels had significantly higher ICU and in-hospital mortality (p < 0.001). The association between the PRR level and ICU and in-hospital mortality exhibited a non-linear relationship (p < 0.05). The threshold breakpoint value of 22.6 was calculated using RCS analysis. When the PRR level was lower than 22.6, the risk of ICU and in-hospital mortality rates decreased with an HR of 0.91 (95%CI: 0.88-0.94, p < 0.001) and 0.94 (95%CI: 0.92-0.96, p < 0.001), respectively. When the PRR level was higher than 22.6, the risk of ICU mortality (HR = 1.03, 95% CI: 0.97-1.10, p = 0.312) and in-hospital mortality (HR = 1.01, 95%CI: 0.95-1.08, p = 0.693) almost hardly increased with the increase in the PRR level. The interaction between the PRR and all subgroup factors was analyzed, and significant interactions were not observed. There was a non-linear connection between the baseline PRR level and in-hospital mortality. A low level of PRR could increase the risk of death in participants with non-traumatic SAH.

The introduction of the pilot flame can stabilize the lean premixed flame and promote its industrial application. However, the interaction mechanism between the pilot and main flames is complicated. To reveal the effect of the pilot flame on the main flame, a laminar lean premixed flame adjacent to a rich premixed pilot flame on one side and a similar lean premixed flame on the other side was considered. A two-dimensional numerical model was adopted with detailed chemistry and species transport, also with no artificial flame anchoring boundary conditions. The results show that the pilot flame could promote the main flame stabilized in different locations with various shapes, by adjusting the stretch, heat transfer, and preferential diffusion in a complicated manner. The pilot flame improves the local equivalence ratio and transfer more heat to the main flame. The growth of the pilot flame equivalence ratio and inlet velocity enhances the combustion on the rich side of the main flame and helps it anchor closer to the flame wall. Both the curvature and strain rate show a significant effect on the flame root, which contributes to the main flame bending towards the pilot flame.

Umbralisib is a dual inhibitor of phosphatidylinositol 3-kinase delta (PI3Kδ) and casein kinase 1 epsilon (CK1ε) for treating marginal zone lymphoma (MZL) and follicular lymphoma (FL). This study aimed to develop a fast and stable ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for quantitative analysis of umbralisib in rat plasma and its application for evaluating the effect of sophocarpine on the pharmacokinetics of umbralisib. A direct protein preparation with acetonitrile was used to deal with rat plasma. Umbralisib and duvelisib (internal standard, IS) were isolated on a Waters Acquity UPLC BEH C18 column with mobile phase consisted of acetonitrile and 0.1% formic acid in water. The linear range was from 0.5 to 1,000 ng/ml. Both of the precision (RSD%) and accuracy (RE%) were less than 15% in a permissible range. The mean recovery and matrix effect of umbralisib were 86.3–96.2% and 97.8–112.0%, respectively. When umbralisib was combined with sophocarpine, AUC 0→∞ of umbralisib was significantly reduced to 2462.799 ± 535.736 ng/ml•h from 5416.665 ± 1,451.846 ng/ml•h, and C max also was markedly diminished. Moreover, CLz/F was increased more than two times. This developed, optimized and technical UPLC-MS/MS method was extremely suitable for detecting the concentrations of umbralisib in rat plasma after an oral administration, and sophocarpine significantly changed the pharmacokinetics of umbralisib in rats. This obvious pharmacokinetic changes indicates that there seems to exist herb-drug interaction between sophocarpine and umbralisib.

At present, a buffer device is installed at the bottom of the elevator shaft to buffer the falling counterweight. When the elevator hits the buffer, the buffer absorbs or consumes the kinetic energy and potential energy of the elevator, so as to make the elevator or counterweight slow down safely until it stops. The corresponding counterweight is fixedly installed at the bottom of the elevator shaft. However, the counterweight installed at the bottom of the elevator shaft has certain disadvantages. In order to overcome the defects of the above existing technology, a counterweight structure with buffer device is studied in this paper. Compared with the prior art, the structure has the advantages of reducing construction time, high safety, simple structure, etc., and has universal popularization significance.

To satisfy the demand of the handing robot using elevator in automatic workshop, we had finished the communication between the control system RCS of the elevator and the handling robot based on Modbus TCP protocol, so as to realize the interaction between the control robot and the Elevator Internet of Things system. The research of this paper provides a solution for the access and application of the handling robot in the Elevator Internet of Things, which solves the problem of the handling robot in the elevator up and down, and provides a new way for the material transportation efficiently in the three-dimensional industrial plant.

