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"Zheng, Hao"
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Categories of quantum liquids I
A
bstract
We develop a mathematical theory of separable higher categories based on Gaiotto and Johnson-Freyd’s work on condensation completion. Based on this theory, we prove some fundamental results on
E
m
-multi-fusion higher categories and their higher centers. We also outline a theory of unitary higher categories based on a ∗-version of condensation completion. After these mathematical preparations, based on the idea of topological Wick rotation, we develop a unified mathematical theory of all quantum liquids, which include topological orders, SPT/SET orders, symmetry-breaking orders and CFT-like gapless phases. We explain that a quantum liquid consists of two parts, the topological skeleton and the local quantum symmetry, and show that all
n
D quantum liquids form a ∗-condensation complete higher category whose equivalence type can be computed explicitly from a simple coslice 1-category.
Journal Article
A mathematical theory of gapless edges of 2d topological orders. Part I
A
bstract
This is the first part of a two-part work on a unified mathematical theory of gapped and gapless edges of 2d topological orders. We analyze all the possible observables on the 1+1D world sheet of a chiral gapless edge of a 2d topological order, and show that these observables form an enriched unitary fusion category, the Drinfeld center of which is precisely the unitary modular tensor category associated to the bulk. This mathematical description of a chiral gapless edge automatically includes that of a gapped edge (i.e. a unitary fusion category) as a special case. Therefore, we obtain a unified mathematical description and a classification of both gapped and chiral gapless edges of a given 2d topological order. In the process of our analysis, we encounter an interesting and reoccurring phenomenon: spatial fusion anomaly, which leads us to propose the Principle of Universality at RG fixed points for all quantum field theories. Our theory also implies that all chiral gapless edges can be obtained from a so-called topological Wick rotations. This fact leads us to propose, at the end of this work, a surprising correspondence between gapped and gapless phases in all dimensions.
Journal Article
Topological band structure via twisted photons in a degenerate cavity
Synthetic dimensions based on particles’ internal degrees of freedom, such as frequency, spatial modes and arrival time, have attracted significant attention. They offer ideal large-scale lattices to simulate nontrivial topological phenomena. Exploring more synthetic dimensions is one of the paths toward higher dimensional physics. In this work, we design and experimentally control the coupling among synthetic dimensions consisting of the intrinsic photonic orbital angular momentum and spin angular momentum degrees of freedom in a degenerate optical resonant cavity, which generates a periodically driven spin-orbital coupling system. We directly characterize the system’s properties, including the density of states, energy band structures and topological windings, through the transmission intensity measurements. Our work demonstrates a mechanism for exploring the spatial modes of twisted photons as the synthetic dimension, which paves the way to design rich topological physics in a highly compact platform.
Tailoring topological physics in optical cavity is a challenge that would allow new possibilities for the design optical components. In this paper, the authors, harnessing the potential of synthetic dimensions, experimentally demonstrate a degenerate cavity containing many optical angular momenta.
Journal Article
Dietary Polyphenol, Gut Microbiota, and Health Benefits
Polyphenols, which are probably the most important secondary metabolites produced by plants, have attracted tremendous attention due to their health-promoting effects, including their antioxidant, anti-inflammatory, antibacterial, anti-adipogenic, and neuro-protective activities, as well as health properties. However, due to their complicated structures and high molecular weights, a large proportion of dietary polyphenols remain unabsorbed along the gastrointestinal tract, while in the large intestine they are biotransformed into bioactive, low-molecular-weight phenolic metabolites through the residing gut microbiota. Dietary polyphenols can modulate the composition of intestinal microbes, and in turn, gut microbes catabolize polyphenols to release bioactive metabolites. To better investigate the health benefits of dietary polyphenols, this review provides a summary of their modulation through in vitro and in vivo evidence (animal models and humans), as well as their possible actions through intestinal barrier function and gut microbes. This review aims to provide a basis for better understanding the relationship between dietary polyphenols, gut microbiota, and host health.
Journal Article
snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology
Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent increase in research on snoRNAs, new evidence has emerged indicating that snoRNAs also participate in tRNA and mRNA modification. Studies suggest that numerous snoRNAs, including tumor-promoting and tumor-suppressing snoRNAs, are not only dysregulated in tumors but also show associations with clinical prognosis. In this review, we summarize the reported functions of snoRNAs and the possible mechanisms underlying their role in tumorigenesis and cancer development to guide the snoRNA-based clinical diagnosis and treatment of cancer in the future.
Journal Article
The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma
Background
Dysfunctions of long non-coding RNA (lncRNAs) have been associated with the initiation and progression of hepatocellular carcinoma (HCC), but the clinicopathologic significance and potential role of lncRNA PTTG3P (pituitary tumor-transforming 3, pseudogene) in HCC remains largely unknown.
Methods
We compared the expression profiles of lncRNAs in 3 HCC tumor tissues and adjacent non-tumor tissues by microarrays. In situ hybridization (ISH) and quantitative real-time polymerase chain reaction (qRT-PCR) were applied to assess the level of PTTG3P and prognostic values of PTTG3P were assayed in two HCC cohorts (
n
= 46 and 90). Artificial modulation of PTTG3P (down- and over-expression) was performed to explore the role of PTTG3P in tumor growth and metastasis in vitro and in vivo. Involvement of PTTG1 (pituitary tumor-transforming 1), PI3K/AKT signaling and its downstream signals were validated by qRT-PCR and western blot.
