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Laser ablation inductively coupled plasma mass spectrometry zircon U-Pb dating and geochemical data document the Early Devonian Sandaogou alkaline complex (409 Ma) from the northern margin of the North China craton. The rock suite includes pyroxene syenite, quartz syenite and monzonite. These rocks exhibit high contents of K2O (5-13 wt%), strong enrichments in large ion lithophile elements and light REE, slightly negative Eu anomalies, and pronounced depletions in high field strength elements. They are characterized by moderate 87Sr/86Sri ratios of 0.7052-0.7071, low εNd(t) values of -12.7 to -17.9 and zircon εHf(t) values from -27.8 to -32.3. These geochemical features and quantitative isotopic modelling suggest that they might have been formed through simultaneous fractional crystallization and lower crustal assimilation of a metasomatized mantle-derived alkali basaltic magma. These trachytic rocks, together with the Middle Devonian alkaline rocks and mafic-ultramafic complex from neighbouring regions, constitute a linear post-collisional magmatic belt along the northern North China craton, possibly formed under a tectonic regime of slab breakoff. They serve not only as a magmatic milestone for marking the termination of Early Palaeozoic orogenic cycle around the northern North China craton, but also as a spatial tracer for locating the position of the potential ancient slab breakoff at the surface.

Direct antihypertensive therapy in hypertensive patients with a high CVD risk can reduce the incidence of cardiovascular death but increase adverse cardiovascular events, so additional ways to identify hypertensive patients at high risk may be needed. Studies have shown that immunity and inflammation affect the prognoses of patients with hypertension and that the pan-immune-inflammation value (PIV) is an index to assess immunity and inflammation, but few studies have applied the PIV index to patients with hypertension. To explore the relationship between the PIV and long-term all-cause and cardiovascular mortality in patients with hypertension. Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 with a mortality follow-up through December 31, 2019, were analyzed. A total of 26,781 participants were evaluated. The patients were grouped based on PIV levels as follows: T1 group ( = 8,938), T2 group ( = 8,893), and T3 group ( = 8,950). The relationship between the PIV and long-term all-cause and cardiovascular death was assessed by survival curves and Cox regression analysis based on the NHANES recommended weights. The PIV was significantly associated with long-term all-cause and cardiovascular mortality in patients with hypertension. After full adjustment, patients with higher PIV have a higher risk of all-cause [Group 3: HR: 1.37, 95% CI: 1.20-1.55, < 0.001] and cardiovascular [Group 3: HR: 1.62, 95% CI: 1.22-2.15, < 0.001] mortality. Elevated PIV was associated with increased all-cause mortality and cardiovascular mortality in hypertensive patients.

Background Malignant peritoneal mesothelioma (MPM) is a rare but aggressive cancer. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) was the preferred choice for selected patients. The purpose of this study was to thoroughly examine the impact of the combined treatment and the prognostic variables, particularly the neutrophil-to-lymphocyte ratio (NLR). Methods Characteristics of MPM patients who underwent CRS combined HIPEC treatment, followed by adjuvant chemotherapy were retrospectively collected. The univariable analysis was performed to identify the decisive influential factor. Using Kaplan-Meier analysis, the cumulative probability of survival was determined. Using Univariate Cox analysis, the prognostic factors—particularly NLR—and its correlation with survival were assessed. In the multivariate Cox proportional hazards model, predictive factors that demonstrated significance in univariate analysis were used. The degree of connection between predictors and survival was evaluated through the use of hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results A total of 64 patients were enrolled in this study. The 1, 3, 5 years survival rates were 70.3%, 65.6%, 59.4%, respectively. According to multivariate Cox analysis, patients’ survival was found to be substantially associated with post-operative NLR (HR 0.180, 0.067–0.531), Ki-67 (HR 0.184, 0.024–0.817), post-operative neutrophil count (HR 0.228, 0.075–0.696), and bidirectional pathological type (HR, 0.375, 0.146–0.964). Conclusions NLR is associated with the patients’ prognosis after CRS combined HIPEC treatment.

