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"Zheng, Dan-Dan"
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Design thinking is ambidextrous
Purpose
The purpose of this paper is to address the theoretical gap between design thinking (DT) and management. DT is a strategic concept in the current business world whereas the discussion of it is still insufficient. Ambidexterity could be a promising concept to explain the benefits of DT in the realm of management and strategy.
Design/methodology/approach
This paper conducts a thorough literature review and theoretical analysis, and offers propositions that engage the outcome of DT and the ambidextrous learning and innovation.
Findings
The author suggests the connection between DT and ambidexterity. By thoroughly discussing the effect of the traits of DT on ambidexterity, the author proposes that DT can facilitate ambidextrous learning, and ambidextrous learning could mediate the relationships between DT and ambidextrous innovation.
Research limitations/implications
This paper offers a preliminary ground for the operationalization of it. Besides, ambidexterity could provide a lens to discuss DT with other strategic concept. Furthermore, the discussion extends understanding of the pursuit of individual ambidexterity.
Practical implications
This paper provides a clearer reason for managers to adopt DT. Furthermore, it might facilitate the management education in management schools to incorporate DT as a section topic, and subsequently propagate education of DT in management schools.
Originality/value
The paper offers a theoretical platform for the study of DT in the field of management and strategy, which was rare before. The integration of DT and ambidexterity offers a decision support to the managers. Furthermore, it serves as a new approach to obtain ambidexterity in organization, which addresses the call of the research on the micro-foundations of management.
Journal Article
Immune cell patterns before and after neoadjuvant immune checkpoint blockade combined with chemoradiotherapy in locally advanced esophageal squamous cell carcinoma
Background
Neoadjuvant immune checkpoint blockade (ICB) combined with chemoradiotherapy offers high pathologic complete response (pCR) rate for patients with locally advanced esophageal squamous cell carcinomas (ESCC). But the dynamic tumor immune microenvironment modulated by such neoadjuvant therapy remains unclear.
Patients and methods
A total of 41 patients with locally advanced ESCC were recruited. All patients received neoadjuvant toripalimab combined with concurrent chemoradiotherapy. Matched pre- and post-treatment tissues were obtained for fluorescent multiplex immunohistochemistry (mIHC) and IHC analyses. The densities and spatial distributions of immune cells were determined by HALO modules. The differences of immune cell patterns before and after neoadjuvant treatment were investigated.
Results
In the pre-treatment tissues, more stromal CD3 + FoxP3 + Tregs and CD86+/CD163 + macrophages were observed in patients with residual tumor existed in the resected lymph nodes (pN1), compared with patients with pCR. The majority of macrophages were distributed in close proximity to tumor nest in pN1 patients. In the post-treatment tissues, pCR patients had less CD86 + cell infiltration, whereas higher CD86 + cell density was significantly associated with higher tumor regression grades (TRG) in non-pCR patients. When comparing the paired pre- and post-treatment samples, heterogeneous therapy-associated immune cell patterns were found. Upon to the treatment, CD3 + T lymphocytes were slightly increased in pCR patients, but markedly decreased in non-pCR patients. In contrast, a noticeable increase and a less obvious decrease of CD86 + cell infiltration were respectively depicted in non-pCR and pCR patients. Furthermore, opposite trends of the treatment-induced alterations of CD8 + and CD15 + cell infiltrations were observed between pN0 and pN1 patients.
Conclusions
Collectively, our data demonstrate a comprehensive picture of tumor immune landscape before and after neoadjuvant ICB combined with chemoradiotherapy in ESCC. The infiltration of CD86 + macrophage may serve as an unfavorable indicator for neoadjuvant toripalimab combined with chemoradiotherapy.
