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Lithium‐ion batteries with fast-charging/discharging properties are urgently needed for the mass adoption of electric vehicles. Here, we show that fast charging/discharging, long-term stable and high energy charge-storage properties can be realized in an artificial electrode made from a mixed electronic/ionic conductor material (Fe/Li x M, where M = O, F, S, N) enabled by a space charge principle. Particularly, the Fe/Li 2 O electrode is able to be charged/discharged to 126 mAh g −1 in 6 s at a high current density of up to 50 A g −1 , and it also shows stable cycling performance for 30,000 cycles at a current density of 10 A g −1 , with a mass-loading of ~2.5 mg cm −2 of the electrode materials. This study demonstrates the critical role of the space charge storage mechanism in advancing electrochemical energy storage and provides an unconventional perspective for designing high-performance anode materials for lithium-ion batteries. Lithium-ion batteries with fast-charging properties are urgently needed for wide adoption of electric vehicles. Here, the authors show a fast charging/discharging and long-term stable electrode made from a mixed electronic/ionic conductor material enabled by a space charge mechanism.

Background Pancreatic adenocarcinoma (PAAD) is a leading cause of malignancy-related deaths worldwide, and the efficacy of immunotherapy on PAAD is limited. Studies report that long non-coding RNAs (lncRNAs) play an important role in modulating genomic instability and immunotherapy. However, the identification of genome instability-related lncRNAs and their clinical significance has not been investigated in PAAD. Methods The current study developed a computational framework for mutation hypothesis based on lncRNA expression profile and somatic mutation spectrum in pancreatic adenocarcinoma genome. We explored the potential of GInLncRNAs(genome instability-related lncRNAs) through co-expression analysis and function enrichment analysis. We further analyzed GInLncRNAs by Cox regression and used the results to construct a prognostic lncRNA signature. Finally, we analyzed the relationship between GILncSig (genomic instability derived 3-lncRNA signature) and immunotherapy. Results A GILncSig was developed using bioinformatics analyses. It could divide patients into high-risk and low-risk groups, and there was a significant difference in OS between the two groups. In addition, GILncSig was associated with genome mutation rate in pancreatic adenocarcinoma, indicating its potential value as a marker for genomic instability. The GILncSig accurately grouped wild type patients of KRAS into two risk groups. The prognosis of the low-risk group was significantly improved. GILncSig was significantly correlated with the level of immune cell infiltration and immune checkpoint. Conclusions In summary, the current study provides a basis for further studies on the role of lncRNA in genomic instability and immunotherapy. The study provides a novel method for identification of cancer biomarkers related to genomic instability and immunotherapy.

Natural hydraulic lime (NHL) can be used as an inorganic cementitious material, as it exhibits low shrinkage, salt-alkali resistance, moderate strength, and good durability with cultural relics. There has been increasing interest in NHL, as it is considered an appropriate material for the restoration and reinforcement of architectural cultural relics. In this study, limestone and potassium feldspar were mixed and calcined at different ratios and high temperatures, and artificial hydraulic lime (HL) was produced. According to the X-ray diffraction (XRD) results, the resulting products after high-temperature calcination were mainly composed of calcium oxide, dicalcium silicate (C2S), and dicalcium aluminosilicate (C2AS). As a compromise, when potassium feldspar accounted for 30% of the total mass, HL contains a more suitable air-hardening component and hydraulic component. Scanning electron microscope (SEM) and Energy Dispersive Spectrometer (EDS) analyses show that the phases of calcium carbonate (CaCO3) and hydrated calcium silicate (C-S-H) gradually increased with prolonged curing time for HL. To study the partial mechanical properties and durability of HL, a comparison was made with NHL. The mechanical properties were investigated with the flexural and compressive strengths and shrinkage. The results show that HL has higher strength than NHL, but NHL has smaller shrinkage. Accelerated aging tests indicated that HL and NHL5 led to higher resistance to water immersion, fluctuations in temperature and humidity, sulphate decay, an alkali environment, and frost–thaw action than NHL2. HL has excellent mechanical properties and durability and can be considered a conservation material for stone relics in the future.

The performance of electrode materials depends intensively on the lithium (Li)‐ion storage mechanisms correlating ultimately with the Coulombic efficiency, reversible capacity, and morphology variation of electrode material upon cycling. Transition metal nitrides anode materials have exhibited high‐energy density and superior rate capability; however, the intrinsic mechanism is largely unexplored and still unclear. Here, a typical 3D porous Fe2N micro‐coral anode is prepared and, an intercalation–conversion–heterogeneity hybrid Li‐ion storage mechanism that is beyond the conventional intercalation or conversion reaction is revealed through various characterization techniques and thermodynamic analysis. Interestingly, using advanced in situ magnetometry, the ratio (ca. 24.4%) of the part where conversion reaction occurs to the entire Fe2N can further be quantified. By rationally constructing a Li‐ion capacitor comprising 3D porous Fe2N micro‐corals anode and commercial AC cathode, the hybrid full device delivers a high energy‐density (157 Wh kg−1) and high power‐density (20 000 W kg−1), as well as outstanding cycling stability (93.5% capacitance retention after 5000 cycles). This research provides an original and insightful method to confirm the reaction mechanism of material related to transition metals and a fundamental basis for emerging fast charging electrode materials to be efficiently explored for a next‐generation battery. Combining various characterization techniques and thermodynamic analysis, the Li‐ion storage process in transition metal nitrides (TMNs) is reacquainted, showing an intercalation–conversion–heterogeneity hybrid mechanism, which may be one of the reasons for the fast charging and high energy output of TMNs electrode materials.

