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"Zhao, Yang"
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The Impact of Green Finance on High-Quality Economic Development in China: Vertical Fiscal Imbalance as the Moderating Effect
The vigorous development of green finance has become a national strategy in China. Green finance is gradually becoming a key driver of high-quality economic development and a key area of concern for China’s economy and ecological environment. Based on the panel data of 30 Chinese provinces from 2001 to 2019, we analyzed the impact and mechanism of vertical fiscal imbalance (VFI) and green finance (GF) on high-quality economic development (HQD) and then used the fixed-effect model and spatial Durbin model for empirical testing. We found that GF can significantly contribute to HQD, but VFI has a negative moderating effect in contrast to the positive effect of GF on HQD. This negative moderating effect is strongest in the central region. According to the analysis of the spatial econometric model based on geography, economy, and the nested spatial weight matrix, we found that the local GF has a negative spatial transmission effect on the HQD of other regions. Therefore, it is recommended that the coordinated development of green finance among regions be promoted, while affairs and expenditure responsibilities be reasonably distributed between the central and local governments to drive HQD effectively.
Journal Article
First principles calculation of interface interactions and photoelectric properties of ZnSe/SnSe heterostructure
Heterostructure engineering is an effective technology to improve photo-electronic properties of two dimensional layered semiconductors. In this paper, based on first principles method, we studied the structure, stability, energy band, and optical properties of ZnSe/SnSe heterostructure change with film layer. Results show that all heterostructures are the type-II band arrangement, and the interlayer interaction is characterized by van der Waals. The electron concentration and charge density difference implies the electron (holes) transition from SnSe to monolayer ZnSe. By increasing the layer of SnSe films, the quantum effects are weakened leading to the band gap reduced, and eventually show metal properties. The optical properties also have obvious change, the excellent absorption ability of ZnSe/SnSe heterostructures mainly near the infrared spectroscopy. These works suggest that ZnSe/SnSe heterostructure has significant potential for future optoelectronic applications.
Journal Article
Nanotechnology for Cancer Therapy Based on Chemotherapy
Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.
Journal Article
Investigating Land Surface Effects on the Moisture Transport over South America with a Moisture Tagging Model
Land–atmosphere interactions are a critical component of precipitation processes within the Amazon basin and La Plata River basin (LPRB) in South America. Two of the possible pathways through which the land surface can affect precipitation are 1) by changing the amount of moisture available for precipitation (moisture recycling) and 2) by changing the atmospheric thermal structure and consequently affecting circulation patterns. In this study, the Weather Research and Forecasting (WRF) Model with embedded water vapor tracers (WVT) is used to disentangle these relative contributions, with a particular focus on the precipitation of LPRB. Using WRF-WVT we track the moisture that originates from the Amazon basin over a 10-yr period. It is estimated that Amazon evapotranspiration (ET) contributes to around 30% of the total precipitation over the Amazon and around 16% over the LPRB. Focusing on large-scale circulation patterns that transport moisture into the LPRB, we show that land surface conditions in northwestern Argentina are critical for the meridional transport of moisture to higher latitudes via Chaco jet events (CJEs). Warm surface air temperature associated with dry soil moisture over northwestern Argentina is linked to enhanced CJE northerly low-level winds that intensify moisture transport by changing continental-scale circulation patterns. WRF sensitivity tests confirm that soil moisture variations over this region affect meridional moisture transport.
Journal Article
Ligand engineering to achieve enhanced ratiometric oxygen sensing in a silver cluster-based metal-organic framework
Ratiometric luminescent oxygen sensing based on dual fluorescence and phosphorescence emission in a single matrix is highly desirable, yet the designed synthesis remains challenging. Silver-chalcogenolate-cluster-based metal-organic frameworks that combine the advantages of silver clusters and metal-organic frameworks have displayed unique luminescent properties. Herein, we rationally introduce −NH
2
groups on the linkers of a silver-chalcogenolate-cluster-based metal-organic framework (Ag
12
bpy-NH
2
) to tune the intersystem crossing, achieving a dual fluorescence-phosphorescence emission from the same linker chromophore. The blue fluorescence component has a 100-nm gap in wavelength and 8,500,000-fold difference in lifetime relative to a yellow phosphorescence component. Ag
12
bpy-NH
2
quantifies oxygen during hypoxia with the limit of detection of as low as 0.1 ppm and 0.3 s response time, which is visualized by the naked eye. Our work shows that metal cluster-based MOFs have great potential in luminescent sensing, and the longer-lived charge-separated states could find more photofunctional applications in solar energy transformation and photocatalysis.
