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"Zhao, Li"
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Genetic landscape of esophageal squamous cell carcinoma
Jie He and colleagues report exome sequencing of 113 tumor-normal pairs of esophageal squamous cell carcinoma. They highlight mutations in genes involved in cell cycle and apoptosis regulation, histone modifier genes and genes encoding members of the Hippo and Notch pathways.
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers
1
. We performed exome sequencing on 113 tumor-normal pairs, yielding a mean of 82 non-silent mutations per tumor, and 8 cell lines. The mutational profile of ESCC closely resembles those of squamous cell carcinomas of other tissues but differs from that of esophageal adenocarcinoma. Genes involved in cell cycle and apoptosis regulation were mutated in 99% of cases by somatic alterations of
TP53
(93%),
CCND1
(33%),
CDKN2A
(20%),
NFE2L2
(10%) and
RB1
(9%). Histone modifier genes were frequently mutated, including
KMT2D
(also called
MLL2
; 19%),
KMT2C
(
MLL3
; 6%),
KDM6A
(7%),
EP300
(10%) and
CREBBP
(6%).
EP300
mutations were associated with poor survival. The Hippo and Notch pathways were dysregulated by mutations in
FAT1
,
FAT2
,
FAT3
or
FAT4
(27%) or
AJUBA
(
JUB
; 7%) and
NOTCH1
,
NOTCH2
or
NOTCH3
(22%) or
FBXW7
(5%), respectively. These results define the mutational landscape of ESCC and highlight mutations in epigenetic modulators with prognostic and potentially therapeutic implications.
Journal Article
The hospitality and tourism industry in ASEAN and East Asian destinations : new growth, trends, and developments
\"This new volume addresses the growing interest to understand tourism and hospitality in Southeast and South Asia, two regions that have seen tremendous growth in international tourists in recent years. It explores the current development of hospitality and tourism industry in the regions of Hong Kong, Macao and Taiwan as well as other key countries in Southeast and South Asia. The Hospitality and Tourism Industry in ASEAN and East Asian Destinations: New Growth, Trends, and Developments provides updated findings and case studies that highlight opportunities and issues of tourism and hospitality development in ASEAN. Chapters cover such diverse topics as online marketing strategies, sustainable hospitality development, diversification efforts of the tourism industry Innovations in independent hotels, wildlife tourism in urban destinations, the Vietnamese national park system, consumers' positive and negative images of certain destinations. While academicians will benefit from the updated research findings summarized by the respected scholars, hospitality professionals will also find the book a valuable source of information as the chapters delve into the most recent topical and industry focused issues.\"-- Provided by publisher.
Book
Protective effects of trimetazidine and coenzyme Q10 on cisplatin-induced cardiotoxicity by alleviating oxidative stress and mitochondrial dysfunction
The objective of this study was to investigate the effects of trimetazidine (TMZ) and coenzyme Q10 (CoQ10) on cisplatin-induced cardiotoxicity in rat cardiomyocytes.
Rat cardiomyocytes were isolated and subjected to cisplatin (200 μM) treatment with and without TMZ (200 μM) and CoQ10 (200 mg/L) pretreatment. The cell viability, apoptosis, oxidant and antioxidant indicators, and mitochondrial dysfunction were examined.
TMZ or CoQ10 significantly attenuated cisplatin-induced cell viability inhibition (p<0.01) and apoptosis (p<0.001), and the combined use of TMZ and CoQ10 pretreatment exerted a pronounced effect compared to the effects of using each of these agents individually (p<0.05). TMZ or CoQ10 inhibited the levels of reactive oxidative species (ROS, p<0.01) and malondialdehyde (MDA, p<0.001 and p<0.01, respectively), elevated the activities of antioxidant enzymes superoxide dismutase (SOD, p<0.01) and catalase (CAT, p<0.01 and p<0.05, respectively), evidently enhanced nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2, p<0.05), alleviated mitochondrial membrane potential (ΔΨm) loss (p<0.05), and down-regulated the release of cytochrome c (cyto-c) into the cytosol (p<0.01) in cisplatin-treated cells. The combined use of TMZ and CoQ10 treatment was more effective than using either agent alone (p<0.01 for ROS, MDA, CAT, and cytosolic cyto-c; p<0.05 for SOD, nuclear Nrf2, and ΔΨm loss).
TMZ and CoQ10 showed protective effects against cisplatin-induced cardiotoxicity via attenuating oxidative stress.
Journal Article
المتاحف الصينية /
يتناول كتاب (المتاحف الصينية) والذي قام بتأليفه (لي شيا نياو، لوه تشهون) في حوالي (195) صفحة من القطع المتوسط موضوع (المتاحف) مستعرضا المحتويات التالية : قراءة حضارة الأمة الصينية من المتاحف-الكنوز في الوطن-المساهمات من الأقليات القومية في الصين-البحث عن أصل التاريخ-كنوز الكهوف الحجرية الصينية-القصورتحت الأرض-الحضارة الصينية-البلوارت الإنسانية-أم الحدائق-موطن الأسلاف-السماء السوداء والأرض الصفراء.