Journal Article
High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy
Mitochondrial dysfunction and impaired Ca
2+
handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of phosphorylation, and the Orai1 (Ca
2+
release-activated calcium channel protein 1) calcium channel is important for the increase in Ca
2+
entry into cardiomyocytes. We aimed to explore the mechanism of Drp1 and Orai1 in cardiomyocyte hypertrophy caused by high glucose (HG). We found that Zucker diabetic fat rats induced by administration of a high-fat diet develop cardiac hypertrophy and impaired cardiac function, accompanied by the activation of mitochondrial dynamics and calcium handling pathway-related proteins. Moreover, HG induces cardiomyocyte hypertrophy, accompanied by abnormal mitochondrial morphology and function, and increased Orai1-mediated Ca
2+
influx. Mechanistically, the Drp1 inhibitor mitochondrial division inhibitor 1 (Mdivi-1) prevents cardiomyocyte hypertrophy induced by HG by reducing phosphorylation of Drp1 at serine 616 (S616) and increasing phosphorylation at S637. Inhibition of Orai1 with single guide RNA (sgOrai1) or an inhibitor (BTP2) not only suppressed Drp1 activity and calmodulin-binding catalytic subunit A (CnA) and phosphorylated-extracellular signal-regulated kinase (p-ERK1/2) expression but also alleviated mitochondrial dysfunction and cardiomyocyte hypertrophy caused by HG. In addition, the CnA inhibitor cyclosporin A and p-ERK1/2 inhibitor U0126 improved HG-induced cardiomyocyte hypertrophy by promoting and inhibiting phosphorylation of Drp1 at S637 and S616, respectively. In summary, we identified Drp1 as a downstream target of Orai1-mediated Ca
2+
entry, via activation by p-ERK1/2-mediated phosphorylation at S616 or CnA-mediated dephosphorylation at S637 in DCM. Thus, the Orai1–Drp1 axis is a novel target for treating DCM.
Journal Article
Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice
Diabetes mellitus (DM) is a common chronic metabolic disease caused by significant accumulation of advanced glycation end products (AGEs). Atrial fibrillation (AF) is a common cardiovascular complication of DM. Here, we aim to clarify the role and mechanism of atrial myocyte senescence in the susceptibility of AF in diabetes. Rapid transesophageal atrial pacing was used to monitor the susceptibility of mice to AF. Whole‐cell patch‐clamp was employed to record the action potential (AP) and ion channels in single HL‐1 cell and mouse atrial myocytes. More importantly, anti‐RAGE antibody and RAGE‐siRNA AAV9 were used to investigate the relationship among diabetes, aging, and AF. The results showed that elevated levels of p16 and retinoblastoma (Rb) protein in the atrium were associated with increased susceptibility to AF in diabetic mice. Mechanistically, AGEs increased p16/Rb protein expression and the number of SA‐β‐gal‐positive cells, prolonged the action potential duration (APD), reduced protein levels of Cav1.2, Kv1.5, and current density of ICa,L, IKur in HL‐1 cells. Anti‐RAGE antibody or RAGE‐siRNA AAV9 reversed these effects in vitro and in vivo, respectively. Furthermore, downregulating p16 or Rb by siRNA prevented AGEs‐mediated reduction of Cav1.2 and Kv1.5 proteins expression. In conclusion, AGEs accelerated atrial electrical remodeling and cellular senescence, contributing to increased AF susceptibility by activating the p16/Rb pathway. Inhibition of RAGE or the p16/Rb pathway may be a potential therapeutic target for AF in diabetes. Diabetes mellitus (DM) is a common chronic metabolic disease and an independent risk factor for atrial fibrillation (AF). However, the regulatory mechanisms underlying atrial electrical remodeling in diabetes are not fully understood. This study presents new insights into the role and mechanism of atrial myocyte senescence in diabetic‐induced AF. Inhibition of RAGE or the p16/Rb pathway may be a potential therapeutic target for AF in diabetes.
