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Neurodegenerative diseases are prevalent and currently incurable conditions that progressively impair cognitive, behavioral, and psychiatric functions of the central or peripheral nervous system. Fibrinogen, a macromolecular glycoprotein, plays a crucial role in the inflammatory response and tissue repair in the human body and interacts with various nervous system cells due to its unique molecular structure. Accumulating evidence suggests that fibrinogen deposits in the brains of patients with neurodegenerative diseases. By regulating pathophysiological mechanisms and signaling pathways, fibrinogen can exacerbate the neuro-pathological features of neurodegenerative diseases, while depletion of fibrinogen contributes to the amelioration of cognitive function impairment in patients. This review comprehensively summarizes the molecular mechanisms and biological functions of fibrinogen in central nervous system cells and neurodegenerative diseases, including Alzheimer’s disease, Multiple Sclerosis, Parkinson’s disease, Vascular dementia, Huntington’s disease, and Amyotrophic Lateral Sclerosis. Additionally, we discuss the potential of fibrinogen-related treatments in the management of neurodegenerative disorders.

Alzheimer’s disease (AD) is the primary cause of dementia and is anticipated to impose a substantial economic burden in the future. Over a significant period, the widely accepted amyloid cascade hypothesis has guided research efforts, and the recent FDA approval of an anti- amyloid-beta (Aβ) protofibrils antibody, believed to decelerate AD progression, has further solidified its significance. However, the excessive emphasis placed on the amyloid cascade hypothesis has overshadowed the physiological nature of Aβ and tau proteins within axons. Axons, specialized neuronal structures, sustain damage during the early stages of AD, exerting a pivotal influence on disease progression. In this review, we present a comprehensive summary of the relationship between axonal damage and AD pathology, amalgamating the physiological roles of Aβ and tau proteins, along with the impact of AD risk genes such as APOE and TREM2. Furthermore, we underscore the exceptional significance of axonal damage in the context of AD.

Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B receptor (TrkB) are expressed in human osteoblasts and mediate fracture healing. BDNF/TrkB signaling activates Akt that phosphorylates and inhibits asparagine endopeptidase (AEP), which regulates the differentiation fate of human bone marrow stromal cells (hBMSC) and is altered in postmenopausal osteoporosis. Here we show that R13, a small molecular TrkB receptor agonist prodrug, inhibits AEP and promotes bone formation. Though both receptor activator of nuclear factor kappa-Β ligand (RANK-L) and osteoprotegerin (OPG) induced by ovariectomy (OVX) remain comparable between WT and BDNF+/− mice, R13 treatment significantly elevates OPG in both mice without altering RANKL, blocking trabecular bone loss. Strikingly, both R13 and anti-RANK-L exhibit equivalent therapeutic efficacy. Moreover, OVX increases RANK-L and OPG in WT and AEP KO mice with RANK-L/OPG ratio lower in the latter than the former, attenuating bone turnover. 7,8-DHF, released from R13, activates TrkB and its downstream effector CREB, which is critical for OPG augmentation. Consequently, 7,8-DHF represses C/EBPβ/AEP pathway, inhibiting RANK-L-induced RAW264.7 osteoclastogenesis. Therefore, our findings support that R13 exerts its therapeutic efficacy toward osteoporosis via inhibiting AEP and escalating OPG. BDNS and TrkB are involved in bone fracture healing by inhibiting AEP. Here the authors show that a TrkB agonist prodrug can inhibit AEP and promote bone formation in osteoporotic mice.

Acute pancreatitis (AP) can result in acute kidney injury (AKI), which is linked to poor outcomes. We aimed to assess the relationship between the hematocrit-to-albumin ratio (HAR) and AKI in this population. This retrospective cohort study included consecutive patients diagnosed with AP and admitted to hospital. Data were systematically extracted from electronic medical records, covering baseline demographic and clinical characteristics. Total 1514 AP patients were enrolled, with 17% (257/1514) developing AKI. Multivariable-adjusted regression analysis, curve fitting, threshold effects analyses, and subgroup analyses were conducted to evaluate the relationship between HAR and AKI incidence in AP patients. Compared to the reference tertile of HAR, the adjusted OR values for the lower and higher tertiles of HAR were 1.25 (95% CI, 0.82–1.91, P  = 0.297) and 1.50 (95% CI, 1.03–2.20, P  = 0.037), respectively, after adjusting for covariates. The curve fitting results showed a J-shaped relationship between HAR and AKI (non-linear, p  = 0.001), with an inflection point of 8.969. Furthermore, validation using the Medical Information Mart for Intensive Care (MIMIC-IV) database AP population revealed a similar relationship with an inflection point at 10.257. Our findings suggest a J-shaped relationship between HAR and AKI in AP patients, indicating higher risk of AKI when HAR exceeds 8.969.