Salmonella enteritidis (SE) infection disrupts the homeostasis of the intestinal microbiota, causing an intestinal inflammatory response and posing a great threat to human and animal health. The unreasonable use of antibiotics has led to an increase in the prevalence of drug-resistant SE, increasing the difficulty of controlling SE. Therefore, new drug strategies and research are urgently needed to control SE. Rosmarinic acid (RA) is a natural phenolic acid with various pharmacological activities, including antioxidant, anti-inflammatory and antibacterial properties. However, the protective effects and mechanism of RA on intestinal inflammation and the gut microbial disorders caused by SE have not been fully elucidated. In this study, RAW264.7 cells, MCECs and BALB/c mice were challenged with SE to assess the protective effects and mechanisms of RA. The results showed that RA enhanced the phagocytic ability of RAW264.7 cells, reduced the invasion and adhesion ability of SE in MCECs, and inhibited SE-induced inflammation in cells. Moreover, RA inhibited the activation of the NF-κB signaling pathway by upregulating TLR9 expression. Importantly, we found that RA provided protection against SE and increased the diversity and abundance of the intestinal microbiota in mice. Compared with infection control, RA significantly increased the abundance of Firmicutes and Acidibacteria and decreased the abundance of Proteobacteria, Epsilonbacteraeota and Bacteroidota. However, RA failed to alleviate SE-induced inflammation and lost its regulatory effects on the TLR9/NF-κB signaling pathway after destroying the gut microbiota with broad-spectrum antibiotics. These results indicated that RA attenuated SE-induced inflammation by regulating the TLR9/NF-κB signaling pathway and maintaining the homeostasis of the gut microbiota. Our study provides a new strategy for preventing SE-induced intestinal inflammation.

Silicate material is one of the most typical materials used in both traditional and modern buildings. This paper presents a comparative analysis of two silicate materials (ginger nut and Aga soil) used in ancient Chinese buildings. The research suggests that ginger nut and Aga soil have similar chemical compositions and physical properties. After they are burned at a temperature of 700°C ~ 1400°C, they will have a dual characteristic of hydraulicity and non-hydraulicity. As the temperature rises, the non-hydraulic constituent increases at first and then decreases, while the hydraulic constituent is increasing regularly. Their chemical composition and characteristics are similar to those of the “hydraulic lime” in Europe, and the modified ginger nut and Aga soil can be used for repairing and reinforcing the stone, earthen, brick and ceramic relics.

Differences in housing prices and rental prices across cities or regions and the relationship between prices and socioeconomic fundamentals are frequent research foci in urban and real estate economics, but the existing studies on China's housing market rarely consider both housing price and rent. This study provides a framework for a quantitative analysis of a country's housing market from the perspective of supply and demand, and takes China's housing market as a case study. The current study first explores the key factors that affect housing prices and rental prices using data from 202 cities and collected from 2011 to 2014. Then, theoretical values of housing prices and rental prices in each city are estimated, and the spatiotemporal characteristics of deviation of housing prices and rental prices are analysed. The empirical findings of the current study mainly reveal the following three points. First, the determinants of housing prices and rental prices have similarities. Second, the effect of above factors shows obvious spatial heterogeneity. The coefficients of the variables are different between coastal and inland regions, indicating different demand and supply elasticities across regions. Third, the price deviation presents significant spatial agglomeration. Cities with higher price deviations are clustered in the Yangtze River Delta and Beijing-Tianjin-Hebei, while the price deviations are relatively mild in the Pearl River Delta region.

With the rapid development of urbanization, high-intensity human activities in Beijing profoundly impact the changes of ecological environment, especially on vegetation coverage. Vegetation can provide a variety of ecological services for the city. Based on the data of NDVI (Normalized vegetation Index) from 2000 to 2019, the study analysed the Spatio-temporal changes of vegetation variation and land use pattern in Beijing by GIS analysis. The proportion of the significantly increased pixels of NDVI occupied 76.71% while that of the significantly decreased pixels only occupied 4.99% of the total. The significant positive trends of NDVI were concentrated in the urban core functional areas within the Fifth Ring Road and in the northern and western mountainous areas. The significant negative trends of NDVI were concentrated from the 5th Ring Road to the outside areas of the 6th Ring Road. And the gradual change of land use type is a prominent feature in significantly positive trend area. The reflection of the vegetation coverage and land use change on a large time scale in Beijing has a certain reference value for future land pattern planning and urban policy revision.

A couple with a proband child of GJB2 （encoding the gap junction protein connexin 26）-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a cus- tomized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagno- sis （PGD）, noninvasive prenatal testing （NIPT）, and noninvasive prenatal diagnosis （N1PD） into the strategy. Auditory and ge- netic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2c.235delC heterozygous embryo resulted in a sin- gleton pregnancy. At the 13th week of gestation, genomic DNA （gDNA） from the trio family and cell-free DNA （cfDNA） from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by inva- sire procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing im- pairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders.