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Accumulating data indicate that strigolactones (SLs) are implicated in the response to environmental stress, implying a potential effect of SLs on stomatal response and thus stress acclimatization. In this study, we investigated the molecular mechanism underlying the effect of SLs on stomatal response and their interrelation with abscisic acid (ABA) signaling. The impact of SLs on the stomatal response was investigated by conducting SL-feeding experiments and by analyzing SL-related mutants. The involvement of endogenous ABA and ABA-signaling components in SL-mediated stomatal closure was physiologically evaluated using genetic mutants. Pharmacological and genetic approaches were employed to examine hydrogen peroxide (H2O2) and nitric oxide (NO) production. SL-related mutants exhibited larger stomatal apertures, while exogenous SLs were able to induce stomatal closure and rescue the more widely opening stomata of SL-deficient mutants. The SL-biosynthetic genes were induced by abiotic stress in shoot tissues. Disruption of ABA-biosynthetic genes, as well as genes that function in guard cell ABA signaling, resulted in no impairment in SL-mediated stomatal response. However, disruption of MORE AXILLARY GROWTH2 (MAX2), DWARF14 (D14), and the anion channel gene SLOW ANION CHANNEL-ASSOCIATED 1 (SLAC1) impaired SL-triggered stomatal closure. SLs stimulated a marked increase in H2O2 and NO contents, which is required for stomatal closure. Our results suggest that SLs play a prominent role, together with H2O2/NO production and SLAC1 activation, in inducing stomatal closure in an ABA-independent mechanism.

The Zn/Cr-MOFs/TiO2 composites were synthesized using the solvothermal method. XRD, FTIR, and SEM techniques were utilized to characterize the Zn/Cr-MOFs/TiO2 composites employed for simulating levofloxacin hydrochloride in wastewater. The impact of the mass of the Zn/Cr-MOFs/TiO2 composite, concentration of levofloxacin hydrochloride, solution pH, and temperature on the adsorption performance was investigated. Experimental findings indicated that at pH 6, the maximum removal efficiency of levofloxacin hydrochloride by the Zn/Cr-MOFs/TiO2 composite was achieved at 88.8%, with an adsorption capacity of 246.3 mg/g. To analyze the experimental data, both pseudo-first-order and pseudo-second-order kinetics models were applied, revealing that the pseudo-second-order model provided a better fit to the data. Additionally, Langmuir and Freundlich isotherm models were used to study equilibrium adsorption behavior and showed good agreement with both kinetic modeling and Langmuir isotherm analysis results. These observations suggest that monolayer adsorption predominates during the removal process of levofloxacin hydrochloride by Zn/Cr-MOFs/TiO2 composites.

Lasers and electricity are commonly used energy sources in urological surgery. They all have both advantages and disadvantages in tissue removal efficiency and hemostasis, and it is difficult for them to replace one another in clinical practice. This study aimed to develop a special surgical tool which can simultaneously transmit high-power laser energy and conduct electricity for urologic surgical procedures. Since this tool integrates the function of conducting laser and electrical energy through a laser fiber, we call it integrated fiber. As a product of this study, the integrated fiber can connect with a thulium laser and a bipolar plasma generator simultaneously. Using this fiber, an ex vivo simulation of transurethral vaporization of porcine kidney tissues was conducted. In terms of tissue removal efficiency, the laser-plasma and the plasma group showed the highest and the lowest, respectively. For thermal damage, there was no significant difference between the laser-plasma and laser group. Though a prototype, with this integrated fiber, the combined laser-plasma energy can vaporize kidney tissue more efficiently without additional thermal damage. This integrated dual-functional laser-electric optical fiber shows good application prospects in urological surgery.

Red mud of low cost is regarded as a promising alternative to heterogeneous catalysts for activating peroxymonosulfate (PMS) to degrade m-cresol. Improper valence states of metal oxides and coated active substances in red mud greatly hampered its wide application. To solve this problem, the modified red mud (WRMG/700) was prepared by the pyrolysis reduction of glucose in N2 atmosphere. X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray photoelectron spectrum (XPS) analysis confirmed the production of Fe3O4, MnO and NiO in red mud and their gathering on the surface of particles. WRMG/700 exhibited the excellent performance toward PMS activation for the m-cresol degradation with 99.02% degradation efficiency and a pH-independent catalytic activity between initial pH 3–8. The removal efficiency of COD increased with the reaction time under the optimized degradation conditions. The free radical scavenging experiments and electron paramagnetic resonance (EPR) test confirmed 1O2 played a dominant role during m-cresol degradation in the WRMG/700/PMS system, implying m-cresol degradation was a non-radical oxidation process. Accordingly, the possible reaction mechanism was proposed. WRMG/700 retained its activation performance even after five recycles. This study showed a low cost and simple operation process for m-cresol elimination.

In this study, Co/Cd-MOFs were synthesized via a solvothermal method. The resulting material was subjected to calcination at 900 °C for 2 h and characterized using FT-IR, XRD, and SEM techniques to assess its efficacy in moxifloxacin removal. The experimental findings revealed that the maximum adsorption capacity of Co/Cd-MOFs for moxifloxacin was observed at 350.4 mg/g within a 5 h timeframe. Furthermore, the analysis based on the pseudo-second-order kinetic model demonstrated that the adsorption process adhered to this specific model. Additionally, the adsorption isotherm analysis indicated that Freundlich multilayer adsorption provided the best description of the interaction between moxifloxacin and the Co/Cd-MOF material. These experimental and theoretical results collectively suggest that employing Co/Cd-MOFs as adsorbents holds promise for wastewater treatment applications.

The objective of this study was to investigate the clinical significance and roles of tumor progression locus 2 (TPL2) and peptidyl-prolyl cis–trans isomerase 1 (Pin1) in the occurrence and development of breast invasive ductal carcinoma (IDC). Immunohistochemistry was used to detect the expression of TPL2 and Pin1 in human breast tissues, which included normal breast tissues (Normal), tissues with fibrocystic changes (FCC), ductal carcinoma in situ (DCIS), and IDC. The roles of TPL2 and Pin1 in the occurrence and development of IDC, as well as the correlation between their expression levels and clinicopathological parameters, were analyzed. Compared with Normal and FCC groups, the overexpression of TPL2 and Pin1 was significantly increased in DCIS and IDC groups (DCIS vs Normal: P  = 0.002/ P  < 0.001; IDC vs Normal: P  = 0.007/ P  = 0.003; DCIS vs. FCC: P  = 0.008/ P  = 0.004; IDC vs. FCC: P  = 0.04/ P  = 0.043). The expression levels of TPL2 and Pin1 were positively correlated in DCIS and IDC groups ( P  = 0.001, P  = 0.011). In the IDC group, the Ki67 level in the TPL2 overexpression group was significantly lower than that in the TPL2 low expression group ( P  = 0.02). The TPL2 overexpression rate was significantly higher in IDC with histological grades 1–2 than that in IDC with histological grade 3 ( P  = 0.029). The TPL2 overexpression rate in IDC with tumor-node-metastasis (TNM) stage I was significantly higher than that in IDC with TNM stages II–III ( P  = 0.035). We conclude that TPL2 and Pin1 may synergistically promote the occurrence and development of IDC, but TPL2 overexpression may be an early molecular event in IDC development. TPL2 overexpression is significantly related with IDC with lower malignancy or earlier TNM stage, suggesting that the prognosis of IDC patients with TPL2 overexpression may be better and TPL2 overexpression may be a predictor of good prognosis in IDC.

Clean fire extinguishing systems applicable to the pottery jar liquor warehouse are in demand. In this study, taking 53vol% liquor as the research subject, fire models of various clean fire extinguishing systems comprising water mist, liquid carbon dioxide (LCO 2 ) and liquid nitrogen (LN 2 ) were established using a fire dynamic simulator to determine their fire extinguishing effect. A feasibility assessment of systems was performed under different fire source types, fire source sizes, and ventilation conditions. The fire extinguishing efficiency was analyzed in terms of the fire extinguishing time, oxygen concentration, and space temperature. The results showed that the success rate of the LCO 2 and LN 2 fire extinguishing systems was 100%, whereas the success rate of the water mist fire extinguishing system was 95%. In terms of reducing the oxygen concentration at the bottom of the space and the temperature in the space, the LCO 2 system exhibited the best performance, followed by the LN 2 system, and lastly the water mist. Under different ventilation conditions and fire source types, the LCO 2 fire extinguishing system was least affected, whereas the effectiveness of the water mist fire extinguishing system reduced under natural ventilation conditions, and the extinguishing efficiency of the LN 2 fire extinguishing system was affected by the fire source type. Overall, the LCO 2 system presented more advantages in extinguishing fires in pottery jar liquor warehouses and can provide a new idea for the development and application of clean and efficient fire extinguishing systems.

To explore the correlation and spatial variation law of cadmium (Cd) in the soil around enterprises in the Fujiang River Basin, Global Moran's I and Anselin Local Moran's I were used to analyze the correlation, and the spatial structure was analyzed by using semivariogram. The results show that: the overall level of Cd in the soil around the enterprises in Fujiang River Basin is relatively low, which does not exceed the risk screening value of the national soil environmental quality standard in China (GB15618-2018), and only a few parts exceeded the risk screening value; The spatial correlations of Cd vary with the directions and distances. The distribution area of high-value clustering points and abnormal value points of soil Cd is small, most of the area belongs to the low-value cluster and insignificant points, which correlates with the number of distributed enterprises and the geological background to some extent. The spatial variation of Cd in soil is of moderate intensity, and the spatial differences vary with the directions, according to the order from large to small: 0° > 90° > 45° > 135°, the spatial differences are consistent with the distribution of local cold hot spots and outliers.

Glioma classification is crucial for effective diagnosis and treatment. Heat Shock Proteins (HSPs) have been associated with tumor development and progression. In this study, we established a prognostic model for glioma based on Heat Shock Proteins-associated genes (HSPGs). Using the Cancer Genome Atlas (TCGA) cohorts and the Chinese Glioma Genome Atlas (CGGA), we identified a signature of 4 HSPGs as an independent prognostic factor for glioma. The risk model demonstrated excellent performance in both training and validation sets. Additionally, we developed a nomogram incorporating clinical parameters and the HSPGs signature to enhance prognostic prediction. Immunoenrichment analysis revealed a correlation between the risk score and the immunosuppressive status of glioma. In the functional assays, HSPA5 was identified as a key participant in several critical biological processes associated with glioma. Silencing HSPA5 expression may lead to the inhibition of glioma cell proliferation, migration, invasion and resistance to apoptosis. These findings present a novel classification for glioma prognosis with enhanced accuracy and offer valuable insights into the potential use of HSPGs as prognostic indicators for gliomas.

In this paper, the Malan loess is considered as the research object, through the direct shear test and electron microscope scanning test (SEM test), and based on studying the macroscopic shear deformation of loess, the formation and evolution of the shear surface of Malan loess are analyzed from the macroscopic, microscopic and granular scales, and the microscopic mechanism of the shear deformation characteristics of Malan loess is deeply revealed. The test results show that the shear strength of soil is controlled by the moisture state and the stress state, and the shear strength parameters c and φ are mainly related to the moisture state. The dry density highly affects the cohesion, but has a small influence on the internal friction angle. On the macroscopic level, the larger the vertical load, the smaller the shear surface roughness. In addition, the higher the water content, the higher the flatness of the shear surface. On the microscopic level, some skeleton particles near the shear surface are damaged and rearranged along the shearing direction during the shearing process, and some surface scratches appear. On the granular level, the basic shearing structural functional units mainly include the “core–coat” covering structure and the aggregate structure, and the performance of the basic structural functional units is related to the moisture state and the stress state. The results and conclusions obtained in this study have an important reference significance for the in-depth understanding of the strength characteristics and microscopic mechanisms of loess as well as similar soil materials.