Global changes threaten marine species, making marine climate refugia essential for biodiversity conservation and climate change mitigation. Our analysis maps sensitive and stability zones across the global ocean. We define marine climate refugia as climate-resilient zones with global conservation consensus under the worst-case emissions scenario for 2100. Marine climate refugia span 17.6 million square kilometres, with 96% within exclusive economic zones. Only 34% of oceanic areas and 29% of marine protected areas (MPAs) and other effective area-based conservation measures (OECMs) lie in stability zones. Twenty large-scale patches form the principal bodies of marine climate refugia, with 85% crossing multiple exclusive economic zones. Conservation gaps cover 70% of marine climate refugia. Closing these gaps could increase global ocean protection to 14% and exclusive economic zones protection to 30%. To achieve the 30 by 30 target, we recommend expanding MPAs and OECMs based on marine climate refugia locations and addressing transnational management challenges. Zhuang et al. define climate-resilient zones with global conservation consensus as marine climate refuges. They find that only 14% of marine protected areas and other effective area-based conservation measures are within these refuges, highlighting the need to expand marine conservation coverage.

The mining and smelting of manganese ores and the accumulation of slag not only pollute the environment and increase the threat to biodiversity, but also adversely affect the health of human and other organisms. Therefore, it’s important to study the restoration of manganese mining area. Since mosses play an irreplaceable role in the ecological restoration of mine sites, this study is carried out in a slag heap area that has been in continuous operation for about 50 years, and spatial variation is used instead of temporal variation to study the diversity of moss plants, the characteristics of soil heavy metal changes under moss cover, and the characteristics of bacterial communities in manganese mine sites at different time scales. A total of 20 moss taxa from 8 genera and 5 families are recorded, the dominant families are Bryaceae (50%) and Pottiaceae (25%), with the development of succession, the alpha-diversity index of mosses increases with the development of succession. The study area has a relatively high level of heavy metal contamination, the heavy metals Mn, V, Cu and Ni are significantly affected by succession in the Manganese mining area, and the soil heavy metal content generally shows a decreasing trend with the development of succession. Actinobacteriota, Proteobacteria, Chloroflexi Acidobacteriota and Gemmatimonadota are the dominant soil bacterial phyla in manganese mining areas (relative abundance > 10%), the composition of soil bacteria at different successional stages at the phylum level was the same, but the abundance of each bacterial community differed. The soil bacterial community in the manganese mining area is significantly affected by soil heavy metals.

Background The Diplolepideae are the larger group within the Arthrodontae mosses, characterized by peristomes formed from residual cell walls. It is now understood that these peristomes exhibit diverse hygroscopic movements, playing a crucial role in spore release. However, the exact mechanism behind this movement remains unclear, lacking direct evidence. This study investigated the microscopic and submicroscopic structures of the peristomes in three Diplolepideae species: Hypopterygium fauriei (Besch.), Pylaisia levieri (Müll. Hal.) Arikawa and Regmatodon declinatus (Hook.) Brid. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to reveal the differences in their hygroscopic movement mechanisms. Results The three species exhibited distinct responses upon wetting: H. fauriei ’s exostome closed inwards, P. levieri ’ opened outwards, and R. declinatus ’ elongated significantly. These differences are attributed to the varying microfibril deposition in the exostome layers. Uniform deposition in the inner layer and minimal deposition in the outer layer enabled exostome opening upon wetting and closing when dry. Our findings suggest that the diastole and contraction of fine microfibrils in the exostome plates and ridges are the key drivers of hygroscopic movement. Conclusions This study provides further evidence at both the structural and submicroscopic levels, contributing to the unraveling of the hygroscopic movement mechanism in Diplolepideae peristomes. This enhanced understanding sheds light on the relationship between peristome structure and function.

Background Lima bean ( Phaseolus lunatus L.) is a member of subfamily Phaseolinae belonging to the family Leguminosae and an important source of plant proteins for the human diet. As we all know, lima beans have important economic value and great diversity. However, our knowledge of the chloroplast genome level of lima beans is limited. Results The chloroplast genome of lima bean was obtained by Illumina sequencing technology for the first time. The Cp genome with a length of 150,902 bp, including a pair of inverted repeats (IRA and IRB 26543 bp each), a large single-copy (LSC 80218 bp) and a small single-copy region (SSC 17598 bp). In total, 124 unique genes including 82 protein-coding genes, 34 tRNA genes, and 8 rRNA genes were identified in the P. lunatus Cp genome. A total of 61 long repeats and 290 SSRs were detected in the lima bean Cp genome. It has a typical 50 kb inversion of the Leguminosae family and an 70 kb inversion to subtribe Phaseolinae. rpl16 , accD , petB , rsp16 , clpP , ndhA , ndhF and ycf1 genes in coding regions was found significant variation, the intergenic regions of trnk - rbcL , rbcL - atpB , ndhJ - rps4 , psbD - rpoB , atpI - atpA , atpA - accD , accD - psbJ , psbE - psbB , rsp11 - rsp19 , ndhF - ccsA was found in a high degree of divergence. A phylogenetic analysis showed that P. lunatus appears to be more closely related to P. vulgaris , V.unguiculata and V. radiata . Conclusions The characteristics of the lima bean Cp genome was identified for the first time, these results will provide useful insights for species identification, evolutionary studies and molecular biology research.

Karst desertification (KD) is a major ecological and environmental problem threatening human survival and development in karst areas. In order to explore the research situation and development trend of KD based on forest ecology, this paper provides a systematic literature review based on the CNKI and WoS databases, which involves search, appraisal, synthesis, and analysis. We performed a statistical and visual analysis of 2955 studies acquired between 1 January 1995 and 30 June 2023, including the time distribution of the studies, hot research trends, pivotal research clusters, literature co-citations, main publishing trends, and keyword bursts. The results show the following. (1) The literature shows a fluctuating growth trend, and the research trends are divided into accumulation, development, and expansion stages. (2) The pivotal research clusters comprised three major aspects: study area and method, driving and genetic mechanisms, and control technology and models. (3) KD research forms a China-centered research network, dominated by institutions and scholars in southwestern China. (4) Future research needs to solve a series of related scientific issues and technological needs for forest ecosystem function optimization, ecological product supply capacity enhancement, ecological product value realization, ecological industry formation, and rural revitalization in KD control. The purpose of this paper is to reveal research trends relating to KD and highlight the future direction of KD research and control.

The Zhanjiang Mangrove National Nature Reserve (ZMNNR) is the largest mangrove in China. However, fluxes of lateral exports of dissolved inorganic carbon (DIC), dissolved organic carbon (DOC), and nitrate from the ZMNNR remain unknown, hindering us from evaluating its blue carbon capacity and its resilience to environmental changes. We conducted a comprehensive study of temporal variations in DIC, DOC, nitrate, and sulfate in creek and pore waters, and time-series measurements of 222 Rn in creek waters, in response to tidal cycles. Nitrate and sulfate concentrations varied in tidal cycles, forming a tightly negative correlation. DIC and DOC were significantly rich in, but nitrate was substantially depleted in pore waters compared to creek waters. Depleted δ 13 C values of DIC and DOC in tidal creek waters suggest that both of them were predominantly from organic matter derived from mangroves. Radiocarbon ages of DIC ranged from 149 to 236 years, suggesting minimal or absent mineralization of aged (i.e., centuries-old) organic matter. Time-series measurements of 222 Rn in creek waters revealed pore water exchange rate at 14.2 ± 24.5 cm d −1 , and the lateral fluxes of DIC and DOC from the mangroves to the neighboring Yingluo Bay, based on an FVCOM model, were 411.6 ± 311.8 and 104.5 ± 145.7 mmol m −2 d −1 , respectively. Outwelling fluxes of dissolved carbon were estimated to be equivalent to 7.7% ± 6.8% of annual carbon fixed by mangroves in the study area. The flux of nitrate from the study area to Yingluo Bay was 8.5 ± 7.6 mmol m −2 d −1 , making mangroves the sink of nitrate and the source of ammonium.