Incorporating dual fluorescence and phosphorescence into a single matrix is attractive for oxygen sensing, but material design is challenging. Here the authors achieve dual fluorescence-phosphorescence from a single linker chromophore in a silver chalcogenolate-cluster-based metal-organic framework.
Journal Article
Analysis of axial shortening induced by orthokeratology lenses and its mechanical mechanisms
This study aims to examine the short-term axial shortening effects of orthokeratology (ortho-K) lenses and investigate their mechanical mechanisms.
We conducted a retrospective analysis on 80 myopic children, aged 8-18, who wore ortho-K lenses for one week. Axial lengths were measured pre- and post-treatment using AL-Scan Optical Biometer. We developed a finite element model of the eye using ABAQUS software to explore mechanical changes.
A significant reduction in axial length was observed after one week of ortho-K lens wear, with an average decrease of 0.028 ± 0.032 mm (P = 4.02 x 10-11). Approximately 82.5% of participants exhibited axial length reduction. The biomechanical model indicated that ortho-K lenses exerted forces altering the tension dynamics within the ocular structure, notably decreasing tension in the posterior ciliary muscle-lens complex. This differential change in tension may account for the mechanical basis of the observed short-term reduction in axial length.
Orthokeratology lenses induce a short-term shortening in axial length, likely due to mechanical changes in ocular tension dynamics. The finite element model suggests that these lenses decrease posterior ciliary-lens complex tension, leading to axial shortening. These findings enhance comprehension of the mechanical basis for myopia control via ortho-K treatment, highlighting potential avenues for further applied research in myopia management.
Journal Article
Radiomics analysis of multiparametric MRI for prediction of pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
ObjectivesTo develop and validate a radiomics predictive model based on pre-treatment multiparameter magnetic resonance imaging (MRI) features and clinical features to predict a pathological complete response (pCR) in patients with locally advanced rectal cancer (LARC) after receiving neoadjuvant chemoradiotherapy (CRT).MethodsOne hundred and eighty-six consecutive patients with LARC (training dataset, n = 131; validation dataset, n = 55) were enrolled in our retrospective study. A total of 1,188 imaging features were extracted from pre-CRT T2-weighted (T2-w), contrast-enhanced T1-weighted (cT1-w) and ADC images for each patient. Three steps including least absolute shrinkage and selection operator (LASSO) regression were performed to select key features and build a radiomics signature. Combining clinical risk factors, a radiomics nomogram was constructed. The predictive performance was evaluated by receiver operator characteristic (ROC) curve analysis, and then assessed with respect to its calibration, discrimination and clinical usefulness.ResultsThirty-one of 186 patients (16.7%) achieved pCR. The radiomics signature derived from joint T2-w, ADC, and cT1-w images, comprising 12 selected features, was significantly associated with pCR status and showed better predictive performance than signatures derived from either of them alone in both datasets. The radiomics nomogram, incorporating the radiomics signature and MR-reported T-stages, also showed good discrimination, with areas under the ROC curves (AUCs) of 0.948 (95% CI, 0.907-0.989) and 0.966 (95% CI, 0.924-1.000), as well as good calibration in both datasets. Decision curve analysis confirmed its clinical usefulness.ConclusionsThis study demonstrated that the pre-treatment radiomics nomogram can predict pCR in patients with LARC and potentially guide treatments to select patients for a “wait-and-see” policy.Key Points• Radiomics analysis of pre-CRT multiparameter MR images could predict pCR in patients with LARC.• Proposed radiomics signature from joint T2-w, ADC and cT1-w images showed better predictive performance than individual signatures.• Most of the clinical characteristics were unable to predict pCR.
Journal Article
circMAN1A2 could serve as a novel serum biomarker for malignant tumors
Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real‐time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer. We verified that circMAN1A2 was significantly upregulated in the sera of patients with NPC, oral cancer, thyroid cancer, ovarian cancer, and lung cancer and had good clinical diagnostic value. We speculate that circMAN1A2 could be a serum biomarker for malignant cancers and provide effective clues for the early diagnosis of malignant cancers.
Journal Article