In order to solve the problem of elevator braking test inspection, this paper combs the requirements of relevant national standards and inspection rules on braking performance, and develops an elevator braking test inspection instrument. With the help of the instrument, the elevator braking effect can be expressed quantitatively, and the inspectors can conveniently judge whether the braking test results meet the requirements of elevator inspection rules remotely. A way to standardize and rationalize the test is given. In order to solve the problem of elevator brake test inspection, this paper sorted out the national standards and inspection rules on braking performance, and developed an instrument of elevator brake test inspection. With the help of the instrument, we could quantitatively give the expression on the elevator braking effect, and the inspectors can conveniently judge whether the braking test results meet the requirements of the elevator inspection rules in the remote.

Introduced the inspection requirements of the main transmission components in the hoisting machinery in the current special equipment regulation; Checked the technical requirements related to safety in the relevant standards of the synchronous belt. Based on the physical structure, failure mode and regulatory standard requirements of the synchronous belt, summarized the inspection method of the synchronous belt.

Laser cladding technology has been widely applied in industrial production because of its prominent advantage in surface modification. To achieve improved microstructure characteristics and performance, it is essential to investigate the solidification mechanism of the microstructures formed during laser cladding. In this study, the columnar-to-equiaxed transition for laser-clad 316L was predicted using a three-dimensional finite element model coupled with electron backscatter diffraction analysis. First, the distribution of thermodynamic variables at different laser powers was examined. Then, the fitting curve for predicting the columnar-to-equiaxed transition was established, and the results indicate that the solidification of laser-clad 316L can be accurately predicted. Moreover, the grain size distribution for different laser powers was counted, and the average grain size of the molten pool was shown to increase with increasing laser power. This work will serve as a guide for the crystal transition in the solidification process for laser cladding.

The influences of acidic properties and pore structures of H-Beta and H-ZSM-5 zeolites on the reaction properties of n -butane isomerization at low temperatures were investigated. The results showed that bimolecular pathway of n -butane conversion predominates over H-ZSM-5 zeolites, while the monomolecular and bimolecular pathways occur simultaneously over H-Beta zeolites. The conversion rate of n -butane strongly relies on the amount of strong Brønsted acid sites regardless of zeolite topology. However, the topology of zeolites crucially determines the products distribution, and the density of strong Brønsted acid sites plays a secondary role. The cavities of zeolites, formed in the intersections of channels, provide the places for the bimolecular reaction. The formation of trimethyl C 8 intermediates is spatially restricted in the narrow channel intersections of H-ZSM-5 zeolites, resulting in higher contribution of n -butane disproportionation reaction. In addition, the narrow pore channels of H-ZSM-5 zeolite limit the monomolecular isomerization of n -butane molecules and affect the diffusion of heavier products (pentane) produced from bimolecular reaction, leading to the severe secondary reaction and high selectivity to propane. In contrast, the pore channels of H-Beta zeolite allow the monomolecular isomerization of n -butane and the deposition of coke. Graphical Abstract The topology of zeolites crucially determines the products distribution.

The non-oxidative dehydrogenation of light alkanes to alkenes is thermodynamically limited by the trade-off between the cleavage of C-H and C-C bonds. Unlocking the thermodynamic bottleneck with photocatalysis is prone to eliminate undesirable side reactions such as deep dehydrogenation, cracking, isomerization, and polymerization. Herein, we show the photocatalytic non-oxidative dehydrogenation of ethane to ethene and hydrogen at ambient conditions, which is enabled by grafting of Ni single atoms to modulate the surface electronic structure of Pd nanoparticles photo-deposited on the surface of anatase TiO 2 nanoparticles, modifying the ethane dehydrogenation pathway. A high rate of 8.2 ± 0.2 mmol·g −1 ·h −1 for the stoichiometric conversion of ethane to ethene and hydrogen is achieved with a 100% ethene selectivity in a flow reactor under solar light irradiation. The apparent quantum efficiency reaches ~22.3% at 350 nm by using the optimal T-Ni 0.6 Pd 0.24 photocatalyst. Solar-driven non-oxidative alkane dehydrogenation offers a route to light alkenes with high performance, and selectivity. Non-oxidative alkene dehydrogenation is hindered by side reactions like cracking, iso- or polymerization, or alkyne formation. Here the authors report a Pd/TiO2 photocatalyst decorated with Ni single sites for selective ethane to ethylene production under simulated solar light conditions with high yields.