Journal Article
Molecular modeling of CO2 affecting competitive adsorption within anthracite coal
This study aimed to investigate the adsorption properties of CO
2
, CH
4
, and N
2
on anthracite. A molecular structural model of anthracite (C
208
H
162
O
12
N
4
) was established. Simulations were performed for the adsorption properties of single-component and multi-component gases at various temperatures, pressures, and gas ratios. The grand canonical ensemble Monte Carlo approach based on molecular mechanics and dynamics theories was used to perform the simulations. The results showed that the isotherms for the adsorption of single-component CO
2
, CH
4
, and N
2
followed the Langmuir formula, and the CO
2
adsorption isotherm growth gradient was negatively correlated with pressure but positively correlated with temperature. When the CO
2
injection in the gas mixture was increased from 1 to 3% for the multi-component gas adsorption, the proportion of CO
2
adsorption rose from 1/3 to 2/3, indicating that CO
2
has a competing-adsorption advantage. The CO
2
adsorption decreased faster with increasing temperature, indicating that the sensitivity of CO
2
to temperature is stronger than that of CH
4
and N
2
. The adsorbent potential energies of CO
2
, CH
4
, and N
2
diminished with rising temperature in the following order: CO
2
< CH
4
< N
2
.
Journal Article
Comparative plastomes of Pueraria montana var. lobata (Leguminosae: Phaseoleae) and closely related taxa: insights into phylogenomic implications and evolutionary divergence
Background
Pueraria montana
var.
lobata
(kudzu) is an important food and medicinal crop in Asia. However, the phylogenetic relationships between
Pueraria montana
var.
lobata
and the other two varieties (
P. montana
var.
thomsonii
and
P. montana
var.
montana
) remain debated. Although there is increasing evidence showing that
P. montana
var.
lobata
adapts to various environments and is an invasive species in America, few studies have systematically investigated the role of the phylogenetic relationships and evolutionary patterns of plastomes between
P. montana
var.
lobata
and its closely related taxa.
Results
26 newly sequenced chloroplast genomes of
Pueraria
accessions resulted in assembled plastomes with sizes ranging from 153,360 bp to 153,551 bp. Each chloroplast genome contained 130 genes, including eight rRNA genes, 37 tRNA genes, and 85 protein-coding genes. For 24 newly sequenced accessions of these three varieties of
P. montana
, we detected three genes and ten noncoding regions with higher nucleotide diversity (π). After incorporated publically available chloroplast genomes of
Pueraria
and other legumes, 47 chloroplast genomes were used to construct phylogenetic trees, including seven
P. montana
var.
lobata
, 14
P. montana
var.
thomsonii
and six
P. montana
var.
montana
. Phylogenetic analysis revealed that
P. montana
var.
lobata
and
P. montana
var.
thomsonii
formed a clade, while all sampled
P. montana
var.
montana
formed another cluster based on cp genomes, LSC, SSC and protein-coding genes. Twenty-six amino acid residues were identified under positive selection with the site model. We also detected six genes (
accD, ndhB, ndhC, rpl2, rpoC2
, and
rps2
) that account for among-site variation in selective constraint under the clade model between accessions of the
Pueraria montana
var.
lobata
clade and the
Pueraria montana
var.
montana
clade.
Conclusion
Our data provide novel comparative plastid genomic insights into conservative gene content and structure of cp genomes pertaining to
P. montana
var.
lobata
and the other two varieties, and reveal an important phylogenetic clue and plastid divergence among related taxa of
P. montana
come from loci that own moderate variation and underwent modest selection.