Results
We found that PTTG3P was frequently up-regulated in HCC and its level was positively correlated to tumor size, TNM stage and poor survival of patients with HCC. Enforced expression of PTTG3P significantly promoted cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Conversely, PTTG3P knockdown had opposite effects. Mechanistically, over-expression of PTTG3P up-regulated PTTG1, activated PI3K/AKT signaling and its downstream signals including cell cycle progression, cell apoptosis and epithelial-mesenchymal transition (EMT)-associated genes.
Conclusions
Our findings suggest that PTTG3P, a valuable marker of HCC prognosis, promotes tumor growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in HCC and might represent a potential target for gene-based therapy.
Journal Article
Fucoxanthin Induces Ferroptosis in Cancer Cells via Downregulation of the Nrf2/HO−1/GPX4 Pathway
This study investigated the mechanism by which fucoxanthin acts as a novel ferroptosis inducer to inhibit tongue cancer. The MTT assay was used to detect the inhibitory effects of fucoxanthin on SCC−25 human tongue squamous carcinoma cells. The levels of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and total iron were measured. Reverse transcription–quantitative polymerase chain reaction (RT−qPCR) and Western blotting were used to assess glutathione peroxidase 4 (GPX4), nuclear factor erythroid 2−related factor 2 (Nrf2), Keap1, solute carrier family 7 member 11 (SLC7A11), transferrin receptor protein 1 (TFR1), p53, and heme oxygenase 1 (HO−1) expression. Molecular docking was performed to validate interactions. Compared with the control group, the activity of fucoxanthin−treated SCC−25 cells significantly decreased in a dose− and time−dependent manner. The levels of MMP, GSH, and SOD significantly decreased in fucoxanthin−treated SCC−25 cells; the levels of ROS, MDA, and total iron significantly increased. mRNA and protein expression levels of Keap1, GPX4, Nrf2, and HO−1 in fucoxanthin−treated cells were significantly decreased, whereas levels of TFR1 and p53 were significantly increased, in a concentration−dependent manner. Molecular docking analysis revealed that binding free energies of fucoxanthin with p53, SLC7A11, GPX4, Nrf2, Keap1, HO−1, and TFR1 were below −5 kcal/mol, primarily based on active site hydrogen bonding. Our findings suggest that fucoxanthin can induce ferroptosis in SCC−25 cells, highlighting its potential as a treatment for tongue cancer.
Journal Article
Ferroptosis at the crossroads of infection, aging and cancer
Despite significant developments and persistent efforts by scientists, cancer is one of the primary causes of human death worldwide. No form of life on Earth can survive without iron, although some species can live without oxygen. Iron presents a double‐edged sword. Excess iron is a risk for carcinogenesis, while its deficiency causes anemia, leading to oxygen shortage. Every cell is eventually destined to death, either through apoptosis or necrosis. Regulated necrosis is recognized in distinct forms. Ferroptosis is defined as catalytic Fe(II)‐dependent regulated necrosis accompanied by lipid peroxidation. The main observation was necrosis of fibrosarcoma cells through inhibition of cystine/glutamate antiporter with erastin, which reduced intracellular cysteine and, thus, glutathione levels. Our current understanding of ferroptosis is relative abundance of iron (catalytic Fe[II]) in comparison with sulfur (sulfhydryls). Thus, either excess iron or sulfur deficiency causes ferroptosis. Cell proliferation inevitably requires iron for DNA synthesis and energy production. Carcinogenesis is a process toward iron addiction with ferroptosis resistance. Conversely, ferroptosis is associated with aging and neurodegeneration. Ferroptosis of immune cells during infection is advantageous for infectious agents, whereas ferroptosis resistance incubates carcinogenic soil as excess iron. Cancer cells are rich in catalytic Fe(II). Directing established cancer cells to ferroptosis is a novel strategy for discovering cancer therapies. Appropriate iron regulation could be a tactic to reduce and delay carcinogenesis. Ferroptosis is defined as catalytic Fe(II)‐dependent regulated necrosis accompanied by lipid peroxidation. Carcinogenesis is a process to establish iron addiction with ferroptosis resistance. Directing established cancer cells to ferroptosis is a novel strategy to discover new cancer therapies.
Journal Article
Research on Customized Method of Post-processing of DMU125P Five-axis Machine Tool
With the increasing improvement of China’s industrial production technology, more and more attention is paid to the application of new five-axis CNC machine tools, and it is also urgent to strengthen the post-processing design. However, there are still many problems in the post-processing of DMU125P five-axis machine tools at this stage. The method is analyzed by combining the post-processing requirements of the DMU125P five-axis machine tool. At the same time, most studies in recent years have found that the use of post-processing application design is critical to improving the processing of complex mechanical parts. This study will analyze the post-processing customization method of the DMU125P five-axis machine tool, and provide a basis for the next step of work.
Journal Article