Osteoporosis is characterized by reduced bone mass due to imbalanced bone metabolism. Exosomes derived from bone mesenchymal stem cells (BMSCs) have been shown to play roles in various diseases. This study aimed to clarify the regulatory function and molecular mechanism of BMSCs-derived exosomes in osteogenic differentiation and their potential therapeutic effects on osteoporosis. Exosomes were extracted from BMSCs. Bone marrow-derived macrophages (BMDMs) were cultured and internalized with BMSCs-derived exosomes. Real-time quantitative PCR was used to detect the expression of macrophage surface markers and tripartite motif (TRIM) family genes. BMDMs were co-cultured with human osteoblasts to assess osteogenic differentiation. Western blot was performed to analyze the ubiquitination of triggering receptor expressed on myeloid cell 1 (TREM1) mediated by TRIM25. An ovariectomized mice model was established to evaluate the role of TRIM25 and exosomes in osteoporosis. Exosomes were successfully isolated from BMSCs. BMSCs-derived exosomes upregulated TRIM25 expression, promoting M2 macrophage polarization and osteogenic differentiation. TRIM25 facilitated the ubiquitination and degradation of TREM1. Overexpression of TREM1 reversed the enhanced M2 macrophage polarization and osteogenic differentiation caused by TRIM25 overexpression. TRIM25 enhanced the protective effect of BMSCs-derived exosomes against bone loss in mice. These findings suggested that BMSCs-derived exosomes promoted osteogenic differentiation by regulating M2 macrophage polarization through TRIM25-mediated ubiquitination and degradation of TREM1. This mechanism might provide a novel approach for treating osteoporosis.

The purpose of this meta-analysis was to assess the effect of statins on major adverse cardiovascular events (MACE) related to coronary artery spasm (CAS) and to evaluate the effectiveness of statins in patients with CAS. A systematic search of electronic databases, including Google Scholar, the Cochrane Central Register of Controlled Trials, and PubMed, was conducted. These studies were all published in English, and the databases were searched from inception to July 2021. All articles were evaluated independently by 2 researchers on the basis of inclusion and exclusion criteria. In the research, data about the incidence of major adverse cardiovascular events in CAS patients undergoing statin therapy was included and divided into different subgroups. A random effects model was conducted to synthesize the data. Five cohort studies were included in the analysis. These results indicated that statins failed to reduce the incidence of stroke in patients with CAS in general. However, subgroup analysis revealed that statins were more effective in improving outcomes for CAS patients without severe coronary stenosis compared with those with severe coronary stenosis. Statins may have a potential benefit in patients with CAS who do not have coronary stenosis. To investigate these findings further, future prospective, randomized controlled research will be required.

This paper discusses desired disturbance response model + desired reference response model for simultaneously satisfying an impedance control and a position orientation tracking control for nonlinear hydraulic arms. First, we review hydraulic cylinder dynamics with nonlinear pressure dynamics. Second, through the reviewed hydraulic cylinder dynamics and an existing controller design procedure, we discuss two desired models for achieving an impedance control and a position orientation tracking control simultaneously. Finally, the effectiveness of the proposed desired models is confirmed by a preliminary indoor experiment including a simulated open channel.

To search for potential protein markers of colorectal cancer (CRC), the changes in protein expression levels between microdissected tumor cells and normal mucosa epithelia were analyzed by an acetylation stable isotopic labeling method coupled with linear quadrupole ion trap fourier transform mass spectrometry (LTQ‐FTMS). In total, 137 proteins were up‐regulated or down‐regulated significantly in cancer by at least two‐fold. Based on gene ontology analysis, the largest part of differential proteins were unknown for both subcellular localization and biological process. In particular, the significant up‐regulation of transgelin‐2 (TAGLN2) in CRC was validated by Western blot analysis and further evaluated by immunohistochemistry in paired tumor and normal mucosa samples from 120 consecutive CRC patients, 20 adenomas, and eight synchronous hepatic metastases of CRC. TAGLN2 expression was frequently observed in cancer cells, precancerous lesions, and hepatic metastases, whereas in normal epithelia expression was rarely observed. The overexpression of TAGLN2 was associated with lymph node and distant metastasis, advanced clinical stage (P < 0.001), and shorter overall survival in CRCs. Cox regression analysis indicated that high tumor‐TAGLN2 expression represents an independent prognostic factor. Consequently, over‐expression of TAGLN2 may serve as a new biomarker for predicting progression and prognosis of CRC. (Cancer Sci 2009)