Journal Article
Increased matrix stiffness promotes tumor progression of residual hepatocellular carcinoma after insufficient heat treatment
Aggravated behaviors of hepatocellular carcinoma (HCC) will occur after inadequate thermal ablation. However, its underlying mechanisms are not fully understood. Here, we assessed whether the increased matrix stiffness after thermal ablation could promote the progression of residual HCC. Heat‐treated residual HCC cells were cultured on tailorable 3D gel with different matrix stiffness, simulating the changed physical environment after thermal ablation, and then the mechanical alterations of matrix stiffness on cell phenotypes were explored. Increased stiffness was found to significantly promote the proliferation of the heat‐treated residual HCC cells when the cells were cultured on stiffer versus soft supports, which was associated with stiffness‐dependent regulation of ERK phosphorylation. Heat‐exposed HCC cells cultured on stiffer supports showed enhanced motility. More importantly, vitamin K1 reduced stiffness‐dependent residual HCC cell proliferation by inhibiting ERK phosphorylation and suppressed the in vivo tumor growth, which was further enhanced by combining with sorafenib. Increased matrix stiffness promotes the progression of heat‐treated residual HCC cells, proposing a new mechanism of an altered biomechanical environment after thermal ablation accelerates HCC development. Vitamin K1 plus sorafenib can reverse this protumor effect. Increased matrix stiffness after thermal ablation accelerates the progression of heat‐exposed residual HCC cells. Vitamin K1 and sorafenib disrupt the stiffness‐induced ERK activation to reverse the pro‐tumor effect as the potential therapeutic drugs. This new finding will help design strategy to treat the local tumor progression and prevent its rapid progression after RFA in the treatment of medium or large HCC.
Journal Article
Analysis of Chinese consumers’ willingness and behavioral change to purchase Green agri-food product online
Internet coupled with agricultural development in full swing, green agri-food product e-commerce has become a hot topic in the development of e-commerce. However, due to the seasonality, territoriality, weak quality, difference, and dispersion of agri-food products, e-commerce of green agri-food products are facing difficulties. Based on the gap between consumers’ willingness and behavior to buy green agri-food products online, this paper quantitatively studied the factors that affect consumers’ behavior deviation to buy green agri-food products online. The method of constructing the binary Logistic regression model was adopted, and analysis tools such as SPSS and Excel were used for analysis, to study the influence of various factors on consumers’ purchase willingness and behavior. The research conclusion shows that: consumers’ gender, age, understanding of online agri-food products, and monthly disposable income have a positive impact on the consistency of consumers’ behavior and willingness, while the price of green agri-food products and online purchasing frequency have a negative impact on consumers’ willingness and behavior of online purchasing. The results are discussed in the context of existing studies. Suggestions and research prospects are presented at the end of the article.
Journal Article
The quality and reliability of endometrial cancer-related videos on social short video platforms: a cross-sectional study
Background
With the increasing public awareness of health, TikTok and Bilibili have become the domain source of short-video platforms for health-related information. This study aims to investigate the quality and reliability of short videos about endometrial cancer on two platforms.
Methods
This cross-sectional study was conducted on TikTok and Bilibili to evaluate short videos related to endometrial cancer. The two platforms were searched using the term ‘endometrial cancer’ from 15:00 to 22:00 on 29 September 2025. The quality of related information was assessed by the Global Quality Score (GQS) and the modified DISCERN score (mDISCERN), and analyzed by descriptive statistics, inter-group comparison, and correlation analysis.
Results
200 initial endometrial cancer-related videos were searched, and finally, 174 videos were included from TikTok and Bilibili. The GQS and mDISCERN scores of both platforms were low (median 2/5), and the median(Q1-Q3) duration of these videos was 80 s (46.50-144.50), and the duration of Bilibili videos was longer (111 s to 63 s,
P
< 0.001). The engagement with TikTok videos was relatively high (median likes: 1342 to 6,
P
< 0.001). Expert-uploaded videos were longer than those from other origins (median 109 s) and of better quality (median mDISCERN 3/5,
P
< 0.001). The quality component was positively associated with the duration of short videos(
r
= 0.42–0.46). The five major dimensions of health demonstrated “fragmented content and insufficient depth”: the highest coverage rate of symptoms was 36.2%, while the lowest coverage rate of prevention was 3.5%; the coverage rates of etiology, diagnosis, and therapy were all below 20%.
Conclusions
Significant quality gaps exist in endometrial cancer videos. To enhance the structure and completeness of health information, professional participation should be strengthened in the future.
Journal Article