Book
Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library
Recent years have witnessed rapid progress in the field of epitranscriptomics. Functional interpretation of the epitranscriptome relies on sequencing technologies that determine the location and stoichiometry of various RNA modifications. However, contradictory results have been reported among studies, bringing the biological impacts of certain RNA modifications into doubt. Here, we develop a synthetic RNA library resembling the endogenous transcriptome but without any RNA modification. By incorporating this modification-free RNA library into established mapping techniques as a negative control, we reveal abundant false positives resulting from sequence bias or RNA structure. After calibration, precise and quantitative mapping expands the understanding of two representative modification types, N6-methyladenosine (m6A) and 5-methylcytosine (m5C). We propose that this approach provides a systematic solution for the calibration of various RNA-modification mappings and holds great promise in epitranscriptomic studies.This work describes the generation of a modification-free RNA library that resembles endogenous transcriptome sequence and expression level, which can be used as a negative control in epitranscriptomic sequencing methods to obtain high-confidence and quantitative maps of various RNA modifications.
Journal Article
Transcriptomic and Metabolomic Analyses Reveal Key Metabolites, Pathways and Candidate Genes in Sophora davidii (Franch.) Skeels Seedlings Under Drought Stress
Soil aridification and desertification are particularly prominent in China’s karst areas, severely limiting crop yields and vegetation restoration. Therefore, it is very important to identify naturally drought-tolerant plant species. Sophora davidii (Franch.) Skeels is resistant to drought and soil infertility, is deeply rooted and is an excellent plant material for soil and water conservation. We studied the transcriptomic and metabolomic changes in S. davidii in response to drought stress (CK, control; LD, mild drought stress; MD, moderate drought stress; and SD, severe drought stress). Sophora davidii grew normally under LD and MD stress but was inhibited under SD stress; the malondialdehyde (MDA), hydrogen peroxide (H 2 O 2 ), soluble sugar, proline, chlorophyll a, chlorophyll b and carotenoid contents and ascorbate peroxidase (APX) activity significantly increased, while the superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activities and soluble protein content significantly decreased. In the LD/CK, MD/CK and SD/CK comparison groups, there were 318, 734 and 1779 DEGs, respectively, and 100, 168 and 281 differentially accumulated metabolites, respectively. Combined analysis of the transcriptomic and metabolomic data revealed the metabolic regulation of S. davidii in response to drought stress. First, key candidate genes such as PRR7 , PRR5 , GI , ELF3 , PsbQ , PsaK , INV , AMY , E2.4.1.13 , E3.2.1.2 , NCED , PP2C , PYL , ABF , WRKY33 , P5CS , PRODH , AOC3 , HPD , GPX , GST , CAT and SOD1 may govern the drought resistance of S. davidii . Second, three metabolites (oxidised glutathione, abscisic acid and phenylalanine) were found to be related to drought tolerance. Third, several key candidate genes and metabolites involved in 10 metabolic pathways were identified, indicating that these metabolic pathways play an important role in the response to drought in S. davidii and possibly other plant species.
Journal Article
Slowing down the heat in thermoelectrics
Heat transport has various applications in solid materials. In particular, the thermoelectric technology provides an alternative approach to traditional methods for waste heat recovery and solid‐state refrigeration by enabling direct and reversible conversion between heat and electricity. For enhancing the thermoelectric performance of the materials, attempts must be made to slow down the heat transport by minimizing their thermal conductivity (κ). In this study, a continuously developing heat transport model is reviewed first. Theoretical models for predicting the lattice thermal conductivity (κlat) of materials are summarized, which are significant for the rapid screening of thermoelectric materials with low κlat. Moreover, typical strategies, including the introduction of extrinsic phonon scattering centers with multidimensions and internal physical mechanisms of materials with intrinsically low κlat, for slowing down the heat transport are outlined. Extrinsic defect centers with multidimensions substantially scatter various‐frequency phonons; the intrinsically low κlat in materials with various crystal structures can be attributed to the strong anharmonicity resulting from weak chemical bonding, resonant bonding, low‐lying optical modes, liquid‐like sublattices, off‐center atoms, and complex crystal structures. This review provides an overall understanding of heat transport in thermoelectric materials and proposes effective approaches for slowing down the heat transport to depress κlat for the enhancement of thermoelectric performance. This review focuses on the recent progress of heat transport and thermal conductivity manipulation in thermoelectric materials. The heat transport models and strategies of both the extrinsic multidimensional defects scattering and intrinsic phonon–phonon scattering in various crystal structures, to reduce the thermal conductivity are summarized and discussed.
Journal Article