Carbon fiber-reinforced polymer (CFRP) easily realizes the integrated manufacturing of components with high specific strength and stiffness, and it has become the preferred material in the aerospace field. Grinding is the key approach to realize precision parts and matching the positioning surface for assembly and precision. Hygroscopicity limits the application of flood lubrication in CFRP grinding, and dry grinding leads to large force, surface deterioration, and wheel clogging. To solve the above technical bottleneck, this study explored the grindability and frictional behavior of CNT biological lubricant MQL through grinding experiments and friction-wear tests. Results showed that the CNT biological lubricant reduced the friction coefficient by 53.47% compared with dry condition, showing optimal and durable antifriction characteristics. The new lubrication was beneficial to suppressing the removal of multifiber block debris, tensile fracture, and tensile-shear fracture, with the advantages of tribological properties and material removal behavior, the tangential and normal grinding force, and the specific grinding energy were reduced by 40.41%, 31.46%, and 55.78%, respectively, compared with dry grinding. The proposed method reduced surface roughness and obtained the optimal surface morphology by preventing burrs, fiber pull-out, and resin smearing, and wheel clogging was prevented by temperature reduction and lubricating oil film formation. S a and S q of the CNT biological lubricant were reduced by 8.4% and 7.9%, respectively, compared with dry grinding. This study provides a practical basis for further application of CNT biological lubricant in CFRP grinding.

More than ten Triassic syenite plutons are revealed to be distributed in North Korea along the boundary to South Korea. The Tokdal Complex is one of these but is unique in its incorporation of early pyroxenite cumulate in the clinopyroxene/amphibole/biotite/nepheline-bearing syenite main body. A SHRIMP U–Pb zircon age of 224 ± 4 Ma was obtained from a biotite syenite sample. Clinopyroxene in pyroxenite is zoned, with either phlogopite and apatite inclusion or ilmenite and magnetite exsolution, and may have resulted from crystallization at high pressure in an active continental margin arc environment followed by ascent and decompression. The pyroxenite and syenite are enriched in light REE and LILE, but strongly depleted in HFSE, with 87Sr/86Srt values of ~0.7115 and ϵNdt values of −14 to −20 (t = 224 Ma). The Tokdal Complex could have originated from an enriched lithospheric mantle and undergone assimilation of juvenile materials during differentiation. It indicates an extension of post-collisional magmatism in the Sino-Korean craton. This complex along with many other Triassic plutons in the Sino-Korean craton together constitute three syenite belts along the northern, southern and eastern margins of the craton, possibly resulting in its final configuration in eastern Asia.

Nanofluid minimum quantity lubrication (NMQL) technique has many technological and economic advantages in grinding operation. NMQL can improve grinding performance in terms of cooling and lubrication and is ecofriendly because it consumes a small amount of grinding fluid. Ultrasonic machining can improve grinding performance owing to its reciprocating vibration mechanism and furrow widening. Consequently, the simultaneous utilization of these techniques is anticipated to improve the surface quality, especially for hard brittle materials. In this research, multiangle two-dimensional (2D) ultrasonic vibration is utilized in zirconia ceramic grinding. Results reveal that the adhesion and material peeling phenomenon on the workpiece surface is obviously reduced compared with dry grinding without ultrasonic vibration. The synergistic effect of multiangle 2D ultrasonic and NMQL is also studied. With increased angle, the roughness value is found to initially increase (from 45° to 90°) and then decreases (from 90° to 135°). Moreover, the lubricating effect under 90° is the poorest, with the highest R a and RS m values of 0.703 μm and 0.106 mm, respectively; conversely, the minimum R a value (0.585 μm) is obtained under 45°, and the lowest RS m value (0.076 mm) is obtained under 135°.